The ubiquitin/proteasome system-dependent control of mitochondrial steps in apoptosis.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Seminars in Cell and Developmental Biology

• Publication date

  2012-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.semcdb.2012.03.019PMID 22516642PMCID PMC11500647
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bortezomib‐induced sensitization of malignant human glioma cells to vorinostat‐induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl‐1 cleavage, and DNA damage

  2013cited by this paper
• INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis

  2011cited by this paper
• BIMEL, an intrinsically disordered protein, is degraded by 20S proteasomes in the absence of poly-ubiquitylation

  2011cited by this paper
• Bim Protein Degradation Contributes to Cisplatin Resistance*

  2011cited by this paper
• The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover

  2011cited by this paper
• Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation.

  2011cited by this paper
• Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases

  2011cited by this paper
• Gene expression control by protein deubiquitinases.

  2011cited by this paper
• A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis*

  2011cited by this paper
• Caspase substrates and cellular remodeling.

  2011cited by this paper
• Identification of a Novel Bcl-2-interacting Mediator of Cell Death (Bim) E3 Ligase, Tripartite Motif-containing Protein 2 (TRIM2), and Its Role in Rapid Ischemic Tolerance-induced Neuroprotection*

  2011cited by this paper
• SCFFbw7 Regulates Cellular Apoptosis By Targeting Mcl-1 for Ubiquitination and Destruction

  2010cited by this paper
• Differential modulation of BRCA1 and BARD1 nuclear localisation and foci assembly by DNA damage.

  2010cited by this paper
• Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

  2010cited by this paper
• IBRDC2, an IBR‐type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation

  2010cited by this paper
• The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C‐terminal portion of Bid

  2010cited by this paper
• Activation of GluR6-containing Kainate Receptors Induces Ubiquitin-dependent Bcl-2 Degradation via Denitrosylation in the Rat Hippocampus after Kainate Treatment*

  2010cited by this paper
• Mitochondria on guard: role of mitochondrial fusion and fission in the regulation of apoptosis.

  2010cited by this paper
• Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

  2010cited by this paper
• Parkin Mono-ubiquitinates Bcl-2 and Regulates Autophagy*

  2010cited by this paper
• Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

  2009cited by this paper
• Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

  2009cited by this paper
• Ubiquitin-mediated regulation of apoptosis.

  2009cited by this paper
• Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells.

  2009cited by this paper
• Oncogenic activities of human papillomaviruses.

  2009cited by this paper
• The nanny model for IDPs.

  2009cited by this paper
• Baxbeta: a constitutively active human Bax isoform that is under tight regulatory control by the proteasomal degradation mechanism.

  2009cited by this paper
• TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process.

  2009cited by this paper
• Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release.

  2009cited by this paper
• Identification of the regions of the HPV 5 E6 protein involved in Bak degradation and inhibition of apoptosis

  2008cited by this paper
• Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.

  2008cited by this paper
• The BCL-2 protein family: opposing activities that mediate cell death

  2008cited by this paper
• Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL.

  2008cited by this paper
• Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.

  2008cited by this paper
• How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

  2008cited by this paper
• Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

  2008cited by this paper
• C-RAF activation promotes BAD poly-ubiquitylation and turn-over by the proteasome.

  2008cited by this paper
• E6 Proteins from Multiple Human Betapapillomavirus Types Degrade Bak and Protect Keratinocytes from Apoptosis after UVB Irradiation

  2008cited by this paper
• GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth

  2008cited by this paper
• BIK, the founding member of the BH3-only family proteins: mechanisms of cell death and role in cancer and pathogenic processes

  2008cited by this paper
• Mitochondrial dynamics and apoptosis.

  2008cited by this paper
• Regulation of apoptosis by XIAP ubiquitin-ligase activity.

  2008cited by this paper
• Increased proteasomal degradation of Bax is a common feature of poor prognosis chronic lymphocytic leukemia.

  2008cited by this paper
• BARD1 Translocation to Mitochondria Correlates with Bax Oligomerization, Loss of Mitochondrial Membrane Potential, and Apoptosis*

  2007cited by this paper
• The Bcl-2 apoptotic switch in cancer development and therapy

  2007cited by this paper
• The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division

  2007cited by this paper
• Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria

  2007cited by this paper
• Cdc48 (p97): a "molecular gearbox" in the ubiquitin pathway?

  2007cited by this paper
• Functions and dysfunctions of mitochondrial dynamics

  2007cited by this paper
• Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets

  2007cited by this paper
• Apoptosis induction by Bid requires unconventional ubiquitination and degradation of its N-terminal fragment

  2007cited by this paper
• Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death

  2007cited by this paper
• S-Nitrosylation of Bcl-2 Inhibits Its Ubiquitin-Proteasomal Degradation

  2006cited by this paper
• Mitochondria: Dynamic Organelles in Disease, Aging, and Development

  2006cited by this paper
• Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes

  2006cited by this paper
• Auto-activation of the Apoptosis Protein Bax Increases Mitochondrial Membrane Permeability and Is Inhibited by Bcl-2*

  2006cited by this paper
• Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER

  2006cited by this paper
• Role of ubiquitylation in cellular membrane transport.

  2006cited by this paper
• p97: The cell's molecular purgatory?

  2006cited by this paper
• MARCH‐V is a novel mitofusin 2‐ and Drp1‐binding protein able to change mitochondrial morphology

  2006cited by this paper
• A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

  2006cited by this paper
• BH3‐ligand regulates access of MCL‐1 to its E3 ligase

  2005cited by this paper
• Life in the balance: how BH3-only proteins induce apoptosis.

  2005cited by this paper
• Pro-apoptotic Bid induces membrane perturbation by inserting selected lysolipids into the bilayer.

  2005cited by this paper
• IAPs, RINGs and ubiquitylation

  2005cited by this paper
• Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.

  2005cited by this paper
• Regulation of the Proapoptotic ARTS Protein by Ubiquitin-mediated Degradation*

  2005cited by this paper
• Ubiquitin and ubiquitin-like proteins as multifunctional signals

  2005cited by this paper
• Proteolysis: anytime, any place, anywhere?

  2005cited by this paper
• X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO.

  2005cited by this paper
• Expression of the pro‐apoptotic protein ARTS in astrocytic tumors

  2004cited by this paper
• A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

  2004cited by this paper
• Three Novel Bid Proteins Generated by Alternative Splicing of the Human Bid Gene*

  2004cited by this paper
• The mitochondrial ARTS protein promotes apoptosis through targeting XIAP

  2004cited by this paper
• The novel functions of ubiquitination in signaling.

  2004cited by this paper
• Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway*

  2004cited by this paper
• Mitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patients

  2004cited by this paper
• Regulation of apoptosis proteins in cancer cells by ubiquitin

  2004cited by this paper
• BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors.

  2004cited by this paper
• Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3‐only Bcl‐2 family member Bim

  2003cited by this paper
• BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization*

  2003cited by this paper
• DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells.

  2003cited by this paper
• Effects of the proteasome inhibitor, bortezomib, on apoptosis in isolated lymphocytes obtained from patients with chronic lymphocytic leukemia.

  2003cited by this paper
• Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

  2003cited by this paper
• Dynamics of mitochondrial morphology in healthy cells and during apoptosis

  2003cited by this paper
• Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation.

  2003cited by this paper
• IAP proteins: blocking the road to death's door

  2002cited by this paper
• The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis

  2002cited by this paper
• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  2002cited by this paper
• Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells*

  2001cited by this paper
• The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol

  2001cited by this paper
• MAP-1, a Novel Proapoptotic Protein Containing a BH3-like Motif That Associates with Bax through Its Bcl-2 Homology Domains*

  2001cited by this paper
• Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

  2000cited by this paper
• The Destabilization of Lipid Membranes Induced by the C-terminal Fragment of Caspase 8-cleaved Bid Is Inhibited by the N-terminal Fragment*

  2000cited by this paper
• Ubiquitin-mediated Degradation of the Proapoptotic Active Form of Bid

  2000cited by this paper
• The ubiquitin system

  2000cited by this paper
• Bax degradation by the ubiquitin/proteasome-dependent pathway: involvement in tumor survival and progression.

  2000cited by this paper
• Structure of Bax: coregulation of dimer formation and intracellular localization.

  2000cited by this paper
• Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis.

  2000cited by this paper
• A Novel BH3-like Domain in BID Is Required for Intramolecular Interaction and Autoinhibition of Pro-apoptotic Activity*

  1999cited by this paper

• NSC632839 suppresses esophageal squamous cell carcinoma cell proliferation in vitro by triggering spindle assembly checkpoint-mediated mitotic arrest and CREB-Noxa-dependent apoptosis

  2025cites this paper
• The inhibition of SLC8A1 promotes Ca2+-dependent cell death in Gastric Cancer.

  2024cites this paper
• Clinical applications of circulating biomarkers in non-small cell lung cancer

  2024cites this paper
• Comprehensive review of Bcl‐2 family proteins in cancer apoptosis: Therapeutic strategies and promising updates of natural bioactive compounds and small molecules

  2024cites this paper
• The Role of Parkin in Rat Pancreatic Beta Cells Fate.

  2023cites this paper
• Outer mitochondrial membrane E3 Ub ligase MARCH5 controls mitochondrial steps in peroxisome biogenesis

  2023cites this paper
• Mechanisms of MCL-1 protein stability induced by MCL-1 antagonists in B-cell malignancies.

  2022cites this paper
• Mechanistic insight into the role of metformin in Alzheimer's disease.

  2022cites this paper
• Upregulated Proteasome Subunits in COVID-19 Patients: A Link with Hypoxemia, Lymphopenia and Inflammation

  2022cites this paper
• The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts

  2022cites this paper
• The Role of Cancer Stem Cell-Derived Exosomes in Cancer Progression

  2022cites this paper
• Mitochondrial proteotoxicity: implications and ubiquitin-dependent quality control mechanisms

  2022cites this paper
• Integrated genomic analysis of proteasome alterations across 11,057 patients with 33 cancer types: clinically relevant outcomes in framework of 3P medicine

  2021cites this paper
• The global proteome and ubiquitinome of bacterial and viral co-infected bronchial epithelial cells.

  2021cites this paper
• Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion

  2019cites this paper
• Biological Entanglement–Like Effect After Communication of Fish Prior to X-Ray Exposure

  2018cites this paper
• Proteasome Activator 28γ: Impact on Survival Signaling and Apoptosis

  2018influential citation
• Glutathione monoethyl ester prevents TDP‐43 pathology in motor neuronal NSC‐34 cells

  2018cites this paper
• Régulation de la stabilité de la protéine anti-apoptotique BCL2A1

  2018cites this paper
• Impact of San-mediated Signaling on Glioblastoma and Neuroblastoma Metabolism

  2018influential citation
• UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy

  2018cites this paper
• Hepatitis B virus upregulates host microRNAs that target apoptosis‐regulatory genes in an in vitro cell model

  2018cites this paper
• Expression de GALIG, gène inducteur de la mort cellulaire, dans des cellules normales et pathologiques

  2017influential citation
• Prohibitin-mediated mitochondrial ubiquitination during spermiogenesis in Chinese mitten crab Eriocheir sinensis

  2017cites this paper
• The bioefficacy of flavokawain C against colon cancer and the underlying mechanistic insights / Phang Chung Weng

  2017cites this paper
• Retrograde Activation of a Somatic Transcriptional Program Regulates Distal Axon Degeneration

  2016influential citation
• Influence of metformin on mitochondrial subproteome in the brain of apoE knockout mice.

  2016cites this paper
• Decitabine enhances bortezomib treatment in RPMI 8226 multiple myeloma cells.

  2016cites this paper
• Transcriptional landscapes at the intersection of neuronal apoptosis and substance P-induced survival: exploring pathways and drug targets

  2016cites this paper
• Synergistic effects of cisplatin and proteasome inhibitor bortezomib on human bladder cancer cells.

  2015cites this paper
• Toxic mitochondrial effects induced by "red devil" chemotherapy

  2015cites this paper
• New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways.

  2015cites this paper
• Ubiquitination by SAG regulates macrophage survival/death and immune response during infection

  2014cites this paper
• Mcl-1 Ubiquitination: Unique Regulation of an Essential Survival Protein

  2014cites this paper
• Mitochondrial prohibitin and its ubiquitination during crayfish Procambarus clarkii spermiogenesis

  2014cites this paper
• Identification and characterization of a proteasome deubiquitinase inhibitor

  2014cites this paper
• Targeting the Ubiquitin-Proteasome System in Atherosclerosis: Status Quo, Challenges, and Perspectives

  2014cites this paper
• Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65

  2013cites this paper