Intrinsic and extrinsic control of effector T cell survival and memory T cell development

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Immunologic research

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12026-008-8027-zPMID 18629449
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction.

  2008cited by this paper
• Effector CD8 T Cell Development: A Balancing Act between Memory Cell Potential and Terminal Differentiation1

  2008cited by this paper
• BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection

  2008cited by this paper
• Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

  2008cited by this paper
• Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene

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• Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice.

  2008cited by this paper
• Constitutive Expression of IL-7 Receptor α Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following Listeria monocytogenes Infection1

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• Generation of CD8 T Cell Memory Is Regulated by IL-121

  2007cited by this paper
• Unrestrained Glycogen Synthase Kinase-3β Activity Leads to Activated T Cell Death and Can Be Inhibited by Natural Adjuvant1

  2007cited by this paper
• Antiviral CD4+ memory T cells are IL-15 dependent

  2007cited by this paper
• Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation.

  2007cited by this paper
• Differential Survival of Cytotoxic T Cells and Memory Cell Precursors1

  2007cited by this paper
• CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent1

  2007cited by this paper
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection.

  2007cited by this paper
• Non‐redundant role for IL‐7R signaling for the survival of CD8+ memory T cells

  2007cited by this paper
• Expression of IL-7 receptor α is necessary but not sufficient for the formation of memory CD8 T cells during viral infection

  2007cited by this paper
• Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory.

  2007cited by this paper
• The Antiviral CD8+ T Cell Response Is Differentially Dependent on CD4+ T Cell Help Over the Course of Persistent Infection1

  2007cited by this paper
• Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

  2007cited by this paper
• Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

  2007cited by this paper
• Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα–expressing cells

  2007cited by this paper
• Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.

  2007cited by this paper
• Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

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• TNF family ligands define niches for T cell memory.

  2007cited by this paper
• Viral antigen and extensive division maintain virus-specific CD8 T cells during chronic infection

  2007cited by this paper
• Direct Interferon-γ Signaling Dramatically Enhances CD4+ and CD8+ T Cell Memory1

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• Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak

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• Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells

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• Loss of T cell receptor-induced Bmi-1 in the KLRG1+ senescent CD8+ T lymphocyte

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• Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7Rα mutant mice

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• Cutting Edge: Limiting Amounts of IL-7 Do Not Control Contraction of CD4+ T Cell Responses1

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• Dual Roles of IL-15 in Maintaining IL-7RαlowCCR7− Memory CD8+ T Cells in Humans via Recovering the Phosphatidylinositol 3-Kinase/AKT Pathway1

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• A critical role for TNF receptor-associated factor 1 and Bim down-regulation in CD8 memory T cell survival

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• Adoptive immunotherapy for cancer: building on success

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• PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

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• Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells

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• Do CD8 effector cells need IL-7R expression to become resting memory cells?

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• Transcriptional repressor Blimp-1 is essential for T cell homeostasis and self-tolerance

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• Caspases at the crossroads of immune-cell life and death

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• The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

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• Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

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• Augmented IL-7 Signaling during Viral Infection Drives Greater Expansion of Effector T Cells but Does Not Enhance Memory1

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• FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

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• PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion

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• Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis.

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• Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation1

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• Aberrant Contraction of Antigen-Specific CD4 T Cells after Infection in the Absence of Gamma Interferon or Its Receptor

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• Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules.

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• Homeostasis of memory T cells

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• IL-15 Regulates CD8+ T Cell Contraction during Primary Infection1

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• Transcriptional repressor Blimp-1 regulates T cell homeostasis and function

  2006cited by this paper
• Bim mediates apoptosis of CD127lo effector T cells and limits T cell memory

  2006cited by this paper
• Inflaming the CD8+ T cell response.

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• Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

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• Innate immune cells contribute to the IFN-gamma-dependent regulation of antigen-specific CD8+ T cell homeostasis.

  2006cited by this paper
• Long‐lived memory CD8+ T cells are programmed by prolonged antigen exposure and low levels of cellular activation

  2006cited by this paper
• Cutting Edge: IL-7-Independent Regulation of IL-7 Receptor α Expression and Memory CD8 T Cell Development1

  2006cited by this paper
• IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival1

  2006cited by this paper
• Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation1

  2006cited by this paper
• Signals required for programming effector and memory development by CD8+ T cells

  2006cited by this paper
• TRAIL Deficiency Delays, but Does Not Prevent, Erosion in the Quality of “Helpless” Memory CD8 T Cells1

  2006cited by this paper
• Cutting Edge: Innate Immune Cells Contribute to the IFN-γ-Dependent Regulation of Antigen-Specific CD8+ T Cell Homeostasis1

  2006cited by this paper
• The NF-κB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells

  2006cited by this paper
• Restoring function in exhausted CD8 T cells during chronic viral infection

  2006cited by this paper
• Transcriptional regulator Id2 mediates CD8+ T cell immunity

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• Cutting Edge: Bcl-3 Up-Regulation by Signal 3 Cytokine (IL-12) Prolongs Survival of Antigen-Activated CD8 T Cells1

  2005cited by this paper
• Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

  2005cited by this paper
• IL-7 Receptor Expression Levels Do Not Identify CD8+ Memory T Lymphocyte Precursors following Peptide Immunization1

  2005cited by this paper
• Evolution of diverse antiviral CD8+ T cell populations after murine cytomegalovirus infection

  2005cited by this paper
• Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

  2005cited by this paper
• Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool.

  2005cited by this paper
• Cell biology of IL-7, a key lymphotrophin.

  2005cited by this paper
• Interferon-γ acts directly on CD8+ T cells to increase their abundance during virus infection

  2005cited by this paper
• The role of BH3-only proteins in the immune system

  2005cited by this paper
• Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis.

  2005cited by this paper
• BCL6b mediates the enhanced magnitude of the secondary response of memory CD8+ T lymphocytes.

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• Role of Tumor Necrosis Factor Receptors in Regulating CD8 T-Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection

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• OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen1

  2005cited by this paper
• CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death

  2005cited by this paper
• Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

  2005cited by this paper
• A Role for the Granzyme B Inhibitor Serine Protease Inhibitor 6 in CD8+ Memory Cell Homeostasis1

  2004cited by this paper
• CD8+ T cell contraction is controlled by early inflammation

  2004cited by this paper
• Serine protease inhibitor 2A inhibits caspase‐independent cell death

  2004cited by this paper
• High expression of active CDK6 in the cytoplasm of CD8 memory cells favors rapid division

  2004cited by this paper
• CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection

  2004cited by this paper
• Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets.

  2004cited by this paper
• Bcl6 Acts as an Amplifier for the Generation and Proliferative Capacity of Central Memory CD8+ T Cells1

  2004cited by this paper
• Antigen-independent memory CD8 T cells do not develop during chronic viral infection.

  2004cited by this paper
• Antioxidant Treatment Reduces Expansion and Contraction of Antigen-Specific CD8+ T Cells during Primary but Not Secondary Viral Infection

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• Serine protease inhibitor 2A is a protective factor for memory T cell development

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• T-bet Controls Autoaggressive CD8 Lymphocyte Responses in Type 1 Diabetes

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• The Contraction Phase of Virus-Specific CD8+ T Cells Is Unaffected by a Pan-Caspase Inhibitor1

  2004cited by this paper
• Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells.

  2004cited by this paper
• Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

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• The structure of a Bcl-xL/Bim fragment complex: implications for Bim function.

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• Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

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• Control of T cell viability.

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• NF‐κB protects from the lysosomal pathway of cell death

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• Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

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• Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

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