Recent advances in the genetics of Parkinson's disease.

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Annual review of genomics and human genetics (Print)

• Publication date

  2011-09-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/annurev-genom-082410-101440PMID 21639795PMCID PMC4120236
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.

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  2011influential reference
• Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson’s disease

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• PGC-1α, A Potential Therapeutic Target for Early Intervention in Parkinson’s Disease

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• The role of parkin in familial and sporadic Parkinson's disease

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• Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

  2010cited by this paper
• Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

  2010influential reference
• The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation

  2010cited by this paper
• Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling.

  2010cited by this paper
• Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy.

  2010cited by this paper
• Genetic Analysis of Pathways to Parkinson Disease

  2010cited by this paper
• 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

  2010cited by this paper
• The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

  2010cited by this paper
• Increased Expression of a-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

  2010cited by this paper
• Signal Transduction Protein Array Analysis Links LRRK2 to Ste20 Kinases and PKC Zeta That Modulate Neuronal Plasticity

  2010cited by this paper
• Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice

  2010cited by this paper
• The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

  2010cited by this paper
• DJ-1, a cancer and Parkinson's disease associated protein, regulates autophagy through JNK pathway in cancer cells.

  2010cited by this paper
• Genetic Etiology of Parkinson Disease Associated with Mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 Genes: A Mutation Update

  2010cited by this paper
• Reduced Basal Autophagy and Impaired Mitochondrial Dynamics Due to Loss of Parkinson's Disease-Associated Protein DJ-1

  2010cited by this paper
• Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.

  2010cited by this paper
• PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

  2010influential reference
• Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function

  2010cited by this paper
• PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

  2010cited by this paper
• The Role of Glucocerebrosidase Mutations in Parkinson Disease and Lewy Body Disorders

  2010cited by this paper
• DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function

  2010cited by this paper
• PINK1 points Parkin to mitochondria

  2010cited by this paper
• LRRK2 and Parkinson disease.

  2010influential reference
• POLG1 polyglutamine tract variants associated with Parkinson's disease.

  2010cited by this paper
• α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

  2010cited by this paper
• The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway

  2010cited by this paper
• DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway

  2010cited by this paper
• Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.

  2010cited by this paper
• Inhibitors of Leucine Rich Repeat Kinase 2 (LRRK2) Protect Against LRRK2-Models of Parkinson’s Disease

  2010cited by this paper
• αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

  2010cited by this paper
• Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

  2010cited by this paper
• EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

  2010cited by this paper
• Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis.

  2010cited by this paper
• Genetic animal models of Parkinson's disease.

  2010cited by this paper
• Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

  2009cited by this paper
• Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

  2009cited by this paper
• Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

  2009cited by this paper
• Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization*

  2009cited by this paper
• Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

  2009cited by this paper
• Parkinson's disease: from monogenic forms to genetic susceptibility factors.

  2009cited by this paper
• DJ-1 and prevention of oxidative stress in Parkinson's disease and other age-related disorders.

  2009cited by this paper
• Silencing DJ‐1 reveals its contribution in paraquat‐induced autophagy

  2009cited by this paper
• No association between common POLG1 variants and sporadic idiopathic Parkinson's disease

  2009cited by this paper
• 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

  2009cited by this paper
• Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence

  2009cited by this paper
• The genetics of Parkinson's syndromes: a critical review.

  2009cited by this paper
• Neuropathology of Parkinson's disease with the R1441G mutation in LRRK2

  2009cited by this paper
• Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis.

  2009cited by this paper
• Alpha-synuclein multiplications with parkinsonism, dementia or progressive myoclonus?

  2009cited by this paper
• Dopamine-Induced Conformational Changes in Alpha-Synuclein

  2009cited by this paper
• The PINK1/Parkin pathway: a mitochondrial quality control system?

  2009cited by this paper
• PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

  2009cited by this paper
• Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.

  2009cited by this paper
• DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

  2009cited by this paper
• Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease

  2009cited by this paper
• The Parkinson disease‐associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

  2009cited by this paper
• Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)

  2009cited by this paper
• LRRK2 is a component of granular alpha‐synuclein pathology in the brainstem of Parkinson's disease

  2008cited by this paper
• Phosphorylation of 4E‐BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

  2008cited by this paper
• The kinase domain of mitochondrial PINK1 faces the cytoplasm

  2008cited by this paper
• Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR.

  2008cited by this paper
• PINK1 controls mitochondrial localization of Parkin through direct phosphorylation.

  2008cited by this paper
• RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

  2008cited by this paper
• Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases

  2008cited by this paper
• Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

  2008cited by this paper
• EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

  2008cited by this paper
• Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

  2008cited by this paper
• Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein.

  2008cited by this paper
• Structure of membrane-bound α-synuclein from site-directed spin labeling and computational refinement

  2008cited by this paper
• Mitochondria in the aetiology and pathogenesis of Parkinson's disease.

  2008cited by this paper
• What causes cell death in Parkinson's disease?

  2008cited by this paper
• Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

  2008cited by this paper
• Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity.

  2007cited by this paper
• Expression and localization of Parkinson's disease‐associated leucine‐rich repeat kinase 2 in the mouse brain

  2007cited by this paper
• DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

  2007cited by this paper
• Importance of low-range CAG expansion and CAA interruption in SCA2 Parkinsonism.

  2007cited by this paper
• Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease

  2007cited by this paper
• Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

  2007cited by this paper
• The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease

  2007cited by this paper
• Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.

  2007cited by this paper
• Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease.

  2007cited by this paper
• G2019S LRRK2 mutation causing Parkinson’s disease without Lewy bodies

  2007cited by this paper
• Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by Parkin

  2007cited by this paper
• Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

  2006cited by this paper
• DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

  2006cited by this paper
• Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery.

  2006cited by this paper
• Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

  2006cited by this paper
• Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

  2006influential reference
• Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila

  2006cited by this paper
• Kinase activity of mutant LRRK2 mediates neuronal toxicity

  2006cited by this paper
• Lrrk2 and Lewy body disease

  2006cited by this paper
• Identification of Far Upstream Element-binding Protein-1 as an Authentic Parkin Substrate*

  2006cited by this paper
• Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

  2006cited by this paper
• Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

  2006cited by this paper

• Cis or trans: a puzzle of Parkin activation mechanism.

  2026cites this paper
• Epigenetic mechanisms linking environmental exposure to Parkinson's disease: A comprehensive review.

  2025cites this paper
• Therapeutic Potential of Sea Cucumber-Derived Bioactives in the Prevention and Management of Brain-Related Disorders: A Comprehensive Review

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• Built differently or defective: can RNA exosomopathies cause ribosome heterogeneity?

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• Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in Drosophila

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• ANKK1, ANKRD50, GRK5, PACSIN1 and VPS8 are novel candidate genes associated with late onset Parkinson's disease: Definition of a novel predictive protocol based on polygenic model of inheritance.

  2025cites this paper
• Animal Models of Parkinson's Disease.

  2025cites this paper
• Autophagy related genes polymorphisms in Parkinson’s Disease; A systematic review of literature

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• Genetic mutations in kinases: a comprehensive review on marketed inhibitors and unexplored targets in Parkinson's disease

  2025cites this paper
• Oxidative modification of methionine residue in α-synuclein by dopamine induces cellular vulnerability, oligomerization and secretion of α-synuclein

  2025cites this paper
• Drug Repurposing for the Discovery of Potential Inhibitors Targeting DJ-1 (PARK7) Against Parkinson’s Disease

  2025cites this paper
• Neuroprotective Agents: Implications for Parkinson's Disease Treatment.

  2025cites this paper
• Age-related nigral downregulation of the Parkinson’s risk factor FAM49B primes human microglia for inflammaging

  2025cites this paper
• TUDCA combined with Syndopa protects the midbrain and gut from MPTP toxicity in a Parkinson’s disease mouse model: Immunohistochemical evidence

  2025cites this paper
• Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrils

  2025cites this paper
• Navigating the landscape of protein folding and proteostasis: from molecular chaperones to therapeutic innovations

  2025cites this paper
• Arrestin‐3 binds parkin and enhances parkin‐dependent mitophagy

  2024cites this paper
• The role of ubiquitination in health and disease

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• Molecular Mechanisms of Degeneration in Parkinson’s Disease; Deep Brain Stimulation, Pluripotent Stem Cell Therapy, and Cutting Edge Technology in Treatment Of Parkinson’s Disease

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• Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span

  2024cites this paper
• Mechanism of phospho-Ubls' specificity and conformational changes that regulate Parkin activity.

  2024cites this paper
• Specific interactions with phospho-Ubls and allosteric conformational changes regulate the E3 ligase activity of Parkin

  2024cites this paper
• Proteomic Profiling of Messenger Ribonucleoproteins in Mouse Tissues Based on Formaldehyde Cross-Linking.

  2024cites this paper
• Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

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• Cooperative Substructure and Energetics of Allosteric Regulation of the Catalytic Core of the E3 Ubiquitin Ligase Parkin by Phosphorylated Ubiquitin

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• Role of Mitochondrial Dysfunctions in Neurodegenerative Disorders: Advances in Mitochondrial Biology

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• Advancements in Genetic and Biochemical Insights: Unraveling the Etiopathogenesis of Neurodegeneration in Parkinson’s Disease

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• In vivo self-assembled siRNAs within small extracellular vesicles attenuate LRRK2-induced neurodegeneration in Parkinson's disease models.

  2024cites this paper
• Selective dopaminergic neurotoxicity modulated by inherent cell-type specific neurobiology.

  2024cites this paper
• Targeting mitochondria with small molecules: A promising strategy for combating Parkinson's disease.

  2024cites this paper
• The Genetic Architecture of Parkinson's Disease in the AfrAbia Population: Current State and Future Perspectives.

  2024cites this paper
• Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats

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• Cell-Based Covalent-Capture Deubiquitinase Assay for Inhibitor Discovery.

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• Advancing Age and the rs6265 BDNF SNP are Permissive to Graft-induced Dyskinesias in Parkinsonian Rats

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• Irisin's emerging role in Parkinson's disease research: A review from molecular mechanisms to therapeutic prospects.

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• The role of mitochondrial dynamics in disease

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• Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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