De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

C. D. Del Vecchio,Yu-Xiong Feng,E. Sokol,Erik J. Tillman,Sandhya Sanduja,Ferenc Reinhardt,Piyush B. Gupta

Published 2014 in PLoS Biology

ABSTRACT

Upregulation of PERK-Nrf2 signaling is a key mechanism by which de-differentiated cancer cells gain multi-drug resistance.

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