Electroacupuncture Pretreatment Alleviates Myocardial Ischemia–Reperfusion Injury by Inhibiting Engulfment by Microglia in the Lateral Hypothalamus

Xiang Zhou,Peiyi Yang,Chaonan Dong,Hui-Min Chang,Fan Zhang,Qi Shu,Nai-Xuan Wei,Bin Zhang,Yan Wu,Wen-Jing Shao,Rong-lin Cai,Qing Yu

Published 2025 in CNS Neuroscience & Therapeutics

ABSTRACT

The occurrence of myocardial ischemia–reperfusion injury (MIRI) is accompanied by neuroinflammatory reactions and is closely related to the overactivation of microglia. Currently, effective clinical strategies to prevent MIRI are unclear. This study investigated potential therapeutic targets and the mechanisms of electroacupuncture pretreatment (EA‐pre) for MIRI.

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