Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1.

Incubation of cultured human umbilical vein endothelial cells with factors derived from human peripheral blood mononuclear cells (MNCF) or adherent monocytes (AMF) resulted in concentration-and time-dependent increases in prostacyclin and prostaglandin E2 (PGE2) production. MNCF and AMF also stimulated prostacyclin and PGE2 biosynthesis in cultured human arterial smooth muscle cells and human dermal fibroblasts. The effect of these monokines on endothelial cells and fibroblasts was mimicked by treatment with purified human interleukin 1 (IL 1). Mononuclear cell-conditioned medium subjected to gel filtration yielded fractions (Mr 12,000 to 18,000 daltons) which simultaneously contained endothelial cell and fibroblast prostaglandin-stimulating activity and IL 1 activity. Therefore, monokines, specifically IL 1, appear to serve as chemical mediators of the interaction between monocytes and vascular cells as would occur in blood vessel injury, inflammation, and atherosclerosis.

• Publication year

  1985

• Venue

  Journal of Immunology

• Publication date

  1985-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.137.12.4021.aPMID 3874907
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effects of endogenously produced leukotrienes, thromboxane, and prostaglandins on coronary vascular resistance in rabbit myocardial infarction.

  1985cited by this paper
• Cytostatic and cytolytic activities of macrophages regulation by prostaglandins.

  1984cited by this paper
• Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells

  1984cited by this paper
• Stimulation of prostacyclin synthesis in vascular cells by mononuclear cell products.

  1984cited by this paper
• Macrophage-dependent arachidonate metabolism in hydronephrosis.

  1984cited by this paper
• Macrophage‐Derived Growth Factor for Fibroblasts and Interleukin‐1 Are Distinct Entities

  1984cited by this paper
• Silica-stimulated monocytes release fibroblast proliferation factors identical to interleukin 1. A potential role for interleukin 1 in the pathogenesis of silicosis.

  1984cited by this paper
• Cellular Interactions and Exaggerated Arachidonic Acid Metabolism in Rabbit Renal Injury

  1984cited by this paper
• Studies of Hypercholesterolemia in the Nonhuman Primate: I. Changes that Lead to Fatty Streak Formation

  1984cited by this paper
• Mechanism of enhanced fibroblast arachidonic acid metabolism by mononuclear cell factor.

  1984cited by this paper
• Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation.

  1984cited by this paper
• Macrophage-derived growth factor for osteoblast-like cells and chondrocytes.

  1984cited by this paper
• Interleukin 1 stimulation of collagenase production by cultured fibroblasts

  1983cited by this paper
• Bleomycin-induced pulmonary fibrosis in hamsters. An alveolar macrophage product increases fibroblast prostaglandin E2 and cyclic adenosine monophosphate and suppresses fibroblast proliferation and collagen production.

  1983cited by this paper
• Mononuclear Cell Factors that Inhibit Fibroblast Collagen Synthesis

  1983cited by this paper
• Aortic smooth muscle cell migration caused by platelet-derived growth factor is mediated by lipoxygenase product(s) of arachidonic acid.

  1983cited by this paper
• Human arterial wall cells secrete factors that are chemotactic for monocytes.

  1983cited by this paper
• Metabolic and cellular alterations underlying the exaggerated renal prostaglandin and thromboxane synthesis in ureter obstruction in rabbits. Inflammatory response involving fibroblasts and mononuclear cells.

  1983cited by this paper
• Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells

  1983cited by this paper
• Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

  1982cited by this paper
• Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells

  1982cited by this paper
• 6-Ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and thromboxane B2 production by endothelial cells, smooth muscle cells and fibroblasts cultured from piglet aorta.

  1982cited by this paper
• Stimulation of prostaglandin formation by vasoactive mediators in cultured human endothelial cells.

  1982cited by this paper
• Properties of rheumatoid and normal synovial tissue in vitro and cells derived from them

  1982cited by this paper
• Human alveolar macrophage growth factor for fibroblasts. Regulation and partial characterization.

  1982cited by this paper
• Serotonin receptor-mediated stimulation of bovine smooth muscle cell prostacyclin synthesis and its modulation by platelet-derived growth factor.

  1981cited by this paper
• The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

  1981cited by this paper
• Differential biosynthesis of prostaglandins by hydronephrotic rabbit and cat kidneys.

  1981cited by this paper
• Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).

  1981cited by this paper
• Recovery of prostacyclin production by de-endothelialized rabbit aorta. Critical role of neointimal smooth muscle cells.

  1981cited by this paper
• Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor.

  1981cited by this paper
• Optimized conditions for the growth of human epidermal cells in culture.

  1980cited by this paper
• Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor

  1980cited by this paper
• Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.

  1980cited by this paper
• Exaggerated Prostaglandin and Thromboxane Synthesis in the Rabbit with Renal Vein Constriction

  1980cited by this paper
• Characterization of prostacyclin synthesis in cultured human arterial smooth muscle cells, venous endothelial cells and skin fibroblasts.

  1979cited by this paper
• Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.

  1976cited by this paper
• A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro.

  1974cited by this paper
• Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria.

  1973cited by this paper
• THE SMOOTH MUSCLE CELL

  1971cited by this paper

• Role of Eicosanoids in Renal Disease

  2020cites this paper
• Inflammatory Mediators and the Blood-Brain Barrier

  2015cites this paper
• Entzündungsinduktion durch mikropartikuläre Knochenersatzmittel in vitro

  2009cites this paper
• Interleukin 1 and the pathogenesis of inflammatory diseases.

  2009cites this paper
• Endo toxin and Tumor Necrosis Factor Induce Interleukin-1 Gene Expression in Adult Human Vascular Endothelial Cells

  2007cites this paper
• Antitumor Effect Of Interleukin l a in Combination with Hyperthermia 1

  2007cites this paper
• Cyclooxygenase expression in human diabetes

  2006cites this paper
• Tutorial in Molecular and Cellular Biology Pharmacology of Smooth Muscle Cell Replication

  2005cites this paper
• Cyclooxygenase and 5‐lipoxygenase pathways in the vessel wall: Role in atherosclerosis

  2004cites this paper
• Helicobacter pylori induces cyclooxygenase‐1 and cyclooxygenase‐2 expression in vascular endothelial cells

  2003cites this paper
• Cyclooxygenase isoforms and atherosclerosis

  2003cites this paper
• Nitric Oxide Expression by Interleukin-10 in the Endoscopic and Open Methods of Vein Harvesting in Coronary Artery Bypass Surgery

  2002cites this paper
• Keratinocytes inhibit expression of connective tissue growth factor in fibroblasts in vitro by an interleukin-1alpha-dependent mechanism.

  2002cites this paper
• special topic Pre- and Postnatal Lung Development, Maturation, and Plasticity Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung

  2002cites this paper
• Hyperalgesia and Edema Responses Induced by Rat Peripheral Blood Mononuclear Cells Incubated with Carrageenin

  2001cites this paper
• Interleukin-1, interleukin-2 and interleukin-10 expression in different techniques of saphenous vein harvesting.

  2001cites this paper
• Kiyotaka Cells Derived From Patients With Moyamoya Disease in Arterial Smooth Muscle β Production by Interleukin-12 Increase in Prostaglandin

  1999cites this paper
• Increase in Prostaglandin E 2 Production by Interleukin-1 (cid:98) in Arterial Smooth Muscle Cells Derived From Patients With Moyamoya Disease Cellular Biology

  1999cites this paper
• Spontaneous activation of endothelial cells: A central role for endogenous IL-1α

  1999cites this paper
• Increase in Prostaglandin E2 Production by Interleukin-1β in Arterial Smooth Muscle Cells Derived From Patients With Moyamoya Disease

  1999cites this paper
• Increase in prostaglandin E(2) production by interleukin-1beta in arterial smooth muscle cells derived from patients with moyamoya disease.

  1999cites this paper
• COX-2 and cytosolic PLA2mediate IL-1β-induced cAMP production in human vascular smooth muscle cells.

  1999cites this paper
• Cyclooxygenase-2 Expression and Prostaglandin I Synthase Activity Rate of Vasoconstrictor Prostanoids Released by Endothelial Cells Depends On

  1998cites this paper
• Rate of vasoconstrictor prostanoids released by endothelial cells depends on cyclooxygenase-2 expression and prostaglandin I synthase activity.

  1998cites this paper
• Induction of cyclooxygenase-2 in human saphenous vein and internal mammary artery.

  1997cites this paper
• Differential response to dexamethasone on the TXB2 release in guinea-pig alveolar macrophages induced by zymosan and cytokines

  1997cites this paper
• Thrombin receptor-dependent prostaglandin E2 synthesis in hamster fibroblasts: synergistic interactions with interleukin-1beta.

  1997cites this paper
• Chapter 35 Anti-inflammatory drugs: Mechanisms of action

  1997cites this paper
• Glucocorticoids inhibit the autoregulatory induction of interleukin-1 in monocytes after endotoxin stimulation.

  1996cites this paper
• The role of omega-3 fatty acids in renal disorders.

  1996cites this paper
• Fibroblast growth factor and heparin protect endothelial cells from the effects of interleukin 1

  1996cites this paper
• Interleukin-1beta-mediated beta-cell inhibition in vivo.

  1996cites this paper
• Interleukin-1 stimulates prostaglandin E production by human trophoblast cells from first and third trimesters.

  1995cites this paper
• Interleukin 1 induces prostacyclin-dependent increases in cyclic AMP production and does not affect cyclic GMP production in human vascular smooth muscle cells.

  1995cites this paper
• Platelet activating factor (PAF) stimulates release of PGI2 from inflamed rabbit gallbladder cell cultures.

  1995cites this paper
• INTERLEUKIN‐1 AND INTERLEUKIN‐1 ANTAGONISM IN SEPSIS, SYSTEMIC INFLAMMATORY RESPONSE SYNDROME, AND SEPTIC SHOCK

  1995cites this paper
• Pharmacology of Smooth Muscle Cell Proliferation

  1995cites this paper
• Distribution of cyclooxygenase isoforms in murine chronic granulomatous inflammation. Implications for future anti‐inflammatory therapy

  1995cites this paper
• The role of extraplatelet thromboxane A2 in unstable angina investigated with a dual thromboxane A2 inhibitor: importance of activated monocytes

  1994cites this paper
• Immune mechanisms in atherosclerosis.

  1994cites this paper
• Intravenous prostacyclin (as epoprostenol) infusion in thrombotic thrombocytopenic purpura. Four case reports and review of the literature. Italian Cooperative Group for Thrombotic Thrombocytopenic Purpura.

  1994cites this paper
• 1 – Metabolism of Arachidonic Acid: An Overview

  1994cites this paper
• Induction of cyclooxygenase II in human synovial microvessel endothelial cells by interleukin-1. Inhibition by glucocorticoids.

  1994cites this paper
• Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

  1994cites this paper
• Phospholipid metabolite expression by head and neck squamous cell carcinoma.

  1994cites this paper
• DP-1904, a specific inhibitor of thromboxane A2 synthesizing enzyme, suppresses ICAM-1 expression by stimulated vascular endothelial cells.

  1994cites this paper
• Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.

  1994cites this paper
• Interleukin-1 down-regulates type I interleukin 1 receptor mRNA expression in a human fibroblast cell line TIG-1 in the absence of prostaglandin E2 synthesis.

  1994cites this paper
• Traumatic injury induces interleukin-6 production by human astrocytes.

  1994cites this paper
• Koronare Herzerkrankung und akuter Herzinfarkt — Aktuelle Aspekte der Pathogenese, Symptomatologie und des klinischen Verlaufs

  1994cites this paper
• Interactions between the monocyte/macrophage and the vascular smooth muscle cell. Stimulation of mitogenesis by a soluble factor and of prostanoid synthesis by cell-cell contact.

  1993cites this paper
• Effects of interleukin-1, -2, -4, -6, interferon-gamma and granulocyte/macrophage colony stimulating factor on human vascular endothelial cells.

  1993cites this paper
• Effects of cytokines on prostaglandin production and steroidogenesis of incubated preovulatory follicles of the rat.

  1993cites this paper
• Cytokines et eicosanoïdes dans les processus inflammatoires

  1993cites this paper
• Haemolytic—Uraemic Syndrome and Thrombotic Thrombocytopenic Purpura

  1993cites this paper
• Nitric oxide activates cyclooxygenase enzymes.

  1993cites this paper
• The metabolic stressor 2-deoxy-D-glucose (2-DG) enhances LPS-stimulated cytokine production in mice.

  1993cites this paper
• Antitumor effect of interleukin 1 alpha in combination with hyperthermia.

  1993cites this paper
• The effects of interleukin 1 on myocardial function and metabolism.

  1993cites this paper
• Effect of culture conditions on mast cell eicosanoid synthesis.

  1993cites this paper
• Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression.

  1993cites this paper
• Mononuclear cell-conditioned medium enhances thrombin-stimulated PGI2 production by human umbilical vein endothelial cells in culture.

  1993cites this paper
• The azaspirane SKF 105685 ameliorates renal allograft rejection in rats.

  1993cites this paper
• Effects of human recombinant interleukin-1 on electrical properties of guinea pig ventricular cells.

  1993cites this paper
• Culture of human dermal fibroblasts in collagen gels: modulation of interleukin 1-induced prostaglandin E2 synthesis by an extracellular matrix.

  1992cites this paper
• Pharmacology of smooth muscle cell replication.

  1992cites this paper
• Acute gastric mucosal injury associated with the systemic administration of interleukin-4.

  1992cites this paper
• Role of nitric oxide in hemodialysis hypotension.

  1992cites this paper
• Interleukin‐1 up‐regulates transcription of its own receptor in a human fibroblast cell line TIG‐1: role of endogenous PGE2 and cAMP

  1992cites this paper
• Cytokine gene regulation by PGE2, LTB4 and PAF

  1992cites this paper
• Effects of Heparin and Endothelial Cell Growth Supplement on Haemostatic Functions of Vascular Endothelium

  1992cites this paper
• Modulation of prostacyclin production by cytokines in vascular endothelial cells.

  1992cites this paper
• Prostaglandin synthetase, interleukin 1 and inflammation in the skin.

  1992cites this paper
• Dexamethasone attenuates altered insulin secretion elicited by interleukin-1 beta in HIT cells.

  1992cites this paper
• Dexamethasone attenuates altered insulin secretion elicited by interleukin-1β in HIT cells

  1992cites this paper
• Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs

  1992cites this paper
• Mediators of increased blood flow in porcine skin

  1992cites this paper
• Monocytes enhance endothelial von Willebrand factor release and prostacyclin production with different kinetics and dependency on intercellular contact between these two cell types

  1992cites this paper
• Interleukin-1 and beta-cell function: more than one second messenger?

  1992cites this paper
• Inflammatory edema induced by interactions between IL-1 and the neuropeptide calcitonin gene-related peptide.

  1991cites this paper
• Expression of monocyte chemotactic protein and interleukin-8 by cytokine-activated human vascular smooth muscle cells.

  1991cites this paper
• Prostaglandin and thromboxane biosynthesis.

  1991cites this paper
• Role of eicosanoids and the cytokine network in transmembrane signaling in vascular cells.

  1991cites this paper
• Recombinant human IL-1 beta and TNF-alpha stimulate production of IL-1 alpha and IL-1 beta by vascular smooth muscle cells and IL-1 alpha by vascular endothelial cells.

  1991cites this paper
• A model for the transcriptional regulation of a mouse PGH synthase gene.

  1991cites this paper
• Immunophysiology of Intestinal Electrolyte Transport

  1991cites this paper
• Recombinant human IL-1β and TNF-α stimulate production of IL-1α and IL-1β by vascular smooth muscle cells and IL-1α by vascular endothelial cells

  1991cites this paper
• Aspirin inhibits interleukin 1-induced prostaglandin H synthase expression in cultured endothelial cells.

  1991cites this paper
• Interleukin-1 inhibits in vitro decidualization of human endometrial stromal cells.

  1991cites this paper
• Prostaglandin endoperoxide synthase: regulation of enzyme expression.

  1991cites this paper
• Platelet-activating factor (PAF-acether) enhances the concomitant production of tumour necrosis factor-alpha and interleukin-1 by subsets of human monocytes.

  1991cites this paper
• The Biochemical Basis of Atherosclerosis: Roles for Cytokines

  1991cites this paper
• Excretion of metabolites of prostacyclin and thromboxane by rats with nephrotoxic nephritis: effects of interleukin‐1

  1991cites this paper
• Immune Regulation by Platelet‐Activating Factor: II. Mediation of Suppression by Cytokine‐Stimulated Endothelial Cells In Vitro

  1991cites this paper
• Interactions between endothelial cells and the cells of the immune system.

  1991cites this paper
• Interleukin 1: the first interleukin.

  1990cites this paper
• Chapter 20 Pharmacological Modulation of Interleukin-1

  1990cites this paper
• The immunology of sepsis and meningitis--cytokine biology.

  1990cites this paper
• Interleukin-1 (IL-1) regulation of human endometrial function: presence of IL-1 receptor correlates with IL-1-stimulated prostaglandin E2 production.

  1990cites this paper
• IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-gamma.

  1990cites this paper