Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies

No abstract is available for this paper.

• Publication year

  2025

• Venue

  Genes & Diseases

• Publication date

  2025-11-01

• Fields of study

  Not labeled

• Identifiers
  DOI 10.1016/j.gendis.2025.101925
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility

  2025cited by this paper
• Optical Tweezer-Driven Mechanotransduction: Probing pN-Scale Forces and Calcium-Mediated Redox Signaling in Single Endothelial Cells.

  2025cited by this paper
• PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence

  2025cited by this paper
• Stratification of enterochromaffin cells by single-cell expression analysis

  2025cited by this paper
• Intestinal L-cell mechanoreception regulates hepatic lipid metabolism through GLP-1

  2025cited by this paper
• TLR4 interaction with PIEZO1 facilitates the 5-HT-mediated intestinal motility dysfunction in offspring mice induced by LPS exposure during pregnancy

  2025cited by this paper
• CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa

  2025cited by this paper
• Piezo2+ mechanosensory neurons orchestrate postnatal development through mechano-chemo-transduction of PDGFA signaling

  2025cited by this paper
• PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice

  2025cited by this paper
• Spatiotemporal H2O2 flashes coordinate actin cytoskeletal remodeling and regulate cell migration and wound healing

  2025cited by this paper
• Impact of Adenosine Triphosphate Synthase Subunit β on TLR Signaling Pathway in Promoting Airway Remodeling and Heterogeneity of Small Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease

  2025cited by this paper
• Piezo1: structural pharmacology and mechanotransduction mechanisms.

  2025cited by this paper
• Oxidative modulation of Piezo1 channels

  2025cited by this paper
• Exploring the Multifactorial Regulation of PIEZO1 in Chondrocytes: Mechanisms and Implications

  2025cited by this paper
• Diet-Induced mechanical stress promotes immune and metabolic alterations in the Drosophila melanogaster digestive tract.

  2025cited by this paper
• Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway.

  2025cited by this paper
• Piezo knockdown reduces 5-hydroxytryptamine release from enterochromaffin cells and exacerbates intestinal dyskinesia in mice with functional constipation

  2025cited by this paper
• Visualizing PIEZO1 localization and activity in hiPSC-derived single cells and organoids with HaloTag technology

  2025cited by this paper
• Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force.

  2025cited by this paper
• Smooth muscle cell Piezo1 depletion results in impaired contractile properties in murine small bowel

  2025cited by this paper
• Piezo1-specific Deletion in Macrophage Protects the Progression of Chronic Inflammatory Bowel Disease in Mice

  2025cited by this paper
• Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism.

  2025cited by this paper
• Piezo1 promotes the progression of necrotizing enterocolitis by activating the Ca2(+)/CaMKII-dependent pathway

  2025cited by this paper
• Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives

  2025cited by this paper
• Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression

  2025cited by this paper
• Digestive cancers: mechanisms, therapeutics and management

  2025cited by this paper
• Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications

  2025cited by this paper
• Laminarin ameliorates iodoacetamide-induced functional dyspepsia via modulation of 5-HT3 receptors and the gut microbiota.

  2024cited by this paper
• An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel.

  2024cited by this paper
• Macrophages regulate angiogenesis-osteogenesis coupling induced by mechanical loading through the Piezo1 pathway.

  2024cited by this paper
• Piezo1 Regulates Stiffness‐Dependent DRG Axon Regeneration via Modifying Cytoskeletal Dynamics

  2024cited by this paper
• The Calcium Homeostasis of Human Red Blood Cells in Health and Disease: Interactions of PIEZO1, the Plasma Membrane Calcium Pump, and Gardos Channels.

  2024cited by this paper
• Chemical mapping of the surface interactome of PIEZO1 identifies CADM1 as a modulator of channel inactivation

  2024cited by this paper
• Enhanced Tumor‐Targeted Delivery of Arginine‐Rich Peptides via a Positive Feedback Loop Orchestrated by Piezo1/integrin β1 Signaling Axis

  2024cited by this paper
• Mechanisms of mechanotransduction and physiological roles of PIEZO channels

  2024cited by this paper
• Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis.

  2024cited by this paper
• Role of Piezo1 in Terminal Density Reversal of Red Blood Cells

  2024cited by this paper
• Piezo1 expression in neutrophils regulates shear-induced NETosis

  2024cited by this paper
• Forces Bless You: Mechanosensitive Piezo Channels in Gastrointestinal Physiology and Pathology

  2024cited by this paper
• Microscale geometrical modulation of PIEZO1 mediated mechanosensing through cytoskeletal redistribution

  2024cited by this paper
• A novel suppressor of Piezo2 in rodent nociceptors.

  2024cited by this paper
• Plp1-expresssing perineuronal DRG cells facilitate colonic and somatic chronic mechanical pain involving Piezo2 upregulation in DRG neurons.

  2024cited by this paper
• RNAi-based drug design: considerations and future directions

  2024cited by this paper
• TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction.

  2024cited by this paper
• Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake

  2024cited by this paper
• PIEZO1 is a distal nephron mechanosensor and is required for flow-induced K+ secretion

  2024cited by this paper
• Mechanical stiffness promotes skin fibrosis via Piezo1-Wnt2/Wnt11-CCL24 positive feedback loop

  2024cited by this paper
• PIEZO2 expression is an independent biomarker prognostic for gastric cancer and represents a potential therapeutic target

  2024cited by this paper
• Inhibition of Piezo1 Ameliorates Intestinal Inflammation and Limits the Activation of Group 3 Innate Lymphoid Cells in Experimental Colitis

  2023cited by this paper
• A synergistic regulation works in matrix stiffness-driven invadopodia formation in HCC.

  2023cited by this paper
• Joining forces: crosstalk between mechanosensitive PIEZO1 ion channels and integrin-mediated focal adhesions.

  2023cited by this paper
• H. pylori‐induced NF‐κB‐PIEZO1‐YAP1‐CTGF axis drives gastric cancer progression and cancer‐associated fibroblast‐mediated tumour microenvironment remodelling

  2023cited by this paper
• Varying mechanical forces drive sensory epithelium formation

  2023cited by this paper
• Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress

  2023cited by this paper
• Identification of Piezo1 as a potential target for therapy of colon cancer stem-like cells

  2023cited by this paper
• Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis

  2023cited by this paper
• Activation of Piezo1 Channels in Compressed Red Blood Cells Augments Platelet-Driven Contraction of Blood Clots.

  2023cited by this paper
• Cardiac Piezo1 Exacerbates Lethal Ventricular Arrhythmogenesis by Linking Mechanical Stress with Ca2+ Handling After Myocardial Infarction

  2023cited by this paper
• Microbial sensing in the intestine

  2023cited by this paper
• Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice

  2023cited by this paper
• Matrix stiffness induces epithelial-to-mesenchymal transition via Piezo1-regulated calcium flux in prostate cancer cells

  2023cited by this paper
• C-terminus of PIEZO1 governs Ca2+ influx and intracellular ERK1/2 signaling pathway in mechanotransduction.

  2023cited by this paper
• Expression and clinical significance of PIEZO2 in gastric cancer.

  2023cited by this paper
• PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.

  2023cited by this paper
• Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification

  2023cited by this paper
• Mechanosensing Piezo channels in gastrointestinal disorders

  2023cited by this paper
• DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon

  2022cited by this paper
• Tethering Piezo channels to the actin cytoskeleton for mechanogating via the cadherin-β-catenin mechanotransduction complex.

  2022cited by this paper
• Reevaluation of Piezo1 as a gut RNA sensor

  2022cited by this paper
• Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2

  2022cited by this paper
• Initiation and severity of experimental pancreatitis are modified by phosphate.

  2022cited by this paper
• Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

  2022cited by this paper
• Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling

  2022cited by this paper
• A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells

  2022cited by this paper
• The Mechanosensitive Ion Channel PIEZO1 in Intestinal Epithelial Cells Mediates Inflammation through the NOD-Like Receptor 3 Pathway in Crohn's Disease.

  2022cited by this paper
• The function of Piezo1 in hepatoblastoma metastasis and its potential transduction mechanism

  2022cited by this paper
• Piezo1 Mechano-Activation Is Augmented by Resveratrol and Differs between Colorectal Cancer Cells of Primary and Metastatic Origin

  2022cited by this paper
• Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma

  2022cited by this paper
• Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

  2022cited by this paper
• Piezo2 voltage-block regulates mechanical pain sensitivity

  2022cited by this paper
• Reprogrammed fecal and mucosa-associated intestinal microbiota and weakened mucus layer in intestinal goblet cell- specific Piezo1-deficient mice

  2022cited by this paper
• Intestinal enteroendocrine cells rely on ryanodine and IP3 calcium store receptors for mechanotransduction

  2022cited by this paper
• PIEZO2 in somatosensory neurons controls gastrointestinal transit

  2022cited by this paper
• Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.

  2022cited by this paper
• Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5c

  2021cited by this paper
• Specialized mechanosensory epithelial cells in mouse gut intrinsic tactile sensitivity.

  2021cited by this paper
• The tactile sensors of the gut.

  2021cited by this paper
• Mechanical stimulation activates Piezo1 to promote mucin2 expression in goblet cells

  2021cited by this paper
• Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans

  2021cited by this paper
• C. elegans PEZO-1 is a mechanosensitive ion channel involved in food sensation

  2021cited by this paper
• Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis

  2021cited by this paper
• Vinculin controls endothelial cell junction dynamics during vascular lumen formation

  2021cited by this paper
• Piezo1 regulates intestinal epithelial function by affecting the tight junction protein claudin-1 via the ROCK pathway.

  2021cited by this paper
• Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis

  2021cited by this paper
• Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study.

  2020cited by this paper
• The function of Piezo1 in colon cancer metastasis and its potential regulatory mechanism

  2020cited by this paper
• The Emerging Role of Mechanosensitive Piezo Channels in Migraine Pain

  2020cited by this paper
• TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.

  2020cited by this paper
• Levering Mechanically Activated Piezo Channels for Potential Pharmacological Intervention.

  2020cited by this paper
• Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1

  2020cited by this paper

• No citing papers are available for this paper.