X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Biochemistry (Tokyo)

• Publication date

  2005-02-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1093/JB/MVI029PMID 15749826
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Smac3, a Novel Smac/DIABLO Splicing Variant, Attenuates the Stability and Apoptosis-inhibiting Activity of X-linked Inhibitor of Apoptosis Protein*

  2003cited by this paper
• Cellular Inhibitor of Apoptosis 1 and 2 Are Ubiquitin Ligases for the Apoptosis Inducer Smac/DIABLO*

  2003cited by this paper
• A Novel Ubiquitin Fusion System Bypasses the Mitochondria and Generates Biologically Active Smac/DIABLO*

  2003cited by this paper
• Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition

  2002cited by this paper
• Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1

  2002cited by this paper
• Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

  2002cited by this paper
• Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro *

  2002cited by this paper
• Morgue mediates apoptosis in the Drosophila melanogaster retina by promoting degradation of DIAP1

  2002cited by this paper
• Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

  2001cited by this paper
• A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

  2001cited by this paper
• Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

  2000cited by this paper
• Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

  2000cited by this paper
• Structural and biochemical basis of apoptotic activation by Smac/DIABLO

  2000cited by this paper
• Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.

  2000cited by this paper
• Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.

  2000cited by this paper
• RING finger proteins: mediators of ubiquitin ligase activity.

  2000cited by this paper
• The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7.

  2000cited by this paper
• NMR Structure and Mutagenesis of the Third Bir Domain of the Inhibitor of Apoptosis Protein XIAP*

  2000cited by this paper
• Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

  1999cited by this paper
• NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

  1999cited by this paper
• IAP family proteins--suppressors of apoptosis.

  1999cited by this paper
• Cytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 Activation*

  1999cited by this paper
• The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.

  1999cited by this paper
• Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

  1999cited by this paper
• ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.

  1999cited by this paper
• Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.

  1999cited by this paper
• An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9*

  1999cited by this paper
• Ligand-induced Ubiquitination of the Epidermal Growth Factor Receptor Involves the Interaction of the c-Cbl RING Finger and UbcH7*

  1999cited by this paper
• An exegesis of IAPs: salvation and surprises from BIR motifs.

  1999cited by this paper
• A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

  1999cited by this paper
• Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization.

  1998cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death.

  1998cited by this paper
• Proteases to die for.

  1998cited by this paper
• The ubiquitin system.

  1998cited by this paper
• A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases*

  1998cited by this paper
• IAPs block apoptotic events induced by caspase‐8 and cytochrome c by direct inhibition of distinct caspases

  1998cited by this paper
• Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade.

  1997cited by this paper
• Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

  1997cited by this paper
• X-linked IAP is a direct inhibitor of cell-death proteases

  1997cited by this paper
• Subcellular Localization and Ubiquitin-conjugating Enzyme (E2) Interactions of Mammalian HECT Family Ubiquitin Protein Ligases*

  1997cited by this paper
• Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.

  1997cited by this paper
• Apoptosis in the pathogenesis and treatment of disease

  1995cited by this paper
• Mechanisms and genes of cellular suicide

  1995cited by this paper
• Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.

  1994cited by this paper
• An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs

  1994cited by this paper
• An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif

  1993cited by this paper

• Cell death triad: Integrating apoptotic, autophagic, and necrotic cell death mechanisms.

  2025cites this paper
• SMAD7 Sustains XIAP Expression and Migration of Colorectal Carcinoma Cells

  2024cites this paper
• E3 ubiquitin ligase gene BIRC3 modulates TNF-induced cell death pathways and promotes aberrant proliferation in rheumatoid arthritis fibroblast-like synoviocytes

  2024cites this paper
• E3 ubiquitin ligases in lung cancer: Emerging insights and therapeutic opportunities.

  2023cites this paper
• Small Molecule Inhibitors Targeting the "Undruggable" Survivin: The Past, Present, and Future from a Medicinal Chemist's Perspective.

  2023cites this paper
• Inhibition of Caspase 3 and Caspase 9 Mediated Apoptosis: A Multimodal Therapeutic Target in Traumatic Brain Injury

  2022cites this paper
• The concept of intrinsic versus extrinsic apoptosis.

  2022cites this paper
• Cross-talk between ubiquitin ligase and breast carcinogenesis

  2022cites this paper
• Novel recombinant porcine enterovirus G viruses lacking structural proteins are maintained in pig farms in Japan

  2022cites this paper
• Endoplasmic Reticulum Stress Signaling and Neuronal Cell Death

  2022cites this paper
• XIAP and PHB1 regulate anoikis through competitive binding to TRAF6.

  2022cites this paper
• The conservation of IAP-like proteins in fungi, and their potential role in fungal programmed cell death.

  2022cites this paper
• The roles of ubiquitination‐mediated intrinsic apoptotic signalling in cancer therapy

  2022cites this paper
• Ubiquitination/de-ubiquitination: A promising therapeutic target for PTEN reactivation in cancer.

  2022cites this paper
• Molecular Insights into the Roles of E3-Ligases in ROS-Mediated Cancer from a Bioinformatics Perspective

  2021cites this paper
• Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System

  2021cites this paper
• Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells

  2020cites this paper
• A Genome-Wide Study of Single-Nucleotide Polymorphisms in MicroRNAs and Further In Silico Analysis Reveals Their Putative Role in Susceptibility to Late-Onset Alzheimer’s Disease

  2020cites this paper
• The prognostic significance and immuno-expression of survivin, mutant p53 and bcl-2 in 92 cases of epithelial ovarian cancer

  2020influential citation
• A Genome-Wide Study of Single-Nucleotide Polymorphisms in MicroRNAs and Further In Silico Analysis Reveals Their Putative Role in Susceptibility to Late-Onset Alzheimer’s Disease

  2020cites this paper
• Effects of Different Degrees of Carotid Artery Stenosis on the Expression of XIAP and Smac in the Ischemic Penumbra of Rats with Cerebral Ischemia-Reperfusion.

  2020cites this paper
• Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy

  2020cites this paper
• E3 Ubiquitin Ligases in Cancer and Their Pharmacological Targeting

  2019cites this paper
• Effects of ammonia stress on the hemocytes of the Pacific white shrimp Litopenaeus vannamei.

  2019cites this paper
• Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity

  2019cites this paper
• Characterizing Cellular Responses During Oncolytic Maraba Virus Infection

  2019cites this paper
• A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes

  2019cites this paper
• Investigation of the pathophysiology of granulosa cell tumours of the ovary

  2019cites this paper
• Regulation of Cell Death and Immunity by XIAP.

  2019cites this paper
• Diablo ubiquitination analysis by sandwich immunoassay.

  2019cites this paper
• Co-expression of XIAP and CIAP1 Play Synergistic Effect on Patient’s Prognosis in Head and Neck Cancer

  2018cites this paper
• Rôle de la Caspase-2 au cours des processus neurodégénératifs associés au vieillissement. Conception rationnelle d’inhibiteurs sélectifs et évaluation sur des modèles biologique

  2018cites this paper
• Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

  2018cites this paper
• Concomitance of downregulated active caspase-3 and upregulated X-chromosome linked inhibitor of apoptosis protein as a sensitive diagnostic approach for breast cancer

  2018cites this paper
• Regulation of the Drosophila Initiator Caspase Dronc through Ubiquitylation

  2017cites this paper
• Deletion of Pdcd5 in mice led to the deficiency of placenta development and embryonic lethality

  2017cites this paper
• An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways

  2017cites this paper
• Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model of mammary adenocarcinoma

  2017cites this paper
• XIAP Interacts with and Regulates the Activity of FAF1.

  2017cites this paper
• Emerging role of DUBs in tumor metastasis and apoptosis: Therapeutic implication

  2017cites this paper
• Exploitation and Regulation of Apoptotic Caspases

  2017cites this paper
• Etude de la voie d’action intracrine et nucléaire du Fibroblast Growth Factor 1 dans des cellules de type neuronal

  2016cites this paper
• Molecular mechanisms controlling neuronal Bak expression

  2016cites this paper
• XIAP inhibits mature Smac-induced apoptosis by degrading it through ubiquitination in NSCLC

  2016cites this paper
• Virus life cycle and the parthenogenesis of malignant catarrhal fever

  2016cites this paper
• Co-Expression of XIAP and CIAP1 Play Synergistic Effect on PatientâÂÂs Prognosis in Head and Neck Cancer

  2016cites this paper
• A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy.

  2016cites this paper
• Exploring the potential of glycogen synthase kinase-3 (GSK3) mediated therapy in castrate-resistant prostate cancer

  2016cites this paper
• Apoptosis resistance, mitotic catastrophe, and loss of ploidy control in Burkitt lymphoma

  2015cites this paper
• IAPs: Modular regulators of cell signalling.

  2015cites this paper
• Valproic acid induces neuronal cell death through a novel calpain‐dependent necroptosis pathway

  2015cites this paper
• In vitro and in vivo characterization of the E3 ubiquitin ligase RNF157 in the brain

  2015cites this paper
• Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-κB-activating potential

  2015cites this paper
• Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis.

  2015cites this paper
• Phenotypical and functional characterization of polarized human macrophages

  2015cites this paper
• IAP Family of Proteins as Therapeutic Targets for Acute Myeloid Leukemia

  2015cites this paper
• Mitochondrial pro-apoptotic indices do not precede the transient caspase activation associated with myogenesis.

  2014cites this paper
• Molecular Studies On The Anti-Tumor Effects Of Metal-Based Complexes: Involvement Of The Ubiquitin-Proteasome And Apoptotic Pathways

  2014cites this paper
• A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.

  2014cites this paper
• Free Radicals in Cross Talk Between Autophagy and Apoptosis

  2014cites this paper
• New insights into the MAPK function in meiotic progression and the regulation of osmostress-induced apoptosis in Xenopus oocytes

  2014cites this paper
• Thesis committee members

  2014cites this paper
• Mecanismos de regulación de la muerte del oocito por shock hiperosmótico

  2014cites this paper
• Novel Role of CHK2 in the Intrinsic and Extrinsic Apoptosis Pathway

  2014cites this paper
• Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase

  2014cites this paper
• The molecular intersection between axon-specific pruning and neuronal apoptosis

  2014cites this paper
• A Complex between Atg7 and Caspase-9

  2013cites this paper
• VCP Phosphorylation-Dependent Interaction Partners Prevent Apoptosis in Helicobacter pylori-Infected Gastric Epithelial Cells

  2013cites this paper
• X-linked Inhibitor of Apoptosis Protein negatively regulates neuronal differentiation through interaction with cRAF and Trk

  2013cites this paper
• Mechanism of ubiquitin transfer by RING E3 ligases

  2013cites this paper
• Antiapoptotic Proteins in Human Macrophage Survival, Differentiation, Innate Immunity and Protection from HIV-induced Apoptosis

  2013influential citation
• Withanone as an inhibitor of survivin: a potential drug candidate for cancer therapy.

  2013cites this paper
• DIABLO (diablo, IAP-binding mitochondrial protein)

  2013cites this paper
• Cellular mechanisms controlling caspase activation and function.

  2013cites this paper
• Inhibitor of apoptosis proteins as E3 ligases for ubiquitin and NEDD8

  2013cites this paper
• Inhibitor of Apoptosis Proteins: Promising Targets for Cancer Therapy

  2013cites this paper
• Regulation of Apoptosis by Inhibitors of Apoptosis (IAPs)

  2013cites this paper
• Apoptosis of rat ovarian granulosa cells by 2,5‐hexanedione in vitro and its relevant gene expression

  2013cites this paper
• X-linked Inhibitor of Apoptosis Protein promotes the degradation of its antagonist, the pro-apoptotic ARTS protein.

  2012cites this paper
• X‐linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8–E3 ligase for caspase‐7

  2012cites this paper
• Screening for components involved in NLR-mediated immune signalling

  2012influential citation
• Tunicamycin sensitizes human prostate cells to TRAIL-induced apoptosis by upregulation of TRAIL receptors and downregulation of cIAP2.

  2012cites this paper
• Expression of Smac and the relationship with cell apoptosis and proliferation in hepatocarcinoma tissues

  2012cites this paper
• Low circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancer

  2012cites this paper
• HECT and RING finger families of E3 ubiquitin ligases at a glance

  2012cites this paper
• The Inhibitor of Apoptosis (IAPs) in Adaptive Response to Cellular Stress

  2012cites this paper
• The ubiquitin/proteasome system-dependent control of mitochondrial steps in apoptosis.

  2012cites this paper
• BnRCH gene inhibits cell growth of Hela cells through increasing the G2 phase of cell cycle

  2011cites this paper
• Inhibitor of apoptosis proteins: fascinating biology leads to attractive tumor therapeutic targets.

  2011cites this paper
• Regulation of Skeletal Muscle Formation and Regeneration by the Cellular Inhibitor of Apoptosis 1 (cIAP1) Protein

  2011influential citation
• AN N-terminal Smac peptide sensitizes human prostate carcinoma cells to methyl jasmonate-induced apoptosis.

  2011cites this paper
• Nondegradative ubiquitination of apoptosis inducing factor (AIF) by X-linked inhibitor of apoptosis at a residue critical for AIF-mediated chromatin degradation.

  2011cites this paper
• Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis

  2011influential citation
• ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists

  2011cites this paper
• Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome.

  2011influential citation
• Inhibitor of Apoptosis (IAP)-like Protein Lacks a Baculovirus IAP Repeat (BIR) Domain and Attenuates Cell Death in Plant and Animal Systems*

  2011cites this paper
• X-linked Inhibitor of Apoptosis Protein (XIAP) Mediates Cancer Cell Motility via Rho GDP Dissociation Inhibitor (RhoGDI)-dependent Regulation of the Cytoskeleton*

  2011cites this paper
• Prognostic significance of second mitochondria-derived activator of caspase (Smac/DIABLO) expression in bladder cancer and target for therapy.

  2010cites this paper
• Monomerization of Cytosolic Mature Smac Attenuates Interaction with IAPs and Potentiation of Caspase Activation

  2010cites this paper
• Therapeutic potential of siRNA-mediated combined knockdown of the IAP genes (Livin, XIAP, and Survivin) on human bladder cancer T24 cells.

  2010cites this paper