From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Neurochemistry International

• Publication date

  2011-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.neuint.2011.03.024PMID 21600947
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009influential reference
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• Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis.

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• Untangling the glutamate dehydrogenase allosteric nightmare.

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