Chemical mapping of the surface interactome of PIEZO1 identifies CADM1 as a modulator of channel inactivation

Significance The process by which the body senses and responds to mechanical pressure (mechanosensation) is often carried out by PIEZO ion channels that reside in the plasma membrane. Local calcium flux through these force sensors is postulated to be upstream of many intracellular pathways that drive inherently mechanical processes. However, the mechanisms of signal transduction regulated by proteins surrounding PIEZOs at the cell surface have been difficult to study directly, as have the molecular details that govern detection of mechanical stimuli over many orders of magnitude within different tissues and organs. In this study, we aimed to capture a snapshot of the local endogenous protein network that may enable calibration of PIEZO-mediated mechanosensation within different cellular contexts.

• Publication year

  2024

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2024-10-02

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.2415934121PMID 39356664PMCID 11474052
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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