Protein Translation in Parkinson's Disease

During protein translation, cells generate proteins based on the genetic information stored in nucleotides. This is a fundamental, and therefore a very tightly regulated process. Neurons are known to extensively utilize translational regulation to fulfill their functional needs, thereby increasing their susceptibility to translational defects. Recent studies on the molecular mechanisms of familial Parkinson’s disease (PD) suggested that protein translation is one of the major cellular processes implicated in the pathology. In this chapter, we summarize translational defects found in familial PD mutants. Furthermore, we discuss molecular mechanisms involved in the pathology, and also possibilities of targeting the translational machinery for therapeutic intervention in PD.

• Publication year

  2017

• Venue

  Unknown venue

• Publication date

  2017-01-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/B978-0-12-803783-6.00009-2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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