Eating the enemy within: autophagy in infectious diseases

Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.

• Publication year

  2008

• Venue

  Cell Death and Differentiation

• Publication date

  2008-09-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/cdd.2008.130PMID 18772897PMCID 2736877
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
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  2007cited by this paper
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  2007cited by this paper
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  2007cited by this paper
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  2007influential reference
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  2007cited by this paper
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  2007cited by this paper
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  2007influential reference
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  2007cited by this paper
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  2004influential reference
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  2003cited by this paper
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  2003cited by this paper
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