Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non‐genetic Model to Study Hirschsprung Disease?

Retinoic acid (RA) is pivotal for the development of the enteric nervous system (ENS), guiding the migration and differentiation of vagal neural crest cells in the gastrointestinal tract. Despite its recognized influence on other intestinal cell types, the specific roles of RA on these cells are less understood. This study investigates the extensive impact of RA inhibition on the intestinal composition using zebrafish, while also considering its potential use as a model for Hirschsprung disease (HSCR).

• Publication year

  2025

• Venue

  Neurogastroenterology and Motility

• Publication date

  2025-09-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/nmo.70155PMID 40937495PMCID 12534589
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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