Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature Genetics

• Publication date

  2004-09-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng1431PMID 15378063
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Comparative analysis of processed pseudogenes in the mouse and human genomes.

  2004cited by this paper
• Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.

  2004cited by this paper
• Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size.

  2004cited by this paper
• Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.

  2003cited by this paper
• Glutamine synthetase and glutamate dehydrogenase in the prefrontal cortex of patients with schizophrenia.

  2003cited by this paper
• Elevated gene expression levels distinguish human from non-human primate brains

  2003cited by this paper
• Nerve Tissue‐Specific (GLUD2) and Housekeeping (GLUD1) Human Glutamate Dehydrogenases Are Regulated by Distinct Allosteric Mechanisms

  2000cited by this paper
• Astrocytes: Glutamate producers for neurons

  1999cited by this paper
• Toward a phylogenetic classification of Primates based on DNA evidence complemented by fossil evidence.

  1998cited by this paper
• Evaluation of two X chromosomal candidate genes for Rett syndrome: glutamate dehydrogenase-2 (GLUD2) and rab GDP-dissociation inhibitor (GDI1).

  1998cited by this paper
• Glutamate transport and metabolism in astrocytes

  1997cited by this paper
• Late memory-related genes in the hippocampus revealed by RNA fingerprinting.

  1997cited by this paper
• Glutamate transport and metabolism in astrocytes.

  1997cited by this paper
• Molecular Evolution by Wen-Hsiung Li. Published by Sinauer Associates, Sunderland, MA, USA. ISBN: 0-87893-463-4 (cloth).

  1997cited by this paper
• Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene.

  1994cited by this paper

• The splicing paralogues SNRPB and SNRPN control differential metabolic states

  2026cites this paper
• Gene retroposition and functional diversification of retrocopies in the Rhus gall aphid Schlechtendalia chinensis.

  2026cites this paper
• Unveiling the functional nature of retrogenes in dinoflagellates

  2025cites this paper
• Neanderthal and Denisovan Glutamate Dehydrogenase 2 Evolution and Clinical Significance

  2025influential citation
• Mitochondrial glutamic-oxaloacetic transaminase (GOT2) in the growth of C2C12 myoblasts

  2025cites this paper
• Lifting the veil on tumor metabolism: A GDH1-focused perspective

  2025cites this paper
• The role of glutamate dehydrogenase in the ageing brain

  2025cites this paper
• Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes

  2024cites this paper
• Evolution of Glutamate Metabolism via GLUD2 Enhances Lactate-Dependent Synaptic Plasticity and Complex Cognition

  2024influential citation
• Unraveling glioblastoma diversity: Insights into methylation subtypes and spatial relationships

  2024cites this paper
• Harmonic Activity of Glutamate Dehydrogenase and Neuroplasticity: The Impact on Aging, Cognitive Dysfunction, and Neurodegeneration.

  2024cites this paper
• CryoEM-sampling of metastable conformations appearing in cofactor-ligand association and catalysis of glutamate dehydrogenase

  2024cites this paper
• Evolution of retrocopies in the context of HUSH silencing

  2024cites this paper
• Mitochondrial dynamics and psychiatric disorders: The missing link.

  2024cites this paper
• Evolutionary Changes in Primate Glutamate Dehydrogenases 1 and 2 Influence the Protein Regulation by Ligands, Targeting and Posttranslational Modifications

  2024cites this paper
• RCPedia: a global resource for studying and exploring retrocopies in diverse species

  2023cites this paper
• Structural Evolution of Primate Glutamate Dehydrogenase 2 as Revealed by In Silico Predictions and Experimentally Determined Structures

  2023cites this paper
• Diversification and Functional Evolution of HOX Proteins

  2022cites this paper
• Retrogene survival is not impacted by linkage relationships

  2022cites this paper
• Recurrent evolution of an inhibitor of ESCRT-dependent virus budding and LINE-1 retrotransposition in primates.

  2022cites this paper
• Quantitative proteomic profiling of hepatocellular carcinoma at different serum alpha-fetoprotein level

  2022cites this paper
• Study of Alzheimer's disease- and frontotemporal dementia-associated genes in the Cretan Aging Cohort.

  2022cites this paper
• Sirtuin 4 Inhibits Prostate Cancer Progression and Metastasis by Modulating p21 Nuclear Translocation and Glutamate Dehydrogenase 1 ADP-Ribosylation

  2022cites this paper
• The Transposable Element Environment of Human Genes Differs According to Their Duplication Status and Essentiality

  2021cites this paper
• Crystal structure of glutamate dehydrogenase 2, a positively selected novel human enzyme involved in brain biology and cancer pathophysiology

  2021cites this paper
• Processed pseudogenes: A substrate for evolutionary innovation

  2021cites this paper
• IDH Mutations in Glioma: Double-Edged Sword in Clinical Applications?

  2021cites this paper
• Ammonia inhibits energy metabolism in astrocytes in a rapid and glutamate dehydrogenase 2-dependent manner

  2020cites this paper
• Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

  2020cites this paper
• Genetic diversity underlying behavioral plasticity in human adaptation.

  2019cites this paper
• Overcoming challenges and dogmas to understand the functions of pseudogenes

  2019cites this paper
• Improved glucose homeostasis in GLUD2 Tg mice.

  2019cites this paper
• Dissecting the antenna in human glutamate dehydrogenase; understanding its role in subunit communication and allosteric regulation.

  2019cites this paper
• Friend or foe—IDH1 mutations in glioma 10 years on

  2019cites this paper
• Genetics of human brain evolution.

  2019cites this paper
• GenTree, an integrated resource for analyzing the evolution and function of primate-specific coding genes

  2019cites this paper
• Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution

  2018cites this paper
• Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1R132H-Induced Metabolic Liabilities.

  2018cites this paper
• Young genes have distinct gene structure, epigenetic profiles, and transcriptional regulation

  2018cites this paper
• Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes

  2018cites this paper
• Evolution of the RH gene family in vertebrates revealed by brown hagfish (Eptatretus atami) genome sequences.

  2017cites this paper
• Evidence of a Conserved Molecular Response to Selection for Increased Brain Size in Primates

  2017cites this paper
• The Genomic Impact of Gene Retrocopies: What Have We Learned from Comparative Genomics, Population Genomics, and Transcriptomic Analyses?

  2017cites this paper
• Glutamate Dehydrogenase, a Complex Enzyme at a Crucial Metabolic Branch Point

  2017cites this paper
• Genetics of Cerebellar and Neocortical Expansion in Anthropoid Primates: A Comparative Approach

  2017cites this paper
• The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease

  2017cites this paper
• Emergence and evolution of inter-specific segregating retrocopies in cynomolgus monkey (Macaca fascicularis) and rhesus macaque (Macaca mulatta)

  2016cites this paper
• Three Distinct Glutamate Decarboxylase Genes in Vertebrates

  2016cites this paper
• Multiple Forms of Glutamate Dehydrogenase in Animals: Structural Determinants and Physiological Implications

  2016cites this paper
• Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions

  2016cites this paper
• Evolution and genomics of the human brain.

  2015cites this paper
• Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.

  2015cites this paper
• Dominant and Protective Role of the CYTH4 Primate-Specific GTTT-Repeat Longer Alleles Against Neurodegeneration

  2015cites this paper
• Evolution of GLUD2 Glutamate Dehydrogenase Allows Expression in Human Cortical Neurons

  2015cites this paper
• Significant Microsynteny with New Evolutionary Highlights Is Detected through Comparative Genomic Sequence Analysis of Maize CCCH IX Gene Subfamily

  2015cites this paper
• Insights into the Evolution of Longevity from the Bowhead Whale Genome

  2015cites this paper
• Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission.

  2015cites this paper
• Side‐chain interactions in the regulatory domain of human glutamate dehydrogenase determine basal activity and regulation

  2015cites this paper
• The Odyssey of a Young Gene: Structure–Function Studies in Human Glutamate Dehydrogenases Reveal Evolutionary-Acquired Complex Allosteric Regulation Mechanisms

  2014cites this paper
• Heterogeneous Cellular Distribution of Glutamate Dehydrogenase in Brain and in Non-neural Tissues

  2014cites this paper
• Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma

  2014cites this paper
• Causes of metabolic syndrome and obesity-related co-morbidities Part 1: A composite unifying theory review of human-specific co-adaptations to brain energy consumption

  2014cites this paper
• New genes contribute to genetic and phenotypic novelties in human evolution.

  2014cites this paper
• Diversity through duplication: Whole-genome sequencing reveals novel gene retrocopies in the human population

  2014cites this paper
• Primary Immunodeficiency Caused by an Exonized Retroposed Gene Copy Inserted in the CYBB Gene

  2014cites this paper
• The Discovery of Human of GLUD2 Glutamate Dehydrogenase and Its Implications for Cell Function in Health and Disease

  2013cites this paper
• RNA-Mediated Gene Duplication and Retroposons: Retrogenes, LINEs, SINEs, and Sequence Specificity

  2013cites this paper
• The role of mRNA‐based duplication in the evolution of the primate genome

  2013cites this paper
• Analysis of variable retroduplications in human populations suggests coupling of retrotransposition to cell division

  2013cites this paper
• Human brain evolution: transcripts, metabolites and their regulators

  2013cites this paper
• Neofunctionalization of young duplicate genes in Drosophila

  2013cites this paper
• Genetic causes of microcephaly and lessons for neuronal development

  2013cites this paper
• Robustness of Helicobacter pylori Infection Conferred by Context-Variable Redundancy among Cysteine-Rich Paralogs

  2013cites this paper
• Deregulation of glutamate dehydrogenase in human neurologic disorders

  2013cites this paper
• Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila.

  2012cites this paper
• Reshaping of global gene expression networks and sex‐biased gene expression by integration of a young gene

  2012cites this paper
• Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications.

  2012cites this paper
• Evolution of the couple cytochrome c and cytochrome c oxidase in primates.

  2012cites this paper
• “Orphan” Retrogenes in the Human Genome

  2012cites this paper
• The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.

  2012cites this paper
• Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures.

  2012cites this paper
• Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA

  2012cites this paper
• Alpha helical structures in the leader sequence of human GLUD2 glutamate dehydrogenase responsible for mitochondrial import.

  2012cites this paper
• Genetic correlates of the evolving primate brain.

  2012cites this paper
• Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.

  2011cites this paper
• Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression.

  2011cites this paper
• Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster.

  2011cites this paper
• The human GLUD2 glutamate dehydrogenase and its regulation in health and disease.

  2011influential citation
• Characterization of nuclear glutamate dehydrogenase of chicken liver and brain.

  2011cites this paper
• From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis.

  2011influential citation
• Gene Duplication and Ectopic Gene Conversion in Drosophila

  2011cites this paper
• The Role of Glutamate Dehydrogenase in Mammalian Ammonia Metabolism

  2011cites this paper
• Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates

  2011cites this paper
• Rapid metabolic evolution in human prefrontal cortex

  2011cites this paper
• Origins, evolution, and phenotypic impact of new genes.

  2010cites this paper
• Estrogen Modification of Human Glutamate Dehydrogenases Is Linked to Enzyme Activation State*

  2010cites this paper
• Inference for the initial stage of domain shuffling: tracing the evolutionary fate of the PIPSL retrogene in hominoids.

  2010cites this paper
• Gain-of-function variant in GLUD2 glutamate dehydrogenase modifies Parkinson's disease onset

  2010cites this paper
• The rapid generation of chimerical genes expanding protein diversity in zebrafish

  2010cites this paper
• Phylogenomic evidence of adaptive evolution in the ancestry of humans

  2010cites this paper