N-myc Promotes Survival and Induces S-Phase Entry of Postmitotic Sympathetic Neurons

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Neuroscience

• Publication date

  2002-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1523/JNEUROSCI.22-03-00815.2002PMID 11826111PMCID PMC6758514
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• TrkA mediates developmental sympathetic neuron survival in vivo by silencing an ongoing p75NTR-mediated death signal

  2001cited by this paper
• Repression of transcription of the p27Kip1 cyclin-dependent kinase inhibitor gene by c-Myc

  2001cited by this paper
• Inhibition of JNK by Overexpression of the JNK Binding Domain of JIP-1 Prevents Apoptosis in Sympathetic Neurons*

  2001cited by this paper
• Induction of cyclin E–cdk2 kinase activity, E2F‐dependent transcription and cell growth by Myc are genetically separable events

  2000cited by this paper
• Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

  2000cited by this paper
• An anti-apoptotic role for the p53 family member, p73, during developmental neuron death.

  2000cited by this paper
• Regulation of G(1) cyclin-dependent kinases in the mammalian cell cycle.

  2000influential reference
• Neurotrophin signal transduction in the nervous system.

  2000cited by this paper
• Evidence That Helix-Loop-Helix Proteins Collaborate with Retinoblastoma Tumor Suppressor Protein to Regulate Cortical Neurogenesis

  2000cited by this paper
• Neuronal life and death: an essential role for the p53 family

  2000cited by this paper
• Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion.

  1999cited by this paper
• Early induction of Talpha1 alpha-tubulin transcription in neurons of the developing nervous system.

  1999cited by this paper
• Cyclins D1 and D2 mediate Myc‐induced proliferation via sequestration of p27Kip1 and p21Cip1

  1999cited by this paper
• Depolarization and Neurotrophins Converge on the Phosphatidylinositol 3-Kinase–Akt Pathway to Synergistically Regulate Neuronal Survival

  1999cited by this paper
• Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27

  1999cited by this paper
• Early induction of Tα1 α‐tubulin transcription in neurons of the developing nervous system

  1999cited by this paper
• Ras Regulates Sympathetic Neuron Survival by Suppressing the p53-Mediated Cell Death Pathway

  1999cited by this paper
• P53 Is Essential for Developmental Neuron Death as Regulated by the TrkA and p75 Neurotrophin Receptors

  1998cited by this paper
• A Critical Temporal Requirement for the Retinoblastoma Protein Family During Neuronal Determination

  1998cited by this paper
• The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death

  1998cited by this paper
• Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3.

  1998cited by this paper
• A simplified system for generating recombinant adenoviruses.

  1998cited by this paper
• Rescue of dorsal root sensory neurons by nerve growth factor and neurotrophin-3, but not brain-derived neurotrophic factor or neurotrophin-4, is dependent on the level of the p75 neurotrophin receptor.

  1998cited by this paper
• Targeted expression of MYCN causes neuroblastoma in transgenic mice

  1997cited by this paper
• Regulation of the neural crest cell fate by N-myc: promotion of ventral migration and neuronal differentiation.

  1997cited by this paper
• Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons

  1997cited by this paper
• Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis

  1997cited by this paper
• Inhibitors of Cyclin-dependent Kinases Promote Survival of Post-mitotic Neuronally Differentiated PC12 Cells and Sympathetic Neurons (*)

  1996cited by this paper
• Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

  1996cited by this paper
• Loss of Rb activates both p53‐dependent and independent cell death pathways in the developing mouse nervous system.

  1996cited by this paper
• Retinoblastoma gene in mouse neural development.

  1996cited by this paper
• Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support

  1996cited by this paper
• Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins

  1996cited by this paper
• The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization.

  1996cited by this paper
• Cytostatic gene therapy for vascular proliferative disorders with a constitutively active form of the retinoblastoma gene product

  1995cited by this paper
• Dividing neuron precursors express neuron-specific tubulin.

  1995cited by this paper
• Expression of neuron-specific tubulin defines a novel population in the proliferative layers of the developing telencephalon

  1994cited by this paper
• Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation.

  1994cited by this paper
• The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein.

  1994cited by this paper
• Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death.

  1994influential reference
• Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse.

  1993cited by this paper
• Absence of p53 gene mutations in primary neuroblastomas.

  1993cited by this paper
• Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop.

  1992cited by this paper
• Concentration-dependent regulation of neuronal gene expression by nerve growth factor

  1992cited by this paper
• Absence of p53 gene mutations in primary nasopharyngeal carcinomas.

  1992cited by this paper
• Requirement for a functional Rb-1 gene in murine development

  1992influential reference
• Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

  1992cited by this paper
• Effects of an Rb mutation in the mouse

  1992influential reference
• The N-myc proto-oncogene: developmental expression and in vivo site-directed mutagenesis.

  1992cited by this paper
• The N‐myc Proto‐oncogene: Developmental Expression and in vivo Site‐Directed Mutagenesis

  1991cited by this paper
• Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product

  1991influential reference
• Early commitment of precursor cells from the rat superior cervical ganglion to neuronal or nonneuronal fates.

  1991cited by this paper
• Phenotypic diversification in human neuroblastoma cells: expression of distinct neural crest lineages.

  1989cited by this paper
• Relationship between differentiation and terminal mitosis: chick sensory and ciliary neurons differentiate after terminal mitosis of precursor cells, whereas sympathetic neurons continue to divide after differentiation

  1987cited by this paper
• Enhanced expression of the N-myc gene in Wilms' tumors.

  1986cited by this paper
• Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage.

  1984influential reference
• Neuronal acquisition of tetanus toxin binding sites: relationship with the last mitotic cycle.

  1983cited by this paper
• Catecholamine biosynthetic enzymes are expressed in replicating cells of the peripheral but not the central nervous system.

  1980cited by this paper
• The relationship of cell division to the acquisition of adrenergic characteristics by developing sympathetic ganglion cell precursors.

  1978cited by this paper
• Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat

  1975cited by this paper
• Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiation

  1974cited by this paper

• Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for AlzheimerâÂÂs disease

  2023cites this paper
• Interplay: The Essential Role between INSM1 and N-Myc in Aggressive Neuroblastoma

  2022cites this paper
• Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: possible implication for Alzheimer's disease.

  2022cites this paper
• Pharmacophore-Model-Based Virtual-Screening Approaches Identified Novel Natural Molecular Candidates for Treating Human Neuroblastoma

  2022cites this paper
• Genome-Wide Analysis of The ID Family of Bhlh TF’s In Glial Tumours

  2021cites this paper
• Neuroblastoma—A Neural Crest Derived Embryonal Malignancy

  2019cites this paper
• LncRNA EPIC1 downregulation mediates hydrogen peroxide-induced neuronal cell injury

  2019cites this paper
• Neuroblastoma Origin and Therapeutic Targets for Immunotherapy

  2018cites this paper
• CD114: A New Member of the Neural Crest‐Derived Cancer Stem Cell Marker Family

  2017cites this paper
• An mRNA-reprogramming method with improved kinetics and efficiency and the successful transdifferentiation of human fibroblasts using modified mRNA

  2017cites this paper
• Porcine Neural Progenitor Cells Derived from Tissue at Different Gestational Ages Can Be Distinguished by Global Transcriptome

  2017cites this paper
• Expression of Sam68 Associates with Neuronal Apoptosis and Reactive Astrocytes After Spinal Cord Injury

  2017cites this paper
• The zebrafish as a model for studying neuroblastoma

  2016cites this paper
• Up-regulation of MCM3 Relates to Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats

  2016cites this paper
• Neuroblastoma, a Paradigm for Big Data Science in Pediatric Oncology

  2016cites this paper
• mRNA Transcriptomics of Galectins Unveils Heterogeneous Organization in Mouse and Human Brain

  2016cites this paper
• Lentiviral Vector-Mediated p27kip1 Expression Facilitates Recovery After Spinal Cord Injury

  2015cites this paper
• Up-Regulation of CCT8 Related to Neuronal Apoptosis after Traumatic Brain Injury in Adult Rats

  2015cites this paper
• Spatiotemporal Expression of EAPP Modulates Neuronal Apoptosis and Reactive Astrogliosis After Spinal Cord Injury

  2015cites this paper
• Mechanosensitvity of isolated myenteric neuronal networks

  2014cites this paper
• The prenatal origins of cancer

  2014cites this paper
• Neuronal Injury External to the Retina Rapidly Activates Retinal Glia, Followed by Elevation of Markers for Cell Cycle Re-Entry and Death in Retinal Ganglion Cells

  2014cites this paper
• Direct effects of Bmi1 on p53 protein stability inactivates oncoprotein stress responses in embryonal cancer precursor cells at tumor initiation

  2013cites this paper
• Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling

  2013cites this paper
• Synthetic Genetic Targeting of Genome Instability in Cancer

  2013cites this paper
• MCM7 Expression Is Altered in Rat After Spinal Cord Injury

  2013cites this paper
• Control of vertebrate development by MYC.

  2013cites this paper
• Neural crest-derived sympathoadrenergic-like progenitors of the postnatal murine adrenal gland

  2013cites this paper
• The investigation of oxidative damage to nucleic acids during ageing and motor neuron disease

  2013cites this paper
• The Role of Ciliary Neurotrophic Factor and TRKB Signaling in Neuroblastoma

  2013cites this paper
• Targeting the Cell Cycle for Cancer Treatment and Neuroprotection

  2013cites this paper
• The interplay between MYCN and the DNA damage response : modulation of MYCN expression, its interactions with components of the DNA damage response and cellular responses to N-myc following genotoxic stress

  2012cites this paper
• Clusterin (CLU) and its interacting proteins in cell signalling and neuroblastoma

  2012cites this paper
• Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury

  2012cites this paper
• The transcription factor Elk-1 belongs to the ternary complex factor family of erythroblast transformation specific (ETS)-

  2012cites this paper
• Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

  2012cites this paper
• Activation of Elk‐1 participates as a neuroprotective compensatory mechanism in models of Huntington’s disease

  2012cites this paper
• Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn

  2012cites this paper
• Mab21l2 Is Essential for Embryonic Heart and Liver Development

  2012cites this paper
• TOXIC SIGNALING OF METABOTROPIC GLUTAMATE 1 RECEPTOR IN CEREBELLAR NEURONS: INVOLVEMENT IN ABERRANT CELL CYCLE RE-ENTRY

  2012cites this paper
• Cell Cycle Activation and Spinal Cord Injury

  2011cites this paper
• Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death

  2011cites this paper
• The connections between neural crest development and neuroblastoma.

  2011cites this paper
• Phospho-Rb Mediating Cell Cycle Reentry Induces Early Apoptosis Following Oxygen–Glucose Deprivation in Rat Cortical Neurons

  2011cites this paper
• Programmed Neuronal Cell Death Mechanisms in CNS Injury

  2010cites this paper
• TAp63 is a transcriptional target of NF‐κB

  2010cites this paper
• Bridging the Divide between Neuroprosthetic Design, Tissue Engineering and Neurobiology

  2009cites this paper
• Alterations in cyclin A, B, and D1 in mouse dentate gyrus following TMT-induced hippocampal damage

  2009cites this paper
• DNA damage response and neuroprotection.

  2008cites this paper
• ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.

  2008cites this paper
• Translocations targeting CCND2, CCND3, and MYCN do occur in t(11;14)-negative mantle cell lymphomas.

  2008cites this paper
• Identification of PAX3‐FKHR‐regulated genes differentially expressed between alveolar and embryonal rhabdomyosarcoma: Focus on MYCN as a biologically relevant target

  2008cites this paper
• N-myc coordinates retinal growth with eye size during mouse development.

  2008cites this paper
• Role of Cell Cycle Proteins in CNS Injury

  2007cites this paper
• Chapter 6 – The Cell Cycle and Oxidative Neuronal Cell Death

  2007cites this paper
• MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells.

  2006cites this paper
• APPL1 Associates with TrkA and GIPC1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction

  2006cites this paper
• Structure-function Analysis of NRAGE : A Protein Involved in Developmental Neural Apoptosis

  2006cites this paper
• Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration.

  2006cites this paper
• APPL 1 Associates with TrkA and GIPC 1 and Is Required for Nerve Growth Factor-Mediated Signal Transduction

  2006cites this paper
• Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc

  2005cites this paper
• TrkA Induces Apoptosis of Neuroblastoma Cells and Does So via a p53-dependent Mechanism*[boxs]

  2005cites this paper
• Differentiation and Retinoids

  2005cites this paper
• Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation

  2005cites this paper
• Anti-gene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis

  2005cites this paper
• Role of the Cell Cycle in the Pathobiology of Central Nervous System Trauma

  2005cites this paper
• Enhanced expression of MYCN leads to centrosome hyperamplification after DNA damage in neuroblastoma cells

  2004cites this paper
• Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis.

  2004cites this paper
• Oxidative stress‐induced death in the nervous system: Cell cycle dependent or independent?

  2004cites this paper
• Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation

  2004cites this paper
• Id proteins in neural cancer.

  2004cites this paper
• Why do Neurons Enter the Cell Cycle?

  2004cites this paper
• N-myc transcription molecule and oncoprotein.

  2004cites this paper
• Methods for the study of lipid metabolism in neurons.

  2004cites this paper
• Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification.

  2004cites this paper
• Cell cycle regulation of neuronal apoptosis in development and disease.

  2004cites this paper
• Endogenously Produced Neurotrophins Regulate Survival and Differentiation of Cortical Progenitors via Distinct Signaling Pathways

  2003influential citation
• SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase

  2003influential citation
• Genomic medicine and neuroblastoma

  2003cites this paper
• The E2F–Cdc2 Cell-Cycle Pathway Specifically Mediates Activity Deprivation-Induced Apoptosis of Postmitotic Neurons

  2003cites this paper
• p73 Is Required for Survival and Maintenance of CNS Neurons

  2002cites this paper
• An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis.

  2002cites this paper