Enhanced expression of the N-myc gene in Wilms' tumors.

No abstract is available for this paper.

• Publication year

  1986

• Venue

  Cancer Research

• Publication date

  1986-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 2430692
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Human small-cell lung cancers show amplification and expression of the N-myc gene.

  1986cited by this paper
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  1985cited by this paper
• Human N-myc gene contributes to neoplastic transformation of mammalian cells in culture

  1985cited by this paper
• Expression of N-myc in teratocarcinoma stem cells and mouse embryos

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• Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues

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• Evolution of tumours and the impact of molecular oncology

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• Expression of insulin-like growth factor-II transcripts in Wilms' tumour

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• N-myc can cooperate with ras to transform normal cells in culture.

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• Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas.

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• V-myc- and c-myc-encoded proteins are associated with the nuclear matrix

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• Hereditary cancer, oncogenes, and antioncogenes.

  1985cited by this paper
• Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.

  1984cited by this paper
• Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.

  1984cited by this paper
• Functional role for c-myc in mitogenic response to platelet-derived growth factor

  1984cited by this paper
• The molecular genetics of cellular oncogenes.

  1984cited by this paper
• Activated expression of the N-myc gene in human neuroblastomas and related tumors.

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• The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related

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  1983cited by this paper
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  1983cited by this paper
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  1983cited by this paper
• onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient

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• Nuclear localization and DNA binding of the transforming gene product of avian myelocytomatosis virus

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• Distal-less homeobox 5 transactivated by MYCN contributes to progression of neuroblastoma through AKT signaling pathway.

  2025cites this paper
• SMARCE1 promotes neuroblastoma tumorigenesis through assisting MYCN-mediated transcriptional activation

  2022cites this paper
• MYC modulators in cancer: a patent review

  2019cites this paper
• Plasma C-MYC level manifesting as an indicator in progression of breast cancer.

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• Genetic and epigenetic analyses guided by high resolution whole-genome SNP array reveals a possible role of CHEK2 in Wilms tumour susceptibility

  2018cites this paper
• Prognostic significance of MYCN gene amplification and protein expression in primary brain tumors: Astrocytoma and meningioma

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• The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance

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• The yin and yang of kidney development and Wilms’ tumors

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• Energy metabolism in neuroblastoma and Wilms tumor.

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• Edinburgh Research Explorer The Yin and Yang of kidney development and Wilms’ tumours

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• Unraveling the MYCN-driven transcriptional landscape of neuroblastoma : a cross-species integrated transcriptome approach

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• Quantification of Plasma DNA with Cancer by Real-time PCR

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• Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

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• High hopes for cannabinoid agonists in the treatment of rheumatic diseases

  2014cites this paper
• MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation

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• Synthetic Genetic Targeting of Genome Instability in Cancer

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• Nephroblastoma/Wilms Tumor: A Corrupted Cap Stem Cell Caricature

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• Statin induced effects on MYCN in neuroblastoma cell lines

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• The interplay between MYCN and the DNA damage response : modulation of MYCN expression, its interactions with components of the DNA damage response and cellular responses to N-myc following genotoxic stress

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• MYCN: from oncoprotein to tumor-associated antigen

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• Analysis of senescence markers and impact of drug-induced senescent neuroblastoma cells on tumour cell proliferation and immunomodulation

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• Control of kidney development by calcium ions.

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• Molecular profiling reveals frequent gain of MYCN and anaplasia‐specific loss of 4q and 14q in wilms tumor

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• The MYCN oncogene and differentiation in neuroblastoma.

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• MYCN as a target for cancer immunotherapy

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• Effects of Retinoic Acid on Beta-Catenin Transcriptional Activity in Melanoma Cells

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• Presence ofthe Long Chain Form ofPolysialic Acid

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• Expression of MYCN in pediatric synovial sarcoma

  2007cites this paper
• Identification of a Neuroepithelioma Tumor Cell Line , NUB-20 Importance of Phenotypic and Molecular Characterization for Updated Version

  2006cites this paper
• Primitive Neuroectodermal Tumor with Wilms' Tumor

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• Recurrent NMYC copy number gain and high protein expression in basal cell carcinoma.

  2006cites this paper
• Pilot Study to Evaluate MYCN Expression as a Neuroblastoma Cell Marker to Detect Minimal Residual Disease by RT-PCR

  2006cites this paper
• The Wilms' tumor gene WTJ functions as a tumor suppressor gene, repressing transcription of several growth factors and growth factor receptors. The bcl-2 and c-myc proto-oncogenes are essential for regula tion of apoptosis and cell proliferation with roles in development

  2006cites this paper
• Immunofluorescence Staining and Flow Cytometry Established Neuroblastoma Cell Lines : A Study by Proteins in Newly MDR-1 , and myc , c-myc Expression of N-Updated

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• Oncogene Amplification in Pediatrie Brain Tumors'

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• Wilms' tumor: starting off the kidney all over again?

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• Molecular Biology of Medulloblastoma: Will It Ever Make a Difference to Clinical Management?

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• MYCN in neuronal tumours.

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• Prognostic classification of relapsing favorable histology Wilms tumor using cDNA microarray expression profiling and support vector machines

  2004influential citation
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• Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells.

  2004cites this paper
• Changes in WT1 splicing are associated with a specific gene expression profile in Wilms' tumour

  2002cites this paper
• Regulation of N-myc expression in development and disease.

  2002cites this paper
• Molecular Genetic Alterations in Primary Hepatocellular Neoplasms

  2002cites this paper
• MYCN expression in human rhabdomyosarcoma cell lines and tumour samples

  2002cites this paper
• N-myc Promotes Survival and Induces S-Phase Entry of Postmitotic Sympathetic Neurons

  2002cites this paper
• Multiple Genomic Alterations Including N-myc Amplification in a Primary Large Cell Medulloblastoma

  2000cites this paper
• The genetic basis of medulloblastoma

  2000cites this paper
• Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon

  2000cites this paper
• Expression of glypican 3 (GPC3) in embryonal tumors

  2000cites this paper
• A Novel Intron Element Operates Posttranscriptionally To Regulate Human N-mycExpression

  1999cites this paper
• c-myc oncogene family expression in glioblastoma and survival.

  1999cites this paper
• Proto-oncogene N-myc promoter is down regulated by the Wilms' tumor suppressor gene WT1.

  1999cites this paper
• Diagnosis and classification of the small round-cell tumors of childhood.

  1999cites this paper
• Molecular Genetic Changes in Alveolar Soft Part Sarcoma

  1998cites this paper
• Expression myc N-Posttranscriptionally To Regulate Human A Novel Intron Element Operates

  1998cites this paper
• Transgenic N-myc mouse model for indolent B cell lymphoma: tumor characterization and analysis of genetic alterations in spontaneous and retrovirally accelerated tumors

  1998cites this paper
• A new pineoblastoma cell line, PER-480, with der(10)t(10;17), der(16)t(1;16), and enhanced MYC expression in the absence of gene amplification.

  1998cites this paper
• Expression of c-Myc, TGF-alpha and EGF-receptor in sporadic medullary thyroid carcinoma.

  1997cites this paper
• Decreased N-myc expression in human medulloblastoma cell lines during differentiation.

  1997cites this paper
• Expression of c-Myc, TGF-α and EGF-Receptor in Sporadic Medullary Thyroid Carcinoma

  1997cites this paper
• Differential regulation of the human Wilms tumour suppressor gene (WT1) promoter by two isoforms of PAX2

  1997cites this paper
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  1996cites this paper
• Effect of cisplatin exposure on the degree of N-myc amplification in small cell lung carcinoma cell lines with N-myc amplification.

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  1995cites this paper
• Retroviruses and Oncogenes

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• Genetics of embryonal tumours of childhood: retinoblastoma, Wilms' tumour and neuroblastoma.

  1995cites this paper
• Transcription factors and pattern formation in the developing lung.

  1995cites this paper
• Generation of normal lymphocytes derived from N-myc-deficient embryonic stem cells.

  1995cites this paper
• Immunohistology, cytogenetics, and molecular studies of small round cell tumors of childhood. A review.

  1995cites this paper
• Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1.

  1995cites this paper
• Fluorescence in situ hybridization (FISH) detection of MYCN oncogene amplification in neuroblastoma using paraffin-embedded tissues.

  1995cites this paper
• p53 mutations, O6‐alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors

  1995cites this paper
• Proto-oncogenes and tumor suppressor genes in human urological malignancies.

  1994cites this paper
• Enhanced MYCN expression and lsochromosome 17q in pineoblastoma cell lines

  1994cites this paper
• Restriction fragment length polymorphisms of the human N-myc gene in normal healthy individuals and oral cancer patients in India.

  1994cites this paper
• Genetic changes in hepatoblastoma.

  1994cites this paper
• Paired box gene expression in Wilms' tumor.

  1994cites this paper
• Development of a subtractive hybridization technique and the cloning of the mouse epsilon isoform 14-3-3 protein, a gene involved in fetal kidney development

  1994cites this paper
• Prognostic value of N‐myc immunoreactivity in medullary thyroid carcinoma

  1994cites this paper
• Aggressive medulloblastoma with high-level N-myc amplification.

  1994cites this paper
• Infrequency of MDM2 gene amplification in pediatric solid tumors and lack of association with p53 mutations in adult squamous cell carcinomas.

  1993cites this paper
• Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus.

  1993cites this paper
• Experimental Pathology as a Basis for Understanding the Biology of Posterior Fossa Tumors

  1993cites this paper
• The G401 cell line, utilized for studies of chromosomal changes in Wilms' tumor, is derived from a rhabdoid tumor of the kidney.

  1993cites this paper
• [Nephroblastoma (Wilms' tumor): cytogenetic and molecular biology principles].

  1993cites this paper
• Nephroblastom (Wilms' Tumor): Zytogenetische und molekularbiologische Grundlagen

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• Molecular and cellular heterogeneity of wilms' tumor

  1993cites this paper
• Infrequency of ras, p53, WT1, or RB gene alterations in Wilms tumors

  1993cites this paper
• Prognostic factors in purged marrow from patients with neuroblastoma receiving myeloablative treatment - tumor-cell number, N-myc protein, N-myc gene amplification and rate of hematologic recovery.

  1993cites this paper
• Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.

  1992cites this paper
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  1992cites this paper
• Molecular characterization of congenital mesoblastic nephroma and its distinction from wilms Tumor

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  1992cites this paper
• High frequency of myelomonocytic tumors in aging E mu L-myc transgenic mice

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• Distribution of cells expressing myc proteins in human colorectal epithelium, polyps, and malignant tumors.

  1992cites this paper