A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Neurochemistry

• Publication date

  2007-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1471-4159.2007.04595.xPMID 17442042PMCID PMC2822402
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Functional imaging of focal brain activation in conscious rats: Impact of [14C]glucose metabolite spreading and release

  2007cited by this paper
• Energy Metabolism in Astrocytes: High Rate of Oxidative Metabolism and Spatiotemporal Dependence on Glycolysis/Glycogenolysis

  2007influential reference
• Astrocyte Glycogen Sustains Neuronal Activity during Hypoglycemia: Studies with the Glycogen Phosphorylase Inhibitor CP-316,819 ([R-R*,S*]-5-Chloro-N-[2-hydroxy-3-(methoxymethylamino)-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide)

  2007cited by this paper
• Human brain glycogen content and metabolism: implications on its role in brain energy metabolism.

  2007cited by this paper
• Astrocyte-mediated control of cerebral blood flow

  2006cited by this paper
• Neuronal–Glial Glucose Oxidation and Glutamatergic–GABAergic Function

  2006cited by this paper
• Inhibition of glycogenolysis in astrocytes interrupts memory consolidation in young chickens

  2006cited by this paper
• Glycogen phosphorylase reactivity in the entorhinal complex in familiar and novel environments: evidence for labile glycogenolytic modules in the rat.

  2006cited by this paper
• Astrocyte activation in working brain: energy supplied by minor substrates.

  2006cited by this paper
• Astrocytic contributions to bioenergetics of cerebral ischemia

  2005cited by this paper
• Transfer of glycogen‐derived lactate from astrocytes to axons via specific monocarboxylate transporters supports mouse optic nerve activity

  2005cited by this paper
• Astrocytes, from brain glue to communication elements: the revolution continues

  2005cited by this paper
• Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter

  2005cited by this paper
• Lactate transport and transporters: General principles and functional roles in brain cells

  2005cited by this paper
• Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain

  2005cited by this paper
• Astrocytic control of glutamatergic activity: astrocytes as stars of the show.

  2004cited by this paper
• Neuroglial Metabolism in the Awake Rat Brain: CO2 Fixation Increases with Brain Activity

  2004cited by this paper
• Immunohistochemical co-localization of glycogen phosphorylase with the astroglial markers glial fibrillary acidic protein and S-100 protein in rat brain sections

  2004cited by this paper
• Tracing the Neuroanatomical Profiles of Reward Pathways with Markers of Neuronal Activation

  2004cited by this paper
• Neuroenergetics: Calling Upon Astrocytes to Satisfy Hungry Neurons

  2004cited by this paper
• Brain glycogen re‐awakened

  2004cited by this paper
• Immunohistochemical demonstration of glycogen phosphorylase in rat brain slices

  2004cited by this paper
• Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought?

  2004cited by this paper
• Roles for gliotransmission in the nervous system

  2004cited by this paper
• Reciprocal changes in forebrain contents of glycogen and of glutamate/glutamine during early memory consolidation in the day-old chick.

  2003cited by this paper
• New roles for astrocytes: regulation of synaptic transmission.

  2003cited by this paper
• Energy Substrates for Neurons during Neural Activity: A Critical Review of the Astrocyte-Neuron Lactate Shuttle Hypothesis

  2003cited by this paper
• Glycogen: The forgotten cerebral energy store

  2003cited by this paper
• Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme‐specific antibodies

  2003cited by this paper
• Strain and Gender Specific Effects in the Forced Swim Test: Effects of Previous Stress Exposure

  2003cited by this paper
• Brain Glycogen Decreases with Increased Periods of Wakefulness: Implications for Homeostatic Drive to Sleep

  2002cited by this paper
• High Glycogen Levels in Brains of Rats with Minimal Environmental Stimuli: Implications for Metabolic Contributions of Working Astrocytes

  2002cited by this paper
• The effects of chronic mild stress on male Sprague-Dawley and Long Evans rats: I. Biochemical and physiological analyses.

  2002cited by this paper
• Generalized Sensory Stimulation of Conscious Rats Increases Labeling of Oxidative Pathways of Glucose Metabolism When the Brain Glucose–Oxygen Uptake Ratio Rises

  2002cited by this paper
• Glucose and lactate metabolism during brain activation

  2001cited by this paper
• Cerebral energetics and the glycogen shunt: Neurochemical basis of functional imaging

  2001cited by this paper
• Glycogen phosphorylase inhibitors for treatment of type 2 diabetes mellitus

  2001cited by this paper
• Role of astrocytes in the clearance of excess extracellular potassium.

  2000cited by this paper
• Histochemical mapping of the substrate for brain-stimulation reward with glycogen phosphorylase.

  1999cited by this paper
• Cerebral Oxygen/Glucose Ratio is Low during Sensory Stimulation and Rises above Normal during Recovery: Excess Glucose Consumption during Stimulation is Not Accounted for by Lactate Efflux from or Accumulation in Brain Tissue

  1999cited by this paper
• Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.

  1998cited by this paper
• Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

  1998cited by this paper
• Metabolic pathways for glucose in astrocytes

  1997cited by this paper
• [Brain energy metabolism].

  1997cited by this paper
• Ultrastructural localization of glycogen phosphorylase predominantly in astrocytes of the gerbil brain

  1996cited by this paper
• Medial forebrain bundle stimulation in rats activates glycogen phosphorylase in layers 4, 5b and 6 of ipsilateral granular neocortex.

  1995cited by this paper
• Glycogen in astrocytes: possible function as lactate supply for neighboring cells.

  1993cited by this paper
• Physiologic coupling of glial glycogen metabolism to neuronal activity in brain.

  1992cited by this paper
• Sensory stimulation induces local cerebral glycogenolysis: demonstration by autoradiography.

  1992cited by this paper
• Chapter 24: Effects of monoamine transmitters on neurons and astrocytes: correlation between energy metabolism and intracellular messengers

  1992cited by this paper
• Axon‐glia interactions in the crayfish: Glial cell oxygen consumption is tightly coupled to axon metabolism

  1991cited by this paper
• Glucose Utilization in Rat Hippocampus after Long-Term Recovery from Ischemia

  1990cited by this paper
• Why the Deoxyglucose Method Has Proven So Useful in Cerebral Activation Studies: The Unappreciated Prevalence of Stimulation-Induced Glycolysis

  1989cited by this paper
• Glycolysis-Induced Discordance between Glucose Metabolic Rates Measured with Radiolabeled Fluorodeoxyglucose and Glucose

  1989cited by this paper
• K+ at concentrations reached in the extracellular space during neuronal activity promotes a Ca2+-dependent glycogen hydrolysis in mouse cerebral cortex

  1988cited by this paper
• Single vibrissal cortical column in SI cortex of rat and its alterations in neonatal and adult vibrissa-deafferented animals: a quantitative 2DG study.

  1988cited by this paper
• Comparison of Cerebral Glucose Metabolic Rates Measured with Fluorodeoxyglucose and Glucose Labeled in the 1, 2, 3–4, and 6 Positions Using Double Label Quantitative Digital Autoradiography

  1988cited by this paper
• Cerebral Glucose Utilization: Comparison of [14C]Deoxyglucose and [6‐14C]Glucose Quantitative Autoradiography

  1987cited by this paper
• Cytochemical identification of cerebral glycogen and glucose-6-phosphatase activity under normal and experimental conditions. II. Choroid plexus and ependymal epithelia, endothelia and pericytes

  1986cited by this paper
• Cytochemical identification of cerebral glycogen and glucose‐6‐phosphatase activity under normal and experimental conditions: I. Neurons and glia

  1986cited by this paper
• The effect of light on glycogen turnover in the retina of the intact honeybee drone (Apis mellifera)

  1983cited by this paper
• Cerebral Oxidative Metabolism and Blood Flow During Acute Hypoglycemia and Recovery in Unanesthetized Rats

  1982cited by this paper
• Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.

  1981cited by this paper
• Brain energy metabolism

  1978cited by this paper
• Labile metabolites and phosphorylase a in rapidly frozen rat cerebral cortex

  1978cited by this paper
• THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1

  1977cited by this paper
• FACTORS AFFECTING THE TURNOVER OF CEREBRAL GLYCOGEN AND LIMIT DEXTRIN IN VIVO

  1973cited by this paper

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• Brain Metabolism in Health and Neurodegeneration: The iInterplay Among Neurons and Astrocytes

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• Milestone Review: Metabolic dynamics of glutamate and GABA mediated neurotransmission — The essential roles of astrocytes

  2023cites this paper
• In vivo calibration of genetically encoded metabolite biosensors must account for metabolite metabolism during calibration and cellular volume

  2023influential citation
• The dentate gyrus differentially metabolizes glucose and alternative fuels during rest and stimulation

  2023cites this paper
• Association between cerebrospinal fluid parameters and developmental and neurological status in glucose transporter 1 deficiency syndrome.

  2023cites this paper
• Lactate Metabolism, Signaling, and Function in Brain Development, Synaptic Plasticity, Angiogenesis, and Neurodegenerative Diseases

  2023cites this paper
• Metabolic aspects of genetic ion channel epilepsies

  2023cites this paper
• From a Demand-Based to a Supply-Limited Framework of Brain Metabolism

  2022cites this paper
• Metabolically driven action potentials serve neuronal energy homeostasis and protect from reactive oxygen species

  2022cites this paper
• Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases

  2022cites this paper
• Insights into the regulation of podocyte and glomerular function by lactate and its metabolic sensor G‐protein‐coupled receptor 81

  2022cites this paper
• Gray and white matter astrocytes differ in basal metabolism but respond similarly to neuronal activity

  2022cites this paper
• Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue

  2022cites this paper
• Evaluation of Hydroxycarboxylic Acid Receptor 1 (HCAR1) as a Building Block for Genetically Encoded Extracellular Lactate Biosensors

  2022cites this paper
• Metabolic Contribution and Cerebral Blood Flow Regulation by Astrocytes in the Neurovascular Unit

  2022cites this paper
• Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease

  2022cites this paper
• Glucose sparing by glycogenolysis (GSG) determines the relationship between brain metabolism and neurotransmission

  2022cites this paper
• Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity

  2021cites this paper
• Lactate and Ketone Bodies Act as Energy Substrates as Well as Signal Molecules in the Brain

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• Stop the rot. Enzyme inactivation at brain harvest prevents artifacts

  2021cites this paper
• Protein lactylation induced by neural excitation

  2021cites this paper
• Neuromodulation of Glial Function During Neurodegeneration

  2020cites this paper
• Metabolic compartmentalization between astroglia and neurons in physiological and pathophysiological conditions of the neurovascular unit

  2020cites this paper
• A thermodynamic function of glycogen in brain and muscle.

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  2020cites this paper
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  2020cites this paper
• Hyperbaric oxygen toxicity in brain: A case of hyperoxia induced hypoglycemic brain syndrome.

  2019cites this paper
• Glycogenolysis in Cerebral Cortex During Sensory Stimulation, Acute Hypoglycemia, and Exercise: Impact on Astrocytic Energetics, Aerobic Glycolysis, and Astrocyte-Neuron Interactions.

  2019cites this paper
• State-Dependent Changes in Brain Glycogen Metabolism.

  2019cites this paper
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  2019cites this paper
• Brain Glucose Metabolism: Integration of Energetics with Function.

  2019cites this paper
• Does shuttling of glycogen‐derived lactate from astrocytes to neurons take place during neurotransmission and memory consolidation?

  2019influential citation
• Methodological considerations for studies of brain glycogen

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits

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  2019cites this paper
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• Impact of Hypoglycemia on Brain Metabolism During Diabetes

  2018cites this paper
• Astrocytic glycogen metabolism in the healthy and diseased brain

  2018cites this paper
• Investigating adrenoceptor regulation of the astroglial glycogen reserve

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
• Contributions of glycogen to astrocytic energetics during brain activation

  2015cites this paper
• Metabolic Alterations Associated to Brain Dysfunction in Diabetes.

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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Sugar for the brain: the role of glucose in physiological and pathological brain function.

  2013cites this paper
• The monoaminergic tripartite synapse: a putative target for currently available antidepressant drugs.

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• Studies of Brain Metabolism: A Historical Perspective

  2012cites this paper
• Brain glycogen—new perspectives on its metabolic function and regulation at the subcellular level

  2012influential citation
• Brain glycogen and its role in supporting glutamate and GABA homeostasis in a type 2 diabetes rat model.

  2012influential citation
• Brain Lactate Metabolism: The Discoveries and the Controversies

  2012cites this paper
• β2-adrenergic receptor and astrocyte glucose metabolism.

  2012cites this paper
• Rapid Turnover of Glycogen in Memory Formation

  2012cites this paper
• Fueling and imaging brain activation

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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
• Brain Glycogen Content and Metabolism in Subjects with Type 1 Diabetes and Hypoglycemia Unawareness

  2012influential citation
• Why does the brain (not) have glycogen?

  2011influential citation
• Simultaneous measurement of glucose transport and utilization in the human brain.

  2011cites this paper
• Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.

  2011influential citation