Caffeine Inhibits Adenosine-Induced Accumulation of Hypoxia-Inducible Factor-1α, Vascular Endothelial Growth Factor, and Interleukin-8 Expression in Hypoxic Human Colon Cancer Cells

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Molecular Pharmacology

• Publication date

  2007-08-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1124/mol.106.032920PMID 17488804
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Coffee, tea, and caffeine consumption and incidence of colon and rectal cancer.

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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

  2003cited by this paper
• Expression and function of A2B adenosine receptors in the U87MG tumor cells

  2003cited by this paper
• HIF-1 as a target for drug development

  2003cited by this paper
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  2002cited by this paper
• Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.

  2002cited by this paper
• Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.

  2001cited by this paper
• Pharmacological and biochemical characterization of A3 adenosine receptors in Jurkat T cells

  2001cited by this paper
• International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors.

  2001influential reference
• Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line

  2001cited by this paper
• Food, nutrition and the prevention of cancer : a global perspective

  2001cited by this paper
• Interleukin-8 and human cancer biology.

  2001cited by this paper
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  2000cited by this paper
• Suppression of tumor growth through disruption of hypoxia-inducible transcription

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
• Human Cancers and Their Metastases in Common α Overexpression of Hypoxia-inducible Factor 1 Updated Version

  1999cited by this paper
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  1999cited by this paper
• Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases.

  1999cited by this paper
• Actions of caffeine in the brain with special reference to factors that contribute to its widespread use.

  1999cited by this paper
• Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

  1998cited by this paper
• Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998)

  1998cited by this paper
• Inhibition of melanoma pulmonary metastasis by methylxanthines due to decreased invasion and proliferation

  1998cited by this paper
• Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

  1997cited by this paper
• Upregulation of Interleukin 8 by Oxygen-deprived Cells in Glioblastoma Suggests a Role in Leukocyte Activation, Chemotaxis, and Angiogenesis

  1997cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996influential reference
• Caffeine and theophylline as adenosine receptor antagonists in humans.

  1991cited by this paper
• Actions of Caffeine

  1991cited by this paper

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  2022cites this paper
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  2018cites this paper
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  2018cites this paper
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• The A3 Adenosine Receptor: History and Perspectives

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