Biological and clinical implications of the MTHFR C677T polymorphism.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  TIPS - Trends in Pharmacological Sciences

• Publication date

  2001-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0165-6147(00)01675-8PMID 11282420
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD.

  2001cited by this paper
• Smoking, folate and methylenetetrahydrofolate reductase status as interactive determinants of adenomatous and hyperplastic polyps of colorectum.

  2001cited by this paper
• 5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review.

  2000cited by this paper
• Pathogenicity of thermolabile methylenetetrahydrofolate reductase for vascular dementia.

  2000cited by this paper
• The C677T methylenetetrahydrofolate reductase gene mutation in hemodialysis patients.

  2000cited by this paper
• Methylenetetrahydrofolate Reductase Polymorphisms Are Not a Risk Factor for Pre-Eclampsia/Eclampsia in Australian Women

  2000cited by this paper
• Homocysteine and cardiovascular disease: cause or effect?

  2000cited by this paper
• The controversy over homocysteine and cardiovascular risk.

  2000cited by this paper
• The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients.

  2000cited by this paper
• 677 C→T Polymorphism of the Methylenetetrahydrofolate Reductase Gene and Preeclampsia

  2000cited by this paper
• Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene.

  2000cited by this paper
• Riboflavin as a determinant of plasma total homocysteine: effect modification by the methylenetetrahydrofolate reductase C677T polymorphism.

  2000cited by this paper
• Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: results of the Vienna multicenter study.

  2000cited by this paper
• Inflammatory Bowel Diseases Are Not Associated with Major Hereditary Conditions Predisposing to Thrombosis

  2000cited by this paper
• The C677T Mutation in the Methylenetetrahydrofolate Reductase (MTHFR) Gene and Vascular Dementia

  2000cited by this paper
• Association between the methylenetetrahydrofolate reductase 677C→T missense mutation and schizophrenia

  2000cited by this paper
• Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women.

  2000cited by this paper
• Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins.

  2000cited by this paper
• A common mutation in the 5,10-methylenetetrahydrofolate reductase gene as a new risk factor for placental vasculopathy.

  2000cited by this paper
• Molecular biology of 5,10-methylenetetrahydrofolate reductase.

  2000cited by this paper
• The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.

  2000cited by this paper
• MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil (CMF)

  2000cited by this paper
• The Role of Vitamin B12 in Fasting Hyperhomocysteinemia and Its Interaction with the Homozygous C677T Mutation of the Methylenetetrahydrofolate Reductase (MTHFR) Gene

  2000cited by this paper
• Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.

  2000cited by this paper
• Plasma homocysteine and MTHFR C677T genotype in levodopa-treated patients with PD

  2000cited by this paper
• Methylenetetrahydrofolate reductase polymorphisms, folate, and cancer risk: a paradigm of gene-nutrient interactions in carcinogenesis.

  2000cited by this paper
• Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with IBD.

  2000cited by this paper
• Homocysteine and vascular disease.

  1999cited by this paper
• Folic acid and homocyst(e)ine metabolic defects and the risk of placental abruption, pre-eclampsia and spontaneous pregnancy loss: A systematic review.

  1999cited by this paper
• The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia

  1999cited by this paper
• A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants.

  1999cited by this paper
• Folate and carcinogenesis: evidence, mechanisms, and implications.

  1999cited by this paper
• Allelic association of the MTHFR gene with schizophrenia

  1999cited by this paper
• The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother.

  1999cited by this paper
• Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome.

  1999cited by this paper
• Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: metabolic significance, risks and impact on folate requirement.

  1999cited by this paper
• Hyperhomocysteinemia in chronic renal disease.

  1999cited by this paper
• Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects.

  1999cited by this paper
• Methylenetetrahydrofolate reductase, diet, and risk of colon cancer.

  1999cited by this paper
• Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications

  1999cited by this paper
• Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?

  1999cited by this paper
• MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis.

  1999cited by this paper
• Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis

  1999cited by this paper
• Homocysteine and cardiovascular disease.

  1998cited by this paper
• A common methylenetetrahydrofolate reductase gene mutation and longevity.

  1998cited by this paper
• Trimethoprim and fasting plasma homocysteine.

  1998cited by this paper
• Neural tube and craniofacial defects with special emphasis on folate pathway genes.

  1998cited by this paper
• Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: differences between the radioassay and microbiological assays.

  1998cited by this paper
• A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells.

  1998cited by this paper
• Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida.

  1998cited by this paper
• Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis.

  1998cited by this paper
• Determinants of plasma homocysteine.

  1998cited by this paper
• Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages.

  1998cited by this paper
• The C677T mutation in the methylenetetrahydrofolate reductase gene predisposes to hyperhomocysteinemia in children with familial hypercholesterolemia treated with cholestyramine.

  1998cited by this paper
• Opposite effects of plasma homocysteine and the methylenetetrahydrofolate reductase C677T mutation on carotid artery geometry in asymptomatic adults.

  1998cited by this paper
• Analysis of alpha-1 antichymotrypsin, presenilin-1, angiotensin-converting enzyme, and methylenetetrahydrofolate reductase loci as candidates for dementia.

  1997cited by this paper
• The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes.

  1997cited by this paper
• Methionine synthase deficiency without megaloblastic anaemia

  1997cited by this paper
• The effect of L-dopa administration and folate deficiency on plasma homocysteine concentrations in rats

  1997cited by this paper
• Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study.

  1996cited by this paper
• Homocysteine and cardiovascular disease

  1996cited by this paper
• A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

  1995cited by this paper
• Riboflavin deficiency is associated with selective preservation of critical flavoenzyme-dependent metabolic pathways.

  1992cited by this paper
• The effect of riboflavin deficiency on methylenetetrahydrofolate reductase (NADPH)(EC 1.5.1.20) and folate metabolism in the rat

  1986cited by this paper
• Vitamin B12-folate interrelationships.

  1985cited by this paper

• Genetically reduced MTHFR activity confers protection against multiple sclerosis.

  2025cites this paper
• Advances in moyamoya disease: pathogenesis, diagnosis, and therapeutic interventions

  2025cites this paper
• DASH Diet and Preeclampsia Prevention: A Literature Review

  2025influential citation
• Methylenetetrahydrofolate reductase (MTHFR) 677C>T rs1801133 genetic variant, homocysteine, folate, and vitamin B12 levels in patients with multiple sclerosis: a scoping review.

  2025cites this paper
• Gene Variant Related Neurological and Molecular Biomarkers Predict Psychosis Progression, with Potential for Monitoring and Prevention

  2024cites this paper
• The combined effect of MTHFR C677T and A1298C polymorphisms on the risk of digestive system cancer among a hypertensive population

  2024cites this paper
• The effects of the MTHFR 677C>T (rs1801133) genetic variant on susceptibility and disability worsening in multiple sclerosis patients are mediated by homocysteine.

  2024cites this paper
• Association of MTHFR C677T polymorphism with risk of preterm birth in Indian mothers: a case–control study

  2023cites this paper
• MTHFR gene polymorphisms and susceptibility to myocardial infarction: Evidence from meta-analysis and trial sequential analysis

  2023cites this paper
• Folate and Folic Acid Metabolism: A Significant Nutrient-Gene-Environment Interaction

  2023cites this paper
• Molecular Mechanism Biomarkers Predict Diagnosis in Schizophrenia and Schizoaffective Psychosis, with Implications for Treatment

  2023cites this paper
• MTHFR Gene C677T Polymorphism (rs1801133) and Susceptibility to Colorectal Polyps in an Azerbaijani Population

  2023cites this paper
• Association of C677T and A1298C polymorphisms of the MTHFR gene with maternal risk for Down syndrome: a meta-analysis of case-control studies.

  2023cites this paper
• Variations in folate prescriptions for patients with the MTHFR genetic polymorphisms: A case series study

  2023cites this paper
• Dual mapping of MTHFR C677T (A1298C) and BDNF G196A (Val66Met) polymorphisms in patients with diabetic peripheral neuropathy.

  2023cites this paper
• A protocol for systematic review and/or meta-analysis

  2022cites this paper
• Prevalence of Three Prothrombotic Genes Polymorphisms: Factor II, Factor V and MTHFR in Referred Population of Gujarat

  2022cites this paper
• Genetics and Epigenetics in Personalized Nutrition: Evidence, Expectations and Experiences.

  2022cites this paper
• Investigation of Urinary Exosome Metabolic Patterns in Membranous Nephropathy by Titania‐Assisted Intact Exosome Mass Spectrometry

  2022cites this paper
• Translational Genomic Research: The Association between Genetic Profiles and Cognitive Functioning or Cardiac Function Among Breast Cancer Survivors Completing Chemotherapy

  2022cites this paper
• Changes of Serum Homocysteine and Vitamin B12, but Not Folate Are Correlated With Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Case-Control Studies

  2022cites this paper
• Association of methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphisms (C677T and A1298C) with thyroid dysfunction: A meta-analysis and trial sequential analysis

  2022cites this paper
• The Effects of the MTHFR 677C>T (rs1801133) Genetic Variant on Susceptibility and Disability in Multiple Sclerosis Patients are Mediated by Homocysteine but Not Folate Levels

  2021cites this paper
• The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review.

  2021cites this paper
• Genetic Testing and Personalized Nutrition System for Men's Health Care

  2021cites this paper
• Antioxidant vitamins and genetic polymorphisms in breast cancer

  2021cites this paper
• Effect of Methylenetetrahydrofolate Reductase (MTHFR) gene mutations and oxidative stress in silent brain infarction

  2021cites this paper
• Osteonecrosis of the Femoral Head in Patients with Hypercoagulability—From Pathophysiology to Therapeutic Implications

  2021cites this paper
• Association of MTHFR C677T Polymorphism With Antipsychotic-Induced Change of Weight and Metabolism Index

  2021cites this paper
• A COMPARATIVE STUDY ON RISK OF OSTEOPOROSIS ASSOCIATED WITH THE USE OF VALPROATE VERSUS LEVETIRACETAM IN EPILEPTIC PATIENTS AND ITS RELATIONSHIP WITH METHYLENE TETRA-HYDRO FOLATE REDUCTASE GENOTYPES

  2021cites this paper
• Correlation of TP53 (rs1625895), TP73 (rs3765730), MMP9 (rs17576), and MTHFR (rs868014) polymorphisms with low ovarian reserve.

  2021cites this paper
• 1-C Metabolism—Serine, Glycine, Folates—In Acute Myeloid Leukemia

  2021cites this paper
• An extensive meta-analysis of the association of MTHFR c.677C > T and c.1298A > C polymorphisms with gliomas

  2021cites this paper
• An AutoML Approach for Predicting Risk of Progression to Active Tuberculosis based on Its Association with Host Genetic Variations

  2021cites this paper
• Nutrition and Central Nervous System

  2020cites this paper
• C677T Polymorphism in the MTHFR Gene Is Associated With Risperidone-Induced Weight Gain in Schizophrenia

  2020cites this paper
• Associations of methylenetetrahydrofolate reductase gene (MTHFR) rs1801131 and rs1801133 polymorphisms with susceptibility to vitiligo: A meta‐analysis

  2020cites this paper
• Prevalence of the methylenetetrahydrofolate reductase 677C>T polymorphism in the pregnant women of Yunnan Province, China

  2020cites this paper
• Global trends in pesticides: A looming threat and viable alternatives.

  2020cites this paper
• Pregnancy outcomes in patients with MTHFR gene polymorphism: A case series

  2020cites this paper
• MTHFR C677T and TS 5’-UTR 3R/3R Gene Polymorphism in Methotrexate-Resistant Childhood Acute Lymphoblastic Leukemia

  2020cites this paper
• The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment

  2020cites this paper
• Association between gene polymorphism of folate metabolism and recurrent spontaneous abortion in Asia

  2020cites this paper
• Association of Homocysteine, Methionine, and MTHFR 677C>T Polymorphism With Rate of Cardiovascular Multimorbidity Development in Older Adults in Sweden

  2020cites this paper
• Association between MTHFR C677T polymorphism and non-traumatic osteonecrosis of the femoral head: An update meta-analysis

  2020cites this paper
• Predictive biomarkers of IgA vasculitis with nephritis by metabolomic analysis.

  2020cites this paper
• Association of Intake Folate and Related Gene Polymorphisms with Breast Cancer.

  2019cites this paper
• Organochlorine pesticides exposure may disturb homocysteine metabolism in pregnant women.

  2019cites this paper
• Association of MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM) susceptibility

  2019cites this paper
• The Role of Single-Nucleotide Polymorphisms in the Function of Candidate Tumor Suppressor ALDH1L1

  2019cites this paper
• Genetic polymorphism of MTHFR C 677 T contributes to the risk of ovarian cancer : a meta-analysis

  2019cites this paper
• B-vitamins & one-carbon metabolism

  2019cites this paper
• Association of Genetic Variants with Hyperhomocysteinemia in Indian Patients with Thrombosis

  2019cites this paper
• Recurrent Myocardial Infarction Despite Normal C-reactive Protein in a Patient with Behcet’s Disease and Compound Heterozygous Methylenetetrahydrofolate Reductase (MTHFR) Mutations (C677T and A1298C)

  2019cites this paper
• MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndrome

  2019cites this paper
• Preconception and Prenatal Nutrition and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis

  2019cites this paper
• Genetic and molecular biology of breast cancer among Iranian patients

  2019cites this paper
• Role of Personalized Nutrition in Chronic-Degenerative Diseases

  2019cites this paper
• Association of plasma homocysteine level with vaso-occlusive crisis in sickle cell anemia patients of Odisha, India

  2019cites this paper
• Lack of association between methylenetetrahydrofolate reductase C677T polymorphism, HPV infection and cervical intraepithelial neoplasia in Brazilian women

  2019cites this paper
• The implication of single‐nucleotide polymorphisms in ovarian hyperstimulation syndrome

  2019cites this paper
• Roles of 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in early- and late-onset obsessive-compulsive disorder

  2019cites this paper
• Association Between MTHFR Gene Common Variants, Serum Homocysteine, and Risk of Early-Onset Coronary Artery Disease: A Case–Control Study

  2019cites this paper
• Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss

  2018cites this paper
• Epilepsy control with carbamazepine monotherapy from a genetic perspective

  2018cites this paper
• Evaluation of serum homocysteine and oxidative stress during lactation in ewes

  2018cites this paper
• Anti-Müllerian Hormone: genetic and environmental effects.

  2018cites this paper
• Association between MTHFR 677C>T Polymorphism and Vitamin B12 Deficiency: A Case-control Study

  2018cites this paper
• Clinical Importance of MTHFR Gene Polymorphism in Coronary Artery Disease: A Study from India

  2018cites this paper
• Impact of maternal methylenetetrahydrofolate reductase C677T polymorphism on intervillous and decidual pathology with pregnancy loss

  2018cites this paper
• A Meta-Analysis: Methylenetetrahydrofolate Reductase C677T Polymorphism in Gastric Cancer Patients Treated with 5-Fu Based Chemotherapy Predicts Serious Hematologic Toxicity but Not Prognosis

  2018cites this paper
• Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients

  2018cites this paper
• In silico characterization of functional single nucleotide polymorphisms of folate pathway genes

  2018influential citation
• Association between Decreased Plasma Folate Levels and MTHFR C677T, and MTRR A66G Gene Polymorphisms as Determinants for Elevated Total Homocysteine Concentrations in Pregnant Women

  2018cites this paper
• Association of methylenetetrahydrofolate reductase C677T polymorphism with femoral head necrosis: a meta‐analysis

  2018cites this paper
• Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]).

  2018cites this paper
• A probe directed recombinase amplification assay for detection of MTHFR A1298C polymorphism associated with congenital heart disease.

  2018cites this paper
• Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population

  2018cites this paper
• A duplex polymerase chain reaction‐restriction fragment length polymorphism for rapid screening of methylenetetrahydrofolate reductase gene variants: Genotyping in acute leukemia

  2018cites this paper
• A Study of C677T Polymorphism of Methylenetetrahydrofolate Reductase (MTHFR) Gene and It’s Susceptibility in Coronary Artery Disease

  2018cites this paper
• Spaceflight-related ocular changes: the potential role of genetics, and the potential of B vitamins as a countermeasure

  2018cites this paper
• A plasma proteomics method reveals links between ischemic stroke and MTHFR C677T genotype

  2017cites this paper
• Association of MTHFR C 677 T and A 1298 C polymorphisms with the development of type 2 diabetic nephropathy and their interaction with environmental factors

  2017cites this paper
• Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis

  2017cites this paper
• Hyperhomocysteinemia and Its Role in Cognitive Impairment and Alzheimer's Disease: Recent Updates from the Literature

  2017cites this paper
• Predictive genetic markers in neoadjuvant chemoradiotherapy for locally advanced esophageal cancer: a long way to go. Review of the literature

  2017cites this paper
• The Role of Folate Dependent Genetic Susceptibility in The Risk of Multiple Sclerosis

  2017cites this paper
• Associations between C677T and A1298C polymorphisms of MTHFR and susceptibility to rheumatoid arthritis: a systematic review and meta-analysis

  2017cites this paper
• Embryo quality: the missing link between pregnancy sickness and pregnancy outcome

  2017cites this paper
• Deleterious Effects of Chronic Folate Deficiency in the Ts65Dn Mouse Model of Down Syndrome

  2017cites this paper
• Genetic variants and increased risk of meningioma: an updated meta-analysis

  2017cites this paper
• Genetic polymorphism of methylenetetrahydrofolate reductase as a potential risk factor for congenital heart disease

  2017cites this paper
• A Computational Approach to Identify the Biophysical and Structural Aspects of Methylenetetrahydrofolate Reductase (MTHFR) Mutations (A222V, E429A, and R594Q) Leading to Schizophrenia.

  2017cites this paper
• Mediterranean diet–gene interactions: A targeted metabolomics study in Greek‐Cypriot women

  2017cites this paper
• Advances in single-particle detection for DNA sensing

  2017cites this paper
• Metabolic Regulation of DNA Methylation in Mammalian Cells

  2017cites this paper
• The effect of dietary folic acid intake on somatic and germ cell mutations in the transgenic MutaMouse model

  2017cites this paper
• The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Fertile Men: A Systematic Review and Meta-Analysis.

  2017cites this paper
• Alzheimer's disease pathogenesis: Is there a role for folate?

  2017cites this paper
• The Relationship Between the MTHFR C677T Genotypes to Serum Anti-Müllerian Hormone Concentrations and In Vitro Fertilization/Intracytoplasmic Sperm Injection Outcome.

  2017cites this paper