Targeting Notch signaling for cancer therapeutic intervention.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Advances in Pharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-397927-8.00007-5PMID 22959027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Notch signaling in the immune system.

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• Notch Promotes Radioresistance of Glioma Stem Cells

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• Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy.

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• gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity.

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• Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells.

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• Regulation of Notch1/NICD and Hes1 expressions by GSK-3α/β

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• Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta.

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• Regulation of Notch and Wingless signalling by phyllopod, a transcriptional target of the EGFR pathway

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• Ligand-dependent Notch Signaling Is Involved in Tumor Initiation and Tumor Maintenance in Pancreatic Cancer

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• Active Notch1 confers a transformed phenotype to primary human melanocytes.

  2009cited by this paper
• TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway.

  2009cited by this paper
• Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

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• Modulation of γ-secretase specificity using small molecule allosteric inhibitors

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• Structural and functional characterization of the NHR1 domain of the Drosophila neuralized E3 ligase in the notch signaling pathway.

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• The tumor microenvironment and its contribution to tumor evolution toward metastasis

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• Neuroendocrine differentiation in the 12T‐10 transgenic prostate mouse model mimics endocrine differentiation of pancreatic beta cells

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• Notch signaling regulates tumor angiogenesis by diverse mechanisms

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• Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling*

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• Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3*

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• Activity of gamma-secretase on substrates other than APP.

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• Kuz and TACE can activate Notch independent of ligand

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• Inhibition of Notch signaling induces apoptosis of myeloma cells and enhances sensitivity to chemotherapy.

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• ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a γ-secretase inhibitor

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• Notch signaling inhibits growth of the human lung adenocarcinoma cell line A549.

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