Resuscitation with 100% O2 Increases Cerebral Injury in Hypoxemic Piglets

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Pediatric Research

• Publication date

  2004-11-01

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1203/01.PDR.0000141988.89820.E3PMID 15347772
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Is 100% oxygen necessary for the resuscitation of newborn infants?

  2004cited by this paper
• Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease : Possible role for left ventricular remodelling

  2004influential reference
• Resuscitation of asphyxiated newborns with room air or 100% oxygen at birth: a multicentric clinical trial.

  2003cited by this paper
• Neuronal activity‐dependent increase of net matrix metalloproteinase activity is associated with MMP‐9 neurotoxicity after kainate

  2003cited by this paper
• Neurodegeneration in Striatum Induced by the Mitochondrial Toxin 3-Nitropropionic Acid: Role of Matrix Metalloproteinase-9 in Early Blood-Brain Barrier Disruption?

  2003cited by this paper
• Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

  2003cited by this paper
• Oxygen Toxicity at Birth: The Pieces Are Put Together

  2003cited by this paper
• Correlation of oxidative stress with activity of matrix metalloproteinase in patients with coronary artery disease. Possible role for left ventricular remodelling.

  2003cited by this paper
• Gelatinase B and TIMP‐1 are regulated in a cell‐ and time‐dependent manner in association with neuronal death and glial reactivity after global forebrain ischemia

  2002cited by this paper
• A gelatin in situ-overlay technique localizes brain matrix metalloproteinase activity in experimental focal cerebral ischemia.

  2002cited by this paper
• Regulation of Endothelial Matrix Metalloproteinase-2 by Hypoxia/Reoxygenation

  2002cited by this paper
• Matrix Metalloproteinase-9 Undergoes Expression and Activation during Dendritic Remodeling in Adult Hippocampus

  2002cited by this paper
• Activation of Matrix Metalloproteinase-2 by Overexpression of Manganese Superoxide Dismutase in Human Breast Cancer MCF-7 Cells Involves Reactive Oxygen Species*

  2002cited by this paper
• Interleukin-10 reverses acute detrimental effects of endotoxin-induced inflammation on perinatal cerebral hypoxia-ischemia.

  2002cited by this paper
• Oxygen and resuscitation: beyond the myth.

  2002cited by this paper
• Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia

  2001cited by this paper
• How matrix metalloproteinases regulate cell behavior.

  2001cited by this paper
• Hypoxic-ischemic encephalopathy : Biochemical and physiological aspects

  2001cited by this paper
• Resuscitation With 100% Oxygen: Should We Change Our Ways?

  2001cited by this paper
• Increase of interstitial glycerol reflects the degree of ischaemic brain damage: a PET and microdialysis study in a middle cerebral artery occlusion-reperfusion primate model

  2001cited by this paper
• Oxidant Mechanisms in Neonatal Hypoxia-Ischemia

  2001cited by this paper
• Antioxidants as Therapy in the Newborn: Some Words of Caution

  2001cited by this paper
• Metalloproteinases in biology and pathology of the nervous system

  2001cited by this paper
• Resuscitation With Room Air Instead of 100% Oxygen Prevents Oxidative Stress in Moderately Asphyxiated Term Neonates

  2001cited by this paper
• Inflammatory Mediators and Neonatal Brain Damage

  2001cited by this paper
• Chemiluminescence because of the Production of Reactive Oxygen Species in the Lungs of Newborn Piglets during Resuscitation Periods after Asphyxiation Load

  2000cited by this paper
• Matrix metalloproteinases: effectors of development and normal physiology.

  2000cited by this paper
• Estimation of gelatinase content in rat brain: effect of focal ischemia.

  2000cited by this paper
• Neuronal death in newborn striatum after hypoxia-ischemia is necrosis and evolves with oxidative stress.

  2000cited by this paper
• Early Appearance of Activated Matrix Metalloproteinase-9 after Focal Cerebral Ischemia in Mice: A Possible Role in Blood—Brain Barrier Dysfunction

  1999cited by this paper
• Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

  1999cited by this paper
• Early appearance of activated matrix metalloproteinase-9 and blood-brain barrier disruption in mice after focal cerebral ischemia and reperfusion.

  1999cited by this paper
• Measurement of oxygen radical absorbance capacity in biological samples.

  1999cited by this paper
• Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size.

  1998cited by this paper
• Gelatinase B modulates selective opening of the blood-brain barrier during inflammation.

  1998cited by this paper
• Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain

  1998cited by this paper
• Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain.

  1998cited by this paper
• Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets.

  1998cited by this paper
• Resuscitation of Asphyxiated Newborn Infants With Room Air or Oxygen: An International Controlled Trial: The Resair 2 Study

  1998cited by this paper
• Glycerol as a marker for post‐traumatic membrane phospholipid degradation in rat brain

  1997cited by this paper
• Increased gelatinase A (MMP-2) and gelatinase B (MMP-9) activities in human brain after focal ischemia.

  1997cited by this paper
• Oxidants as stimulators of signal transduction.

  1997cited by this paper
• Cerebral blood flow and energy metabolism in the newborn.

  1997cited by this paper
• Antioxidant Capacity in Different Tissues of Young and Old Rats

  1996cited by this paper
• Upregulation of basement membrane-degrading metalloproteinase secretion after balloon injury of pig carotid arteries.

  1996cited by this paper
• Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: an experimental study in the immature rat.

  1995cited by this paper
• Postnatal development of the cerebral blood flow velocity response to changes in CO2 and mean arterial blood pressure in the piglet

  1995cited by this paper
• Automated assay of oxygen radical absorbance capacity with the COBAS FARA II.

  1995cited by this paper
• Quantitative zymography: detection of picogram quantities of gelatinases.

  1994cited by this paper
• Resuscitation of Asphyxic Newborn Infants with Room Air or 100% Oxygen

  1993cited by this paper
• Pathophysiology of perinatal asphyxia.

  1993cited by this paper
• Hypoxemia and Reoxygenation with 21% or 100% Oxygen in Newborn Pigs: Changes in Blood Pressure, Base Deficit, and Hypoxanthine and Brain Morphology

  1992cited by this paper
• Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

  1988cited by this paper
• Physiology of resuscitation.

  1983cited by this paper

• The Role of 100% Oxygen in the Resuscitation and Neurologic Recovery of Neonates Born with Perinatal Depression and Arrested Circulation.

  2026cites this paper
• Cerebral microdialysis values in healthy brain tissue – a scoping review

  2025cites this paper
• RECOVER Guidelines: Newborn Resuscitation in Dogs and Cats. Evidence and Knowledge Gap Analysis With Treatment Recommendations

  2025cites this paper
• The effects of anaesthesia on cell death in a porcine model of neonatal hypoxic-ischaemic brain injury

  2024cites this paper
• Oxygenation of the newborn. The impact of one molecule on newborn lives

  2022cites this paper
• Initial Use of 100% but Not 60% or 30% Oxygen Achieved a Target Heart Rate of 100 bpm and Preductal Saturations of 80% Faster in a Bradycardic Preterm Model

  2022cites this paper
• Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia [version 1; peer review: 1 approved, 1 approved with reservations]

  2021cites this paper
• Mechanical Ventilation, Partial Pressure of Carbon Dioxide, Increased Fraction of Inspired Oxygen and the Increased Risk for Adverse Short-Term Outcomes in Cooled Asphyxiated Newborns

  2021cites this paper
• Optimal oxygen use in neonatal advanced cardiopulmonary resuscitation—a literature review

  2021cites this paper
• The Children's Oxygen Administration Strategies Trial (COAST)

  2020cites this paper
• Optimizing oxygen therapy for preterm infants at birth: Are we there yet?

  2020cites this paper
• Oxygen Therapy for Neonatal Resuscitation in the Delivery Room.

  2019cites this paper
• 2019 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations.

  2019cites this paper
• 2019 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Pediatric Life Support; Neonatal Life Support; Education, Implementation, and Teams; and First Aid Task

  2019cites this paper
• Nasal High Flow in Room Air for Hypoxemic Bronchiolitis Infants

  2019cites this paper
• Newborn Resuscitation in Settings Without Access to Supplemental Oxygen.

  2019cites this paper
• Novel interventions to reduce oxidative-stress related brain injury in neonatal asphyxia.

  2019cites this paper
• Pediatric Respirology and Critical Care Medicine

  2018influential citation
• The Goldilocks principle. Oxygen in the delivery room: When is it too little, too much, and just right?

  2018cites this paper
• Oxygen Therapy in the Delivery Room: What Is the Right Dose?

  2018cites this paper
• Pathophysiology: General Principles

  2018cites this paper
• Impact of the Neonatal Resuscitation Program–Recommended Low Oxygen Strategy on Outcomes of Infants Born Preterm

  2017cites this paper
• Children’s Oxygen Administration Strategies Trial (COAST): A randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia

  2017cites this paper
• Monitoring Oxygen Toxicity in the Preterm Infant : Mechanisms , Critical Questions and Clinical Challenges

  2016cites this paper
• Respiratory support for children in the emergency department

  2016cites this paper
• Monitoring of cerebral blood flow during hypoxia‐ischemia and resuscitation in the neonatal rat using laser speckle imaging

  2016cites this paper
• Hydrogen is neuroprotective and preserves neurovascular reactivity following asphyxia in newborn pigs

  2015cites this paper
• Acute pathophysiological responses in the normal lungs of newborn piglets exposed to pure oxygen.

  2015cites this paper
• Newborn resuscitation - An experimental study of inflammatory and hemodynamic responses in newborn pigs

  2015cites this paper
• Monitoring Oxygen Toxicity in the Preterm Infant : Mechanisms , Critical Questions and Clinical Challenges

  2015cites this paper
• A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy.

  2015cites this paper
• The effect of oxygen content during an initial sustained inflation on heart rate in asphyxiated near-term lambs

  2015cites this paper
• Hypoxia-reoxygenation affects whole-genome expression in the newborn eye.

  2014cites this paper
• Hyaluronan in the neonatal period. An experimental and clinical study in asphyxia and infection

  2014cites this paper
• Doctoral School of Basic Medicine

  2014cites this paper
• Transcriptome profiling of the newborn mouse brain after hypoxia–reoxygenation: hyperoxic reoxygenation induces inflammatory and energy failure responsive genes

  2014cites this paper
• Inhibition of Acetylcholinesterase Modulates NMDA Receptor Antagonist Mediated Alterations in the Developing Brain

  2014cites this paper
• Brain inflammation induced by severe asphyxia in newborn pigs and the impact of alternative resuscitation strategies on the newborn central nervous system

  2013cites this paper
• Oxygen Therapy in Critical Illness: Precise Control of Arterial Oxygenation and Permissive Hypoxemia*

  2013cites this paper
• Increased Inspired Oxygen in the First Hours of Life is Associated with Adverse Outcome in Newborns Treated for Perinatal Asphyxia with Therapeutic Hypothermia

  2013cites this paper
• Erythropoietin as a neuroprotectant for neonatal brain injury: animal models.

  2013cites this paper
• Oxygenation of the Newborn: A Molecular Approach

  2012cites this paper
• Antioxidant Protects against Increases in Low Molecular Weight Hyaluronan and Inflammation in Asphyxiated Newborn Pigs Resuscitated with 100% Oxygen

  2012cites this paper
• Learning and Cognitive Deficits in Hypoxic Neonatal Rats Intensified by BAX Mediated Apoptosis: Protective Role of Glucose, Oxygen, and Epinephrine

  2012cites this paper
• The Impact of Intermittent Umbilical Cord Occlusions on the Inflammatory Response in Pre-Term Fetal Sheep

  2012cites this paper
• Hypoxic-Ischemic Injury in the Developing Brain: The Role of Reactive Oxygen Species Originating in Mitochondria

  2012cites this paper
• Neuroprotective treatment for perinatal asphyxia.

  2012cites this paper
• Cellular, Structural and Functional Characterization of Hyperoxia-induced White Matter Injury in the Developing Brain

  2012cites this paper
• Mild Hypoxemia during Initial Reperfusion Alleviates the Severity of Secondary Energy Failure and Protects Brain in Neonatal Mice with Hypoxic-Ischemic Injury

  2012cites this paper
• Early effects of perinatal hypoxia and resuscitation on cerebral perfusion and metabolism assessed by MRI, CEUS and FDG-PET. : Experimental studies in newborn pigs

  2012cites this paper
• Perinatal Hypoxic-Ischemic Neural Injury and Free Radical Injury: A Fine Balance

  2011cites this paper
• Oxidative Stress in Neonatal Hypoxic-Ischemic Encephalopathy

  2011cites this paper
• CHAPTER 17 – Neonatology for Anesthesiologists

  2011cites this paper
• Short‐ and long‐term behavioral effects of exposure to 21%, 40% and 100% oxygen after perinatal hypoxia–ischemia in the rat

  2011cites this paper
• Impaired Diastolic Function and Disruption of the Force-Frequency Relationship in the Right Ventricle of Newborn Pigs Resuscitated with 100% Oxygen

  2011cites this paper
• Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex

  2011cites this paper
• Decreased GABAB receptor function in the cerebellum and brain stem of hypoxic neonatal rats: Role of glucose, oxygen and epinephrine resuscitation

  2011cites this paper
• Resuscitation of Newborn Piglets. Short-Term Influence of FiO2 on Matrix Metalloproteinases, Caspase-3 and BDNF

  2010cites this paper
• Ejection Time-Corrected Systolic Velocity Improves Accuracy in the Evaluation of Myocardial Dysfunction: A Study in Piglets

  2010cites this paper
• Decreased GABAA Receptors Functional Regulation in the Cerebral Cortex and Brainstem of Hypoxic Neonatal Rats: Effect of Glucose and Oxygen Supplementation

  2010cites this paper
• Alterations in cortical GABAB receptors in neonatal rats exposed to hypoxic stress: role of glucose, oxygen, and epinephrine resuscitation

  2010cites this paper
• Resuscitation of Severely Asphyctic Newborn Pigs with Cardiac Arrest by Using 21% or 100% Oxygen

  2010cites this paper
• Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs

  2010cites this paper
• Exposure to Supplemental Oxygen and Its Effects on Oxidative Stress and Antioxidant Enzyme Activity in Term Newborn Lambs

  2010cites this paper
• The state of systemic circulation, collapsed or preserved defines the need for hyperoxic or normoxic resuscitation in neonatal mice with hypoxia-ischemia.

  2010cites this paper
• Why are we still using oxygen to resuscitate term infants?

  2010cites this paper
• Perspectives on Neonatal Hypoxia/Ischemia-Induced Edema Formation

  2010cites this paper
• Resuscitation of newborn infants: from oxygen to room air.

  2010cites this paper
• Early protective effect of hypothermia in newborn pigs after hyperoxic, but not after normoxic, reoxygenation

  2010cites this paper
• Title : Hydrogen is neuroprotective and preserves cerebrovascular reactivity in asphyxiated newborn pigs Running title : Neuroprotection by hydrogen

  2010cites this paper
• Células-tronco de cordão umbilical em modelo experimental de asfixia neonatal em suínos

  2010cites this paper
• GABA, serotonin, muscarinic receptors - their second messengers and transcription factors functional regulation in the brain regions of hypoxic neonatal rats: Resuscitation with glucose, oxygen and epinephrine

  2010cites this paper
• Room air or 100% oxygen for resuscitation of infants with perinatal depression

  2009cites this paper
• [Air or oxygen for neonatal resuscitation at birth?].

  2009cites this paper
• Newborn piglets exposed to hypoxia after nicotine or saline pretreatment: Long-term effects on brain and heart

  2009cites this paper
• Normobaric hyperoximia increases hypoxia‐induced cerebral injury: DTI study in rats

  2009cites this paper
• Post-hypoxic hypothermia is protective in human NT2-N neurons regardless of oxygen concentration during reoxygenation.

  2009cites this paper
• Superoxide dismutase functional regulation in neonatal hypoxia: effect of glucose, oxygen and epinephrine.

  2009cites this paper
• High Brain Tissue Oxygen Tension During Ventilation With 100% Oxygen After Fetal Asphyxia in Newborn Sheep

  2009cites this paper
• Atrioventricular Valve Annulus Velocity and Acceleration during Global Hypoxia in Newborn Pigs – Assessment of Myocardial Function

  2009cites this paper
• The behaviour of protein carbonyls in newborns with birth respiratory distress and asphyxia.

  2009cites this paper
• Long‐term histological outcome after post‐hypoxic treatment with 100% or 40% oxygen in a model of perinatal hypoxic–ischemic brain injury

  2008influential citation
• Chapter 14 – The Oxygen Versus Room Air Controversy for Neonatal Resuscitation

  2008cites this paper
• Consequences of neonatal resuscitation with supplemental oxygen.

  2008cites this paper
• Acetylcholine esterase activity and behavioral response in hypoxia induced neonatal rats: effect of glucose, oxygen and epinephrine supplementation.

  2008cites this paper
• Brief Exposure to Hyperoxia Depletes the Glial Progenitor Pool and Impairs Functional Recovery after Hypoxic-Ischemic Brain Injury

  2008cites this paper
• Cerebral blood flow regulation following hypoxic attacks and seizures in the newborn piglet

  2008cites this paper
• A Piglet Model for Detection of Hypoxic-Ischemic Brain Injury with Magnetic Resonance Imaging

  2008cites this paper
• Resuscitation of Preterm Infants with Reduced Oxygen Results in Less Oxidative Stress than Resuscitation with 100% Oxygen

  2008cites this paper
• Cardio-renal recovery of hypoxic newborn pigs after 18%, 21% and 100% reoxygenation

  2008cites this paper
• Persistent neurochemical changes in neonatal piglets after hypoxia-ischemia and resuscitation with 100%, 21% or 18% oxygen.

  2008cites this paper
• Perinatal asphyxia and intervention: possible neuroprotective effects of intravenous nicotine administration.

  2008cites this paper
• The First Golden Minutes of the Extremely-Low-Gestational-Age Neonate: A Gentle Approach

  2008cites this paper
• Chapter 6 – Hyperbaric Oxygen Therapy in Newborn Infants and Pediatric Patients

  2008cites this paper
• Hyperthermia, Not Hyperoxia, Exacerbates Hypoxic-Ischemic Brain Injury in the Term-Equivalent Neonatal Rat

  2008cites this paper
• Effects of Nicotine Infusion on Striatal Glutamate and Cortical Non-Protein-Bound Iron in Hypoxic Newborn Piglets

  2008cites this paper
• Oxidative stress and matrix metalloproteinase-9 activity in the liver after hypoxia and reoxygenation with 21% or 100% oxygen in newborn piglets.

  2008cites this paper
• The systemic, pulmonary and regional hemodynamic recovery of asphyxiated newborn piglets resuscitated with 18%, 21% and 100% oxygen.

  2008cites this paper
• Erstversorgung und Reanimation von Neugeborenen*

  2007cites this paper
• EPINEPHRINE VERSUS DOPAMINE TO TREAT SHOCK IN HYPOXIC NEWBORN PIGS RESUSCITATED WITH 100% OXYGEN

  2007cites this paper