Apolipoprotein E secretion by macrophages: its potential physiological functions

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Current Opinion in Lipidology

• Publication date

  1996-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1097/00041433-199610000-00008PMID 8937521
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cell Surface Proteoglycans Modulate Net Synthesis and Secretion of Macrophage Apolipoprotein E*

  1996cited by this paper
• Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice.

  1995cited by this paper
• Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

  1995cited by this paper
• Failure of exogenous apoprotein E-3 to enhance cholesterol egress from J-774 murine macrophages in culture.

  1995cited by this paper
• Effects of the apolipoprotein E polymorphism on uptake and transfer of cell-derived cholesterol in plasma.

  1995cited by this paper
• Atypical xanthomatosis in apolipoprotein E-deficient mice after cholesterol feeding.

  1995cited by this paper
• Apolipoprotein E and atherosclerosis in Alaska Natives.

  1995cited by this paper
• Serum low density lipoprotein of alcoholic patients is chemically modified in vivo and induces apolipoprotein E synthesis by macrophages.

  1995cited by this paper
• Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

  1995cited by this paper
• Evidence that the death of macrophage foam cells contributes to the lipid core of atheroma.

  1995cited by this paper
• Localization of a domain in apolipoprotein E with both cytostatic and cytotoxic activity.

  1995cited by this paper
• Independent Regulation of Cholesterol Incorporation into Free Apolipoprotein-mediated Cellular Lipid Efflux in Rat Vascular Smooth Muscle Cells (*)

  1995cited by this paper
• Involvement of a cellular surface factor(s) in lipid-free apolipoprotein-mediated cellular cholesterol efflux.

  1995cited by this paper
• Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation.

  1995cited by this paper
• Apolipoprotein E expression in Y1 adrenal cells is associated with increased intracellular cholesterol content and reduced free cholesterol efflux.

  1994cited by this paper
• Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.

  1994cited by this paper
• Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice

  1994cited by this paper
• Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.

  1994cited by this paper
• ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

  1994cited by this paper
• Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression.

  1994cited by this paper
• Apolipoprotein E inhibition of proliferation of mitogen-activated T lymphocytes: production of interleukin 2 with reduced biological activity.

  1994cited by this paper
• Apolipoprotein E: A potent inhibitor of endothelial and tumor cell proliferation

  1994cited by this paper
• Oxidative-modified and acetylated low-density lipoproteins differ in their effects on cholesterol synthesis and stimulate synthesis of apolipoprotein E in rat peritoneal macrophages by different mechanisms.

  1994cited by this paper
• Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3.

  1994cited by this paper
• Apolipoprotein E localization in human coronary atherosclerotic plaques by in situ hybridization and immunohistochemistry and comparison with lipoprotein lipase.

  1994cited by this paper
• A plasma lipoprotein containing only apolipoprotein E and with gamma mobility on electrophoresis releases cholesterol from cells.

  1994cited by this paper
• Uptake of high density lipoprotein cholesterol ester by HepG2 cells involves apolipoprotein E localized on the cell surface.

  1993cited by this paper
• Apolipoprotein E modulates low density lipoprotein retention by lipoprotein lipase anchored to the subendothelial matrix.

  1993cited by this paper
• Abundant expression of apoprotein E by macrophages in human and rabbit atherosclerotic lesions.

  1993cited by this paper
• Post-translational regulation of macrophage apoprotein E production.

  1992cited by this paper
• Efflux of lipid from fibroblasts to apolipoproteins: dependence on elevated levels of cellular unesterified cholesterol.

  1992cited by this paper
• Apolipoprotein-E messenger RNA in rat ovary is expressed in theca and interstitial cells and presumptive macrophage, but not in granulosa cells.

  1992cited by this paper
• Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.

  1992cited by this paper
• Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E.

  1991cited by this paper
• Expression of the human apolipoprotein E gene suppresses steroidogenesis in mouse Y1 adrenal cells.

  1991cited by this paper
• Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol.

  1991cited by this paper
• Binding of apoE-rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist-induced platelet aggregation.

  1989cited by this paper
• Regulation of macrophage apolipoprotein E gene expression by cholesterol.

  1989cited by this paper
• Apoprotein E-rich high density lipoproteins inhibit ovarian androgen synthesis.

  1988cited by this paper
• Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.

  1988cited by this paper
• Secretory products of macrophages.

  1987cited by this paper
• Macrophage free cholesterol content regulates apolipoprotein E synthesis.

  1987cited by this paper
• Regional Accumulations of T Cells, Macrophages, and Smooth Muscle Cells in the Human Atherosclerotic Plaque

  1986cited by this paper
• Familial apolipoprotein E deficiency.

  1986cited by this paper

• Genes and Longevity of Lifespan

  2022cites this paper
• Astrocytic expression of the Alzheimer’s disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models

  2021cites this paper
• Molecular mechanisms of tributyltin‐induced alterations in cholesterol homeostasis and steroidogenesis in hamster testis: In vivo and in vitro studies

  2018cites this paper
• Preclinical validation of putative targets in cardiovascular and metabolic disease

  2018cites this paper
• General discussion and future perspective

  2018cites this paper
• Screening of Candidate Coronary Artery Disease Genes in Pakistani Population

  2017cites this paper
• Differential action of glucocorticoids on apolipoprotein E gene expression in macrophages and hepatocytes

  2017cites this paper
• Amyloid-β and amyloid associated proteins in the pathology and diagnosis of Alzheimer's disease

  2016cites this paper
• APOE Gene Polymorphism and Risk of Coronary Stenosis in Pakistani Population

  2015cites this paper
• Selective suppression of adipose tissue apoE expression impacts systemic metabolic phenotype and adipose tissue inflammation

  2015cites this paper
• Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro

  2015cites this paper
• Effects of phenol-enriched olive oils on HDL and endothelial functions in cardiovascular risk individuals

  2015cites this paper
• HDL-mediated mechanisms of protection in cardiovascular disease.

  2014cites this paper
• Role of Pharmacogenetics on Response to Statins: A Genotype-based Approach to Statin Therapy Outcome

  2014cites this paper
• APOE ϵ 2 allele is an independent risk factor for vulnerable carotid plaque in ischemic stroke patients

  2014cites this paper
• Natural antihyperlipidemic agents: Current status and future perspectives

  2013cites this paper
• The Roles of Genetic Polymorphisms and Human Immunodeficiency Virus Infection in Lipid Metabolism

  2013cites this paper
• ApoE derived from adipose tissue does not suppress atherosclerosis or correct hyperlipidemia in apoE knockout mice

  2013cites this paper
• Clinical response to statins: Mechanism(s) of variable activity and adverse effects

  2012cites this paper
• Macrophage, But Not Systemic, Apolipoprotein E Is Necessary for Macrophage Reverse Cholesterol Transport In Vivo

  2011cites this paper
• [The Rotterdam study].

  2011cites this paper
• Apolipoprotein E: from lipid transport to neurobiology.

  2011cites this paper
• Apolipoprotein A-I stimulates cholesteryl ester transfer protein and apolipoprotein E secretion from lipid-loaded macrophages; the role of NF-κB and PKA signaling pathways.

  2011cites this paper
• Some Epidemiological Aspects of The Common Genetic Polymorphism of Apolipoprotein E

  2011influential citation
• Glycosylation and Sialylation of Macrophage-derived Human Apolipoprotein E Analyzed by SDS-PAGE and Mass Spectrometry

  2010cites this paper
• The apolipoprotein E (APOE) gene and the risk of diabetic nephropathy (DN): a meta-analysis in East Asian populations

  2010cites this paper
• Studies of Atherogenic Lipoproteins Using Mass Spectrometry-Based Lipidomics

  2010cites this paper
• PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1

  2010cites this paper
• Pathogenesis of ovarian cancer: clues from selected overexpressed genes.

  2009cites this paper
• Proteomic analysis in ob/ob mice before and after hypoglycemic polysaccharide treatments.

  2009cites this paper
• FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes.

  2009cites this paper
• Clinical significance of ApoE expression in human gastric cancer.

  2008cites this paper
• TNFα-mediated suppression of adipocyte apolipoprotein E gene transcription: Primary Role for the NFκB pathway and NFκB p50

  2008cites this paper
• Association and linkage disequilibrium analyse so fAPOE polymorphism sin atherosclerosis

  2008cites this paper
• Liver-X-receptor-mediated expression of key genes in macrophages implicated in the control of cholesterol homeostasis and atherosclerosis

  2008cites this paper
• Tumor necrosis factor-alpha-mediated suppression of adipocyte apolipoprotein E gene transcription: primary role for the nuclear factor (NF)-kappaB pathway and NFkappaB p50.

  2008cites this paper
• Association and Linkage Disequilibrium Analyses of APOE Polymorphisms in Atherosclerosis

  2008cites this paper
• Relation of apolipoprotein E polymorphism to markers of early atherosclerotic changes in young adults--the Cardiovascular Risk in Young Finns Study.

  2008cites this paper
• Cardiac Surgery

  2007cites this paper
• Apolipoprotein E and Reverse Cholesterol Transport: The Role of Recycling in Plasma and Intracellular Lipid Trafficking

  2007cites this paper
• Nutritional regulation of adipose tissue apolipoprotein E expression.

  2007cites this paper
• The C-terminal lipid-binding domain of apolipoprotein E is a highly efficient mediator of ABCA1-dependent cholesterol efflux that promotes the assembly of high-density lipoproteins.

  2007cites this paper
• Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE.

  2007cites this paper
• Impaired Secretion of Apolipoprotein E2 from Macrophages*

  2007cites this paper
• Ligand activation of LXRβ reverses atherosclerosis and cellular cholesterol overload in mice lacking LXRα and apoE

  2007cites this paper
• Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice.

  2007cites this paper
• Influencia de los factores genéticos y ambientales en el metabolismo lipídico y riesgo cardiovascular asociado al gen apoE

  2006cites this paper
• Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis

  2006cites this paper
• Apolipoprotein E and Coronary Disease: A Puzzling Paradox

  2006cites this paper
• New Insight Into the Association of Apolipoprotein E Genetic Variants With Carotid Plaques and Intima-Media Thickness

  2006cites this paper
• Distinct Cellular Loci for the ABCA1-Dependent and ABCA1-Independent Lipid Efflux Mediated by Endogenous Apolipoprotein E Expression

  2006cites this paper
• [Influence of genetic and environmental factors on lipid metabolism and cardiovascular risk associated with the apoE gene].

  2006cites this paper
• Reverse cholesterol transport

  2006cites this paper
• Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humans

  2005cites this paper
• Induction of apolipoprotein E expression by TR4 orphan nuclear receptor via 5' proximal promoter region.

  2005cites this paper
• APO A-I AND APO E INTERACTION : BEYOND LIPOPROTEINS

  2005cites this paper
• Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers.

  2005cites this paper
• The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I.

  2005cites this paper
• The key role of apolipoprotein E in atherosclerosis

  2005cites this paper
• Apolipoprotein-E-Recycling: Eine intrazelluläre Verbindung zwischen dem Metabolismus Triazylglyzerid-reicher Lipoproteine und HDL

  2005cites this paper
• Apolipoprotein E is required for cell proliferation and survival in ovarian cancer.

  2005cites this paper
• Divergent Effects of Peroxisome Proliferator-activated Receptor γ Agonists and Tumor Necrosis Factor α on Adipocyte ApoE Expression*

  2004cites this paper
• Synergistic Effect of Apolipoprotein E Polymorphisms and Cigarette Smoking on Risk of Ischemic Stroke in Young Adults

  2004cites this paper
• CYTOCHROME P-450-MEDIATED DIFFERENTIAL OXIDATIVE MODIFICATION OF PROTEINS: ALBUMIN, APOLIPOPROTEIN E, AND CYP2E1 AS TARGETS

  2004cites this paper
• Oleic Acid Modulates the Post-translational Glycosylation of Macrophage ApoE to Increase Its Secretion*

  2004cites this paper
• Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression.

  2004cites this paper
• Triglyceride-rich lipoproteins inhibit cholesterol efflux to apolipoprotein (apo) A1 from human macrophage foam cells.

  2004cites this paper
• What do we know about apolipoprotein E and the prevention of cardiovascular disease?

  2004cites this paper
• Effect of polymorphism of the endothelial nitric oxide synthase and apolipoprotein E genes on carotid atherosclerosis in hemodialysis patients.

  2003cites this paper
• Quantitative analysis of apolipoprotein E secretion by human monocyte-derived macrophages in culture.

  2003cites this paper
• Disruption of TR4 Orphan Nuclear Receptor Reduces the Expression of Liver Apolipoprotein E/C-I/C-II Gene Cluster*

  2003cites this paper
• Association Between Apolipoprotein E Alleles and Calcific Valvular Heart Disease

  2003cites this paper
• Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study.

  2003cites this paper
• Isoform-Dependent Cholesterol Efflux From Macrophages by Apolipoprotein E Is Modulated by Cell Surface Proteoglycans

  2003cites this paper
• Independent effects of the −219 G>T and ε2/ε3/ε4 polymorphisms in the apolipoprotein E gene on coronary artery disease: The Southampton Atherosclerosis Study

  2003cites this paper
• Expression of Nuclear Receptors and Apo E Secretion During the Differentiation of Monocytic THP-1 cells into Macrophages

  2003cites this paper
• Secreted apolipoprotein E reduces macrophage‐mediated LDL oxidation in an isoform‐dependent way

  2003cites this paper
• Expression of scavenger receptor BI facilitates sterol movement between the plasma membrane and the endoplasmic reticulum in macrophages.

  2003cites this paper
• Effect of Atorvastatin on ApoE and ApoC-I Synthesis and Secretion by THP-1 Macrophages

  2003cites this paper
• Regulation of Macrophage ApoE Expression and Processing by Extracellular Matrix*

  2002cites this paper
• Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

  2002cites this paper
• ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression.

  2002cites this paper
• Effect of atorvastatin on plasma apoE metabolism in patients with combined hyperlipidemia DOI 10.1194/jlr.M200016-JLR200

  2002cites this paper
• Genetic predictors of perioperative neurological and cognitive injury and recovery

  2001cites this paper
• Apolipoprotein E and Carotid Artery Atherosclerosis: The Rotterdam Study

  2001cites this paper
• Sterol Efflux Mediated by Endogenous Macrophage ApoE Expression Is Independent of ABCA1

  2001cites this paper
• The Effect of Apolipoprotein E Overexpression via Adenoviral Vector on the Plasma Lipoprotein Profile in C57/BL6 Mice

  2001cites this paper
• Isoform-Specific Effects of Apolipoprotein E on Atherogenesis: Gene Transduction Studies in Mice

  2001cites this paper
• ATP binding cassette transporter ABCA1 modulates the secretion of apolipoprotein E from human monocyte‐derived macrophages

  2001cites this paper
• Interaction with proteoglycans enhances the sterol efflux produced by endogenous expression of macrophage apoE.

  2001cites this paper
• Apolipoprotein E in macrophages and hepatocytes is eegraded via the proteasomal pathway.

  2001cites this paper
• Control of apolipoprotein E secretion in the human hepatoma cell line KYN‐2

  2001cites this paper
• Negative and independent influence of apolipoprotein E on C-reactive protein (CRP) concentration in obese adults. Potential anti-inflammatory role of apoE in vivo

  2001cites this paper
• Chitotriosidase genotype and serum activity in subjects with combined hyperlipidemia: effect of the lipid-lowering agents, atorvastatin and bezafibrate.

  2001cites this paper
• High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport.

  2001cites this paper
• Domains of apolipoprotein E involved in the binding to the protein core of biglycan of the vascular extracellular matrix: potential relationship between retention and anti-atherogenic properties of this apolipoprotein.

  2001cites this paper
• ATP binding cassette transporter ABCA 1 modulates the secretion of apolipoprotein E from human monocyte-derived macrophages

  2001cites this paper
• LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes.

  2001cites this paper
• Reduction of Isoprostanes and Regression of Advanced Atherosclerosis by Apolipoprotein E*

  2001cites this paper
• Apolipoprotein E and Carotid Artery Atherosclerosis

  2001cites this paper