Glycogen synthase kinase-3 beta is a dual specificity kinase differentially regulated by tyrosine and serine/threonine phosphorylation.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of Biological Chemistry

• Publication date

  1994-05-20

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  PMID 7514173
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Phosphorylation of the type-II regulatory subunit of cyclic-AMP-dependent protein kinase by glycogen synthase kinase 3 and glycogen synthase kinase 5.

  2005cited by this paper
• MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3

  1994cited by this paper
• The α‐isoform of glycogen synthase kinase‐3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase‐activated protein kinase‐1 in vitro

  1994cited by this paper
• Isoform differences in substrate recognition by glycogen synthase kinases 3 alpha and 3 beta in the phosphorylation of phosphatase inhibitor 2.

  1994cited by this paper
• Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells.

  1993cited by this paper
• Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila.

  1993cited by this paper
• The when and how of Src regulation.

  1993cited by this paper
• MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.

  1993cited by this paper
• Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.

  1993cited by this paper
• Multiple and cooperative phosphorylation events regulate the CREM activator function.

  1993cited by this paper
• Modulation of the glycogen synthase kinase‐3 family by tyrosine phosphorylation.

  1993cited by this paper
• Expression, purification, crystallization, and biochemical characterization of a recombinant protein phosphatase.

  1993cited by this paper
• Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments.

  1993cited by this paper
• Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling.

  1993cited by this paper
• Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.

  1993cited by this paper
• Signalling by receptor tyrosine kinases.

  1993cited by this paper
• Drosophila shaggy kinase and rat glycogen synthase kinase-3 have conserved activities and act downstream of Notch

  1993cited by this paper
• Mechanisms of multisite phosphorylation and inactivation of rabbit muscle glycogen synthase.

  1993cited by this paper
• The mitogen-activated protein kinase signal transduction pathway.

  1993cited by this paper
• Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2.

  1993cited by this paper
• Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase.

  1993cited by this paper
• The MAP kinase cascade is essential for diverse signal transduction pathways.

  1993cited by this paper
• Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase.

  1993cited by this paper
• Dual-specificity protein kinases: will any hydroxyl do?

  1992cited by this paper
• wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate.

  1992cited by this paper
• Identification of multifunctional ATP-citrate lyase kinase as the alpha-isoform of glycogen synthase kinase-3.

  1992cited by this paper
• Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.

  1992cited by this paper
• The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product.

  1992cited by this paper
• Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase.

  1992cited by this paper
• Baculovirus-mediated expression and characterisation of rat glycogen synthase kinase-3 beta, the mammalian homologue of the Drosophila melanogaster zeste-white 3sgg homeotic gene product.

  1992cited by this paper
• Glycogen synthase kinase-3: functions in oncogenesis and development.

  1992cited by this paper
• Molecular signal integration. Interplay between serine, threonine, and tyrosine phosphorylation.

  1992cited by this paper
• Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase.

  1992cited by this paper
• Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

  1992cited by this paper
• Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

  1991cited by this paper
• Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

  1991cited by this paper
• A common denominator linking glycogen metabolism, nuclear oncogenes and development.

  1991cited by this paper
• Definition of a consensus sequence for peptide substrate recognition by p44mpk, the meiosis-activated myelin basic protein kinase.

  1991cited by this paper
• Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

  1991cited by this paper
• A suppressor of a centromere DNA mutation encodes a putative protein kinase (MCK1).

  1991cited by this paper
• The yeast MCK1 gene encodes a protein kinase homolog that activates early meiotic gene expression.

  1991cited by this paper
• Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase.

  1991cited by this paper
• Autophosphorylation in vitro of recombinant 42-kilodalton mitogen-activated protein kinase on tyrosine.

  1991cited by this paper
• Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation.

  1991cited by this paper
• Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity.

  1991cited by this paper
• Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

  1991cited by this paper
• STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases

  1991cited by this paper
• Multisite and hierarchal protein phosphorylation.

  1991cited by this paper
• Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine.

  1991cited by this paper
• Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

  1991cited by this paper
• Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity

  1990cited by this paper
• Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

  1990cited by this paper
• Protein kinase recognition sequence motifs.

  1990cited by this paper
• Control of glycogen synthase by hierarchal protein phosphorylation

  1990cited by this paper
• Molecular cloning and expression of glycogen synthase kinase‐3/factor A.

  1990cited by this paper
• Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates.

  1990cited by this paper
• Use of T7 RNA polymerase to direct expression of cloned genes.

  1990cited by this paper
• Stimulation of FA and phosphatase‐1 activities by insulin in 3T3‐L1 cells

  1989cited by this paper
• Primary structure of rabbit skeletal muscle glycogen synthase deduced from cDNA clones

  1989cited by this paper
• Multisite phosphorylation of the glycogen‐binding subunit of protein phosphatase‐1G by cyclic AMP‐dependent protein kinase and glycogen synthase kinase‐3

  1989cited by this paper
• Purification and characterization of protein phosphatase 1I activating kinase from bovine brain cytosolic and particulate fractions.

  1989cited by this paper
• Insulin action rapidly decreases multifunctional protein kinase activity in rat adipose tissue.

  1988cited by this paper
• Insulin induces activation and translocation of protein kinase FA (a multifunctional protein phosphatase activator) in human platelet.

  1988cited by this paper
• Phosphoserine as a recognition determinant for glycogen synthase kinase-3: phosphorylation of a synthetic peptide based on the G-component of protein phosphatase-1.

  1988cited by this paper
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

  1988cited by this paper
• Protein serine/threonine kinases.

  1987cited by this paper
• Purification and characterization of a protein-tyrosine kinase from bovine thymus.

  1986cited by this paper
• Synergistic phosphorylation and activation of ATP-Mg-dependent phosphoprotein phosphatase by F A/GSK-3 and casein kinase II (PC0.7).

  1984cited by this paper
• Reconstitution of a Mg‐ATP‐dependent protein phosphatase and its activation through a phosphorylation mechanism

  1982cited by this paper
• Purification of glycogen synthase kinase 3 from rabbit skeletal muscle. Copurification with the activating factor (FA) of the (Mg-ATP) dependent protein phosphatase.

  1981cited by this paper
• DNA sequencing with chain-terminating inhibitors.

  1977cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper

• Gut microbial metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity decline through modulation of GSK-3β activity

  2025cites this paper
• Activation is only the beginning: mechanisms that tune kinase substrate specificity.

  2025cites this paper
• Opioids induce constipation by prompting alpha-Synuclein hyperphosphorylation in the colonic myenteric plexus.

  2025cites this paper
• Presenilin deficiency enhances tau phosphorylation and its secretion

  2024cites this paper
• Exploring New Structures of Kinase Inhibitors and Multitarget Strategies in Alzheimer's Disease Treatment.

  2024cites this paper
• RPF2 and CARM1 cooperate to enhance colorectal cancer metastasis via the AKT/GSK-3β signaling pathway.

  2024cites this paper
• Multi-faceted regulation of CREB family transcription factors

  2024cites this paper
• Glycogen Synthase Kinase-3 Inhibitors Block Morphine-Induced Locomotor Activation, Straub Tail, and Depression of Rearing in Mice Via a Possible Central Action

  2023cites this paper
• Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation

  2023cites this paper
• Fluoride as a Potential Repressor of Glycogen Metabolism in Skeletal Muscle Cell Line CCL136

  2023cites this paper
• Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.

  2023cites this paper
• CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/β-catenin signaling pathway

  2023cites this paper
• Synthetic torpor triggers a neuroprotective and regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation

  2022cites this paper
• GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation

  2022cites this paper
• TLR13 contributes to skeletal muscle atrophy by increasing insulin resistance in chronic kidney disease

  2022cites this paper
• Glycogen Synthase Kinase 3: Ion Channels, Plasticity, and Diseases

  2022cites this paper
• Signaling pathways modulated by monocular enucleation in the superior colliculus of juvenile rats

  2021cites this paper
• Protective effects of a small molecule inhibitor ligand against hyperphosphorylated tau-induced mitochondrial and synaptic toxicities in Alzheimer disease.

  2021cites this paper
• Exercise Pills for Drug Addiction: Forced Moderate Endurance Exercise Inhibits Methamphetamine-Induced Hyperactivity through the Striatal Glutamatergic Signaling Pathway in Male Sprague Dawley Rats

  2021influential citation
• Alzheimer’s Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound

  2021cites this paper
• Metformin Dysregulates the Unfolded Protein Response and the WNT/β-Catenin Pathway in Endometrial Cancer Cells through an AMPK-Independent Mechanism

  2021cites this paper
• TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS.

  2021cites this paper
• Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin and Menadione in SH-SY5Y Cells

  2021cites this paper
• GSK3β inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia

  2020cites this paper
• CD147 promotes epithelial-mesenchymal transition of prostate cancer cells via the Wnt/β-catenin pathway

  2020cites this paper
• The Scaffold Protein Axin Promotes Signaling Specificity within the Wnt Pathway by Suppressing Competing Kinase Reactions.

  2020cites this paper
• Sperm Signaling Specificity: From Sperm Maturation to Oocyte Recognition

  2020cites this paper
• Role of tau protein in Alzheimer's disease: The prime pathological player.

  2020cites this paper
• Isoorientin Inhibits Inflammation in Macrophages and Endotoxemia Mice by Regulating Glycogen Synthase Kinase 3β

  2020cites this paper
• Neuroprotective Effects of Higenamine Against the Alzheimer’s Disease Via Amelioration of Cognitive Impairment, Aβ Burden, Apoptosis and Regulation of Akt/GSK3β Signaling Pathway

  2020cites this paper
• STIP1 down-regulation inhibits glycolysis by suppressing PKM2 and LDHA and inactivating the Wnt/β-catenin pathway in cervical carcinoma cells.

  2020cites this paper
• Beta-Tocotrienol Exhibits More Cytotoxic Effects than Gamma-Tocotrienol on Breast Cancer Cells by Promoting Apoptosis via a P53-Independent PI3-Kinase Dependent Pathway

  2020cites this paper
• Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination

  2020cites this paper
• Tissue-Specific Cell Signaling

  2020cites this paper
• GSK3: A Kinase Balancing Promotion and Resolution of Inflammation

  2020cites this paper
• miR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease

  2019cites this paper
• The Wnt pathway scaffold protein Axin promotes signaling specificity by suppressing competing kinase reactions

  2019cites this paper
• Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs

  2019influential citation
• Exogenous miR‐26a suppresses muscle wasting and renal fibrosis in obstructive kidney disease

  2019cites this paper
• Lithium Pharmacology and a Potential Role of Lithium on Methamphetamine Abuse and Dependence.

  2019cites this paper
• Hydrophilic Glycoproteins of an Edible Green Alga Capsosiphon fulvescens Prevent Aging-Induced Spatial Memory Impairment by Suppressing GSK-3β-Mediated ER Stress in Dorsal Hippocampus

  2019cites this paper
• To be or not to be: PP2A as a dual player in CNS functions, its role in neurodegeneration, and its interaction with brain insulin signaling

  2019cites this paper
• GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

  2019cites this paper
• Paper miR-26 a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease

  2019cites this paper
• Isoform-specific GSK3A activity is negatively correlated with human sperm motility

  2019cites this paper
• Identification of a Novel Selective and Potent Inhibitor of Glycogen Synthase Kinase-3.

  2019cites this paper
• Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis.

  2018cites this paper
• GSK3 Controls Migration of the Neural Crest Lineage

  2018cites this paper
• Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway

  2018cites this paper
• Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation

  2018cites this paper
• Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice.

  2018cites this paper
• Modulation of GSK-3β/β-Catenin Signaling Contributes to Learning and Memory Impairment in a Rat Model of Depression

  2018cites this paper
• Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus

  2018cites this paper
• Characterization of Structures and Dynamics of Intrinsically Disordered Domain and Proteins Using Time Resolved-Hydrogen Deuterium Exchange Mass Spectrometry

  2017cites this paper
• Increased platelet glycogen sysnthase kinase 3beta in first-episode psychosis.

  2017cites this paper
• Past and current perspective on new therapeutic targets for Type-II diabetes

  2017cites this paper
• Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling

  2017cites this paper
• Tannoid principles of Emblica officinalis attenuated aluminum chloride induced apoptosis by suppressing oxidative stress and tau pathology via Akt/GSK-3βsignaling pathway.

  2016cites this paper
• SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress

  2016influential citation
• Pencirian molekul glikogen sintase kinase-3 Dari Eimeria tenella

  2016cites this paper
• Tau pathology-mediated presynaptic dysfunction.

  2016cites this paper
• Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylation

  2016cites this paper
• Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway

  2016cites this paper
• Novel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 Regulation

  2016cites this paper
• Antidepressant and molecular responses to ketamine linked to its inhibition of glycogen synthase kinase-3 (GSK3)

  2016cites this paper
• Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.

  2016cites this paper
• Investigating the mechanisms underlying Alzheimer's disease using a novel organotypic brain slice culture model

  2016influential citation
• Short Title: Gsk3a is essential for male fertility

  2015cites this paper
• Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble

  2015cites this paper
• Increased iPLA2 activity and levels of phosphorylated GSK3B in platelets are associated with donepezil treatment in Alzheimer’s disease patients

  2015cites this paper
• Evaluación del rol de la vía canónica de Wnt en la adicción a cocaína

  2015cites this paper
• Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity

  2015cites this paper
• Anorexigenic Lipopeptides Ameliorate Central Insulin Signaling and Attenuate Tau Phosphorylation in Hippocampi of Mice with Monosodium Glutamate-Induced Obesity

  2015influential citation
• Glycogen Synthase Kinase 3 Regulates IL‐1β Mediated iNOS Expression in Hepatocytes by Down‐Regulating c‐Jun

  2015cites this paper
• Fluoxetine Regulates Neurogenesis In Vitro Through Modulation of GSK-3β/β-Catenin Signaling

  2015cites this paper
• Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways.

  2015cites this paper
• Nuclear PI3K signaling in cell growth and tumorigenesis

  2015influential citation
• Transcriptomic Analysis of Induced Pluripotent Stem Cells Derived from Patients with Bipolar Disorder from an Old Order Amish Pedigree

  2015cites this paper
• Targeted Disruption of Glycogen Synthase Kinase 3a (Gsk3a) in Mice Affects Sperm Motility Resulting in Male Infertility1

  2015cites this paper
• Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation.

  2015cites this paper
• Natural Functions of PLIN2 Mediating Wnt/LiCl Signaling and Glycogen Synthase Kinase 3 (GSK3)/GSK3 Substrate-Related Effects Are Modulated by Lipid

  2015cites this paper
• PI3K mediated activation of GSK-3β reduces at-level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias

  2015cites this paper
• Assays for Insulin and Insulin-Like Signal Transduction Based on Adipocytes, Hepatocytes and Myocytes

  2015cites this paper
• Glycogen Synthase Kinase-3&bgr; Inhibition Prevents Remifentanil-Induced Postoperative Hyperalgesia via Regulating the Expression and Function of AMPA Receptors

  2014cites this paper
• Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats

  2014cites this paper
• Correction: Jejunal Proteins Secreted by db/db Mice or Insulin-Resistant Humans Impair the Insulin Signaling and Determine Insulin Resistance

  2014cites this paper
• Tau Protein Modifications and Interactions: Their Role in Function and Dysfunction

  2014cites this paper
• TLR mediated GSK3β activation suppresses CREB mediated IL-10 production to induce a protective immune response against murine visceral leishmaniasis.

  2014cites this paper
• Direct phosphorylation events involved in HIF-α regulation: the role of GSK-3β

  2014cites this paper
• Glycogen Synthase Kinase 3 Beta (GSK3β) at the Tip of Neuronal Development and Regeneration

  2014cites this paper
• Direct phosphorylation events involved in HiF- α regulation: the role of GSK-3 β

  2014cites this paper
• Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6

  2014cites this paper
• Polo-like kinase 2 activates an antioxidant pathway to promote the survival of cells with mitochondrial dysfunction.

  2014cites this paper
• Targeting Src-mediated Tyr216 phosphorylation and activation of GSK-3 in prostate cancer cells inhibit prostate cancer progression in vitro and in vivo

  2014cites this paper
• Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport.

  2014cites this paper
• Cleavage of GSK‐3β by calpain counteracts the inhibitory effect of Ser9 phosphorylation on GSK‐3β activity induced by H2O2

  2013cites this paper
• Inhibition of GSK3α/β promotes increased pulmonary endothelial permeability to albumin by reactive oxygen/nitrogen species.

  2013cites this paper
• ZNF281 Knockdown Induced Osteogenic Differentiation of Human Multipotent Stem Cells in Vivo and in Vitro

  2013cites this paper
• Something from Nothing: The First Phosphorylation

  2013cites this paper
• Elucidating Human Phosphatase-Substrate Networks

  2013cites this paper