Control of Clostridium difficile Physiopathology in Response to Cysteine Availability

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Infection and Immunity

• Publication date

  2016-06-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/IAI.00121-16PMID 27297391PMCID PMC4962627
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ferric Uptake Regulator Fur Control of Putative Iron Acquisition Systems in Clostridium difficile

  2015cited by this paper
• Time-resolved amino acid uptake of Clostridium difficile 630Δerm and concomitant fermentation product and toxin formation

  2015cited by this paper
• High-Throughput Analysis of Gene Essentiality and Sporulation in Clostridium difficile

  2015cited by this paper
• Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection

  2014cited by this paper
• The changing epidemiology of Clostridium difficile infection

  2014cited by this paper
• Dynamics and Establishment of Clostridium difficile Infection in the Murine Gastrointestinal Tract

  2014cited by this paper
• Pleiotropic Role of the RNA Chaperone Protein Hfq in the Human Pathogen Clostridium difficile

  2014cited by this paper
• Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria

  2013cited by this paper
• Genome-Wide Identification of Regulatory RNAs in the Human Pathogen Clostridium difficile

  2013cited by this paper
• Phenotypic and transcriptomic analyses of Sigma L-dependent characteristics in Listeria monocytogenes EGD-e.

  2012cited by this paper
• Proline-Dependent Regulation of Clostridium difficile Stickland Metabolism

  2012cited by this paper
• Effect of iron limitation and fur gene inactivation on the transcriptional profile of the strict anaerobe Clostridium acetobutylicum.

  2012cited by this paper
• JANSSEN

  2012cited by this paper
• Global transcriptional control by glucose and carbon regulator CcpA in Clostridium difficile

  2012cited by this paper
• Extensive exometabolome analysis reveals extended overflow metabolism in various microorganisms

  2012cited by this paper
• Secretion of Clostridium difficile Toxins A and B Requires the Holin-like Protein TcdE

  2012cited by this paper
• Identification of a Target Gene and Activating Stimulus for the YpdA/YpdB Histidine Kinase/Response Regulator System in Escherichia coli

  2012cited by this paper
• Genome Sequence of Bacillus licheniformis WX-02

  2012cited by this paper
• The Regulation of Sulfur Metabolism in Mycobacterium tuberculosis

  2011cited by this paper
• Deletion of σ54 (rpoN) Alters the Rate of Autolysis and Biofilm Formation in Enterococcus faecalis

  2011cited by this paper
• The Anti-Sigma Factor TcdC Modulates Hypervirulence in an Epidemic BI/NAP1/027 Clinical Isolate of Clostridium difficile

  2011cited by this paper
• Clostridium difficile Has Two Parallel and Essential Sec Secretion Systems*

  2011cited by this paper
• Enteric pathogen exploitation of the microbiota-generated nutrient environment of the gut.

  2011cited by this paper
• Comparative analyses imply that the enigmatic sigma factor 54 is a central controller of the bacterial exterior

  2011cited by this paper
• CcpA‐mediated repression of Clostridium difficile toxin gene expression

  2011influential reference
• The Key Sigma Factor of Transition Phase, SigH, Controls Sporulation, Metabolism, and Virulence Factor Expression in Clostridium difficile

  2011cited by this paper
• A Novel cdsAB Operon Is Involved in the Uptake of l-Cysteine and Participates in the Pathogenesis of Yersinia ruckeri

  2010cited by this paper
• Regulation of CodY Activity through Modulation of Intracellular Branched-Chain Amino Acid Pools

  2010cited by this paper
• Integration of Metabolism and Virulence by Clostridium difficile CodY

  2010influential reference
• The Pleiotropic CymR Regulator of Staphylococcus aureus Plays an Important Role in Virulence and Stress Response

  2010cited by this paper
• Genetics and Regulation of the Major Enzymes of Alanine Synthesis in Escherichia coli

  2010cited by this paper
• Global regulation of gene expression in response to cysteine availability in Clostridium perfringens

  2010cited by this paper
• Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence

  2010cited by this paper
• The Changing Epidemiology of Clostridium difficile Infections

  2010influential reference
• Staphylococcus aureus Fur Regulates the Expression of Virulence Factors That Contribute to the Pathogenesis of Pneumonia

  2010cited by this paper
• Biochemical Features and Functional Implications of the RNA-Based T-Box Regulatory Mechanism

  2009cited by this paper
• Listeria monocytogenes CtaP is a multifunctional cysteine transport‐associated protein required for bacterial pathogenesis

  2009cited by this paper
• A modular system for Clostridium shuttle plasmids.

  2009cited by this paper
• Characterization of the Sporulation Initiation Pathway of Clostridium difficile and Its Role in Toxin Production

  2009cited by this paper
• CymR, the master regulator of cysteine metabolism in Staphylococcus aureus, controls host sulphur source utilization and plays a role in biofilm formation

  2009cited by this paper
• Induction of toxins in Clostridium difficile is associated with dramatic changes of its metabolism.

  2008influential reference
• Comparative genomic analysis of T-box regulatory systems in bacteria.

  2008cited by this paper
• S-box and T-box riboswitches and antisense RNA control a sulfur metabolic operon of Clostridium acetobutylicum

  2008cited by this paper
• Effects of pH and Iron Concentrations on Sulfide Precipitation in Wastewater Collection Systems

  2008cited by this paper
• Formate Acts as a Diffusible Signal To Induce Salmonella Invasion

  2008cited by this paper
• Antibiotics involved in Clostridium difficile-associated disease increase colonization factor gene expression.

  2008cited by this paper
• Burkholderia cenocepacia Requires the RpoN Sigma Factor for Biofilm Formation and Intracellular Trafficking within Macrophages

  2008cited by this paper
• The CymR Regulator in Complex with the Enzyme CysK Controls Cysteine Metabolism in Bacillus subtilis*

  2008cited by this paper
• The ClosTron: a universal gene knock-out system for the genus Clostridium.

  2007cited by this paper
• Functional specialization within the Fur family of metalloregulators

  2007cited by this paper
• Clostridium difficile toxin expression is inhibited by the novel regulator TcdC

  2007cited by this paper
• Repression of Clostridium difficile toxin gene expression by CodY

  2007cited by this paper
• Amino acid biosynthesis : pathways, regulation and metabolic engineering

  2007cited by this paper
• Evaluation of a quantitative screening method for hydrogen sulfide production by cheese-ripening microorganisms: the first step towards l-cysteine catabolism.

  2007cited by this paper
• Current Therapeutics, Their Problems, and Sulfur-Containing-Amino-Acid Metabolism as a Novel Target against Infections by “Amitochondriate” Protozoan Parasites

  2007cited by this paper
• Conversion of Methionine to Cysteine in Bacillus subtilis and Its Regulation

  2006cited by this paper
• The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

  2006cited by this paper
• Global Control of Cysteine Metabolism by CymR in Bacillus subtilis

  2006cited by this paper
• Construction and analysis of chromosomal Clostridium difficile mutants

  2006cited by this paper
• Butyrate Specifically Down-Regulates Salmonella Pathogenicity Island 1 Gene Expression

  2006cited by this paper
• Correlation of Disease Severity with Fecal Toxin Levels in Patients with Clostridium difficile-Associated Diarrhea and Distribution of PCR Ribotypes and Toxin Yields In Vitro of Corresponding Isolates

  2006cited by this paper
• The Many Faces of Glutathione in Bacteria

  2006cited by this paper
• The sigma factor RpoN (sigma54) is involved in osmotolerance in Listeria monocytogenes.

  2006cited by this paper
• Role of the Fur Regulon in Iron Transport in Bacillus subtilis

  2006cited by this paper
• Analysis of Proline Reduction in the Nosocomial Pathogen Clostridium difficile

  2006cited by this paper
• Thioredoxins in bacteria: functions in oxidative stress response and regulation of thioredoxin genes

  2006cited by this paper
• Cysteine Metabolism and Its Regulation in Bacteria

  2006cited by this paper
• A Gene Encoding l-Methionine γ-Lyase Is Present in Enterobacteriaceae Family Genomes: Identification and Characterization of Citrobacter freundiil-Methionine γ-Lyase

  2005cited by this paper
• Generation of an erythromycin-sensitive derivative of Clostridium difficile strain 630 (630Deltaerm) and demonstration that the conjugative transposon Tn916DeltaE enters the genome of this strain at multiple sites.

  2005cited by this paper
• Identification and Functional Analysis of Escherichia coli Cysteine Desulfhydrases

  2005cited by this paper
• The PatB protein of Bacillus subtilis is a C-S-lyase.

  2005influential reference
• A gene encoding L-methionine gamma-lyase is present in Enterobacteriaceae family genomes: identification and characterization of Citrobacter freundii L-methionine gamma-lyase.

  2005cited by this paper
• Comparative genomics of the methionine metabolism in Gram-positive bacteria: a variety of regulatory systems.

  2004cited by this paper
• The metNPQ operon of Bacillus subtilis encodes an ABC permease transporting methionine sulfoxide, D- and L-methionine.

  2004cited by this paper
• Three Different Systems Participate in l-Cystine Uptake in Bacillus subtilis

  2004cited by this paper
• Global analysis of gene expression in an rpoN mutant of Listeria monocytogenes.

  2004cited by this paper
• Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments

  2004cited by this paper
• Normalization of cDNA microarray data.

  2003cited by this paper
• Expression of Clostridium difficile Toxins A and B and Their Sigma Factor TcdD Is Controlled by Temperature

  2003cited by this paper
• MtaR, a Regulator of Methionine Transport, Is Critical for Survival of Group B Streptococcus In Vivo

  2003cited by this paper
• Serine acetyltransferase of Escherichia coli: substrate specificity and feedback control by cysteine.

  2003cited by this paper
• Gene Expression Profile in Neisseria meningitidis and Neisseria lactamica upon Host‐Cell Contact

  2002cited by this paper
• Gene expression profile in Neisseria meningitidis and Neisseria lactamica upon host-cell contact: from basic research to vaccine development.

  2002cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Regulation of toxin synthesis in Clostridium difficile by an alternative RNA polymerase sigma factor

  2001cited by this paper
• Bordetella pertussis Autoregulates Pertussis Toxin Production through the Metabolism of Cysteine

  2001cited by this paper
• Toxins, Butyric Acid, and Other Short-Chain Fatty Acids Are Coordinately Expressed and Down-Regulated by Cysteine in Clostridium difficile

  2000influential reference
• The molecular evolution of pyridoxal-5'-phosphate-dependent enzymes.

  2000cited by this paper
• The rpoN Gene of Enterococcus faecalis Directs Sensitivity to Subclass IIa Bacteriocins

  2000cited by this paper
• Regulated transcription of Clostridium difficile toxin genes

  1998cited by this paper
• Purification and Characterization ofl-Methionine γ-Lyase from Brevibacterium linens BL2

  1998cited by this paper
• Purification and characterization of L-methionine gamma-lyase from brevibacterium linens BL2

  1998cited by this paper
• Controlling the false discovery rate: a practical and powerful approach to multiple testing

  1995cited by this paper
• Cysteine and growth inhibition of Escherichia coli: threonine deaminase as the target enzyme

  1981cited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• Non-targeted metabolomics reveals metabolic signatures associated with Clostridioides difficile virulence

  2026cites this paper
• Development of a high-throughput screening platform for C. difficile toxin synthesis inhibitors unveils meclizine as an antivirulence agent

  2025cites this paper
• Deciphering strain differences in codY regulation of Clostridioides difficiles sporulation

  2025cites this paper
• Downregulation of the cysE/cysK genes of Clostridioides difficile induced by cysteine revealed the response of bacteria to iron homeostasis

  2025cites this paper
• Disulphide bond-forming enzymes in clostridial species

  2025cites this paper
• Discovery of a Widespread Polyamine-Low-Molecular-Weight Thiol Hybrid Pathway in Clostridioides difficile.

  2025cites this paper
• The sigma factor σ54 (rpoN) functions as a global regulator of antibiotic resistance, motility, metabolism, and virulence in Clostridioides difficile

  2025cites this paper
• A Metabolite Dehydrogenase Pathway Represses Sporulation of Clostridioides difficile.

  2025cites this paper
• Environmental and Nutritional Parameters Modulating Genetic Expression for Virulence Factors of Clostridioides difficile

  2024cites this paper
• Regulatory Networks: Linking Toxin Production and Sporulation in Clostridioides difficile.

  2024cites this paper
• Unraveling Cecal Alterations in Clostridioides difficile Colonized Mice through Comprehensive Metabolic Profiling

  2024cites this paper
• Expansion of a Versatile Pathogen: Clostridioides difficile

  2024cites this paper
• Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge

  2024cites this paper
• Regulation of Clostridial Toxin Gene Expression: A Pasteurian Tradition

  2023cites this paper
• Network analysis of toxin production in Clostridioides difficile identifies key metabolic dependencies

  2023cites this paper
• Inhibition of selenoprotein synthesis is not the mechanism by which auranofin inhibits growth of Clostridioides difficile

  2023cites this paper
• Sporulation conditions influence the surface and adhesion properties of Bacillus subtilis spores

  2023cites this paper
• Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics

  2023cites this paper
• Regulatory transcription factors of Clostridioides difficile pathogenesis with a focus on toxin regulation

  2022influential citation
• Identification of a Bile Acid-Binding Transcription Factor in Clostridioides difficile Using Chemical Proteomics.

  2022cites this paper
• Microbial interactions impact the growth response of Clostridioides difficile to antibiotics

  2022cites this paper
• The putative role of gut microbiota in cancer: Cysteine is a pivotal coin

  2022cites this paper
• Thiol Metabolism and Volatile Metabolome of Clostridioides difficile

  2022cites this paper
• Reconsidering the in vivo functions of Clostridial Stickland amino acid fermentations.

  2022cites this paper
• Identification of a bile acid-binding transcription factor in Clostridioides difficile using chemical proteomics

  2022cites this paper
• Effect of diet on pathogen performance in the microbiome

  2022cites this paper
• Cysteine: an overlooked energy and carbon source

  2021cites this paper
• Influence of L-lactate and low glucose concentrations on the metabolism and the toxin formation of Clostridioides difficile

  2021cites this paper
• Metabolic adaption to extracellular pyruvate triggers biofilm formation in Clostridioides difficile

  2021influential citation
• Lactate as an effective electron donor in the sulfate reduction: impacts on the microbial diversity

  2021cites this paper
• Real-time HRMAS 13C NMR of obligately anaerobic cells identifies new metabolic targets in the pathogen Clostridioides difficile

  2021cites this paper
• What’s a Biofilm?—How the Choice of the Biofilm Model Impacts the Protein Inventory of Clostridioides difficile

  2021cites this paper
• Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis

  2021cites this paper
• The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition

  2021cites this paper
• Regulation of Clostridioides difficile toxin production.

  2021cites this paper
• The blueprint for building a biofilm the Clostridioides difficile way.

  2021cites this paper
• Conserved Virulence-Linked Metabolic Reprogramming in Clostridioides Difficile Identified Through Genome-Scale Metabolic Network Analysis

  2021cites this paper
• Title: Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis Running title: Metabolic determinants of C. difficile virulence Authors:

  2021cites this paper
• Genome-Wide Transcription Start Site Mapping and Promoter Assignments to a Sigma Factor in the Human Enteropathogen Clostridioides difficile

  2020cites this paper
• Reuterin disrupts Clostridioides difficile metabolism and pathogenicity through reactive oxygen species generation

  2020cites this paper
• Transcriptomic analysis of a Clostridium thermocellum strain engineered to utilize xylose: responses to xylose versus cellobiose feeding

  2020cites this paper
• Predictive regulatory and metabolic network models for systems analysis of Clostridioides difficile

  2020cites this paper
• Diverse Energy-Conserving Pathways in Clostridium difficile: Growth in the Absence of Amino Acid Stickland Acceptors and the Role of the Wood-Ljungdahl Pathway

  2020cites this paper
• Induced Production, Synthesis, and Immunomodulatory Action of Clostrisulfone, a Diarylsulfone from Clostridium acetobutylicum

  2020cites this paper
• Genome-scale metabolic reconstruction analysis of Clostridioides difficile identifies conserved patterns of virulence-related metabolic reprogramming

  2020cites this paper
• In vivo commensal control of Clostridioides difficile virulence

  2020cites this paper
• Characterization of Clostridioides difficile DSM 101085 with A−B−CDT+ Phenotype from a Late Recurrent Colonization

  2020cites this paper
• Clostridioides difficile para-Cresol Production Is Induced by the Precursor para-Hydroxyphenylacetate

  2020cites this paper
• Effect of sub-MIC values of metronidazole, ciprofloxacin, and imipenem on the growth and toxin production in Clostridioides difficile

  2019cites this paper
• Genomic reconstruction of σ54 regulons in Clostridiales

  2019cites this paper
• Type E Botulinum Neurotoxin-Producing Clostridium butyricum Strains Are Aerotolerant during Vegetative Growth

  2019cites this paper
• Vegetative Cell and Spore Proteomes of Clostridioides difficile Show Finite Differences and Reveal Potential Protein Markers

  2019cites this paper
• Pleiotropic Clostridioides difficile Cyclophilin PpiB Controls Cysteine-Tolerance, Toxin Production, the Central Metabolism and Multiple Stress Responses

  2019cites this paper
• Metabolism the Difficile Way: The Key to the Success of the Pathogen Clostridioides difficile

  2019cites this paper
• Nutrient sulfur acquisition strategies employed by bacterial pathogens.

  2019cites this paper
• A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) difficile Infection in Mice, whereas a High-Carbohydrate Diet Protects

  2019cites this paper
• Iron Regulation in Clostridioides difficile

  2018cites this paper
• A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile

  2018cites this paper
• Ethanolamine is a valuable nutrient source that impacts Clostridium difficile pathogenesis

  2018cites this paper
• Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria

  2018cites this paper
• Clostridium difficile Biofilm: Remodeling Metabolism and Cell Surface to Build a Sparse and Heterogeneously Aggregated Architecture

  2018influential citation
• Time-resolved transcriptome analysis of Clostridium difficile R20291 response to cysteine.

  2018cites this paper
• Metabolic Reprogramming of Clostridioides difficile During the Stationary Phase With the Induction of Toxin Production

  2018influential citation
• The C. difficile clnRAB operon initiates adaptations to the host environment in response to LL-37

  2018cites this paper
• Novel Cysteine Desulfidase CdsB Involved in Releasing Cysteine Repression of Toxin Synthesis in Clostridium difficile

  2018influential citation
• Comprehensive Redox Profiling of the Thiol Proteome of Clostridium difficile *

  2018cites this paper
• RstA Is a Major Regulator of Clostridioides difficile Toxin Production and Motility

  2018cites this paper
• Tracking gene expression and oxidative damage of O2-stressed Clostridioides difficile by a multi-omics approach.

  2018cites this paper
• Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus.

  2017cites this paper
• A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator.

  2017cites this paper
• The alternative sigma factor &sgr;B plays a crucial role in adaptive strategies of Clostridium difficile during gut infection

  2017cites this paper
• High metabolic versatility of different toxigenic and non-toxigenic Clostridioides difficile isolates.

  2017cites this paper
• Making life difficult for Clostridium difficile: augmenting the pathogen’s metabolic model with transcriptomic and codon usage data for better therapeutic target characterization

  2017cites this paper
• Development Of Student Data Visualization Tool, Adaption Of Clostridium Difficile Toxin A Into Protein Delivery Vehicle, And Elucidation Of Tcdc Mechanism Of Toxin Control

  2017cites this paper
• The Regulatory Networks That Control Clostridium difficile Toxin Synthesis

  2016cites this paper
• The Ferrous Iron Transporter FeoB 1 is Essential for Clostridioides difficile Toxin Production 2 and Pathogenesis in Mice 3 4

  year unknowncites this paper