The naked mole-rat as an animal model in biomedical research: current perspectives

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Unknown venue

• Publication date

  2015-08-11

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.2147/OAAP.S50376
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• 14. Hormonal and Behavioral Aspects of Reproductive Suppression in Female Naked Mole-Rats

  2017cited by this paper
• The Biology of the Naked Mole-Rat

  2017cited by this paper
• 10. Social Organization of Naked Mole-Rat Colonies: Evidence for Divisions of Labor

  2017cited by this paper
• 4. The Population Structure of Naked Mole-Rat Colonies

  2017cited by this paper
• 5. The Ecology of Naked Mole-Rat Colonies: Burrowing, Food, and Limiting Factors

  2017influential reference
• 3. Ecology and Behavior of the Family Bathyergidae

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• Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

  2015cited by this paper
• Pain in aquatic animals

  2015cited by this paper
• Ecology, longevity and naked mole-rats: confounding effects of sociality?

  2015cited by this paper
• Sustained high levels of neuroprotective, high molecular weight, phosphorylated tau in the longest-lived rodent.

  2015cited by this paper
• Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

  2015cited by this paper
• Molecular evolution of the hyaluronan synthase 2 gene in mammals: implications for adaptations to the subterranean niche and cancer resistance

  2015cited by this paper
• Repeated functional convergent effects of NaV1.7 on acid insensitivity in hibernating mammals

  2014cited by this paper
• Epigenetic modifications of chronic hypoxia-mediated neurodegeneration in Alzheimer’s disease

  2014cited by this paper
• And the beat goes on: maintained cardiovascular function during aging in the longest-lived rodent, the naked mole-rat.

  2014cited by this paper
• Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax

  2014cited by this paper
• INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform

  2014cited by this paper
• A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.

  2014cited by this paper
• The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations

  2014cited by this paper
• Reproduction Is Associated with a Tissue-Dependent Reduction of Oxidative Stress in Eusocial Female Damaraland Mole-Rats (Fukomys damarensis)

  2014cited by this paper
• No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates

  2014cited by this paper
• Ecology and mode-of-life explain lifespan variation in birds and mammals

  2014cited by this paper
• High Autophagy in the Naked Mole Rat may Play a Significant Role in Maintaining Good Health

  2014cited by this paper
• Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.

  2014cited by this paper
• Investigation of anti-cancer mechanisms by comparative analysis of naked mole rat and rat

  2013cited by this paper
• Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage

  2013cited by this paper
• Plasticity and constraints on social evolution in African mole-rats: ultimate and proximate factors

  2013cited by this paper
• The Long-Lived Queen: Reproduction and Longevity in Female Eusocial Damaraland Mole-Rats (Fukomys damarensis)

  2013cited by this paper
• Hypoxia Increases Aβ-Induced Tau Phosphorylation by Calpain and Promotes Behavioral Consequences in AD Transgenic Mice

  2013cited by this paper
• Spontaneous Histologic Lesions of the Adult Naked Mole Rat (Heterocephalus glaber)

  2013cited by this paper
• IGF1R levels in the brain negatively correlate with longevity in 16 rodent species

  2013influential reference
• Metabolic regulatory clues from the naked mole rat: toward brain regulatory functions during stroke.

  2013cited by this paper
• Hypoxia‐inducible factor‐1 as a therapeutic target in cancer

  2013cited by this paper
• Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease.

  2013cited by this paper
• Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidence

  2013cited by this paper
• Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism

  2012cited by this paper
• Effect of hypoxia on metabolic rate, core body temperature, and c‐fos expression in the naked mole rat

  2012cited by this paper
• Altered Composition of Liver Proteasome Assemblies Contributes to Enhanced Proteasome Activity in the Exceptionally Long-Lived Naked Mole-Rat

  2012cited by this paper
• Synaptic energy use and supply.

  2012cited by this paper
• Blunted Behavioral and C Fos Responses to Acidic Fumes in the African Naked Mole-Rat

  2012cited by this paper
• Hypoxia associated NMDA receptor 2 subunit composition: developmental comparison between the hypoxia-tolerant subterranean mole-rat, Spalax, and the hypoxia-sensitive rat

  2012cited by this paper
• Blunted Neuronal Calcium Response to Hypoxia in Naked Mole-Rat Hippocampus

  2012cited by this paper
• Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum

  2012cited by this paper
• Sustained high levels of neuregulin‐1 in the longest‐lived rodents; a key determinant of rodent longevity

  2012cited by this paper
• Specific Paucity of Unmyelinated C-Fibers in Cutaneous Peripheral Nerves of the African Naked-Mole Rat: Comparative Analysis Using Six Species of Bathyergidae

  2012cited by this paper
• The Long Gestation of the Small Naked Mole-Rat (Heterocephalus glaber RÜPPELL, 1842) Studied with Ultrasound Biomicroscopy and 3D-Ultrasonography

  2011cited by this paper
• The Molecular Basis of Acid Insensitivity in the African Naked Mole-Rat

  2011cited by this paper
• Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent.

  2011cited by this paper
• dult naked mole-rat brain retains the NMDA receptor subunit GluN 2 D ssociated with hypoxia tolerance in neonatal mammals

  2011cited by this paper
• Endothelium-Derived Neuregulin Protects the Heart Against Ischemic Injury

  2011cited by this paper
• Genome sequencing reveals insights into physiology and longevity of the naked mole rat

  2011cited by this paper
• SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

  2011cited by this paper
• Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P

  2010cited by this paper
• Oxidative stress, inflammation, and cancer: how are they linked?

  2010cited by this paper
• Resistance to experimental tumorigenesis in cells of a long‐lived mammal, the naked mole‐rat (Heterocephalus glaber)

  2010cited by this paper
• Nociceptors: the sensors of the pain pathway.

  2010cited by this paper
• Functional Neurokinin and NMDA Receptor Activity in an Animal Naturally Lacking Substance P: The Naked Mole-Rat

  2010cited by this paper
• Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

  2009cited by this paper
• Nociceptors: a phylogenetic view

  2009cited by this paper
• Extreme hypoxia tolerance of naked mole-rat brain

  2009cited by this paper
• Cellular and molecular mechanisms of pain.

  2009cited by this paper
• Targeting the Nrf2 pathway against cardiovascular disease

  2009cited by this paper
• Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

  2009influential reference
• Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

  2009influential reference
• Coevolution of telomerase activity and body mass in mammals: from mice to beavers.

  2009cited by this paper
• Update on Slow Aging and Negligible Senescence – A Mini-Review

  2009cited by this paper
• Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber).

  2009cited by this paper
• Extreme tolerance to ammonia fumes in African naked mole-rats: animals that naturally lack neuropeptides from trigeminal chemosensory nerve fibers

  2009cited by this paper
• The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress*

  2009cited by this paper
• Tolerance to oxygen nutrient deprivation in the hippocampal slices of the naked mole rats.

  2009cited by this paper
• Hypoxia and Neurodegeneration

  2009cited by this paper
• Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species

  2008cited by this paper
• Expression of genes involved in excitatory neurotransmission in anoxic crucian carp (Carassius carassius) brain.

  2008cited by this paper
• Evidence of anoxia-induced channel arrest in the brain of the goldfish (Carassius auratus).

  2008cited by this paper
• Selective Inflammatory Pain Insensitivity in the African Naked Mole-Rat (Heterocephalus glaber)

  2008influential reference
• Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan

  2008cited by this paper
• Hypoxia tolerance in reptiles, amphibians, and fishes: life with variable oxygen availability.

  2007cited by this paper
• Telomerase activity coevolves with body mass not lifespan

  2007cited by this paper
• Nrf2/ARE regulated antioxidant gene expression in endothelial and smooth muscle cells in oxidative stress: implications for atherosclerosis and preeclampsia.

  2007cited by this paper
• P53 in blind subterranean mole rats – loss-of-function versus gain-of-function activities on newly cloned Spalax target genes

  2007cited by this paper
• Decreased NR1 phosphorylation and decreased NMDAR function in hibernating Arctic ground squirrels

  2006cited by this paper
• Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment

  2006cited by this paper
• Stimulation of mu and delta opioid receptors induces hyperalgesia while stimulation of kappa receptors induces antinociception in the hot plate test in the naked mole-rat (Heterocephalus glaber).

  2006cited by this paper
• Adaptive responses of vertebrate neurons to anoxia--matching supply to demand.

  2006cited by this paper
• The naked mole-rat: a new long-living model for human aging research.

  2005cited by this paper
• Telomeres, crisis and cancer.

  2005cited by this paper
• Overview of caloric restriction and ageing.

  2005cited by this paper
• Oxygen and carbon dioxide fluctuations in burrows of subterranean blind mole rats indicate tolerance to hypoxic-hypercapnic stresses.

  2005cited by this paper
• Hypoxic stress tolerance of the blind subterranean mole rat: expression of erythropoietin and hypoxia-inducible factor 1 alpha.

  2004cited by this paper
• Evolution of nociception in vertebrates: comparative analysis of lower vertebrates.

  2004cited by this paper
• Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels.

  2004cited by this paper
• Mechanosensation and pain.

  2004cited by this paper
• Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

  2004cited by this paper
• Physiological and pathological responses to hypoxia.

  2004cited by this paper
• Neuroprotection in hypothermia linked to redistribution of oxygen in brain.

  2003cited by this paper
• Lifespan extension by reduction of the growth hormone‐insulin‐like growth factor‐1 axis: relation to caloric restriction

  2003cited by this paper
• Somatosensory organization and behavior in naked mole‐rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain

  2003cited by this paper
• Oxygen sensitivity of NMDA receptors: relationship to NR2 subunit composition and hypoxia tolerance of neonatal neurons.

  2003cited by this paper
• The RB and p53 pathways in cancer.

  2002cited by this paper
• Prolonged longevity in naked mole-rats: age-related changes in metabolism, body composition and gastrointestinal function.

  2002cited by this paper

• More than one species of the naked mole-rat, a new biomedical model

  2025cites this paper
• Hypoxia-induced downregulation of RNA m6A protein machinery in the naked mole-rat heart.

  2024cites this paper
• Validation of Enzyme Immunoassays via an Adrenocorticotrophic Stimulation Test for the Non-Invasive Quantification of Stress-Related Hormone Metabolites in Naked Mole-Rats

  2023cites this paper
• Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data of Teleostei

  2023cites this paper
• Oral fructose intake does not improve exercise, visual, or cognitive performance during acute normobaric hypoxia in healthy humans

  2023cites this paper
• Not just a cousin of the naked mole-rat: Damaraland mole-rats offer unique insights into biomedicine.

  2022cites this paper
• Unique Features of the Tissue Structure in the Naked Mole Rat (Heterocephalus glaber): Hypertrophy of the Endoplasmic Reticulum and Spatial Mitochondrial Rearrangements in Hepatocytes

  2022cites this paper
• Effects of dexamethasone and acetylsalicylic acid on inflammation caused by Complete Freund's adjuvant in the naked mole rat (Heterocephalus glaber)

  2022cites this paper
• Naked mole-rats resist the accumulation of hypoxia-induced oxidative damage.

  2022cites this paper
• Small RNA sequencing in hypoxic naked mole‐rat hearts suggests microRNA regulation of RNA‐ and translation‐related processes

  2022cites this paper
• Spatial Learning and Memory in the Naked Mole-Rat: Evolutionary Adaptations to a Subterranean Niche

  2022cites this paper
• DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat

  2021cites this paper
• The effects of clonidine and yohimbine in the tail flick and hot plate tests in the naked mole rat (Heterocephalus glaber)

  2021cites this paper
• Utilizing comparative models in biomedical research.

  2021cites this paper
• Abundance and size of hyaluronan in naked mole-rat tissues and plasma

  2021cites this paper
• Utilizing comparative models in biomedical research.

  2021cites this paper
• Moderate Altitude Residence Reduces Male Colorectal and Female Breast Cancer Mortality More Than Incidence: Therapeutic Implications?

  2021cites this paper
• The Unusual Immune System of the Naked Mole-Rat.

  2021cites this paper
• Somatic mutation rates scale with lifespan across mammals

  2021cites this paper
• Hyaluronan as a Prominent Biomolecule with Numerous Applications in Medicine

  2021cites this paper
• Investigation of noradrenergic receptor system in anti-nociception using formalin test in the naked mole rat (Heterocephalus glaber)

  2020cites this paper
• Characterization and internalization of nanodiamond–trehalose conjugates into mammalian fibroblast cells of naked mole rat

  2020cites this paper
• Neurobiology: Crowdsourcing CO2 to Conserve Brain Energy

  2020cites this paper
• Cholesterol rich, highly phase separated, naked mole-rat brain lipids are exquisitely sensitive to amyloid induced membrane damage

  2020cites this paper
• Lipid membranes from naked mole-rat brain lipids are cholesterol-rich, highly phase-separated, and sensitive to amyloid-induced damage

  2020cites this paper
• Reply to: Transformation of naked mole-rat cells

  2020cites this paper
• Imiquimod does not elicit inflammatory responses in the skin of the naked mole rat (Heterocephalus glaber)

  2020cites this paper
• Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro

  2020cites this paper
• Translational control in the naked mole-rat as a model highly resistant to cancer.

  2020cites this paper
• Hypoxic naked mole–rat brains use microRNA to coordinate hypometabolic fuels and neuroprotective defenses

  2020cites this paper
• Unusual Correlation between Rest–Activity and Body Temperature Rhythms in the Naked Mole Rat (Heterocephalus glaber) as Compared to Five Other Mammalian Species

  2020cites this paper
• Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves

  2019cites this paper
• The material properties of naked mole-rat hyaluronan

  2019cites this paper
• Hyaluronan at the Brain-Environment Interface

  2019cites this paper
• The Relationship of Hyaluronic Acid-CD44 on Cancer Progression and Hyaluronic Acid-Based Self-Assembled Nanoparticle Roles

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• Effect of variously-processed rubber seed meals on reproductive performance: The use of Sprague-Dawley laboratory rats as model for pigs

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• Extended Longevity and Stress Resistance in Naked Mole Rats, Heterocephalus glaber

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• Naked mole-rat cortical neurons are resistant to acid-induced cell death

  2018cites this paper
• High Altitude and Cancer Mortality

  2018influential citation
• Naked mole rat hyaluronan - an extreme folding biopolymer

  2018cites this paper
• Naked Mole-Rat Cells are Susceptible to Malignant Transformation by SV40LT and Oncogenic Ras

  2018cites this paper
• Electrophysiological characterization and MCH/orexin neuronal distribution in the lateral hypothalamus of naked mole-rats (Heterocephalus glaber)

  2018cites this paper
• Naked mole-rat brain neurons are resistant to acid-induced cell death

  2018cites this paper
• Reproduction, ageing, and longevity in two species of laboratory rodents with different life histories

  2017cites this paper
• O2 binding and CO2 sensitivity in haemoglobins of subterranean African mole rats

  2017cites this paper
• Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

  2017cites this paper
• Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers

  2017cites this paper
• Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat

  2016cites this paper
• Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

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• Ear Structures of the Naked Mole-Rat, Heterocephalus glaber, and Its Relatives (Rodentia: Bathyergidae)

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