Signaling and Polarized Communication Across the T Cell Immunological Synapse.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Annual Review of Cell and Developmental Biology

• Publication date

  2016-10-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/ANNUREV-CELLBIO-100814-125330PMID 27501450
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolic Maintenance of Cell Asymmetry following Division in Activated T Lymphocytes

  2016cited by this paper
• Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions

  2016cited by this paper
• Phase separation of signaling molecules promotes T cell receptor signal transduction

  2016cited by this paper
• DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

  2016cited by this paper
• Initiation of T cell signaling by CD45 segregation at ‘close-contacts’

  2016cited by this paper
• Size-dependent protein segregation at membrane interfaces

  2016cited by this paper
• Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.

  2016cited by this paper
• Expanding antigen-specific regulatory networks to treat autoimmunity

  2016cited by this paper
• Actin Depletion Initiates Events Leading to Granule Secretion at the Immunological Synapse

  2015cited by this paper
• Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

  2015cited by this paper
• Asymmetric Cell Division in T Lymphocyte Fate Diversification.

  2015cited by this paper
• Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.

  2015cited by this paper
• Cytoskeletal forces during signaling activation in Jurkat T-cells

  2015cited by this paper
• Ectosomes and exosomes: shedding the confusion between extracellular vesicles.

  2015cited by this paper
• A dynamic model of chemoattractant-induced cell migration.

  2015cited by this paper
• Human Primary Immune Cells Exhibit Distinct Mechanical Properties that Are Modified by Inflammation.

  2015cited by this paper
• Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

  2015cited by this paper
• VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity

  2015cited by this paper
• E-cadherin junction formation involves an active kinetic nucleation process

  2015cited by this paper
• The dendritic cell cytoskeleton promotes T cell adhesion and activation by constraining ICAM-1 mobility

  2015cited by this paper
• T-cell activation by transitory neo-antigens derived from distinct microbial pathways

  2014cited by this paper
• Dendritic Cells Control Fibroblastic Reticular Network Tension and Lymph Node Expansion

  2014cited by this paper
• Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g.

  2014cited by this paper
• Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles

  2014cited by this paper
• Polarized release of TCR-enriched microvesicles at the T cell immunological synapse

  2014cited by this paper
• MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

  2014cited by this paper
• Use of TIRF to Monitor T-Lymphocyte Membrane Dynamics with Submicrometer and Subsecond Resolution

  2014cited by this paper
• The intracellular B30.2 domain of butyrophilin 3A1 binds phosphoantigens to mediate activation of human Vγ9Vδ2 T cells.

  2014cited by this paper
• In vitro membrane reconstitution of the T cell receptor proximal signaling network

  2014cited by this paper
• Selection of the lamprey VLRC antigen receptor repertoire

  2014cited by this paper
• The CLEC-2–podoplanin axis controls fibroblastic reticular cell contractility and lymph node microarchitecture

  2014cited by this paper
• Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance.

  2014cited by this paper
• B cell homeostasis and follicle confines are governed by fibroblastic reticular cells

  2014cited by this paper
• MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells

  2014cited by this paper
• CD28 and CD3 have complementary roles in T-cell traction forces

  2014cited by this paper
• Accumulation of dynamic catch bonds between TCR and agonist peptide-MHC triggers T cell signaling.

  2014cited by this paper
• Inhibition of Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full T cell receptor signaling

  2013cited by this paper
• Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage

  2013cited by this paper
• Structural insights into the evolution of the adaptive immune system.

  2013cited by this paper
• An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse

  2013cited by this paper
• Interference with Ca2+ release activated Ca2+ (CRAC) channel function delays T‐cell arrest in vivo

  2013cited by this paper
• Evolutionary implications of a third lymphocyte lineage in lampreys

  2013cited by this paper
• Disparate Individual Fates Compose Robust CD8+ T Cell Immunity

  2013cited by this paper
• Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

  2013cited by this paper
• Membrane fission reactions of the mammalian ESCRT pathway.

  2013cited by this paper
• Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse

  2013cited by this paper
• Phenotypic CD8+ T Cell Diversification Occurs before, during, and after the First T Cell Division

  2013cited by this paper
• Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse

  2013cited by this paper
• Disentangling nestedness from models of ecological complexity

  2012cited by this paper
• Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

  2012cited by this paper
• Cutting Edge: Asymmetric Memory T Cell Division in Response to Rechallenge

  2012cited by this paper
• VLR-based adaptive immunity.

  2012cited by this paper
• Extracellular-matrix tethering regulates stem-cell fate.

  2012cited by this paper
• Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

  2012cited by this paper
• Cells test substrate rigidity by local contractions on submicrometer pillars

  2012cited by this paper
• Super-resolution imaging of remodeled synaptic actin reveals different synergies between NK cell receptors and integrins.

  2012cited by this paper
• Mechanosensing in T lymphocyte activation.

  2012cited by this paper
• Hydrodynamic trapping of molecules in lipid bilayers

  2012cited by this paper
• Biophysical Mechanism of T Cell Receptor Triggering in a Reconstituted System

  2012cited by this paper
• Antigen Recognition Is Facilitated by Invadosome-like Protrusions Formed by Memory/Effector T Cells

  2012cited by this paper
• Non‐catalytic tyrosine‐phosphorylated receptors

  2012cited by this paper
• Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells

  2012cited by this paper
• Substrate Rigidity Regulates Human T Cell Activation and Proliferation

  2012cited by this paper
• Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

  2012cited by this paper
• Live-cell visualization of dynamics of HIV budding site interactions with an ESCRT component

  2011cited by this paper
• Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

  2011cited by this paper
• Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division.

  2011cited by this paper
• Dynamics of ESCRT protein recruitment during retroviral assembly

  2011cited by this paper
• MVB vesicle formation: ESCRT-dependent, ESCRT-independent and everything in between.

  2011cited by this paper
• Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation.

  2011cited by this paper
• The Regulated Secretory Pathway in CD4+ T cells Contributes to Human Immunodeficiency Virus Type-1 Cell-to-Cell Spread at the Virological Synapse

  2011cited by this paper
• T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis.

  2011cited by this paper
• Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.

  2010cited by this paper
• Effects of thymic selection of the T cell repertoire on HLA-class I associated control of HIV infection

  2010cited by this paper
• The right team at the right time to go for a home run: tyrosine kinase activation by the TCR

  2010cited by this paper
• A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey

  2010cited by this paper
• HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse

  2010cited by this paper
• TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

  2010cited by this paper
• Calcium signaling in the development and function of T‐lineage cells

  2009cited by this paper
• JCB_200809136 521..534

  2009cited by this paper
• Human Immunodeficiency Virus Type 1 Envelope gp120-Induced Partial T-Cell Receptor Signaling Creates an F-Actin-Depleted Zone in the Virological Synapse

  2009cited by this paper
• Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse

  2009cited by this paper
• Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif.

  2008cited by this paper
• T Cell-Dendritic Cell Immunological Synapses Contain TCR-dependent CD28-CD80 Clusters That Recruit Protein Kinase Cθ1

  2008cited by this paper
• The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

  2008cited by this paper
• MYELOMONOCYTIC CELL RECRUITMENT CAUSES FATAL CNS VASCULAR INJURY DURING ACUTE VIRAL MENINGITIS

  2008cited by this paper
• From cells to organs: building polarized tissue

  2008cited by this paper
• Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.

  2008cited by this paper
• How polarity shapes the destiny of T cells

  2008cited by this paper
• Quantification and Modeling of Tripartite CD2-, CD58FC Chimera (Alefacept)-, and CD16-mediated Cell Adhesion*

  2007cited by this paper
• Cell adhesion molecules and actin cytoskeleton at immune synapses and kinapses.

  2007cited by this paper
• LFA-1-Mediated T Cell Costimulation through Increased Localization of TCR/Class II Complexes to the Central Supramolecular Activation Cluster and Exclusion of CD45 from the Immunological Synapse1

  2007cited by this paper
• Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist.

  2007cited by this paper
• Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes

  2007cited by this paper
• Asymmetric T Lymphocyte Division in the Initiation of Adaptive Immune Responses

  2007cited by this paper
• Opposing Effects of PKC q and WASp on Symmetry Breaking and Relocation of the Immunological Synapse

  2007cited by this paper
• CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo

  2007cited by this paper
• Lymph node chemokines promote sustained T lymphocyte motility without triggering stable integrin adhesiveness in the absence of shear forces

  2007cited by this paper
• Maintenance and modulation of T cell polarity

  2006cited by this paper
• T cells use two directionally distinct pathways for cytokine secretion

  2006cited by this paper

• How crosstalk at the immune synapse shapes T cell and dendritic cell biologys.

  2026cites this paper
• T-Cell-Derived Exosomes From Multi Core Granules Exhibit Superior Caspase-3-Mediated Tumor-Suppressive Activity Compared to Those From Multivesicular Bodies.

  2026cites this paper
• ANKRD55 is a key regulator of T cell inflammation in multiple sclerosis

  2025cites this paper
• Development and validation of a novel risk stratification signature derived from migrasome and tumor microenvironment-related genes for molecular subtyping and improving clinical outcomes in head and neck squamous cell carcinoma

  2025cites this paper
• Trogocytosis at crossroads: Navigating the duality in tumor-immune cell interactions.

  2025cites this paper
• Targeting collagen to optimize cancer immunotherapy

  2025cites this paper
• Brain and Immune System: Intercellular Communication During Homeostasis and Neuroimmunomodulation upon Dysfunction

  2025cites this paper
• Hem1 controls T cell activation, memory, and the regulated release of immunosuppressive and proinflammatory cytokines

  2025cites this paper
• Current state of cancer immunity cycle: new strategies and challenges of using precision hydrogels to treat breast cancer

  2025cites this paper
• Alpha synuclein and inflammaging

  2025cites this paper
• Cancer ATF4-mediated CD58 endocytosis impairs anti-tumor immunity and immunotherapy

  2025cites this paper
• Collagenase-mediated extracellular matrix targeting for enhanced drug penetration and therapeutic efficacy in nanoscale delivery systems for cancer therapy

  2025cites this paper
• p66Shc deficiency in CLL cells enhances PD-L1 expression and suppresses immune synapse formation

  2024cites this paper
• Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity.

  2024cites this paper
• Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

  2024cites this paper
• From TCR fundamental research to innovative chimeric antigen receptor design

  2024cites this paper
• The hallmarks of cancer immune evasion.

  2024cites this paper
• Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes.

  2024cites this paper
• Editorial: Structure and function of the immunological and redirecting artificial synapses and their clinical implications

  2024cites this paper
• Tumor Cell Communications as Promising Supramolecular Targets for Cancer Chemotherapy: A Possible Strategy

  2024cites this paper
• Lipid switches in the immunological synapse

  2024cites this paper
• Novel insights into the roles of migrasome in cancer

  2024cites this paper
• Extracellular vesicles and microvilli in the immune synapse

  2024cites this paper
• Codependencies of mTORC1 signaling and endolysosomal actin structures

  2023cites this paper
• Phosphatases of regenerating liver balance F-actin rearrangements during T cell activation through WD repeat containing protein 1

  2023cites this paper
• Strategies and rules for tuning TCR-derived therapy

  2023cites this paper
• Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia

  2023cites this paper
• Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8+ T cells

  2023cites this paper
• Membrane organization by tetraspanins and galectins shapes lymphocyte function

  2023influential citation
• A nomogram based on collagen signature for predicting the immunoscore in colorectal cancer

  2023cites this paper
• Dynamics and spatial organization of Kv1.3 at the immunological synapse of human CD4+ T cells

  2023cites this paper
• Activation kinetics of regulatory molecules during immunological synapse in T cells.

  2023cites this paper
• CARs are organized in nanodomains in the plasma membrane of T cells that accumulate at tumor contact sites

  2023cites this paper
• Self-programmed dynamics of T cell receptor condensation

  2023cites this paper
• Chimeric Antigen Receptor T-cell Therapy in Cancer: A Critical Review.

  2023cites this paper
• Imaging the immune synapse: three-dimensional analysis of the immune synapse

  2023cites this paper
• From the Catastrophic Objective Irreproducibility of Cancer Research and Unavoidable Failures of Molecular Targeted Therapies to the Sparkling Hope of Supramolecular Targeted Strategies

  2023cites this paper
• Exploring Mast Cell–CD8 T Cell Interactions in Inflammatory Skin Diseases

  2023cites this paper
• Reprogramming dendritic cells through the immunological synapse: A two‐way street

  2023cites this paper
• A regulatory circuit controlled by extranuclear and nuclear retinoic acid receptor α determines T cell activation and function.

  2023cites this paper
• T Lymphocyte-Derived Exosomes and Their Applications in Cancer Therapy

  2022cites this paper
• Migrasomes, new vescicles as Hansel and Gretel white pebbles?

  2022cites this paper
• T Lymphocyte and CAR-T Cell-Derived Extracellular Vesicles and Their Applications in Cancer Therapy

  2022cites this paper
• Rapid Rerouting of Myosin Traffic at the T Cell Immunological Synapse

  2022cites this paper
• A combined biochemical and cellular approach reveals Zn2+-dependent hetero- and homodimeric CD4 and Lck assemblies in T cells

  2022cites this paper
• Size-dependent activation of CAR-T cells

  2022cites this paper
• CD28 and chemokine receptors: Signalling amplifiers at the immunological synapse

  2022cites this paper
• SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly

  2022cites this paper
• The spatio-temporal control of effector T cell migration

  2021cites this paper
• LFA-1 cluster formation in T-cells depends on l-plastin phosphorylation regulated by P90RSK and PP2A

  2021cites this paper
• Influence of external forces on actin‐dependent T cell protrusions during immune synapse formation

  2021cites this paper
• Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells

  2021cites this paper
• Dynamic Microtubule Arrays in Leukocytes and Their Role in Cell Migration and Immune Synapse Formation

  2021cites this paper
• Luteolin as an adjuvant effectively enhances CTL anti-tumor response in B16F10 mouse model.

  2021cites this paper
• Membraneless organelles restructured and built by pandemic viruses: HIV-1 and SARS-CoV-2

  2021cites this paper
• Editorial: Regulatory Mechanisms of Early Intracellular Signaling in T Lymphocytes

  2021cites this paper
• Clustering of RNA genomes Reverse transcription Viral–host factors interaction

  2021cites this paper
• Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells

  2021cites this paper
• The spatial distribution of target cell ligands determines NK cell degranulation

  2021cites this paper
• The Role of Trogocytosis in the Modulation of Immune Cell Functions

  2021cites this paper
• Emerging Roles of Liquid–Liquid Phase Separation in Cancer: From Protein Aggregation to Immune-Associated Signaling

  2021cites this paper
• F-Actin Dynamics in the Regulation of Endosomal Recycling and Immune Synapse Assembly

  2021influential citation
• Dysfunctional Immune Synapses in T Cell Immunodeficiencies

  2021cites this paper
• Editorial: Genetic and Epigenetic Control of Immune Responses

  2021cites this paper
• Characterization of mechanisms positioning costimulatory complexes in immune synapses

  2021cites this paper
• Cell polarity regulators, multifunctional organizers of lymphocyte activation and function

  2021cites this paper
• Immune Modulatory Properties of Collagen in Cancer

  2021cites this paper
• ADAP’s intrinsically disordered region is an actin sponge regulating T cell motility

  2021cites this paper
• Are Synapse-Like Structures a Possible Way for Crosstalk of Cancer with Its Microenvironment?

  2020cites this paper
• A CVID-associated variant in the ciliogenesis protein CCDC28B disrupts immune synapse assembly

  2020influential citation
• High‐throughput analysis of T cell–monocyte interaction in human tuberculosis

  2020cites this paper
• G-baToN: a versatile cell-cell interaction reporter system

  2020cites this paper
• In silico characterization of mechanisms positioning costimulatory and checkpoint complexes in immune synapses

  2020cites this paper
• Imaging of the immune system – towards a subcellular and molecular understanding

  2020cites this paper
• FluoSim: simulator of single molecule dynamics for fluorescence live-cell and super-resolution imaging of membrane proteins

  2020cites this paper
• Shigella impairs human T lymphocyte responsiveness by hijacking actin cytoskeleton dynamics and T cell receptor vesicular trafficking

  2020cites this paper
• Mucosal Immunity for Inflammation: Regulation of Gut-Specific Lymphocyte Migration by Integrins

  2020cites this paper
• GPCRs in innate and adaptive immune responses

  2020cites this paper
• Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production

  2020cites this paper
• Actin reorganization at the centrosomal area and the immune synapse regulates polarized secretory traffic of multivesicular bodies in T lymphocytes

  2020cites this paper
• G-baToN: a versatile reporter system for cancer cell-stromal cell interactions

  2020cites this paper
• Chimeric antigen receptor signaling: Functional consequences and design implications

  2020cites this paper
• Robust T-cell signaling triggered on soft polydimethylsiloxane-supported lipid-bilayers

  2020cites this paper
• Frontline Science: P2Y11 receptors support T cell activation by directing mitochondrial trafficking to the immune synapse

  2020cites this paper
• Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

  2020cites this paper
• T cell receptor therapy against melanoma—Immunotherapy for the future?

  2020cites this paper
• Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function

  2020cites this paper
• A versatile system to record cell-cell interactions

  2020cites this paper
• Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions

  2020cites this paper
• Soft Polydimethylsiloxane-Supported Lipid Bilayers for Studying T Cell Interactions

  2020cites this paper
• Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism

  2020cites this paper
• T cell co-stimulator inducible co-stimulatory (ICOS) exerts potential anti-atherosclerotic roles through downregulation of vascular smooth muscle phagocytosis and proliferation

  2020cites this paper
• Innate and Adaptive Systems of Immunity

  2020cites this paper
• Emerging Roles of the Intraflagellar Transport System in the Orchestration of Cellular Degradation Pathways

  2019cites this paper
• ERM-Dependent Assembly of T-Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli Prior to Activation

  2019cites this paper
• New Therapies and Immunological Findings in Melanoma and Other Skin Cancers

  2019cites this paper
• Orchestration of Immunological Synapse Assembly by Vesicular Trafficking

  2019cites this paper
• Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors.

  2019cites this paper
• The intraflagellar transport protein IFT20 controls lysosome biogenesis by regulating the post-Golgi transport of acid hydrolases

  2019cites this paper
• The Lateral Organization and Mobility of Plasma Membrane Components.

  2019cites this paper