Eukaryotic Translation Initiation Factor 4EAvailability Controls the Switch between Cap-Dependent andInternal Ribosomal Entry Site-MediatedTranslation

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecular and Cellular Biology

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.25.23.10556-10565.2005PMID 16287867PMCID PMC1291233
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of cap-dependent translation by eIF4E inhibitory proteins

  2005cited by this paper
• Translational control in stress and apoptosis

  2005cited by this paper
• Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells.

  2004cited by this paper
• La Autoantigen Is Necessary for Optimal Function of the Poliovirus and Hepatitis C Virus Internal Ribosome Entry Site In Vivo and In Vitro

  2004cited by this paper
• An efficient system for cap- and poly(A)-dependent translation in vitro.

  2004cited by this paper
• Systemic Therapy of Malignant Human Melanoma Tumors by a Common Cold-Producing Enterovirus, Coxsackievirus A21

  2004cited by this paper
• Epitope mapping of monoclonal antibodies raised to recombinant Mengo 3D polymerase

  2004cited by this paper
• Cellular internal ribosome entry segments: structures, trans-acting factors and regulation of gene expression

  2004cited by this paper
• Eukaryotic Initiation Factors 4G and 4A Mediate Conformational Changes Downstream of the Initiation Codon of the Encephalomyocarditis Virus Internal Ribosomal Entry Site

  2003cited by this paper
• Cell-Free Synthesis of Encephalomyocarditis Virus

  2003cited by this paper
• An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation

  2003cited by this paper
• Molecular biology of picornaviruses

  2002cited by this paper
• Structure and Function of Picornavirus Proteinases

  2002cited by this paper
• Internal ribosome entry sites in eukaryotic mRNA molecules.

  2001cited by this paper
• The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

  2001cited by this paper
• Regulation of translation initiation by FRAP/mTOR.

  2001cited by this paper
• Molecular mechanisms of translation initiation in eukaryotes

  2001cited by this paper
• Hierarchical phosphorylation of the translation inhibitor 4E-BP1.

  2001cited by this paper
• Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation.

  2001cited by this paper
• Intergeneric poliovirus recombinants for the treatment of malignant glioma.

  2000cited by this paper
• RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals.

  2000cited by this paper
• 20 Translational Control and Cancer

  2000cited by this paper
• Translational control of gene expression

  2000cited by this paper
• 2 The Pathway and Mechanism of Initiation of Protein Synthesis

  2000cited by this paper
• Eukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region

  2000cited by this paper
• 6 Regulation of Ribosomal Recruitment in Eukaryotes

  2000cited by this paper
• Physical Association of Eukaryotic Initiation Factor 4G (eIF4G) with eIF4A Strongly Enhances Binding of eIF4G to the Internal Ribosomal Entry Site of Encephalomyocarditis Virus and Is Required for Internal Initiation of Translation

  2000influential reference
• Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray.

  1999cited by this paper
• Cleavage of Eukaryotic Translation Initiation Factor 4G by Exogenously Added Hybrid Proteins Containing Poliovirus 2Apro in HeLa Cells: Effects on Gene Expression

  1999cited by this paper
• Eukaryotic Initiation Factor 4GII (eIF4GII), but Not eIF4GI, Cleavage Correlates with Inhibition of Host Cell Protein Synthesis after Human Rhinovirus Infection

  1999cited by this paper
• Eukaryotic Translation Initiation Factor 4AIII (eIF4AIII) Is Functionally Distinct from eIF4AI and eIF4AII

  1999cited by this paper
• eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.

  1999cited by this paper
• Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.

  1999cited by this paper
• Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.

  1999cited by this paper
• Rapamycin and Wortmannin Enhance Replication of a Defective Encephalomyocarditis Virus

  1998cited by this paper
• The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS‐I; 4E‐BP1) in the reticulocyte lysate

  1997cited by this paper
• eIF4G--A Multipurpose Ribosome Adapter?

  1997cited by this paper
• General RNA binding proteins render translation cap dependent.

  1996cited by this paper
• Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes

  1996cited by this paper
• The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase

  1996cited by this paper
• Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry

  1996cited by this paper
• Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection

  1996cited by this paper
• Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus.

  1996cited by this paper
• 19 Initiation of Translation by Picornavirus RNAs

  1996cited by this paper
• Translational Control of Gene Expression

  1995cited by this paper
• PHAS-I as a link between mitogen-activated protein kinase and translation initiation.

  1994cited by this paper
• Dominant negative mutants of mammalian translation initiation factor eIF‐4A define a critical role for eIF‐4F in cap‐dependent and cap‐independent initiation of translation.

  1994cited by this paper
• Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

  1994cited by this paper
• Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

  1993cited by this paper
• Cap recap: the involvement of eIF-4F in regulating gene expression.

  1992cited by this paper
• Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation.

  1991cited by this paper
• Characterization of the 46,000-dalton subunit of eIF-4F.

  1990cited by this paper
• Shutoff of host translation by encephalomyocarditis virus infection does not involve cleavage of the eucaryotic initiation factor 4F polypeptide that accompanies poliovirus infection

  1985cited by this paper
• Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

  1982cited by this paper
• Preparation and characterization of encephalomyocarditis (EMC) virus.

  1981cited by this paper
• [46] Preparation and characterization of encephalornyocarditis (EMC) virus

  1981cited by this paper
• Shutoff of HeLa cell protein synthesis by encephalomyocarditis virus and poliovirus: a comparative study

  1980cited by this paper
• A cell-free model of the encephalomyocarditis virus-induced inhibition of host cell protein synthesis.

  1978cited by this paper
• Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor.

  1976cited by this paper
• Encephalomyocarditis Virus Infection of Mouse Plasmacytoma Cells I. Inhibition of Cellular Protein Synthesis

  1974cited by this paper
• Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

  1972cited by this paper

• 4E-BP1 differentially regulates translation of a subset of human mRNAs

  2025cites this paper
• Computational inference of eIF4F complex function and structure in human cancers

  2024cites this paper
• Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes

  2024cites this paper
• P53 regulates CCAAT/Enhancer Binding Protein β gene expression.

  2023cites this paper
• Hypoxia-mediated activation of hypoxia-inducible factor-1α in triple-negative breast cancer: A review

  2023cites this paper
• Computational inference of eIF4F complex function and structure in human cancers

  2023cites this paper
• Dihydropyrimidinase-Related Protein 2 Is a New Partner in the Binding between 4E-BP2 and eIF4E Related to Neuronal Death after Cerebral Ischemia

  2023cites this paper
• All eggs in one basket: How potyvirus infection is controlled at a single cap-independent translation event.

  2023cites this paper
• Phosphorylation of Eukaryotic Initiation Factor 4G1 (eIF4G1) at Ser1147 Is Specific for eIF4G1 Bound to eIF4E in Delayed Neuronal Death after Ischemia

  2022cites this paper
• Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

  2022cites this paper
• Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy.

  2022cites this paper
• The Insulin receptor and Insulin like growth factor receptor 5’ UTRs support translation initiation independently of eIF4G1

  2022cites this paper
• Retinal Protein O-GlcNAcylation and the Ocular Renin Angiotensin System: Signaling Cross-Roads in Diabetic Retinopathy.

  2021cites this paper
• Reprogramming translation for gene therapy.

  2021cites this paper
• Synergetic Contributions of Viral VP1, VP3, and 3C to Activation of the AKT-AMPK-MAPK-MTOR Signaling Pathway for Seneca Valley Virus-Induced Autophagy

  2021cites this paper
• Sox9 Determines Translational Capacity During Early Chondrogenic Differentiation of ATDC5 Cells by Regulating Expression of Ribosome Biogenesis Factors and Ribosomal Proteins

  2021cites this paper
• Differential Association of 4E-BP2-Interacting Proteins Is Related to Selective Delayed Neuronal Death after Ischemia

  2021cites this paper
• Eukaryotic initiating factor eIF4E is targeted by EBV-encoded miR-BART11-3p and regulates cell cycle and apoptosis in EBV-associated gastric carcinoma

  2021cites this paper
• LeishIF4E-5 Is a Promastigote-Specific Cap-Binding Protein in Leishmania

  2021cites this paper
• Deep computational analysis details dysregulation of eukaryotic translation initiation complex eIF4F in human cancers.

  2021cites this paper
• eIF4G-driven translation initiation of downstream ORFs in mammalian cells

  2020cites this paper
• A cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis

  2020cites this paper
• Transglutaminase 2 mediates hypoxia-induced selective mRNA translation via polyamination of 4EBPs

  2020cites this paper
• Cap-independent translation initiation of the unspliced RNA of retroviruses.

  2020cites this paper
• 5′-UTR recruitment of the translation initiation factor eIF4GI or DAP5 drives cap-independent translation of a subset of human mRNAs

  2020cites this paper
• Ribosomes as a nexus between translation and cancer progression: Focus on ribosomal Receptor for Activated C Kinase 1 (RACK1) in breast cancer

  2020cites this paper
• Rhinovirus 2A is the key protease responsible for instigating the early block to gene expression in infected cells

  2019cites this paper
• The Prognostic Significance of Eukaryotic Translation Initiation Factors (eIFs) in Endometrial Cancer

  2019cites this paper
• Relevance of Translation Initiation in Diffuse Glioma Biology and its Therapeutic Potential

  2019cites this paper
• Rhinovirus 2A is the predominant protease responsible for instigating the early block to gene expression encountered in infected cells

  2019cites this paper
• Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease

  2019cites this paper
• 5’ UTR recruitment of eIF4GI or DAP5 drives cap-independent translation for a subset of human mRNAs

  2018cites this paper
• Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression

  2018cites this paper
• Recruitment of human eIF4G1 or DAP5 to the 5’ untranslated regions of a subset of cellular mRNAs drives cap-independent translation

  2018cites this paper
• A widespread alternate form of cap-dependent mRNA translation initiation

  2018cites this paper
• Role of MAPK/MNK1 signaling in virus replication

  2018cites this paper
• PERK Signal-Modulated Protein Translation Promotes the Survivability of Dengue 2 Virus-Infected Mosquito Cells and Extends Viral Replication

  2017cites this paper
• Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming

  2017cites this paper
• N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

  2017cites this paper
• Investigation of the subcellular localization of HPeV 3A and 2A proteins

  2017influential citation
• AEG‐1 induces gastric cancer metastasis by upregulation of eIF4E expression

  2017cites this paper
• Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation

  2017cites this paper
• Investigation and identification of functional post-translational modification sites associated with drug binding and protein-protein interactions

  2017cites this paper
• Identification of urinary exosomal noncoding RNAs as novel biomarkers in chronic kidney disease

  2017cites this paper
• Ribosomal Chamber Music: Toward an Understanding of IRES Mechanisms.

  2017cites this paper
• Investigating the mechanism of host translation shut off by human rhinovirus 2A proteinases

  2017cites this paper
• Protein Translation in Parkinson's Disease

  2017cites this paper
• Targeting eukaryotic protein translation in mesothelioma.

  2017cites this paper
• The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment

  2017cites this paper
• Epstein-Barr Virus Protein EB2 Stimulates Translation Initiation of mRNAs through Direct Interactions with both Poly(A)-Binding Protein and Eukaryotic Initiation Factor 4G

  2017cites this paper
• Does HIV-1 mRNA 5'-untranslated region bear an internal ribosome entry site?

  2016cites this paper
• Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis

  2016cites this paper
• Viral protease disruption of host transcription and translation factors in the pathogenesis of coxsackievirus B3 induced viral myocarditis

  2016cites this paper
• IRES-mediated translation of foot-and-mouth disease virus (FMDV) in cultured cells derived from FMDV-susceptible and -insusceptible animals

  2016cites this paper
• A researcher’s guide to the galaxy of IRESs

  2016cites this paper
• eIF4F: A Retrospective*

  2015cites this paper
• Exploring Internal Ribosome Entry Sites as Therapeutic Targets

  2015cites this paper
• The RNA‐binding protein HuR/ELAVL1 regulates IFN‐β mRNA abundance and the type I IFN response

  2015cites this paper
• Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells

  2015cites this paper
• Systems Biology of Cancer: Regulation and dysregulation of protein synthesis in cancer cells

  2015cites this paper
• Eukaryotic initiation factor 4AI interacts with NS4A of Dengue virus and plays an antiviral role.

  2015cites this paper
• Inflammatory Conditions Induce IRES-Dependent Translation of cyp24a1

  2014cites this paper
• The Role of Translational Regulation in Survival after Radiation Damage; an Opportunity for Proteomics Analysis

  2014cites this paper
• Regulation of protein degradation pathways by amino acids and insulin in skeletal muscle of neonatal pigs

  2014cites this paper
• Mitogen-Activated Protein Kinase-Interacting Kinase Regulates mTOR/AKT Signaling and Controls the Serine/Arginine-Rich Protein Kinase-Responsive Type 1 Internal Ribosome Entry Site-Mediated Translation and Viral Oncolysis

  2014cites this paper
• Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation

  2014cites this paper
• A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1

  2014cites this paper
• Comparative analysis of internal ribosomal entry sites as molecular tools for bicistronic expression.

  2014cites this paper
• A novel challenge model to evaluate the efficacy of hepatitis C virus vaccines in mice.

  2014cites this paper
• Regulated in Development and DNA Damage 1 Is Necessary for Hyperglycemia-induced Vascular Endothelial Growth Factor Expression in the Retina of Diabetic Rodents*

  2014cites this paper
• A novel Bcr-Abl – mTOR – eIF 4 A axis regulates IRES-mediated translation of LEF-1 Becky

  2014cites this paper
• Human cell extract-derived cell-free systems for virus synthesis.

  2014cites this paper
• Investigating the cellular mechanisms that determine RNMT dependency in breast cancer cells

  2014cites this paper
• MAPK-interacting kinase regulates mTOR/AKT signaling and controls SRPK-responsive

  2014cites this paper
• Participation of eIF4F complex in Junin virus infection: blockage of eIF4E does not impair virus replication

  2013cites this paper
• Dual Mechanisms of Translation Initiation of the Full-Length HIV-1 mRNA Contribute to Gag Synthesis

  2013cites this paper
• The role of Mnk1 kinase in pancreas biology and exocrine diseases

  2013cites this paper
• Insights into Dynamic Mitotic Chromatin Organization Through the NIMA Kinase Suppressor SonC, a Chromatin-Associated Protein Involved in the DNA Damage Response

  2013cites this paper
• The insulin receptor cellular IRES confers resistance to eIF4A inhibition

  2013cites this paper
• Hyperglycemia Mediates a Shift From Cap-Dependent to Cap-Independent Translation Via a 4E-BP1–Dependent Mechanism

  2013cites this paper
• Ribosomal proteins as novel players in tumorigenesis

  2013cites this paper
• Pathogen signatures activate a ubiquitinylation pathway that modulates function of the metabolic checkpoint kinase mTOR

  2013cites this paper
• The role of c-Src in integrin (α6β4) dependent translational control

  2013cites this paper
• Inactivation of the mTORC1-Eukaryotic Translation Initiation Factor 4E Pathway Alters Stress Granule Formation

  2013cites this paper
• Insulin signaling via Akt2 switches plakophilin 1 function from stabilizing cell adhesion to promoting cell proliferation

  2013cites this paper
• Viral Replication Strategies: Manipulation of ER Stress Response Pathways and Promotion of IRES-Dependent Translation

  2013cites this paper
• A Novel Role for Cet1p mRNA 5′-Triphosphatase in Promoter Proximal Accumulation of RNA Polymerase II in Saccharomyces cerevisiase

  2013cites this paper
• Control of Translation and miRNA-Dependent Repression by a Novel Poly(A) Binding Protein, hnRNP-Q

  2013cites this paper
• Plant-Derived Isoprenoids Mediate Regulation of mTOR Signaling in Tumor Cells

  2012cites this paper
• 4E-BP1 participates in maintaining spindle integrity and genomic stability via interacting with PLK1

  2012cites this paper
• Promotion of viral internal ribosomal entry site-mediated translation under amino acid starvation.

  2012cites this paper
• Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E

  2012cites this paper
• DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs

  2012cites this paper
• Emotional modulation of the synapse

  2012cites this paper
• IRES-Dependent Translational Control during Virus-Induced Endoplasmic Reticulum Stress and Apoptosis

  2012cites this paper
• Memory-enhancing intra-basolateral amygdala infusions of clenbuterol increase Arc and CaMKIIα protein expression in the rostral anterior cingulate cortex

  2012cites this paper
• Cap‐Dependent Translation Initiation Factor eIF4E: An Emerging Anticancer Drug Target

  2012cites this paper
• Influenza virus polymerase confers independence of the cellular cap-binding factor eIF4E for viral mRNA translation.

  2012cites this paper
• Mechanisms of Insulin Action

  2012cites this paper
• Independencia de los factores de la iniciación de la traducción de los mRNAs virales

  2012cites this paper