Epigenetic regulation of hybrid epithelial-mesenchymal cell states in cancer

No abstract is available for this paper.

• Publication year

  2023

• Venue

  Oncogene

• Publication date

  2023-06-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41388-023-02749-9PMID 37344626PMCID PMC10578205
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

  2023cited by this paper
• Hallmarks of Cancer: New Dimensions.

  2022cited by this paper
• EZH2 endorses cell plasticity to non-small cell lung cancer cells facilitating mesenchymal to epithelial transition and tumour colonization

  2022cited by this paper
• Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

  2022cited by this paper
• Epithelial-mesenchymal plasticity in tumor immune evasion.

  2022cited by this paper
• Navigating the DNA methylation landscape of cancer.

  2021cited by this paper
• Snail/PRMT5/NuRD complex contributes to DNA hypermethylation in cervical cancer by TET1 inhibition

  2021influential reference
• Recent developments in epigenetic cancer therapeutics: clinical advancement and emerging trends

  2021cited by this paper
• Distinct contributions of partial and full EMT to breast cancer malignancy.

  2021cited by this paper
• Partial EMT in head and neck cancer biology: a spectrum instead of a switch

  2021cited by this paper
• Loss of ARID1A Promotes Epithelial–Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress

  2020cited by this paper
• BRD4 regulates key transcription factors that drive epithelial–mesenchymal transition in castration-resistant prostate cancer

  2020cited by this paper
• Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis

  2020cited by this paper
• Vimentin filaments drive migratory persistence in polyploidal cancer cells

  2020cited by this paper
• Inhibition of BRD4 prevents proliferation and epithelial–mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis

  2020cited by this paper
• BRD4 regulates key transcription factors that drive epithelial-mesenchymal transition in castration-resistant prostate cancer

  2020cited by this paper
• KDM3A regulates Slug expression to promote the invasion of MCF7 breast cancer cells in hypoxia

  2020cited by this paper
• Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis

  2020cited by this paper
• Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

  2020cited by this paper
• Direct and Indirect Regulators of Epithelial-Mesenchymal Transition (EMT)-mediated Immunosuppression in Breast Carcinomas.

  2020cited by this paper
• Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail

  2019cited by this paper
• Histone deacetylases, Mbd3/NuRD, and Tet2 hydroxylase are crucial regulators of epithelial–mesenchymal plasticity and tumor metastasis

  2019cited by this paper
• A gene regulatory network to control EMT programs in development and disease

  2019cited by this paper
• G9a and histone deacetylases are crucial for Snail2‐mediated E‐cadherin repression and metastasis in hepatocellular carcinoma

  2019cited by this paper
• The diverse roles of DNA methylation in mammalian development and disease

  2019cited by this paper
• BRD4 promotes gastric cancer progression and metastasis through acetylation-dependent stabilization of Snail.

  2019cited by this paper
• Non-redundant functions of EMT transcription factors

  2019cited by this paper
• Epithelial-Mesenchymal Plasticity in Cancer Progression and Metastasis.

  2019cited by this paper
• The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective

  2019cited by this paper
• ZEB1/NuRD complex suppresses TBC1D2b to stimulate E-cadherin internalization and promote metastasis in lung cancer

  2019influential reference
• An EMT‐related gene signature for the prognosis of human bladder cancer

  2019cited by this paper
• p300 promotes proliferation, migration, and invasion via inducing epithelial-mesenchymal transition in non-small cell lung cancer cells

  2018cited by this paper
• Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.

  2018cited by this paper
• TIP60-dependent acetylation of the SPZ1-TWIST complex promotes epithelial–mesenchymal transition and metastasis in liver cancer

  2018cited by this paper
• New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

  2018influential reference
• BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition

  2018cited by this paper
• Identification of the tumour transition states occurring during EMT

  2018influential reference
• A Transcriptional Program for Detecting TGFβ-Induced EMT in Cancer

  2017cited by this paper
• An esophageal squamous cell carcinoma classification system that reveals potential targets for therapy

  2017cited by this paper
• Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.

  2017cited by this paper
• Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

  2017cited by this paper
• Writing, erasing and reading histone lysine methylations

  2017cited by this paper
• DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells.

  2017cited by this paper
• Emerging Biological Principles of Metastasis.

  2017cited by this paper
• Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis

  2017cited by this paper
• Twist1 Promotes Breast Cancer Invasion and Metastasis by Silencing Foxa1 Expression

  2016influential reference
• Metabolic regulation of gene expression through histone acylations

  2016cited by this paper
• Grainyhead-like 2 inhibits the coactivator p300, suppressing tubulogenesis and the epithelial–mesenchymal transition

  2016cited by this paper
• Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications

  2016cited by this paper
• Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma

  2016cited by this paper
• The chromatin-remodeling enzyme BRG1 promotes colon cancer progression via positive regulation of WNT3A

  2016cited by this paper
• EZH2 inhibition promotes epithelial-to-mesenchymal transition in ovarian cancer cells

  2016cited by this paper
• Targeting metastasis-initiating cells through the fatty acid receptor CD36

  2016cited by this paper
• Wound repair: a showcase for cell plasticity and migration.

  2016influential reference
• EMT: 2016.

  2016cited by this paper
• DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis1

  2016influential reference
• A TGFβ-PRMT5-MEP50 Axis Regulates Cancer Cell Invasion through Histone H3 and H4 Arginine Methylation Coupled Transcriptional Activation and Repression

  2016cited by this paper
• The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition

  2016cited by this paper
• The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1

  2016cited by this paper
• TIP60 inhibits metastasis by ablating DNMT1-SNAIL2-driven epithelial-mesenchymal transition program.

  2016cited by this paper
• UTX inhibits EMT‐induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1

  2015cited by this paper
• DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression

  2015cited by this paper
• Histone demethylase RBP2 promotes malignant progression of gastric cancer through TGF-β1-(p-Smad3)-RBP2-E-cadherin-Smad3 feedback circuit

  2015cited by this paper
• Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis.

  2015cited by this paper
• Vimentin-ERK Signaling Uncouples Slug Gene Regulatory Function.

  2015cited by this paper
• ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

  2015cited by this paper
• G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma

  2015cited by this paper
• Lysine-specific demethylase 1 mediates epidermal growth factor signaling to promote cell migration in ovarian cancer cells

  2015cited by this paper
• EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-β

  2015cited by this paper
• Conversion to stem‐cell state in response to microenvironmental cues is regulated by balance between epithelial and mesenchymal features in lung cancer cells

  2015cited by this paper
• PRMT7 induces epithelial-to-mesenchymal transition and promotes metastasis in breast cancer.

  2014cited by this paper
• Transient SNAIL1 expression is necessary for metastatic competence in breast cancer.

  2014cited by this paper
• Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis

  2014cited by this paper
• Molecular mechanisms of epithelial–mesenchymal transition

  2014cited by this paper
• Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.

  2014cited by this paper
• Inhibition of Epithelial to Mesenchymal Transition by E-cadherin Up-regulation via Repression of Slug Transcription and Inhibition of E-cadherin Degradation

  2014cited by this paper
• Epigenetic regulation of EMT: the Snail story.

  2014influential reference
• TGF-β induces global changes in DNA methylation during the epithelial-to-mesenchymal transition in ovarian cancer cells

  2014cited by this paper
• EED regulates epithelial-mesenchymal transition of cancer cells induced by TGF-β.

  2014cited by this paper
• The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

  2014cited by this paper
• An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530)

  2013cited by this paper
• BRG1 Is a Prognostic Marker and Potential Therapeutic Target in Human Breast Cancer

  2013cited by this paper
• RBP2 Induces Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer

  2013cited by this paper
• DNA methylation: roles in mammalian development

  2013cited by this paper
• DNA Methylation and Its Basic Function

  2013cited by this paper
• Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming.

  2013cited by this paper
• JMJD2B Promotes Epithelial–Mesenchymal Transition by Cooperating with β-Catenin and Enhances Gastric Cancer Metastasis

  2013cited by this paper
• SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

  2012cited by this paper
• Meta-Analysis of Gene Expression Signatures Defining the Epithelial to Mesenchymal Transition during Cancer Progression

  2012cited by this paper
• Interaction with Suv39H1 is Critical for Snail-mediated E-cadherin Repression in Breast Cancer

  2012cited by this paper
• H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

  2012cited by this paper
• Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response Element-binding Protein (CREB)-binding Protein (CBP)*

  2012cited by this paper
• G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.

  2012cited by this paper
• Histone Demethylase KDM6B Promotes Epithelial-Mesenchymal Transition*

  2012cited by this paper
• The Histone Methyltransferase MMSET/WHSC1 Activates TWIST1 to Promote an Epithelial-Mesenchymal Transition and Invasive Properties of Prostate Cancer

  2012cited by this paper
• Cooperation of p300 and PCAF in the Control of MicroRNA 200c/141 Transcription and Epithelial Characteristics

  2012cited by this paper
• Human Protein Arginine Methyltransferase 7 (PRMT7) Is a Type III Enzyme Forming ω-NG-Monomethylated Arginine Residues*

  2012cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Functional Cooperation between Snail1 and Twist in the Regulation of ZEB1 Expression during Epithelial to Mesenchymal Transition*

  2011cited by this paper
• Readers of histone modifications

  2011cited by this paper

• SMYD3 synergises with RACK1 to promote colorectal cancer lung metastasis by recruiting SMAD3

  2026cites this paper
• Dynamin‐Related Protein 1‐Dependent Disruption of Mitochondrial Homeostasis Drives Blue Light‐Induced Epithelial‐Mesenchymal Transition in Retinal Aging

  2026cites this paper
• Decoding the Regulatory Code: O-GlcNAcylation in Epithelial-Mesenchymal Transition (EMT).

  2026cites this paper
• Epithelial-mesenchymal Transition Promotes Metabolic Reprogramming to Suppress Ferroptosis.

  2025cites this paper
• Development and Characterization of Three Novel FGFR Inhibitor Resistant Cervical Cancer Cell Lines to Help Drive Cervical Cancer Research

  2025cites this paper
• Independent signaling pathways provide a fail-safe mechanism to prevent tumorigenesis

  2025cites this paper
• Epithelial-mesenchymal transition orchestrates tumor microenvironment: current perceptions and challenges

  2025cites this paper
• Epigenetic regulation of cancer stemness

  2025cites this paper
• TGFβ1–TNFα-regulated secretion of neutrophil chemokines is independent of epithelial–mesenchymal transition in breast tumor cells

  2025cites this paper
• Epithelial-mesenchymal transition.

  2025cites this paper
• Dietary Serine Restriction Impacts H3K27 and H3K4 Methyl Epigenomes to Impede Head and Neck Cancer Cell Plasticity and Tumor Growth

  2025cites this paper
• Hybrid EMT and inflammation: the deadly alliance

  2025cites this paper
• Epigenetic regulation of EZH2 by ncRNAs: mechanisms and oncogenic implications.

  2025cites this paper
• Unravelling the molecular crosstalk between Epithelial-Mesenchymal transition and human papillomavirus in oral cancer

  2025cites this paper
• Gain of function p53 mutant R273H confers distinct methylation profiles and consequent YAP/TAZ signaling mediated activation of partial or full EMT states to colon tumours

  2025cites this paper
• A multilevel formalism to model the hybrid E/M phenotypes in Epithelial-Mesenchymal Plasticity

  2025cites this paper
• HIV-1 Reverse Transcriptase Expression in HPV16-Infected Epidermoid Carcinoma Cells Alters E6 Expression and Cellular Metabolism, and Induces a Hybrid Epithelial/Mesenchymal Cell Phenotype

  2024cites this paper
• Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer

  2024cites this paper
• Epithelial–mesenchymal transition in tissue repair and degeneration

  2024cites this paper
• Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid

  2024cites this paper
• Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation.

  2024cites this paper
• Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles

  2024cites this paper
• High-adhesion ovarian cancer cell resistance to ferroptosis: The activation of NRF2/FSP1 pathway by junctional adhesion molecule JAM3.

  2024cites this paper
• KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.

  2023cites this paper
• Lineage Plasticity: the New Cancer Hallmark on the Block.

  2023cites this paper
• Long non-coding RNA SOX21-AS1: A potential tumor oncogene in human cancers.

  2023cites this paper
• Targeting lipid metabolism in cancer metastasis.

  2023cites this paper