Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Development

• Publication date

  1999-06-15

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 10331988
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture.

  1999cited by this paper
• GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin

  1998cited by this paper
• GFR a 1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney

  1998cited by this paper
• Persephin, a novel neurotrophic factor related to GDNF and neurturin.

  1998cited by this paper
• GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin.

  1998cited by this paper
• Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro.

  1998influential reference
• Age-dependent differences in the effects of GDNF and NT-3 on the development of neurons and glia from neural crest-derived precursors immunoselected from the fetal rat gut: expression of GFRalpha-1 in vitro and in vivo.

  1998cited by this paper
• SOX10 mutation disrupts neural crest development in Dom Hirschsprung mouse model

  1998cited by this paper
• V. Genes, lineages, and tissue interactions in the development of the enteric nervous system.

  1998cited by this paper
• A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture.

  1998influential reference
• Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease.

  1998cited by this paper
• GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family

  1998cited by this paper
• [Neurturin: a relative of glial-cell-line-derived neurotrophic factor].

  1998cited by this paper
• Age-Dependent Differences in the Effects of GDNF and NT-3 on the Development of Neurons and Glia from Neural Crest-Derived Precursors Immunoselected from the Fetal Rat Gut: Expression of GFRα-1in Vitroandin Vivo

  1998influential reference
• GDNF and ET-3 differentially modulate the numbers of avian enteric neural crest cells and enteric neurons in vitro.

  1998cited by this paper
• GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.

  1998cited by this paper
• V. Genes, lineages, and tissue interactions in the development of the enteric nervous system.

  1998cited by this paper
• Hirschsprung's disease genes and the development of the enteric nervous system.

  1998cited by this paper
• GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.

  1998cited by this paper
• Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons

  1998cited by this paper
• A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

  1997cited by this paper
• Neurotrophin switching: where does it stand?

  1997cited by this paper
• Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.

  1997cited by this paper
• Genes and lineages in the formation of the enteric nervous system.

  1997cited by this paper
• Serine/threonine kinase receptors and ligands.

  1997influential reference
• Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons.

  1997cited by this paper
• GFRα-2 and GFRα-3 Are Two New Receptors for Ligands of the GDNF Family

  1997cited by this paper
• Complementary and Overlapping Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF), c-ret Proto-Oncogene, and GDNF Receptor-α Indicates Multiple Mechanisms of Trophic Actions in the Adult Rat CNS

  1997cited by this paper
• Functional rafts in cell membranes

  1997cited by this paper
• Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis.

  1997cited by this paper
• Hirschsprung’s disease: genetic mutations in mice and men

  1997influential reference
• Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy

  1997cited by this paper
• GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family.

  1997cited by this paper
• The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis

  1997cited by this paper
• MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells.

  1997cited by this paper
• TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.

  1997cited by this paper
• Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor for sensory neurons: comparison with the effects of the neurotrophins.

  1997cited by this paper
• Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts.

  1996cited by this paper
• Renal agenesis and the absence of enteric neurons in mice lacking GDNF

  1996influential reference
• GDNF signalling through the Ret receptor tyrosine kinase

  1996cited by this paper
• Functional recovery in parkinsonian monkeys treated with GDNF

  1996cited by this paper
• Functional receptor for GDNF encoded by the c-ret proto-oncogene

  1996cited by this paper
• GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.

  1996cited by this paper
• GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

  1996cited by this paper
• Ret protein in the human fetal rectum.

  1996cited by this paper
• Defects in enteric innervation and kidney development in mice lacking GDNF

  1996influential reference
• Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient

  1996cited by this paper
• Distinct subpopulations of enteric neuronal progenitors defined by time of development, sympathoadrenal lineage markers and Mash-1-dependence.

  1996cited by this paper
• The effect of the ret- mutation on the normal development of the central and parasympathetic nervous systems.

  1996cited by this paper
• Characterization of a multicomponent receptor for GDNF

  1996cited by this paper
• Renal and neuronal abnormalities in mice lacking GDNF

  1996influential reference
• De novo mutation of GDNF, ligand for the RET/GDNFR-alpha receptor complex, in Hirschsprung disease.

  1996influential reference
• Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.

  1996cited by this paper
• De Novo Mutation of GDNF, Ligand for the RET/GDNFR-α Receptor Complex, in Hirschsprung Disease

  1996cited by this paper
• Neurturin, a relative of glial-cell-line-derived neurotrophic factor

  1996influential reference
• Isolation and characterization of a chicken homolog of the c-ret proto-oncogene.

  1995cited by this paper
• Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.

  1995cited by this paper
• GDNF is an age-specific survival factor for sensory and autonomic neurons.

  1995cited by this paper
• Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF

  1995cited by this paper
• Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

  1995cited by this paper
• In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons

  1995cited by this paper
• Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

  1995cited by this paper
• Immunohistochemical localization of RET protein in Hirschsprung's disease.

  1995cited by this paper
• Expression of ret in the chicken embryo suggests roles in regionalisation of the vagal neural tube and somites and in development of multiple neural crest and placodal lineages.

  1995cited by this paper
• Postmigratory neural crest cells expressing c-RET display restricted developmental and proliferative capacities.

  1995influential reference
• Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons

  1995cited by this paper
• Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues.

  1995cited by this paper
• Mapping the origin of the avian enteric nervous system with a retroviral marker

  1994cited by this paper
• Serine/threonine kinase receptors.

  1994cited by this paper
• GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle.

  1994cited by this paper
• Developmental expression of the RET protooncogene.

  1994influential reference
• TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons

  1994cited by this paper
• Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret

  1994cited by this paper
• TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons.

  1994cited by this paper
• Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

  1994cited by this paper
• Mutations of the RET proto-oncogene in Hirschsprung's disease

  1994cited by this paper
• Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia

  1994cited by this paper
• trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.

  1993cited by this paper
• Peripheral nerve and muscle.

  1993cited by this paper
• Ablation of various regions within the avian vagal neural crest has differential effects on ganglion formation in the fore‐, mid‐ and hindgut

  1993cited by this paper
• GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.

  1993influential reference
• Expression of the c-ret proto-oncogene during mouse embryogenesis.

  1993cited by this paper
• A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes

  1993cited by this paper
• From neural crest to bowel: development of the enteric nervous system.

  1993cited by this paper
• A transgenic model for studying development of the enteric nervous system in normal and aganglionic mice.

  1992cited by this paper
• Goosecoid and the organizer.

  1992influential reference
• Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: precursors of noncatecholaminergic enteric neurons.

  1990influential reference
• Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: relationship to the development of enteric neurons.

  1989influential reference
• Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

  1988cited by this paper
• ret transforming gene encodes a fusion protein homologous to tyrosine kinases

  1987cited by this paper
• Inability of neural crest cells to colonize the presumptive aganglionic bowel of ls/ls mutant mice: Requirement for a permissive microenvironment

  1987cited by this paper
• Colonization of the developing murine enteric nervous system and subsequent phenotypic expression by the precursors of peptidergic neurons

  1984influential reference
• The migration of neural crest cells to the wall of the digestive tract in avian embryo.

  1973influential reference
• The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo

  1954cited by this paper

• Retinol dehydrogenase 10-mediated retinoic acid signaling regulates the neural crest cell microenvironment during enteric nervous system formation.

  2026cites this paper
• Safety, pharmacokinetics and efficacy of HA121-28 in patients with advanced solid tumors and RET fusion-positive non-small-cell lung cancer: a multicenter, open-label, single-arm phase 1/2 trial

  2025cites this paper
• Motor learning is regulated by postnatal GDNF levels in Purkinje cells.

  2025cites this paper
• Rdh10-mediated Retinoic Acid Signaling Regulates the Neural Crest Cell Microenvironment During ENS Formation

  2025cites this paper
• Integrating artificial intelligence and optogenetics for Parkinson’s disease diagnosis and therapeutics in male mice

  2025cites this paper
• Retinoic Acid Inhibition Alters Intestinal Composition in Zebrafish: A Non‐genetic Model to Study Hirschsprung Disease?

  2025cites this paper
• Enteric Nervous System Striped Patterning and Disease: Unexplored Pathophysiology

  2024cites this paper
• Motor learning is regulated by GDNF levels in postnatal cerebellar Purkinje cells

  2024cites this paper
• Viral and nonviral approaches.

  2024cites this paper
• The role of enteric nervous system and GDNF in depression: conversation between the brain and the gut.

  2024cites this paper
• [Human glioma malignancy grade and migratory capacity depending on expression of GDNF isoforms in vitro].

  2024cites this paper
• Striatal GDNF Neurons Chemoattract RET-Positive Dopamine Axons at Seven Times Farther Distance Than Medium Spiny Neurons

  2024cites this paper
• Enhancement of enteric neural stem cell neurogenesis by glial cell-derived neurotrophic factor in experimental Hirschsprung’s disease

  2024influential citation
• Genome-wide scan for selection signatures in wild African harlequin quail (Coturnix delegorguei delegorguei) reveals candidate genes associated with immune response, morphological and production traits

  2023cites this paper
• Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

  2023cites this paper
• Treatment of Advanced Non-Small Cell Lung Cancer with RET Fusions: Reality and Hopes

  2023cites this paper
• Low nephron endowment increases susceptibility to renal stress and chronic kidney disease

  2023cites this paper
• Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction

  2023cites this paper
• Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility

  2023cites this paper
• Age-associated changes in lineage composition of the enteric nervous system regulate 1 gut health and disease 2

  2022cites this paper
• The RET gene encodes RET protein, which triggers intracellular signaling pathways for enteric neurogenesis, and RET mutation results in Hirschsprung's disease

  2022cites this paper
• In Toto imaging of early Enteric Nervous System Development reveals that gut colonization is tied to proliferation downstream of Ret

  2022cites this paper
• Multiple Roles of Ret Signalling During Enteric Neurogenesis

  2022cites this paper
• Environmental perception and control of gastrointestinal immunity by the enteric nervous system.

  2022cites this paper
• Targeting RET alterations in cancer: Recent progress and future directions.

  2022cites this paper
• A New Transgenic Tool to Study the Ret Signaling Pathway in the Enteric Nervous System

  2022cites this paper
• Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia

  2022cites this paper
• Discovery and Optimization of Selective RET Inhibitors via Scaffold Hopping.

  2021cites this paper
• Enhanced enteric neurogenesis by Schwann cell precursors in mouse models of Hirschsprung disease

  2021cites this paper
• Gut innervation and enteric nervous system development: a spatial, temporal and molecular tour de force

  2021cites this paper
• Is activation of GDNF/RET signaling the answer for successful treatment of Parkinson's disease? A discussion of data from the culture dish to the clinic

  2021cites this paper
• Age-specific mechanisms regulate neural crest and mesodermal contribution to the 1 enteric nervous system in health and disease

  2021cites this paper
• Literature review: enteric nervous system development, genetic and epigenetic regulation in the etiology of Hirschsprung's disease

  2021cites this paper
• Large intestine embryogenesis: Molecular pathways and related disorders (Review)

  2020cites this paper
• Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease

  2020cites this paper
• Development of the Autonomic Nervous System: Clinical Implications

  2020cites this paper
• RET overactivation leads to concurrent Hirschsprung disease and intestinal ganglioneuromas.

  2020cites this paper
• 37/67‐laminin receptor facilitates neural crest cell migration during enteric nervous system development

  2020cites this paper
• Biallelic Pathogenic GFRA1 Variants Cause Autosomal Recessive Bilateral Renal Agenesis.

  2020cites this paper
• Sox10 Is a Specific Biomarker for Neural Crest Stem Cells in Immunohistochemical Staining in Wistar Rats

  2020cites this paper
• Pulmonary Function in Patients with Multiple Endocrine Neoplasia 2B (MEN2B).

  2020cites this paper
• Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice

  2020cites this paper
• Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways

  2020cites this paper
• Intracellular Signaling

  2020cites this paper
• Animal Models of Aganglionosis

  2019cites this paper
• Progenitor populations within the vertebrate enteric nervous system

  2019cites this paper
• Genetics of diverse phenotypes in Hirschsprung disease - extension of aganglionosis, heredity and medullary thyroid carcinoma

  2019cites this paper
• LncRNA-MEG3 protects against ganglion cell dysplasia in congenital intestinal atresia through directly regulating miR-211-5p/GDNF axis.

  2019cites this paper
• Development of the Enteric Nervous System

  2019cites this paper
• Genetics of Hirschsprung’s Disease

  2019cites this paper
• Intimate neuro-immune interactions: breaking barriers between systems to make meaningful progress.

  2019cites this paper
• Fine scale differences within the vagal neural crest for enteric nervous system formation.

  2019cites this paper
• Receptor Tyrosine Kinases as Therapeutic Targets for Alcohol Use Disorder

  2019cites this paper
• The molecular basis of neural crest axial identity.

  2018cites this paper
• Establishment of an induced pluripotent stem cell model of Hirschsrpung disease, a congenital condition of the enteric nervous system, from a patient carrying a novel RET mutation

  2018cites this paper
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  2018cites this paper
• Novel metabolic regulations exerted by LKB1 signaling in polarized cells : impact on tissue ontogeny

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  2018influential citation
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Cell therapy for GI motility disorders: comparison of cell sources and proposed steps for treating Hirschsprung disease.

  2017cites this paper
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  2017cites this paper
• The Effects of Glial Cell Line-Derived Neurotrophic Factor after Spinal Cord Injury

  2017cites this paper
• Genetic Syndromes Affecting Kidney Development.

  2017cites this paper
• Exposure to GDNF Enhances the Ability of Enteric Neural Progenitors to Generate an Enteric Nervous System

  2017influential citation
• Metabolic hormones and physical activity as regulators of brain glial cell functions and neuroimmune status

  2017cites this paper
• Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function.

  2017cites this paper
• Development of the intrinsic and extrinsic innervation of the gut.

  2016cites this paper
• MicroRNA‐211 causes ganglion cell dysplasia in congenital intestinal atresia via down‐regulation of glial‐derived neurotrophic factor

  2016cites this paper
• Expression and prognosis value of SHP2 in patients with pancreatic ductal adenocarcinoma

  2016cites this paper
• Receptor tyrosine kinase signaling pathways: a review

  2016cites this paper
• Multiple Roles of Ret Signaling in Mechanosensory Neuron Development

  2016cites this paper
• Molecular fingerprinting delineates progenitor populations in the developing zebrafish enteric nervous system

  2016influential citation
• Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis.

  2016cites this paper
• Regulators of gene expression in Enteric Neural Crest Cells are putative Hirschsprung disease genes.

  2016cites this paper
• Endogenous GDNF as a regulator of midbrain dopamine neurons

  2016cites this paper
• Decreased expression of NEDL2 in Hirschsprung's disease.

  2016cites this paper
• La perturbation du locus Nr2f1-K12 entraine une différenciation gliale précoce dans un nouveau modèle murin de mégacôlon aganglionnaire

  2016cites this paper
• ENS Development Research Since 1983: Great Strides but Many Remaining Challenges.

  2016cites this paper
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  2015cites this paper
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  2015cites this paper
• FOR DOCTORAL DEGREE ( Ph . D . )

  2015cites this paper
• RET RECEPTOR ACTIVATION TARGETS EXPRESSION OF THE PLEIOTROPIC CYTOKINE INTERLEUKIN-11

  2015cites this paper
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  2015cites this paper
• Functional loss of semaphorin 3C and/or semaphorin 3D and their epistatic interaction with ret are critical to Hirschsprung disease liability.

  2015cites this paper
• Knockout mouse models of Hirschsprung’s disease

  2015cites this paper
• Growth and Neurotrophic Factor Receptors in Neural Differentiation and Phenotype Specification

  2015cites this paper
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