Recent Progress in Understanding the Pathophysiology of Post-Traumatic Stress Disorder

No abstract is available for this paper.

• Publication year

  2013

• Venue

  CNS Drugs

• Publication date

  2013-03-13

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1007/s40263-013-0051-4PMID 23483368PMCID PMC3629370
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2013cited by this paper
• Psychiatric comorbidity of full and partial posttraumatic stress disorder among older adults in the United States: results from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions.

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• Fatty-acid amide hydrolase polymorphisms and post-traumatic stress disorder after penetrating brain injury

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• Salivary α-amylase and cortisol responsiveness following electrical stimulation stress in panic disorder patients.

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• The VA/DOD Clinical Practice Guideline for Management of Post-Traumatic Stress (update 2010): development and methodology.

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• Noradrenergic vs Serotonergic Antidepressant with or without Naltrexone for Veterans with PTSD and Comorbid Alcohol Dependence

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• Treatment with β-blockers and incidence of post-traumatic stress disorder after cardiac surgery: a prospective observational study.

  2012cited by this paper
• Introduction to the special issue on stress, emotional behavior, and the endocannabinoid system: a decade of research.

  2012influential reference
• Impulsive behaviors as an emotion regulation strategy: examining associations between PTSD, emotion dysregulation, and impulsive behaviors among substance dependent inpatients.

  2012cited by this paper
• Pharmacological treatment of PTSD - established and new approaches.

  2012cited by this paper
• Venlafaxine facilitates between-session extinction and prevents reinstatement of auditory-cue conditioned fear.

  2012cited by this paper
• Effect of Acute Posttrauma Propranolol on PTSD Outcome and Physiological Responses During Script‐Driven Imagery

  2012cited by this paper
• Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis.

  2012cited by this paper
• Medical Comorbidity of Full and Partial Posttraumatic Stress Disorder in US Adults: Results From Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions

  2011cited by this paper
• When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders.

  2011cited by this paper
• 5HT(1A) and 5HT(1B) receptors of medial prefrontal cortex modulate anxiogenic-like behaviors in rats.

  2011cited by this paper
• Impulsivity and Alcohol Use Coping Motives in a Trauma-Exposed Sample: The Mediating Role of Distress Tolerance.

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• The serotonin 1B receptor: a new target for depression therapeutics?

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• The role of serotonin receptor subtypes in treating depression: a review of animal studies

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• Glutamate Receptors in Extinction and Extinction-Based Therapies for Psychiatric Illness

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• Extending pharmacological spectrum of opioids beyond analgesia: multifunctional aspects in different pathophysiological states.

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• Glutamate Receptors in Extinction and Extinction-Based Therapies for Psychiatric Illness

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• Serotonin transporter deficient mice are vulnerable to escape deficits following inescapable shocks

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• Hurt people who hurt people: violence amongst individuals with comorbid substance use disorder and post traumatic stress disorder.

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• Prevalence and features of panic disorder and comparison to posttraumatic stress disorder in VA primary care.

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• Overexpression of 5-HT(1B) mRNA in nucleus accumbens shell projection neurons differentially affects microarchitecture of initiation and maintenance of ethanol consumption.

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• Serotonin 1B autoreceptors originating in the caudal dorsal raphe nucleus reduce expression of fear and depression-like behavior.

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• Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

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• Adjunctive atomoxetine to SSRIs or SNRIs in the treatment of adult ADHD patients with comorbid partially responsive generalized anxiety (GA): an open-label study

  2011cited by this paper
• Noradrenergic enhancement of reconsolidation in the amygdala impairs extinction of conditioned fear in rats—a possible mechanism for the persistence of traumatic memories in PTSD

  2011cited by this paper
• Early post-stressor intervention with propranolol is ineffective in preventing posttraumatic stress responses in an animal model for PTSD.

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• Gender Differences in the Clinical Presentation of PTSD and Its Concomitants in Survivors of Interpersonal Assault

  2011cited by this paper
• Altered adrenergic receptor signaling following traumatic brain injury contributes to working memory dysfunction.

  2011cited by this paper
• The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding.

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• Gender differences in PTSD symptoms: an exploration of peritraumatic mechanisms.

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• Full and partial PTSD among young adult survivors 10 months after the L'Aquila 2009 earthquake: gender differences.

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• Considering PTSD for DSM‐5

  2011cited by this paper
• Predictors of posttraumatic stress in children following injury: The influence of appraisals, heart rate, and morphine use.

  2010cited by this paper
• How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD.

  2010cited by this paper
• Childhood Sexual Abuse, Post-Traumatic Stress Disorder, and Use of Heroin Among Female Clients in Israeli Methadone Maintenance Treatment Programs (MMTPs)

  2010cited by this paper
• Serotonin 1B receptor imaging in alcohol dependence.

  2010cited by this paper
• Endogenous cannabinoid signaling is essential for stress adaptation

  2010cited by this paper
• Gender differences in traumatic event exposure and mental health among veteran primary care patients.

  2010cited by this paper
• Current perspectives of the roles of the central norepinephrine system in anxiety and depression

  2010cited by this paper
• Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in Wistar Kyoto Rats

  2010cited by this paper
• Gender differences in depression and PTSD symptoms following combat exposure

  2010cited by this paper
• Limited efficacy of propranolol on the reconsolidation of fear memories.

  2010cited by this paper
• Effects of early-life stress on serotonin(1A) receptors in juvenile Rhesus monkeys measured by positron emission tomography.

  2010cited by this paper
• Sex difference in cell proliferation in developing rat amygdala mediated by endocannabinoids has implications for social behavior

  2010cited by this paper
• CRF receptor blockade prevents initiation and consolidation of stress effects on affect in the predator stress model of PTSD.

  2010cited by this paper
• Morphine use after combat injury in Iraq and post-traumatic stress disorder.

  2010cited by this paper
• Dynorphin, stress, and depression.

  2010cited by this paper
• The combined effect of gender and age on post traumatic stress disorder: do men and women show differences in the lifespan distribution of the disorder?

  2010cited by this paper
• Gender differences in probable posttraumatic stress disorder among police responders to the 2001 World Trade Center terrorist attack.

  2010cited by this paper
• Suppression of Amygdalar Endocannabinoid Signaling by Stress Contributes to Activation of the Hypothalamic-Pituitary-Adrenal Axis

  2009cited by this paper
• Differential effects of chronic unpredictable stress on hippocampal CB1 receptors in male and female rats.

  2009cited by this paper
• Sex-dependent alterations in response to maternal deprivation in rats.

  2009cited by this paper
• Post-traumatic stress disorder: emerging concepts of pharmacotherapy

  2009cited by this paper
• A study of the protective function of acute morphine administration on subsequent posttraumatic stress disorder.

  2009cited by this paper
• Early maternal deprivation induces gender‐dependent changes on the expression of hippocampal CB1 and CB2 cannabinoid receptors of neonatal rats

  2009cited by this paper
• Noradrenergic enhancement of amygdala responses to fear.

  2009cited by this paper
• The 5-HT1B receptor: a novel target for the pathophysiology of depression.

  2009cited by this paper
• Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience.

  2009cited by this paper
• CRF1-R Activation of the Dynorphin/Kappa Opioid System in the Mouse Basolateral Amygdala Mediates Anxiety-Like Behavior

  2009cited by this paper
• Emerging treatments for PTSD.

  2009cited by this paper
• Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review.

  2009cited by this paper
• Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress.

  2009cited by this paper
• Guideline Watch (March 2009): Practice Guideline for the Treatment of Patients with Acute Stress Disorder and Posttraumatic Stress Disorder

  2009cited by this paper
• Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.

  2009cited by this paper
• Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study.

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• Preliminary Evidence for the Effects of Morphine on Posttraumatic Stress Disorder Symptoms in One- to Four-Year-Olds With Burns

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• Extracellular serotonin level in the basolateral nucleus of the amygdala and dorsal periaqueductal gray under unconditioned and conditioned fear states: an in vivo microdialysis study.

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• Noradrenergic dysfunction and the psychopharmacology of posttraumatic stress disorder

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• Regional alterations in the endocannabinoid system in an animal model of depression: effects of concurrent antidepressant treatment

  2008cited by this paper
• Chronic pain in women survivors of intimate partner violence.

  2008cited by this paper
• Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders.

  2008cited by this paper
• Molecular biology of 5-HT receptors.

  2008cited by this paper
• Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice.

  2008cited by this paper
• The Role of the Glutamatergic System in Posttraumatic Stress Disorder

  2008cited by this paper
• Serotoninergic regulation of emotional and behavioural control processes.

  2008cited by this paper
• A 6-week randomized, placebo-controlled trial of CP-316,311 (a selective CRH1 antagonist) in the treatment of major depression.

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• Inhibition of Fatty-Acid Amide Hydrolase Accelerates Acquisition and Extinction Rates in a Spatial Memory Task

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• Anxiolytic-Like Effects of κ-Opioid Receptor Antagonists in Models of Unlearned and Learned Fear in Rats

  2007cited by this paper
• Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting.

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• Imaging of opioid receptors in the central nervous system

  2007cited by this paper
• The Endocannabinoid System and Extinction Learning

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• Repeated cortisol administration attenuates the EEG response to buspirone in healthy volunteers: evidence for desensitization of the 5-HT1 A autoreceptor

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• Impaired Stress-Coping and Fear Extinction and Abnormal Corticolimbic Morphology in Serotonin Transporter Knock-Out Mice

  2007cited by this paper
• Gender differences in the sensitivity to posttraumatic stress disorder: An epidemiological study of urban young adults.

  2007cited by this paper
• Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear.

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• Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients.

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• Pharmacotherapy for prevention of post-traumatic stress disorder

  2006cited by this paper
• Treatment of posttraumatic stress disorder with venlafaxine extended release: a 6-month randomized controlled trial.

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• Pharmacotherapy for post traumatic stress disorder (PTSD)

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• Venlafaxine Extended Release in Posttraumatic Stress Disorder: A Sertraline- and Placebo-controlled Study

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• Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity.

  2006cited by this paper
• Pharmacologic treatment of acute and chronic stress following trauma: 2006.

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• Neurochemical, Neurocircuitry, and Psychopathological Mechanisms of PTSD: Emerging Pharmacotherapies and Clinical Perspectives.

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• Nitrergic Signaling Mediation of Neurobehavioral Responses to Stress in Zebrafish

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• Management of post-traumatic stress disorder: a review of anxiety disorders and PTSD

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• Can the migration process influence the clinical expression of heroin use disorder in migrants to Italy?

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• The endocannabinoid system in mental disorders: Evidence from human brain studies

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  2016cites this paper
• PTSD: from neurobiology to pharmacological treatments

  2016cites this paper
• Effect of Stellate Ganglion Block on Specific Symptom Clusters for Treatment of Post-Traumatic Stress Disorder.

  2016cites this paper
• Enhanced noradrenergic activity in the amygdala contributes to hyperarousal in an animal model of PTSD.

  2016cites this paper
• Influence of the noradrenergic system on the formation of intrusive memories in women: an experimental approach with a trauma film paradigm

  2016cites this paper
• An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials.

  2015cites this paper
• Morphine administration during low ovarian hormone stage results in transient over expression of fear memories in females

  2015cites this paper
• Maladaptive autonomic regulation in PTSD accelerates physiological aging

  2015cites this paper
• A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder.

  2015cites this paper
• Stellate ganglion block used to treat symptoms associated with combat-related post-traumatic stress disorder: a case series of 166 patients.

  2014cites this paper
• Animal models of fear relapse.

  2014cites this paper
• Using Virtual Reality to Explore Self-Regulation in High-Risk Settings

  2014cites this paper
• Anticonvulsants to treat post‐traumatic stress disorder

  2014cites this paper
• Efeito do canabidiol sobre a reconsolidação da memória de medo ao contexto: envolvimento dos receptores CB1 do córtex pré-límbico

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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