Vitamin D3 Supplementation Modulates Inflammatory Protein CHI3L1/YKL‐40 and Oxidative Stress Status in Multiple Sclerosis

Sevda Asadpour,M. Mazdeh,J. Karimi,I. Khodadadi,Gholamreza Shafiee

Published 2025 in Neuropsychopharmacology Reports

ABSTRACT

Multiple sclerosis (MS) is characterized by chronic neuroinflammation and oxidative stress. Vitamin D is believed to exert immunomodulatory and antioxidant effects, yet its impact on specific inflammatory proteins such as CHI3L1 (YKL‐40) in MS remains unclear. This study evaluated whether 8‐week vitamin D3 supplementation affects serum CHI3L1 levels, oxidative stress markers, and antioxidant enzyme activities in patients with MS.

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