Focal adhesion kinase: a promising target for anticancer therapy

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Expert opinion on therapeutic targets

• Publication date

  2007-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1517/14728222.11.10.1315PMID 17907961
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ligand-mimetic anti-aIIbβ3 antibody PAC-1 inhibits tyrosine signaling, proliferation and lung colonization of melanoma cells

  2008cited by this paper
• Focal adhesion kinase: a potential target in cancer therapy.

  2007cited by this paper
• A novel low‐molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

  2007cited by this paper
• Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

  2007influential reference
• Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells

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• Estrogen signaling via a linear pathway involving insulin-like growth factor I receptor, matrix metalloproteinases, and epidermal growth factor receptor to activate mitogen-activated protein kinase in MCF-7 breast cancer cells.

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• Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor*

  2007cited by this paper
• Focal adhesion kinase determines the fate of death or survival of cells in response to TNFalpha in the presence of actinomycin D.

  2007cited by this paper
• Phase 1 study of a focal adhesion kinase (FAK) inhibitor PF-00562271 in patients (pts) with advanced solid tumors

  2007influential reference
• Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.

  2006cited by this paper
• Role of focal adhesion kinase and phosphatidylinositol 3'-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells.

  2006cited by this paper
• Integrin-regulated FAK-Src signaling in normal and cancer cells.

  2006cited by this paper
• Disruption of focal adhesion kinase slows transendothelial migration of AU-565 breast cancer cells.

  2006cited by this paper
• FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.

  2006cited by this paper
• New concepts regarding focal adhesion kinase promotion of cell migration and proliferation

  2006cited by this paper
• Antisense oligonucleodes targeting the focal adhesion kinase inhibit proliferation, induce apoptosis and cooperate with cytotoxic drugs in human glioma cells

  2006influential reference
• Construction of retroviral vector of p(125FAK) specific ribozyme genes and its effects on BGC-823 cells.

  2006cited by this paper
• Integrin α2-mediated ERK and Calpain Activation Play a Critical Role in Cell Adhesion and Motility via Focal Adhesion Kinase Signaling

  2006cited by this paper
• Acquisition of chemoresistance following discontinuous exposures to cisplatin is associated in ovarian carcinoma cells with progressive alteration of FAK, ERK and p38 activation in response to treatment.

  2006cited by this paper
• Construction of retroviral vector of p(125FAK) specific ribozyme genes and its effects on BGC-823 cells.

  2006cited by this paper
• Role of c-Src and focal adhesion kinase in progression and metastasis of estrogen receptor-positive breast cancer.

  2006cited by this paper
• Construction of retroviral vector of p^125FAK specific ribozyme genes and its effects on BGC-823 cells

  2006cited by this paper
• Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway.

  2006cited by this paper
• Focal Adhesion Kinase Controls Cellular Levels of p27/Kip1 and p21/Cip1 through Skp2-Dependent and -Independent Mechanisms

  2006cited by this paper
• Effects of PPARgamma agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line.

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• Focal Adhesion Kinase Signaling and the Aggressive Melanoma Phenotype

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• Enhanced expression of cholecystokinin‐2 receptor promotes the progression of colon cancer through activation of focal adhesion kinase

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• Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells

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• Focal Adhesion Kinase Targeting Using In vivo Short Interfering RNA Delivery in Neutral Liposomes for Ovarian Carcinoma Therapy

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• A role for focal adhesion kinase signaling in tumor necrosis factor-alpha-dependent matrix metalloproteinase-9 production in a cholangiocarcinoma cell line, CCKS1.

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• Effects of PPARγ agonists on cell survival and focal adhesions in a Chinese thyroid carcinoma cell line

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• Focal adhesion kinase is required for bombesin-induced prostate cancer cell motility.

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• Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation.

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• Ligand-mimetic anti-alphaIIb beta3 antibody PAC-1 inhibits tyrosine signaling, proliferation and lung colonization of melanoma cells.

  2005cited by this paper
• Mechanisms for the Apoptosis of Small Cell Lung Cancer Cells Induced by Anti-GD2 Monoclonal Antibodies

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• Focal Adhesion Kinase Silencing Augments Docetaxel-Mediated Apoptosis in Ovarian Cancer Cells

  2005influential reference
• Targeting of focal adhesion kinase by flavonoids and small-interfering RNAs reduces tumor cell migration ability.

  2005cited by this paper
• Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.

  2005cited by this paper
• [Exogenous PTEN gene induces apoptosis in breast cancer cells].

  2005cited by this paper
• Focal Adhesion Kinase is Activated in Invading Fibrosarcoma Cells and Regulates Metastasis

  2005cited by this paper
• Increased expression of ICAM‐3 is associated with radiation resistance in cervical cancer

  2005cited by this paper
• Adenovirus-mediated transfer of FRNK augments drug-induced cytotoxicity in cultured SCCHN cells.

  2005influential reference
• Effect of focal adhesion kinase (FAK) downregulation with FAK antisense oligonucleotides and 5-fluorouracil on the viability of melanoma cell lines

  2005influential reference
• Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.

  2005cited by this paper
• Focal adhesion kinase promotes the aggressive melanoma phenotype.

  2005cited by this paper
• Focal adhesion kinase (FAK) phosphorylation is not required for genistein-induced FAK-β-1-integrin complex formation

  2004cited by this paper
• Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion.

  2004cited by this paper
• Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms

  2004cited by this paper
• Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis.

  2004cited by this paper
• Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling.

  2004cited by this paper
• Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase.

  2004cited by this paper
• Functional analysis of focal adhesion kinase (FAK) reduction by small inhibitory RNAs.

  2004cited by this paper
• [PTEN induces apoptosis and up-regulates p53 expression in HepG2 cells].

  2004influential reference
• Src-Mediated Phosphorylation of Focal Adhesion Kinase Couples Actin and Adhesion Dynamics to Survival Signaling

  2004cited by this paper
• Study of the PTEN gene expression and FAK phosphorylation in human hepatocarcinoma tissues and cell lines

  2004cited by this paper
• SHP-2 promoting migration and metastasis of MCF-7 with loss of E-cadherin, dephosphorylation of FAK and secretion of MMP-9 induced by IL-1 βin vivo andin vitro

  2004cited by this paper
• Cell adhesion receptors, tyrosine kinases and actin modulators: a complex three-way circuitry.

  2004cited by this paper
• Control of motile and invasive cell phenotypes by focal adhesion kinase.

  2004influential reference
• Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.

  2004cited by this paper
• Imatinib mesylate induces apoptosis in human cholangiocarcinoma cells

  2004cited by this paper
• Assessment of the antiinvasive potential of the anthracycline aclacinomycin (Aclarubicin) in a human fibrosarcoma cell line.

  2004influential reference
• Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells.

  2004cited by this paper
• Squamous Cell Carcinoma Cell Aggregates Escape Suspension-induced, p53-mediated Anoikis

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• Involvement of oligosaccharide changes in α5β1 integrin in a cisplatin-resistant human squamous cell carcinoma cell line

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• Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis

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  2003cited by this paper
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  2003cited by this paper
• Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion‐associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro

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• RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity.

  2003cited by this paper
• [Study of adhesion-related molecule beta1-integrin and focal adhesion kinase in chronic myeloid leukemia].

  2003cited by this paper
• [Inhibitory effects of antisense focal adhesion kinase oligodeoxynucleotides on the invasion of Bel 7402 hepatocellular carcinoma cells].

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• RRM1-induced metastasis suppression through PTEN-regulated pathways

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• Differential regulation of components of the focal adhesion complex by heregulin: Role of phosphatase SHP‐2

  2002cited by this paper
• Antiapoptotic Action of Focal Adhesion Kinase (FAK) Against Ionizing Radiation

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  2002cited by this paper
• DAP-kinase induces apoptosis by suppressing integrin activity and disrupting matrix survival signals

  2002cited by this paper
• [Influence of focal adhesion kinase (FAK) on the biological behaviors of human hepatocellular carcinoma cells].

  2001cited by this paper
• Loss of focal adhesion kinase (FAK) inhibits epidermal growth factor receptor-dependent migration and induces aggregation of nh(2)-terminal FAK in the nuclei of apoptotic glioblastoma cells.

  2001cited by this paper
• Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis.

  2001cited by this paper
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  2001cited by this paper
• Focal adhesion kinase affects the sensitivity of human hepatocellular carcinoma cell line SMMC-7721 to tumor necrosis factor-alpha/cycloheximide-induced apoptosis by regulating protein kinase B levels.

  2001cited by this paper
• Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

  2001cited by this paper
• Focal adhesion kinase (FAK) phosphorylation is not required for genistein-induced FAK-beta-1-integrin complex formation.

  2000cited by this paper
• Focal adhesion kinase, Rap1, and transcriptional induction of vascular endothelial growth factor.

  2000cited by this paper
• Etk, a Btk Family Tyrosine Kinase, Mediates Cellular Transformation by Linking Src to STAT3 Activation

  2000cited by this paper
• Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase.

  2000cited by this paper
• Matrix Survival Signaling

  2000cited by this paper
• The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.

  1999cited by this paper
• p53 and Egr-1 additively suppress transformed growth in HT1080 cells but Egr-1 counteracts p53-dependent apoptosis

  1999cited by this paper
• Signaling through focal adhesion kinase.

  1999cited by this paper
• Prostatic carcinoma cell migration via alpha(v)beta3 integrin is modulated by a focal adhesion kinase pathway.

  1999cited by this paper

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