The effect of vitamin D supplementation on oxidative stress parameters: A systematic review and meta‐analysis of clinical trials

&NA; Recent studies have shown that vitamin D supplementation beneficially decreases oxidative stress (OS) parameters; however, there is no consensus on this subject. In this systematic review and meta‐analysis we aimed to investigate the effect of vitamin D supplementation on OS parameters. We searched electronic databases including Medline, Embase, Scopus, Web of Science and Cochrane Library up to July 2018 without any language restriction. Trials were reviewed using preferred reporting items for systematic reviews and meta‐analyses (PRISMA) and Cochrane handbook. To compare the effects of vitamin D with placebo, standardized mean difference (SMD) with 95% confidence intervals (CI) were pooled using random effects model. Across thirteen clinical trials, we found that vitamin D supplementation increased serum levels of total antioxidant capacity (TAC) (SMD: 0.54 mmol/L, 95% CI: 0.29 to 0.79; I2 = 65.4%, P = 0.001) and glutathione (GSH) (SMD: 0.33; 95% CI: 0.11 to 0.54, P = 0.003; I2 = 61.2%, P = 0.001). Besides, malondialdehyde (MDA) concentration decreased significantly (SMD: ‐0.40 mmol/L, 95% CI: ‐0.60 to ‐0.21, P < 0.001) following vitamin D supplementation compared to placebo. However, its effects on nitric oxide (NO) was not significant (0.17, 95% CI: ‐0.10 to 0.45, I2 = 71.1%, P = 0.21). Finally, we showed that vitamin D supplementation can improve OS parameters; however, this finding may not be clinically significant. Further large prospective clinical trials are needed to confirm the effect of vitamin D supplement on other OS parameters.

• Publication year

  2019

• Venue

  Pharmacological Research

• Publication date

  2019-01-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.phrs.2018.11.011PMID 30447293
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress

  2018cited by this paper
• The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile

  2018cited by this paper
• Note of Concern: Clinical Trial on the Effects of Vitamin D Supplementation on Metabolic Profiles in Diabetic Hemodialysis.

  2018cited by this paper
• The Role of Oxidative Stress

  2018cited by this paper
• Clinical trial of the effects of vitamin D supplementation on psychological symptoms and metabolic profiles in maintenance methadone treatment patients.

  2017influential reference
• Effect of Two Different Doses of Vitamin D Supplementation on Metabolic Profiles of Insulin-Resistant Patients with Polycystic Ovary Syndrome

  2017cited by this paper
• The effects of vitamin D supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial.

  2017cited by this paper
• Clinical and Metabolic Response to Vitamin D Supplementation in Endometrial Hyperplasia: a Randomized, Double-Blind, Placebo-Controlled Trial

  2017cited by this paper
• Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial

  2017cited by this paper
• Clinical Trial on the Effects of Vitamin D Supplementation on Metabolic Profiles in Diabetic Hemodialysis

  2017cited by this paper
• Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols

  2017cited by this paper
• Vitamin D supplementation attenuates oxidative stress in paraspinal skeletal muscles in patients with low back pain

  2017influential reference
• Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials.

  2017cited by this paper
• Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

  2017cited by this paper
• The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes

  2017cited by this paper
• Long-Term Vitamin D Supplementation Affects Metabolic Status in Vitamin D-Deficient Type 2 Diabetic Patients with Coronary Artery Disease.

  2017cited by this paper
• The Effects of Vitamin D Supplementation on Metabolic Status of Patients with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

  2016cited by this paper
• Vitamin D Supplementation Affects the Beck Depression Inventory, Insulin Resistance, and Biomarkers of Oxidative Stress in Patients with Major Depressive Disorder: A Randomized, Controlled Clinical Trial.

  2016cited by this paper
• Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.

  2015cited by this paper
• Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers.

  2015cited by this paper
• The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review).

  2015cited by this paper
• Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland

  2015cited by this paper
• Effects of High-Dose Vitamin D Supplementation on Metabolic Status and Pregnancy Outcomes in Pregnant Women at Risk for Pre-Eclampsia

  2015influential reference
• Calcium plus vitamin D supplementation influences biomarkers of inflammation and oxidative stress in overweight and vitamin D‐deficient women with polycystic ovary syndrome: a randomized double‐blind placebo‐controlled clinical trial

  2015cited by this paper
• The Nrf2 regulatory network provides an interface between redox and intermediary metabolism.

  2014cited by this paper
• Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial

  2014cited by this paper
• Vitamin D is a regulator of endothelial nitric oxide synthase and arterial stiffness in mice.

  2014cited by this paper
• Vitamin D and cardiovascular disease.

  2014cited by this paper
• The effect of calcitriol on lipid profile and oxidative stress in hyperlipidemic patients with type 2 diabetes mellitus

  2014influential reference
• Effect of Vitamin D 3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis

  2014cited by this paper
• Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial.

  2013cited by this paper
• Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women.

  2013cited by this paper
• Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes.

  2013cited by this paper
• Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes.

  2013cited by this paper
• The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.

  2012cited by this paper
• 1α,25-Dihydroxycholecalciferol Induces Nitric Oxide Production in Cultured Endothelial Cells

  2011cited by this paper
• Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

  2010cited by this paper
• Effects of calcitriol on calbindins gene expression and lipid peroxidation in human placenta.

  2010cited by this paper
• Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects.

  2009cited by this paper
• Vitamin D analogs: therapeutic applications and mechanisms for selectivity.

  2008cited by this paper
• Protective role of 1α, 25‐dihydroxyvitamin D3 against oxidative stress in nonmalignant human prostate epithelial cells

  2008cited by this paper
• Total antioxidant capacity: appraisal of a concept.

  2007cited by this paper
• Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications.

  2003cited by this paper
• Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR genotype in Bangladeshi Asians.

  2002cited by this paper
• Vitamin D receptor activity and prevention of colonic hyperproliferation and oxidative stress.

  2002cited by this paper
• Susceptibility of glutatione and glutathione-related antioxidant activity to hydrogen peroxide in patients with type 2 diabetes: effect of glycemic control.

  2002cited by this paper
• 1,25‐Dihydroxyvitamin D3 Regulates the Synthesis of γ‐Glutamyl Transpeptidase and Glutathione Levels in Rat Primary Astrocytes

  1999cited by this paper
• Vitamin D is a membrane antioxidant Ability to inhibit iron‐dependent lipid peroxidation in liposomes compared to cholesterol, ergosterol and tamoxifen and relevance to anticancer action

  1993cited by this paper
• Impairment of glutathione metabolism in erythrocytes from patients with diabetes mellitus.

  1989cited by this paper

• Effects of Food Bioactive Compounds on Oxidative Stress and the Antioxidant Defense System in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  2026cites this paper
• Vitamin D Deficiency and Geroscience: Systemic Mechanisms Underlying Multi-organ Aging of the Skin, Liver, Brain, and Kidney

  2026cites this paper
• Vitamin D supplementation and its role in modulating ovarian reserve and oxidative stress in infertile females

  2026cites this paper
• Impact of antioxidants fortified eggs consumption on eye health in individuals with mild to moderate untreated eczema: a randomized controlled trial

  2025cites this paper
• Pathophysiological Role and Therapeutic Potential of Vitamin C in Metabolic Syndrome and Type 2 Diabetes Mellitus

  2025cites this paper
• Investigating the Protective Role of Vitamin D Supplementation on Cyclophosphamide-Induced Liver Enzyme Alterations in Adult Male Rats

  2025cites this paper
• Vitamin D3 Supplementation Modulates Inflammatory Protein CHI3L1/YKL‐40 and Oxidative Stress Status in Multiple Sclerosis

  2025cites this paper
• RATIONALE FOR COMPREHENSIVE NUTRIENT SUPPORT IN SCHIZOPHRENIA: BRIEF LITERATURE REVIEW

  2025cites this paper
• Clinical efficacy of vitamin D combined with conventional therapy for sudden sensorineural hearing loss in patients with vitamin D deficiency: a randomized controlled trial

  2025cites this paper
• Vitamin D Protects Pancreatic Cancer (PC) Cells from Death and DNA Damage Induced by Oxidative Stress

  2025cites this paper
• Effect of Vitamin D Supplementation on Metabolic Parameters in Patients with Metabolic Associated Fatty Liver Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

  2025cites this paper
• Maternal Vitamin D Status, Oxidative Stress, and Implications for Neonatal Development: A Cross-Sectional Study

  2025cites this paper
• Investigating the Role of Vitamin D in Enhancing Duloxetine and Fluoxetine Efficacy: Mechanistic Insights Into NRF2 Activation, Oxidative Stress, and Neurochemical Modulation

  2025cites this paper
• Combined Use of Vitamin D and DPP-4 Inhibitors as a Potential Adjuvant Treatment Strategy to Enhance the Efficacy of Novel Beta-Cell Replacement Therapies for Type 1 Diabetes

  2025cites this paper
• Influence of rutin on LPS-induced inflammation, oxidative stress, and autophagy in bovine mammary epithelial cells.

  2025cites this paper
• Association between serum Vitamin D levels and sperm DNA fragmentation index in varicocele patients: a retrospective cohort study

  2025cites this paper
• Impact of Heavy Metals on the Antioxidant Activity of Vitamin D: A Metabolic Perspective

  2025cites this paper
• Copper Induced Hepatic Toxicity in Male Albino Rats and the Possible Protective Effect of Vitamin D

  2025cites this paper
• Impact of intermittent fasting versus vitamin D on high fat fructose-induced pancreatic steatosis: possible role of aquaporins

  2025cites this paper
• Light physical activity and vitamin D improve sperm quality of male Rattus norvegicus exposed to cigarette smoke

  2025cites this paper
• Adropin contributes to the nephro-protective effect of vitamin D in renal aging in a rat model via MAPK/HIFα/VEGF/eNOS mechanism.

  2025cites this paper
• Impact of Chronic Cold Water Immersion and Vitamin D3 Supplementation on the Hippocampal Metabolism and Oxidative Stress in Rats

  2025cites this paper
• Multivitamin supplementation and its impact in metabolic dysfunction-associated steatotic liver disease

  2025cites this paper
• Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients

  2025cites this paper
• The Effects of Antioxidant Approved Drugs and Under Investigation Compounds with Potential of Improving Sleep Disorders and their Associated Comorbidities associated with Oxidative Stress and Inflammation.

  2025cites this paper
• Cellular and biochemical heterogeneity contributes to the phenotypic diversity of transfusion-dependent β-thalassemia

  2025cites this paper
• Ameliorative effects of avocado oil on bleomycin‐induced lung fibrosis and oxidative stress in rats

  2025cites this paper
• Medikamentöse Therapien des steifen Kniegelenks

  2025cites this paper
• Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-κB/MMP-9 signaling pathway.

  2025cites this paper
• Diabetic Keratopathy: Redox Signaling Pathways and Therapeutic Prospects

  2024cites this paper
• Role of vitamins A, C, D, E in cancer prevention and therapy: therapeutic potentials and mechanisms of action

  2024cites this paper
• Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis

  2024influential citation
• Potential therapeutic impacts of vitamin D on hypothyroid-induced heart and kidney fibrosis and oxidative status in male rat

  2024influential citation
• The Impact of Vitamin D on Androgens and Anabolic Steroids among Adult Males: A Meta-Analytic Review

  2024cites this paper
• No bidirectional association between serum 25-hydroxyvitamin D and erectile dysfunction: Mendelian randomization and genetic association studies

  2024cites this paper
• The effect of antioxidant supplementation on dysmenorrhea and endometriosis-associated painful symptoms: a systematic review and meta-analysis of randomized clinical trials

  2024cites this paper
• The effect of pomegranate supplementation on symptom severity and quality of life in women with premenstrual syndrome: A randomised controlled trial.

  2024cites this paper
• The impact of solid fuel use on major depression and the buffering effect of outdoor time in the UK adults: A 12-year cohort study.

  2024cites this paper
• The relationship between serum vitamin D, testosterone, and oxidative stress levels in women with sexual dysfunction: A case-controlled study.

  2024cites this paper
• Cholecalciferol effect on oxidative stress and novel predictors of inflammation in hemodialysis patients: a prospective randomized trial

  2024cites this paper
• Antioxidant Functions of Vitamin D and CYP11A1-Derived Vitamin D, Tachysterol, and Lumisterol Metabolites: Mechanisms, Clinical Implications, and Future Directions

  2024cites this paper
• Oxidative stress and food as medicine

  2024cites this paper
• Mitigating diabetes-related complications: Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats

  2024cites this paper
• Vitamin D in Type 2 Diabetes and Its Correlation With Heat Shock Protein 70, Ferric Reducing Ability of Plasma, Advanced Oxidation Protein Products and Advanced Glycation End Products

  2024cites this paper
• Modulation of T-Cell-Dependent Humoral Immune Response to Influenza Vaccine by Multiple Antioxidant/Immunomodulatory Micronutrient Supplementation

  2024cites this paper
• Vitamin D supplementation does not alter inflammatory markers in overweight and obese individuals: A systematic review and meta-analysis of randomized controlled trials.

  2024cites this paper
• The Influence of Vitamins D and K on Some Biochemical, Cytochemical, and Clinical Blood Parameters In Vivo with Separate and Combined Administration

  2024cites this paper
• Vitamin D Reduces the Activity of Adenosine Deaminase and Oxidative Stress in Patients with Type Two Diabetes Mellitus.

  2024cites this paper
• The Combined Antioxidant Effects of N-Acetylcysteine, Vitamin D3, and Glutathione from the Intestinal–Neuronal In Vitro Model

  2024cites this paper
• Vitamin D ameliorates celecoxib cardiotoxicity in a doxorubicin heart failure rat model via enhancement of the antioxidant defense and minimizing mitochondrial dysfunction

  2024cites this paper
• Association of serum 25-hydroxyvitamin D concentrations with all-cause and cardiovascular mortality among US adults with prehypertension: a prospective cohort study

  2024cites this paper
• The Study of Correlation between Serum Vitamin D Levels and Cardiovascular Disease: Based on Data from NHANES in the United States from 2011~2020

  2024cites this paper
• Effect of vitamin D supplementation on inflammatory markers and total antioxidant capacity in breast cancer women using a machine learning technique

  2023cites this paper
• Mechanisms of action of vitamin D in delaying aging and preventing disease by inhibiting oxidative stress.

  2023cites this paper
• Vitamin D supplementation alleviates diabetic complications by increasing the amount of irisin in testicular tissues and blood of rats with experimental diabetes.

  2023cites this paper
• Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress

  2023influential citation
• Brain vitamin D3-auto/paracrine system in relation to structural, neurophysiological, and behavioral disturbances associated with glucocorticoid-induced neurotoxicity

  2023cites this paper
• Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency

  2023cites this paper
• Anti-Inflammatory and Vasorelaxant Effects Induced by an Aqueous Aged Black Garlic Extract Supplemented with Vitamins D, C, and B12 on Cardiovascular System

  2023cites this paper
• Effect of a Multispecies Synbiotic Supplementation on Body Composition, Antioxidant Status, and Gut Microbiomes in Overweight and Obese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study

  2023influential citation
• Mixed storm in SARS‐CoV‐2 infection: A narrative review and new term in the Covid‐19 era

  2023cites this paper
• Efficacy, biosafety, and metabolic impacts of feeding mice egg yolks enriched with three bioactive nutrients in different combinations

  2023cites this paper
• Association between Serum Vitamin D Levels and Risk of Sudden Sensorineural Hearing Loss: A cross-sectional Study

  2023cites this paper
• Mechanism of High Dosage Vitamin D Supplementation on The Lung Function and Quality of Life of Stable COPD Patients

  2023cites this paper
• The Role of Vitamin D in Neuroprotection in Multiple Sclerosis: An Update

  2023cites this paper
• Calcium signalling in hepatic metabolism: Health and diseases.

  2023cites this paper
• Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological and biochemical evidence

  2023cites this paper
• Assessment of the oxidative status in mother-child couples from Seville (Spain): A prospective cohort study.

  2023cites this paper
• Association of vitamin D status with redox balance and insulin resistance and its predicting ability for subclinical pregnancy toxemia in pregnant sheep.

  2023cites this paper
• The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art

  2023cites this paper
• Tumor Microbial Communities and Thyroid Cancer Development—The Protective Role of Antioxidant Nutrients: Application Strategies and Future Directions

  2023cites this paper
• Vitamin D and biomarkers of inflammation and oxidative stress among pregnant women: a systematic review of observational studies

  2023cites this paper
• Association of vitamin D deficiency with post-stroke depression: a retrospective cohort study from the TriNetX US collaborative networks

  2023cites this paper
• Vitamin D supplementation improves foot ulcers among diabetic patients: Pooled analysis of randomized controlled trials

  2023cites this paper
• The effect of vitamin D supplementation on oxidative stress and inflammatory biomarkers in pregnant women: a systematic review and meta-analysis of clinical trials

  2022influential citation
• Vitamin D supplementation: an adjunct therapy for improving inflammatory and oxidative stress?

  2022cites this paper
• Coenzyme Q 10 Supplementation and Oxidative Stress Parameters: An Updated Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials

  2022cites this paper
• The effect of vitamin D supplementation on oxidative stress parameters: an updated meta-analysis of clinical trials.

  2022cites this paper
• Potential and Therapeutic Roles of Diosmin in Human Diseases

  2022cites this paper
• Type 2 Diabetes Contributes to Altered Adaptive Immune Responses and Vascular Inflammation in Patients With SARS-CoV-2 Infection

  2022cites this paper
• A Comprehensive Overview of the Complex Role of Oxidative Stress in Aging, The Contributing Environmental Stressors and Emerging Antioxidant Therapeutic Interventions

  2022cites this paper
• Oxidative Stress, Testosterone, Cortisol, and Vitamin D: Differences in Professional Soccer Players of African and Caucasian Origin

  2022cites this paper
• Adherence to Oxidative Balance Scores is Associated with a Reduced Risk of Breast Cancer; A Case-Control Study

  2022cites this paper
• Coenzyme Q10 Supplementation and Oxidative Stress Parameters: An Updated Systematic Review and Meta-analysis of Randomized Controlled Clinical Trials

  2022cites this paper
• Independent Association of 25[OH]D Level on Reduced Glutathione and TNF-α in Patients ‎with Diabetes and/or Hypertension

  2022cites this paper
• Effects of nutrition on metabolic and endocrine outcomes in women with polycystic ovary syndrome: an umbrella review of meta-analyses of randomized controlled trials.

  2022cites this paper
• Neuroprotective and therapeutic effects of calcitriol in rotenone-induced Parkinson’s disease rat model

  2022cites this paper
• Ferric oxide nanoparticles administration suppresses isoniazid induced oxidative stress in the rat brain tissue

  2022cites this paper
• Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis.

  2022cites this paper
• Histomorphology of Norethisterone-Induced

  2022cites this paper
• Response to letter to the editor "Vitamin D supplementation: an adjunct therapy for improving inflammatory and oxidative stress?"

  2022cites this paper
• Role and Mechanism of the Renin-Angiotensin-Aldosterone System in the Onset and Development of Cardiorenal Syndrome

  2022cites this paper
• The effects of vitamin D on learning and memory of hypothyroid juvenile rats and brain tissue acetylcholinesterase activity and oxidative stress indicators

  2022cites this paper
• Inflammation and Oxidative Stress in Chronic Kidney Disease and Dialysis Patients

  2021cites this paper
• Co-treatment of vitamin D supplementation with enriched environment improves synaptic plasticity and spatial learning and memory in aged rats

  2021cites this paper
• Major Meta-Analysis, Randomized Clinical Studies, and International Consensus on Serum Levels and Importance of Supplementing Vitamin D:State of the art

  2021cites this paper
• State of The Art on The Main Randomized Clinical Studies, Meta-Analysis, and International Consensus on The Influence of Serum Levels and Supplementation of Vitamin D on Athletes Performance

  2021cites this paper
• Effects of a Single Oral Megadose of Vitamin D3 on Inflammation and Oxidative Stress Markers in Overweight and Obese Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

  2021cites this paper
• Renal Protective Effect Of Vitamin D3 In Isoproterenol-Induced Myocardial Infarction In Rats

  2021cites this paper
• Probiotic Yogurt Fortified with Vitamin D Can Improve Glycemic Status in Non-Alcoholic Fatty Liver Disease Patients: a Randomized Clinical Trial

  2021cites this paper