Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels.

No abstract is available for this paper.

• Publication year

  2017

• Venue

  TIBS -Trends in Biochemical Sciences. Regular ed

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.tibs.2016.09.004PMID 27743844PMCID PMC5407468
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

  2017cited by this paper
• Piezo1 haploinsufficiency does not alter mechanotransduction in mouse cochlear outer hair cells

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• Localized force application reveals mechanically sensitive domains of Piezo1

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• A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons

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• Evolutionary Specialization of Tactile Perception in Vertebrates.

  2016cited by this paper
• Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function.

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• Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

  2016influential reference
• Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

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• Ion Permeation and Mechanotransduction Mechanisms of Mechanosensitive Piezo Channels.

  2016cited by this paper
• Regulation of Piezo2 Mechanotransduction by Static Plasma Membrane Tension in Primary Afferent Neurons*

  2016cited by this paper
• Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function.

  2016cited by this paper
• Piezo1-dependent regulation of urinary osmolarity

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• Influence of Global and Local Membrane Curvature on Mechanosensitive Ion Channels: A Finite Element Approach

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• Exome sequencing identifies potential novel candidate genes in patients with unexplained colorectal adenomatous polyposis

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• Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling.

  2015cited by this paper
• Activation of TRPV1 channels inhibits mechanosensitive Piezo channel activity by depleting membrane phosphoinositides

  2015cited by this paper
• Architecture of the mammalian mechanosensitive Piezo1 channel

  2015influential reference
• Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia

  2015cited by this paper
• A family of distal arthrogryposis type 5 due to a novel PIEZO2 mutation

  2015cited by this paper
• Astrocytes in the optic nerve head express putative mechanosensitive channels

  2015cited by this paper
• Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis

  2015cited by this paper
• Functional role of mechanosensitive ion channel Piezo1 in human periodontal ligament cells.

  2015cited by this paper
• Piezo1 ion channel pore properties are dictated by C-terminal region

  2015influential reference
• Piezo2 is the principal mechanotransduction channel for proprioception

  2015cited by this paper
• Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

  2015influential reference
• Protonation of the Human PIEZO1 Ion Channel Stabilizes Inactivation*

  2015cited by this paper
• Piezo1 regulates mechanotransductive release of ATP from human RBCs

  2015cited by this paper
• Membrane stiffening by STOML3 facilitates mechanosensation in sensory neurons

  2015cited by this paper
• The role of lipids in mechanosensation

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• Piezo1 links mechanical forces to red blood cell volume

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• Chemical activation of the mechanotransduction channel Piezo1

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• Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl

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• Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

  2014influential reference
• Piezo2 is the major transducer of mechanical forces for touch sensation in mice

  2014cited by this paper
• Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels

  2014cited by this paper
• Piezo2 is required for Merkel cell mechanotransduction

  2014cited by this paper
• Piezo1 integration of vascular architecture with physiological force

  2014cited by this paper
• Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

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• Epidermal Merkel Cells are Mechanosensory Cells that Tune Mammalian Touch Receptors

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• Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells

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• Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch

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• Piezo1, a mechanically activated ion channel, is required for vascular development in mice

  2014influential reference
• Stochastic nanoroughness modulates neuron–astrocyte interactions and function via mechanosensing cation channels

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• Functional Role for Piezo1 in Stretch-evoked Ca2+ Influx and ATP Release in Urothelial Cell Cultures*

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• The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold.

  2014cited by this paper
• Mutations in PIEZO2 cause Gordon syndrome, Marden-Walker syndrome, and distal arthrogryposis type 5.

  2014cited by this paper
• Piezo1‐dependent stretch‐activated channels are inhibited by Polycystin‐2 in renal tubular epithelial cells

  2013cited by this paper
• Xerocytosis is caused by mutations that alter the kinetics of the mechanosensitive channel PIEZO1

  2013cited by this paper
• Dehydrated Hereditary Stomatocytosislinked to gain-of-function mutations in mechanically activated PIEZO1 ion channels

  2013cited by this paper
• Human PIEZO1: removing inactivation.

  2013cited by this paper
• Small-molecule photostabilizing agents are modifiers of lipid bilayer properties.

  2013cited by this paper
• Piezo-electrically driven mechanical stimulation of sensory neurons.

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• The Star-Nosed Mole Reveals Clues to the Molecular Basis of Mammalian Touch

  2013cited by this paper
• Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis

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• Identification and Analysis of Putative Homologues of Mechanosensitive Channels in Pathogenic Protozoa

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• piezo2b Regulates Vertebrate Light Touch Response

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• A role for Piezo2 in EPAC1-dependent mechanical allodynia

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  2013cited by this paper
• Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1.

  2013cited by this paper
• Inflammatory signals enhance piezo2-mediated mechanosensitive currents.

  2012cited by this paper
• Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis.

  2012cited by this paper
• Molecular force transduction by ion channels – diversity and unifying principles

  2012cited by this paper
• Sensing pressure with ion channels.

  2012cited by this paper
• Gating the mechanical channel Piezo1

  2012cited by this paper
• Faculty Opinions recommendation of Piezo proteins are pore-forming subunits of mechanically activated channels.

  2012influential reference
• The role of Drosophila Piezo in mechanical nociception

  2011cited by this paper
• Mechanosensitive channels: what can they do and how do they do it?

  2011cited by this paper
• The mechanosensitive ion channel Piezo1 is inhibited by the peptide GsMTx4.

  2011cited by this paper
• Piezos are pore-forming subunits of mechanically activated channels

  2011cited by this paper
• Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

  2011cited by this paper
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• Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

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