Thermal noise lowers the accuracy of rotationally invariant harmonics of diffusion MRI data and their robustness to experimental variations

Guillem París,Tomasz Pieciak,Derek K. Jones,S. Aja‐Fernández,Antonio Tristán-Vega,J. Veraart

Published 2025 in Magnetic Resonance in Medicine

ABSTRACT

Rotational invariants (RIs) are at the root of many dMRI applications. Among others, they are presented as a sensible way of reducing the dimensionality of biophysical models. While thermal noise impact on diffusion metrics has been well studied, little is known on its effect on spherical harmonics‐based RI (RISH) features and derived markers. In this work, we evaluate the effect of noise on RISH features and downstream Standard Model Imaging (SMI) estimates.

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