Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature Genetics

• Publication date

  2006-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng1707PMID 16380715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Connexin 40, a Target of Transcription Factor Tbx5, Patterns Wrist, Digits, and Sternum

  2005cited by this paper
• Tbx5 and Tbx4 are not sufficient to determine limb-specific morphologies but have common roles in initiating limb outgrowth.

  2005cited by this paper
• Core transcriptional regulatory circuitry in human embryonic stem cells.

  2005cited by this paper
• Novel mutations in the gene SALL4 provide further evidence for acro-renal-ocular and Okihiro syndromes being allelic entities, and extend the phenotypic spectrum

  2004cited by this paper
• TBX5 mutations and congenital heart disease: Holt-Oram syndrome revealed

  2004cited by this paper
• Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

  2004cited by this paper
• The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

  2004cited by this paper
• Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning.

  2004cited by this paper
• Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities.

  2004cited by this paper
• Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling.

  2004cited by this paper
• Animal Cytogenetics and Comparative Mapping

  2003cited by this paper
• Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy

  2003cited by this paper
• GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

  2003cited by this paper
• A global control region defines a chromosomal regulatory landscape containing the HoxD cluster.

  2003cited by this paper
• Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo

  2003cited by this paper
• Structure and function of the feed-forward loop network motif

  2003cited by this paper
• Tbx5 is required for forelimb bud formation and continued outgrowth

  2003cited by this paper
• Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

  2003cited by this paper
• Functional Analysis of TBX5 Missense Mutations Associated with Holt-Oram Syndrome*

  2003cited by this paper
• Expressivity of Holt-Oram syndrome is not predicted by TBX5 genotype.

  2003cited by this paper
• Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois

  2003cited by this paper
• Finger or toe: the molecular basis of limb identity

  2003cited by this paper
• Patterning systems--from one end of the limb to the other.

  2003cited by this paper
• Network motifs in the transcriptional regulation network of Escherichia coli

  2002cited by this paper
• Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation.

  2002cited by this paper
• Shh and Gli3 are dispensable for limb skeleton formation but regulate digit number and identity

  2002cited by this paper
• Transcriptional Regulation of Vertebrate Cardiac Morphogenesis

  2002cited by this paper
• Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family.

  2002cited by this paper
• Transcription factor haploinsufficiency: when half a loaf is not enough.

  2002cited by this paper
• Okihiro syndrome is caused by SALL4 mutations.

  2002cited by this paper
• Progression of Vertebrate Limb Development Through SHH-Mediated Counteraction of GLI3

  2002cited by this paper
• A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.

  2001cited by this paper
• Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome.

  2001cited by this paper
• Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

  2001cited by this paper
• Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function.

  2001cited by this paper
• A model for anteroposterior patterning of the vertebrate limb based on sequential long- and short-range Shh signalling and Bmp signalling.

  2000cited by this paper
• Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling.

  2000cited by this paper
• Hindlimb patterning and mandible development require the Ptx1 gene.

  1999cited by this paper
• Fgf10 is essential for limb and lung formation

  1999cited by this paper
• Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity.

  1999cited by this paper
• Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development.

  1999cited by this paper
• Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome

  1997cited by this paper
• The cardiac transcription factors Nkx2‐5 and GATA‐4 are mutual cofactors

  1997cited by this paper
• Holt-Oram syndrome: a clinical genetic study.

  1996cited by this paper
• Evidence of a role for T-☐ genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity

  1996cited by this paper
• The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome)

  1994cited by this paper
• The Atlas of Mouse Development

  1992cited by this paper
• Skeletal manifestations of the Holt-Oram syndrome.

  1970cited by this paper

• A de novo SALL4 mutation causes unilateral renal agenesis by misregulating genes involved in kidney development

  2025cites this paper
• Developmental Toxicology Profile of the IRAK4 Degrader KT-474.

  2025cites this paper
• Emerging Insights into Sall4’s Role in Cardiac Regenerative Medicine

  2025cites this paper
• Sall4 and Gata4 induce cardiac fibroblast transition towards a partially multipotent state with cardiogenic potential

  2024cites this paper
• A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders

  2024cites this paper
• Sall4 regulates downstream patterning genes during limb regeneration.

  2024cites this paper
• A novel hypothesis about mechanism of thalidomide action on pattern formation

  2024cites this paper
• SALL4 deletion and kidney and cardiac defects associated with VACTERL association

  2024cites this paper
• Cohesin: an emerging master regulator at the heart of cardiac development

  2023cites this paper
• Identification of SALL4 Expressing Islet-1+ Cardiovascular Progenitor Cell Clones

  2023cites this paper
• Integrative Role of the SALL4 Gene: From Thalidomide Embryopathy to Genetic Defects of the Upper Limb, Internal Organs, Cerebral Midline, and Pituitary

  2023influential citation
• Lateral thinking in syndromic congenital cardiovascular disease

  2023cites this paper
• Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome

  2023cites this paper
• Case report: Novel TBX5-related pathogenic mechanism of Holt–Oram syndrome

  2023cites this paper
• A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders

  2023cites this paper
• Sall1/4 cooperatively interact with Myocd/SRF to promote cardiomyocyte proliferation by regulating CDK/cyclin genes.

  2023cites this paper
• SALL4 Phenotype in Four Generations of One Family: An Interplay of the Upper Limb, Kidneys, and the Pituitary

  2023cites this paper
• Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndrome

  2022cites this paper
• Normal embryonic development and neonatal digit regeneration in mice overexpressing a stem cell factor, Sall4

  2022cites this paper
• Identification of SALL4 Expressing Islet-1+ Cardiovascular Progenitor Cell Clones

  2022cites this paper
• Molecular Glues: The Adhesive Connecting Targeted Protein Degradation to the Clinic

  2022cites this paper
• Functional analysis of two novel TBX5 variants present in individuals with Holt–Oram syndrome with different clinical manifestations

  2021cites this paper
• The Impact of Iron Chelators on the Biology of Cancer Stem Cells

  2021influential citation
• Muscle group specific transcriptomic and DNA methylation differences related to developmental patterning in FSHD

  2021cites this paper
• Fibroblast pathology in inflammatory joint disease

  2021cites this paper
• The Classification of VACTERL Association into 3 Groups According to the Limb Defect

  2021cites this paper
• Sall4 and Myocd Empower Direct Cardiac Reprogramming From Adult Cardiac Fibroblasts After Injury

  2021cites this paper
• Embryology and Classification of Congenital Upper Limb Anomalies

  2021cites this paper
• SALL4 controls cell fate in response to DNA base composition

  2020cites this paper
• Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide

  2020cites this paper
• Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emergence of Artiodactyl Traits

  2020cites this paper
• SALL4 Gene

  2020cites this paper
• Recent advances in the molecular mechanism of thalidomide teratogenicity.

  2020cites this paper
• Familial dilated cardiomyopathy associated with pathogenic TBX5 variants: Expanding the cardiac phenotype associated with Holt–Oram syndrome

  2020cites this paper
• Tbx5 inhibits hedgehog signaling in determination of digit identity.

  2019cites this paper
• Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart.

  2019cites this paper
• Identification and functional analysis of genetic variants in TBX5 gene promoter in patients with acute myocardial infarction

  2019cites this paper
• Making and breaking symmetry in development, growth and disease

  2019cites this paper
• The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis

  2019cites this paper
• Temporal changes of Sall4 lineage contribution in developing embryos and the contribution of Sall4-lineages to postnatal germ cells in mice

  2018cites this paper
• SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate

  2018cites this paper
• Chapter 2 Function of the Stem Cell Transcription Factor SALL 4 in Hematopoiesis

  2018cites this paper
• [Recent progress in research of congenital polydactyly].

  2018cites this paper
• Holt-Oram syndrome: clinical and molecular description of 78 patients with TBX5 variants

  2018cites this paper
• Zone of Polarizing Activity Regulatory Sequence Mutations/Duplications with Preaxial Polydactyly and Longitudinal Preaxial Ray Deficiency in the Phenotype: A Review of Human Cases, Animal Models, and Insights Regarding the Pathogenesis

  2018cites this paper
• Unlocking a dark past

  2018cites this paper
• SALL4 as a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis

  2018cites this paper
• Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome

  2018cites this paper
• Function of the Stem Cell Transcription Factor SALL4 in Hematopoiesis

  2018cites this paper
• Regulatory integration of Hox factor activity with T-box factors in limb development

  2018cites this paper
• Genetic Analyses Identified a SALL4 Gene Mutation Associated with Holt–Oram Syndrome

  2018cites this paper
• Postmortem Diagnosis of Heart-hand Syndrome Associated With a 7p22.1p22.3 Deletion in a 16-week-old Fetus

  2018cites this paper
• Prospective: Is Random Monoallelic Expression a Contributor to Phenotypic Variability of Autosomal Dominant Disorders?

  2017cites this paper
• Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation.

  2017cites this paper
• Why location matters — site-specific factors in rheumatic diseases

  2017cites this paper
• SALL 4 and NFATC 2 : two major actors of interstitial 20 q 13 . 2 duplication

  2017cites this paper
• Identification of TNFSF13, SPATC1L, SLC22A25 and SALL4 as novel susceptibility loci for atrial fibrillation by an exome-wide association study

  2017cites this paper
• Prenatal diagnosis of complex phenotype in a 13-week-old fetus with an interstitial multigene deletion 20q13.13.-q13.2 by chromosomal microarray.

  2017cites this paper
• Transcriptional control by Sall4 in blastocysts facilitates lineage commitment of inner cell mass cells

  2017cites this paper
• Discovering and Modeling Genetic Causes of Congenital Heart Disease

  2017cites this paper
• T-box family of transcription factor-TBX5, insights in development and disease.

  2017cites this paper
• Stage-specific expression of Sal-like protein 4 in boar testicular germ cells.

  2017cites this paper
• The two domain hypothesis of limb prepattern and its relevance to congenital limb anomalies

  2017cites this paper
• Human Genetics of Atrial Septal Defect

  2016cites this paper
• Tbx5 Buffers Inherent Left/Right Asymmetry Ensuring Symmetric Forelimb Formation

  2016cites this paper
• Sall4 controls differentiation of pluripotent cells independently of the Nucleosome Remodelling and Deacetylation (NuRD) complex

  2016cites this paper
• Clinical and Genetic Findings in Mexican Patients with Duane Anomaly and Radial Ray Malformations/Okihiro Syndrome.

  2016cites this paper
• Single-Cell Resolution of Temporal Gene Expression during Heart Development.

  2016cites this paper
• Novel frameshift variant in gene SALL4 causing Okihiro syndrome.

  2016cites this paper
• Substantial Downregulation of Myogenic Transcripts in Skeletal Muscle of Atlantic Cod during the Spawning Period

  2016cites this paper
• SALL4, the missing link between stem cells, development and cancer.

  2016cites this paper
• TBX5 and NuRD Divide the Heart.

  2016cites this paper
• Functional Analysis of KLF13 in the Heart

  2016influential citation
• Combinatorial Functions of Transcription Factors and Epigenetic Factors in Heart Development and Disease

  2016cites this paper
• How the embryo makes a limb: determination, polarity and identity

  2015cites this paper
• Stemness factor Sall 4 is required for DNA damage response in embryonic stem cells

  2015cites this paper
• Kiwi genome provides insights into evolution of a nocturnal lifestyle

  2015cites this paper
• Role of Genetic Factors in the Pathogenesis of Radial Deficiencies in Humans

  2015cites this paper
• Mesodermal expression of Moz is necessary for cardiac septum development.

  2015cites this paper
• Sall4 Is Essential for Mouse Primordial Germ Cell Specification by Suppressing Somatic Cell Program Genes

  2015cites this paper
• Hedgehog Signaling during Appendage Development and Regeneration

  2015cites this paper
• JCB_201408106 1..8

  2015cites this paper
• Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements

  2015cites this paper
• SALL 4 is Silenced in most Adult Tissues , but is Aberrantly Expressed in Cancers Including Hematologic Malignancies

  2015cites this paper
• Stemness factor Sall4 is required for DNA damage response in embryonic stem cells

  2015cites this paper
• T-Box Genes and Developmental Anomalies

  2015cites this paper
• SALL4-Related Disorders

  2015cites this paper
• SALL4: engine of cell stemness.

  2014cites this paper
• Strabismus genetics across a spectrum of eye misalignment disorders

  2014cites this paper
• Genetic studies of congenital upper limb anomalies

  2014cites this paper
• Molecular Determinants of Congenital Heart Disease

  2014cites this paper
• Molecular Genetics of Holt–Oram Syndrome

  2014cites this paper
• USING THE TS65DN MOUSE MODEL OF DOWN SYNDROME TO UNDERSTAND THE GENETICS OF CONGENITAL HEART DEFECTS

  2014cites this paper
• Génétique du développement des membres : contribution à son déterminisme moléculaire à partir de modèles d'étude en pathologie humaine

  2014cites this paper
• The next new target in leukemia: The embryonic stem cell gene SALL4

  2014cites this paper
• Proteomic analysis of fibroblastema formation in regenerating hind limbs of Xenopus laevis froglets and comparison to axolotl

  2014cites this paper
• SALL4 and NFATC2: two major actors of interstitial 20q13.2 duplication.

  2014cites this paper
• Review of the Molecular Development of the Thumb: Digit Primera

  2014cites this paper
• Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes)

  2014cites this paper
• Limb Malformations

  2014cites this paper