Fast axonal transport misregulation and Alzheimer’s Disease

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Neuromolecular medicine

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1385/NMM:2:2:089PMID 12428805
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease

  2014cited by this paper
• A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

  2004cited by this paper
• Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25‐transgenic mice

  2002influential reference
• Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

  2002cited by this paper
• In vivo activation and nuclear translocation of phosphorylated glycogen synthase kinase‐3β in neuronal apoptosis: links to tau phosphorylation

  2002cited by this paper
• Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration.

  2002cited by this paper
• Cyclin‐dependent kinase 5 prevents neuronal apoptosis by negative regulation of c‐Jun N‐terminal kinase 3

  2002cited by this paper
• Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin‐based motility

  2002influential reference
• Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila.

  2002cited by this paper
• Glycogen synthase kinase 3: an emerging therapeutic target.

  2002cited by this paper
• GTP , yS Inhibits Organelle Transport along Axonal Microtubules

  2002cited by this paper
• Apolipoprotein E activates Akt pathway in neuro-2a in an isoform-specific manner.

  2002cited by this paper
• Glycogen Synthase Kinase-3β Is Complexed with Tau Protein in Brain Microtubules*

  2002cited by this paper
• Tau and transgenic animal models.

  2001cited by this paper
• Judging a Protein by More Than Its Name: GSK-3

  2001cited by this paper
• Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles

  2001influential reference
• Decreased nuclear β‐catenin, tau hyperphosphorylation and neurodegeneration in GSK‐3β conditional transgenic mice

  2001influential reference
• Kinesin-mediated axonal transport of a membrane compartment containing β-secretase and presenilin-1 requires APP

  2001cited by this paper
• Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage alzheimer’s disease

  2001cited by this paper
• Integrins stimulate phosphorylation of neurofilament NF‐M subunit KSP repeats through activation of extracellular regulated‐kinases (Erk1/Erk2) in cultured motoneurons and transfected NIH 3T3 cells

  2001cited by this paper
• Approaches to study interactions between kinesin motors and membranes.

  2001cited by this paper
• Regulation of Kinesin: Implications for Neuronal Development

  2001cited by this paper
• Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice.

  2001cited by this paper
• Neurofibrillary tangles and tau phosphorylation.

  2001cited by this paper
• Pancreastatin, a chromogranin-A-derived peptide, inhibits insulin-stimulated glycogen synthesis by activating GSK-3 in rat adipocytes.

  2001cited by this paper
• Presenilin-1 Mutations Reduce Cytoskeletal Association, Deregulate Neurite Growth, and Potentiate Neuronal Dystrophy and Tau Phosphorylation

  2001influential reference
• Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta.

  2001cited by this paper
• Dishevelled-1 Regulates Microtubule Stability : A New Function Mediated by Glycogen Synthase Kinase-3 b

  2000cited by this paper
• Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.

  2000cited by this paper
• Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

  2000cited by this paper
• Pro‐apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism

  2000cited by this paper
• Release of kinesin from vesicles by hsc70 and regulation of fast axonal transport.

  2000cited by this paper
• Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein.

  2000cited by this paper
• Phosphorylation of human tau protein by microtubule‐associated kinases: GSK3β and cdk5 are key participants

  2000cited by this paper
• In Vivo Analysis of Wild‐type and FTDP‐17 Tau Transgenic Mice

  2000cited by this paper
• DNA damage and activated caspase-3 expression in neurons and astrocytes: evidence for apoptosis in frontotemporal dementia.

  2000cited by this paper
• Dishevelled-1 Regulates Microtubule Stability

  2000cited by this paper
• The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism*

  1999cited by this paper
• Frequency of tau mutations in three series of non‐Alzheimer's degenerative dementia

  1999influential reference
• Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.

  1999cited by this paper
• Alzheimer's disease: The tangled tale of tau

  1999cited by this paper
• The presenilins in Alzheimer's disease--proteolysis holds the key.

  1999cited by this paper
• A Role for Cyclin-Dependent Kinase(s) in the Modulation of Fast Anterograde Axonal Transport: Effects Defined by Olomoucine and the APC Tumor Suppressor Protein

  1998cited by this paper
• Effects of PS1 deficiency on membrane protein trafficking in neurons.

  1998cited by this paper
• Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation.

  1998cited by this paper
• A specific light chain of kinesin associates with mitochondria in cultured cells.

  1998cited by this paper
• Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria.

  1998cited by this paper
• GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis.

  1998cited by this paper
• Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

  1998cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

  1998cited by this paper
• Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

  1998cited by this paper
• Kinesin and dynein superfamily proteins and the mechanism of organelle transport.

  1998cited by this paper
• Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

  1998cited by this paper
• Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

  1997cited by this paper
• Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

  1997cited by this paper
• Insulin activates protein kinase B, inhibits glycogen synthase kinase‐3 and activates glycogen synthase by rapamycin‐insensitive pathways in skeletal muscle and adipose tissue

  1997cited by this paper
• Distribution, Levels, and Activity of Glycogen Synthase Kinase‐3 in the Alzheimer Disease Brain

  1997cited by this paper
• Immunochemical analysis of kinesin light chain function.

  1997cited by this paper
• Suppression of KIF2 in PC12 Cells Alters the Distribution of a Growth Cone Nonsynaptic Membrane Receptor and Inhibits Neurite Extension

  1997cited by this paper
• Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: the effects on the organization and stability of microtubules.

  1996cited by this paper
• Glycogen synthase kinase 3 alteration in Alzheimer disease is related to neurofibrillary tangle formation.

  1996cited by this paper
• Wingless inactivates glycogen synthase kinase‐3 via an intracellular signalling pathway which involves a protein kinase C.

  1996cited by this paper
• Preferential labeling of Alzheimer neurofibrillary tangles with antisera for tau protein kinase (TPK) I/glycogen synthase kinase-3β and cyclin-dependent kinase 5, a component of TPK II

  1996cited by this paper
• A kinesin medley: biochemical and functional heterogeneity.

  1995influential reference
• Biochemical and functional diversity of microtubule motors in the nervous system.

  1995cited by this paper
• Fast axonal transport of kinesin in the rat visual system: functionality of kinesin heavy chain isoforms.

  1995cited by this paper
• On the structure of microtubules, tau, and paired helical filaments.

  1995cited by this paper
• Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells.

  1995cited by this paper
• Phosphorylation of Kinesin inVivo Correlates with Organelle Association and Neurite Outgrowth (*)

  1995cited by this paper
• β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

  1995cited by this paper
• Regulation and functions of the glycogen synthase kinase-3 subfamily.

  1994cited by this paper
• Altered microtubule organization in small-calibre axons of mice lacking tau protein

  1994cited by this paper
• Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

  1994cited by this paper
• Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

  1993cited by this paper
• Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments.

  1993cited by this paper
• GTP gamma S inhibits organelle transport along axonal microtubules

  1993cited by this paper
• β‐Amyloid Neurotoxicity in Human Cortical Culture Is Not Mediated by Excitotoxins

  1993cited by this paper
• Molecular motors in axonal transport. Cellular and molecular biology of kinesin.

  1992cited by this paper
• Glycogen synthase kinase-3: functions in oncogenesis and development.

  1992influential reference
• Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

  1992cited by this paper
• beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

  1992cited by this paper
• Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides

  1992cited by this paper
• Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

  1992cited by this paper
• Kinesin interactions with membrane bounded organelles in vivo and in vitro

  1991cited by this paper
• Molecular genetics of kinesin light chains: generation of isoforms by alternative splicing.

  1991cited by this paper
• Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis.

  1991influential reference
• Phosphorylation-dependent inhibition by synapsin I of organelle movement in squid axoplasm

  1989cited by this paper
• Copurification of kinesin polypeptides with microtubule-stimulated Mg-ATPase activity and kinetic analysis of enzymatic properties.

  1989cited by this paper
• Attachment of transported vesicles to microtubules in axoplasm is facilitated by AMP-PNP

  1985cited by this paper
• Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility.

  1985cited by this paper
• A novel brain ATPase with properties expected for the fast axonal transport motor

  1985cited by this paper
• Integrin (cid:2) 2 (cid:3) 1 Promotes Activation of Protein Phosphatase 2A and Dephosphorylation of Akt and Glycogen Synthase Kinase 3 (cid:3)

  year unknowncited by this paper

• Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo

  2025cites this paper
• Treponema denticola Has the Potential to Cause Neurodegeneration in the Midbrain via the Periodontal Route of Infection—Narrative Review

  2023cites this paper
• Krabbe disease: New hope for an old disease

  2021cites this paper
• Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice

  2020cites this paper
• Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain.

  2019cites this paper
• Advances in the Potential Biomarkers of Epilepsy

  2019cites this paper
• The Role of Axon Transport in Neuroprotection and Regeneration

  2018cites this paper
• Optical trapping and single molecule measurement technologies for the investigation of biomolecular forces and motion

  2018cites this paper
• Alzheimer's disease in humans and other animals: A consequence of postreproductive life span and longevity rather than aging

  2018cites this paper
• Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane

  2018cites this paper
• Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

  2017cites this paper
• N-methyl-D-aspartate receptors mediate epilepsy-induced axonal impairment and tau phosphorylation via activating glycogen synthase kinase-3β and cyclin-dependent kinase 5.

  2017cites this paper
• The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system

  2017cites this paper
• MGRN1‐mediated ubiquitination of α‐tubulin regulates microtubule dynamics and intracellular transport

  2017cites this paper
• Edinburgh Research Explorer Alzheimer's disease in humans and other animals; a consequence of post-reproductive lifespan and longevity rather than ageing

  2017cites this paper
• Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2

  2017cites this paper
• Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

  2016cites this paper
• HIV Glycoprotein Gp120 Impairs Fast Axonal Transport by Activating Tak1 Signaling Pathways

  2016cites this paper
• The role of hypertension and inflammation on the cognitive symptoms of Alzheimer's disease patients

  2016cites this paper
• Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy

  2016cites this paper
• Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport.

  2016cites this paper
• Conventional kinesin: Biochemical heterogeneity and functional implications in health and disease.

  2016cites this paper
• Role of synucleins in traumatic brain injury — an experimental in vitro and in vivo study in mice.

  2014cites this paper
• Long-distance endosome trafficking drives fungal effector production during plant infection

  2014cites this paper
• Effects of Mutant Alpha-Synuclein In the Activation of Retrograde Fast Axonal Transport

  2013cites this paper
• Region-specific neuron and synapse loss in the hippocampus of APPSL/PS1 knock-in mice

  2013cites this paper
• Alterations in the Nuclear Architecture Produced by the Overexpression of Tau Protein in Neuroblastoma Cells

  2013cites this paper
• Notch signalling in adult neurons: a potential target for microtubule stabilization

  2013cites this paper
• Regulation of Mint 1-dependent APP trafficking by N 1-Src

  2013cites this paper
• Examinations into the Calcium Hypothesis of Alzheimer's Disease

  2013cites this paper
• Effects of Mutant Alpha-Synuclein In the Activation of Retrograde Fast Axonal Transport BY SUN

  2013cites this paper
• Modulation of Neuronal Insulin Signaling Rescues Axonal Transport Defects in an Alzheimer’s Disease Model

  2013cites this paper
• Cargo distributions differentiate pathological axonal transport impairments.

  2012cites this paper
• Axonal transport and neurodegenerative disease: can we see the elephant?

  2012cites this paper
• Localization of Axonal Motor Molecules Machinery in Neurodegenerative Disorders

  2012cites this paper
• Axonal Transport and Mitochondrial Dysfunction in Alzheimer's Disease

  2012cites this paper
• Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.

  2012cites this paper
• Modulation of Alzheimer's Disease Pathology and Neuroplasticity by Environmental Factors

  2012cites this paper
• Spectral analysis methods for the robust measurement of the flexural rigidity of biopolymers.

  2012cites this paper
• Mechanisms of Axonopathy in Krabbe Disease

  2012cites this paper
• Axonal transport of APP and the spatial regulation of APP cleavage and function in neuronal cells

  2012cites this paper
• INVESTIGATION OF THE CYTOPROTECTIVE EFFECTS OF SONIC HEDGEHOG IN CELLULAR AND ANIMAL MODELS OF AMYOTROPHIC LATERAL SCLEROSIS

  2012cites this paper
• 10 The Role of Glycogen Synthase Kinase-3 ( GSK-3 ) in Alzheimer ’ s Disease

  2012cites this paper
• Selenium in Alzheimer’s Disease

  2011cites this paper
• Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal Phosphotransferases

  2011cites this paper
• The Role of Glycogen Synthase Kinase-3 (GSK-3) in Alzheimer’s Disease

  2011cites this paper
• Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel.

  2011cites this paper
• Toward the development of a sensitive, pre-clinical screen for neurological diseases from spontaneous neural coordination in juvenile and young-adult C57BK6 mice.

  2010cites this paper
• Impaired neurogenesis is an early event in the etiology of familial Alzheimer's disease in transgenic mice

  2010influential citation
• Fast intra-axonal transport: Beginning, development and post-genome advances.

  2010cites this paper
• A study of the role of presenilin (1) in regulating synaptic function at hippocampal synapses

  2010cites this paper
• The Molecular Neuropathology of Alzheimer's Disease

  2010cites this paper
• Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease.

  2010cites this paper
• A Perspective on Neuronal Cell Death Signaling and Neurodegeneration

  2010influential citation
• HDAC6 Regulates Mitochondrial Transport in Hippocampal Neurons

  2010cites this paper
• Vías de señalización de la neurotransmisión: enfermedades causadas por difunción de estas rutas

  2009cites this paper
• Axonal Transport Defects in Neurodegenerative Diseases

  2009cites this paper
• Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

  2009cites this paper
• Critical roles for microtubules in axonal development and disease.

  2009cites this paper
• The amino terminus of tau inhibits kinesin‐dependent axonal transport: Implications for filament toxicity

  2009influential citation
• Mitochondrial Function, Morphology, and Axonal Transport in Amyotrophic Lateral Sclerosis

  2009cites this paper
• Modeling Sporadic Alzheimer's Disease: The Insulin Resistant Brain State Generates Multiple Long-Term Morphobiological Abnormalities Including Hyperphosphorylated Tau Protein and Amyloid-β

  2009cites this paper
• Virus-induced neuronal dysfunction and degeneration.

  2009cites this paper
• Microtubules: Organization and Function in Neurons

  2009cites this paper
• Involvement of myosin V and associated proteins in protein trafficking and neuronal morphogenesis

  2009cites this paper
• Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

  2009cites this paper
• In vivo imaging of axonal transport using MRI: aging and Alzheimer’s disease

  2008cites this paper
• Conventional kinesin holoenzymes are composed of heavy and light chain homodimers.

  2008cites this paper
• Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing Familial Alzheimer's Disease-Linked Mutant Presenilin 1

  2007cites this paper
• Inhibition of protein phosphatases induces transport deficits and axonopathy

  2007cites this paper
• Cholinergic forebrain degeneration in the APPswe/PS1DeltaE9 transgenic mouse.

  2007cites this paper
• Protein accumulation in traumatic brain injury

  2007cites this paper
• Tau binding to microtubules does not directly affect microtubule‐based vesicle motility

  2007influential citation
• From Concept to Potential Therapeutics: Neuroprotective Peptides

  2007cites this paper
• In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease

  2007cites this paper
• Chapter 1 – Advances in our Understanding of Neurodegeneration

  2007cites this paper
• Journal of Neuroscience Research: Preface

  2007cites this paper
• Approaches to kinesin-1 phosphorylation.

  2007cites this paper
• Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility.

  2007cites this paper
• ImpairmentsinFastAxonalTransportandMotorNeuron DeficitsinTransgenicMiceExpressingFamilialAlzheimer's Disease-LinkedMutantPresenilin1

  2007cites this paper
• Significance of Molecular Signaling for Protein Translation Control in Neurodegenerative Diseases

  2007cites this paper
• Links Between Amyloid and Tau Biology in Alzheimer’s Disease and Their Cholinergic Aspects

  2007cites this paper
• Cerebrolysin decreases amyloid‐β production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease

  2006cites this paper
• Molecular biology of amyotrophic lateral sclerosis: insights from genetics

  2006cites this paper
• JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport

  2006influential citation
• Deregulation of the phosphatidylinositol-3 kinase signaling cascade is associated with neurodegeneration in Npc1-/- mouse brain.

  2005cites this paper
• Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity.

  2005cites this paper
• Humoral immunity in brain aging and Alzheimer's disease.

  2005cites this paper
• Endothelin‐1 modulates anterograde fast axonal transport in the central nervous system

  2005cites this paper
• Presenilin-1-Dependent Transcriptome Changes

  2005cites this paper
• The roles of vaccinia virus proteins in kinesin-dependent microtubule transport.

  2005cites this paper
• Nigrostriatal Dysfunction in Familial Alzheimer's Disease-Linked APPswe/PS1ΔE9 Transgenic Mice

  2005cites this paper
• Dysfunction in Familial Alzheimer ’ s Disease-Linked APPswe / PS 1 E 9 Transgenic Mice

  2005cites this paper
• Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model.

  2005cites this paper
• Axonal transport hypothesis moves on to implicate presenilin: Alzheimer research forum live discussion

  2004cites this paper
• Melatonin protects SH‐SY5Y neuroblastoma cells from calyculin A‐induced neurofilament impairment and neurotoxicity

  2004cites this paper
• Long-Term Accumulation of Amyloid-β, β-Secretase, Presenilin-1, and Caspase-3 in Damaged Axons Following Brain Trauma

  2004cites this paper
• Perspectives on herpes–APP interactions

  2004cites this paper
• Short communication Cdk5 inhibits anterograde axonal transport of neurofilaments but not that of tau by inhibition of mitogen-activated protein kinase activity

  2004cites this paper
• Neuronal migration and the role of reelin during early development of the cerebral cortex

  2004cites this paper