Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Diabetologia

• Publication date

  2015-08-09

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-015-3705-6PMID 26254576PMCID PMC4793723
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness

  2014cited by this paper
• BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans

  2014cited by this paper
• A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid Composition and Insulin Sensitivity in Young Adults

  2013cited by this paper
• Effects of high‐protein diets on fat‐free mass and muscle protein synthesis following weight loss: a randomized controlled trial

  2013cited by this paper
• Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes.

  2013cited by this paper
• Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.

  2013cited by this paper
• Quantification of branched-chain keto acids in tissue by ultra fast liquid chromatography-mass spectrometry.

  2013cited by this paper
• Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

  2013cited by this paper
• Mitochondria express enhanced quality as well as quantity in association with aerobic fitness across recreationally active individuals up to elite athletes.

  2013cited by this paper
• Metabolomics view on gut microbiome modulation by polyphenol-rich foods.

  2012cited by this paper
• Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

  2012cited by this paper
• Muscle protein synthesis in response to nutrition and exercise

  2012cited by this paper
• Interplay between lipids and branched-chain amino acids in development of insulin resistance.

  2012cited by this paper
• The footprints of gut microbial-mammalian co-metabolism.

  2011cited by this paper
• Metabolite profiles and the risk of developing diabetes

  2011cited by this paper
• Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

  2010cited by this paper
• Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

  2010cited by this paper
• Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels*

  2010cited by this paper
• Exercise-Induced Changes in Metabolic Intermediates, Hormones, and Inflammatory Markers Associated With Improvements in Insulin Sensitivity

  2010cited by this paper
• A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

  2009influential reference
• Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women

  2009cited by this paper
• Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

  2008cited by this paper
• Metabolic flexibility and insulin resistance.

  2008cited by this paper
• Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

  2008influential reference
• Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

  2008cited by this paper
• Novel isolation procedure for short-, medium-, and long-chain acyl-coenzyme A esters from tissue.

  2008cited by this paper
• Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.

  2007influential reference
• Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency*

  2005cited by this paper
• LC/MS/MS method for quantitative determination of long-chain fatty acyl-CoAs.

  2005cited by this paper
• Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis

  2004cited by this paper
• Targeting the metabolic syndrome with exercise: evidence from the HERITAGE Family Study.

  2003cited by this paper
• Resistance-training-induced adaptations in skeletal muscle protein turnover in the fed state.

  2002cited by this paper
• Insulin signalling and the regulation of glucose and lipid metabolism

  2001cited by this paper
• Quantitative analysis of urinary acylglycines for the diagnosis of beta-oxidation defects using GC-NCI-MS.

  2000cited by this paper
• An integrated method for spectrum extraction and compound identification from gas chromatography/mass spectrometry data

  1999cited by this paper
• Deconvolution gas chromatography/mass spectrometry of urinary organic acids--potential for pattern recognition and automated identification of metabolic disorders.

  1999cited by this paper
• Exercise, glucose transport, and insulin sensitivity.

  1998cited by this paper
• Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue.

  1997cited by this paper
• Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans.

  1995cited by this paper
• Measurement of 15N enrichment in multiple amino acids and urea in a single analysis by gas chromatography/mass spectrometry.

  1993cited by this paper
• Tandem mass spectrometry: A new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism

  1990cited by this paper
• Plasma amino acids and insulin levels in obesity: response to carbohydrate intake and tryptophan supplements.

  1988cited by this paper
• Use of reciprocal pool specific activities to model leucine metabolism in humans.

  1985cited by this paper
• Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values.

  1974cited by this paper
• Plasma amino acid levels and insulin secretion in obesity.

  1969cited by this paper

• Serine modulates insulin resistance during short-term bed rest.

  2026cites this paper
• Global loss of metabolic responsiveness and elevated enzyme in leptin deficient obese mice during starvation.

  2026cites this paper
• Amino Acid Regulation in Metabolic Heart Disease: Mechanisms and Therapeutic Potential

  2026cites this paper
• Influence of obesity and IL-6 on human postprandial amino acid and protein metabolism at whole-body and tissue level.

  2025cites this paper
• Targeted and Untargeted Urinary Metabolomics in Exercise Science: A Systematic Review

  2025cites this paper
• Short-term Physical Activity Reduces Metabolic-associated Steatohepatitis by Promoting the Degradation of Branched-chain Amino Acids in Skeletal Muscle

  2025influential citation
• Effect of acute exercise and exercise training on the ability of insulin to clear branched-chain amino acids from plasma in obesity and type 2 diabetes

  2025influential citation
• Biomarkers of Insulin Resistance and Their Performance as Predictors of Treatment Response in Overweight Adults

  2025cites this paper
• Branched chain amino acid metabolism and microbiome in adolescents with obesity during weight loss therapy.

  2025cites this paper
• Molecular correlates of glycine receptor activity in human β cells

  2025cites this paper
• Proteomics-based mechanism of HIIT regulation of hepatic metabolism in aging female rats

  2025cites this paper
• Metabolic impact of dietary glycine supplementation in individuals with severe obesity

  2025cites this paper
• Response to Comment Letter: Muscle Metabolomics and Exercise Effects on Cardiometabolic Risk.

  2024cites this paper
• Metals and polycyclic aromatic hydrocarbons co-exposure: Amino acid omics insights on blood glucose homeostasis.

  2024cites this paper
• Aerobic exercise attenuates insulin resistance via restoring branched chain amino acids homeostasis in obese mice

  2024cites this paper
• Biomarkers of insulin resistance and their performance as predictors of treatment response in adults with risk factors for type 2 diabetes

  2024cites this paper
• Effect of weight loss interventions on metabolomic signatures in obese children with insulin resistance

  2024cites this paper
• Serum dysregulation of serine and glycine metabolism as predictive biomarker for cognitive decline in frail elderly subjects

  2024cites this paper
• D-limonene supplementation does not alter postprandial metabolism of postmenopausal women challenged with a mixed macronutrient tolerance test: a pilot study

  2024cites this paper
• Association between Childhood Overweight and Altered Concentrations of Circulating Amino Acids

  2024cites this paper
• The blood serum metabolome profile after different phases of a 4‐km cycling time trial: Secondary analysis of a randomized controlled trial

  2024cites this paper
• Canagliflozin regulates metabolic reprogramming in diabetic kidney disease by inducing fasting-like and aestivation-like metabolic patterns

  2024cites this paper
• An integrative profiling of metabolome and transcriptome in the plasma and skeletal muscle following an exercise intervention in diet-induced obese mice

  2023cites this paper
• Divergent Skeletal Muscle Metabolomic Signatures of Different Exercise Training Modes Independently Predict Cardiometabolic Risk Factors.

  2023cites this paper
• Acute repeated cage exchange stress modifies urinary stress and plasma metabolic profiles in male mice

  2023cites this paper
• Consumption of Different Egg-Based Diets Alters Clinical Metabolic and Hematological Parameters in Young, Healthy Men and Women

  2023cites this paper
• Preliminary evidence of glycine as a biomarker of cardiovascular disease risk in children with obesity

  2023cites this paper
• A review study on the present and novel treatments for metabolic disorder

  2023cites this paper
• Exploring the association of physical activity with the plasma and urine metabolome in adolescents and young adults

  2023cites this paper
• The Preventive Effect of Exercise and Oral Branched-Chain Amino Acid Supplementation on Obesity-Induced Brain Changes in Ldlr−/−.Leiden Mice

  2023cites this paper
• Cross-sectional relationships between general and central adiposity and plasma amino acids in Chinese adults

  2023cites this paper
• Effects of glycine on metabolic syndrome components: a review

  2022cites this paper
• Branched-Chain Amino Acids and Insulin Resistance, from Protein Supply to Diet-Induced Obesity

  2022cites this paper
• Glycated Proteins, Glycine, Acetate, and Monounsaturated Fatty Acids May Act as New Biomarkers to Predict the Progression of Type 2 Diabetes: Secondary Analyses of a Randomized Controlled Trial

  2022cites this paper
• The causal associations of circulating amino acids with blood pressure: a Mendelian randomization study

  2022cites this paper
• Peripheral fatigue and hormone responses to branched-chain amino acids ingestion and exercise in recovery: a systematic review and meta-analysis.

  2022cites this paper
• Colorimetric acetone sensor based on ionic liquid functionalized drug-mediated silver nanostructures.

  2022cites this paper
• The Importance of Metabolites in Modulating Insulin Sensitivity

  2022cites this paper
• Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes

  2022cites this paper
• Effects of exercise and microbiota transplant on the memory of obesity-induced mice

  2022cites this paper
• Research in the Field of Exercise and Metabolomics: A Bibliometric and Visual Analysis

  2022cites this paper
• Plasma Metabolic Signatures of Healthy Overweight Subjects Challenged With an Oral Glucose Tolerance Test

  2022cites this paper
• De Novo Glycine Synthesis Is Reduced in Adults With Morbid Obesity and Increases Following Bariatric Surgery

  2022influential citation
• Small RNAs are differentially expressed in autoimmune and non-autoimmune diabetes and controls

  2022cites this paper
• Is type 2 diabetes mellitus another intercellular junction-related disorder?

  2022cites this paper
• (Dys)regulation of Protein Metabolism in Skeletal Muscle of Humans With Obesity

  2022cites this paper
• Potential Mechanisms for How Long-Term Physical Activity May Reduce Insulin Resistance

  2022cites this paper
• Calorie restriction improves lipid-related emerging cardiometabolic risk factors in healthy adults without obesity: Distinct influences of BMI and sex from CALERIE™ a multicentre, phase 2, randomised controlled trial

  2022cites this paper
• The effect of physical activity level and exercise training on the association between plasma branched-chain amino acids and intrahepatic lipid content in participants with obesity

  2021cites this paper
• Plasma Branched-Chain Amino Acids Are Associated With Greater Fasting and Postprandial Insulin Secretion in Non-diabetic Chinese Adults

  2021cites this paper
• Impact of lifestyle Intervention on branched‐chain amino acid catabolism and insulin sensitivity in adolescents with obesity

  2021cites this paper
• Dietary Intake of Branched Chain Amino Acids and Breast Cancer Risk in the NHS and NHS II Prospective Cohorts

  2021cites this paper
• Gut Microbiome and Metabolites in Patients with NAFLD and after Bariatric Surgery: A Comprehensive Review

  2021cites this paper
• Metabolic and biological changes in children with obesity and diabetes

  2021cites this paper
• Circulating branch chain amino acids and improvement in liver fat content in response to exercise interventions in NAFLD

  2021cites this paper
• Branched chain amino acid-inflammation relationship in youth with obesity: A randomized controlled intervention study.

  2021cites this paper
• Individual variability in human urinary metabolites identifies age‐related, body mass index‐related, and sex‐related biomarkers

  2021cites this paper
• Hormonal regulation of glycine decarboxylase and its relationship to oxidative stress

  2021cites this paper
• Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects with Type 2 Diabetes.

  2021cites this paper
• Metabolomics in Exercise and Sports: A Systematic Review

  2021cites this paper
• Exercise-induced hormone and blood fatigue factor responses to branched-chain amino acids administration in the recovery period after exercise: a systematic review and meta-analysis

  2021cites this paper
• Effect of Exercise Training on Spexin Level, Appetite, Lipid Accumulation Product, Visceral Adiposity Index, and Body Composition in Adults With Type 2 Diabetes

  2021cites this paper
• Amino acid transporters as modulators of glucose homeostasis.

  2021cites this paper
• Branched-Chain Amino Acid Oxidation Is Elevated in Adults with Morbid Obesity and Decreases Significantly after Sleeve Gastrectomy.

  2020cites this paper
• The Association of Exercise Training Modalities with Circulating Branched Chain Amino Acid and Ketone Body levels in Patients with Type 2 Diabetes

  2020cites this paper
• The Effect of Circuit Resistance Training on Plasma Levels of Amino acids, Alpha-hydroxybutyrate, Mannose, and Urinary Levels of Glycine Conjugated Adducts in Obese Adolescent Boys.

  2020cites this paper
• Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances.

  2020cites this paper
• Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.

  2020cites this paper
• Short-term variability of the human serum metabolome depending on nutritional and metabolic health status

  2020cites this paper
• A Randomized Community-based Exercise Training Trial in African American Men: ARTIIS.

  2020cites this paper
• Ion Channels of the Islets in Type 2 Diabetes.

  2020cites this paper
• A Newly Developed Diabetes Risk Index, Based on Lipoprotein Subfractions and Branched Chain Amino Acids, is Associated with Incident Type 2 Diabetes Mellitus in the PREVEND Cohort

  2020cites this paper
• Moderate, Rather Than Vigorous Exercise Benefits Plasma Amino Acids Profile in Patients With Nonalcoholic Fatty Liver Disease

  2020cites this paper
• Diet, Physical Activity and Adiposity as Determinants of Circulating Amino Acid Levels in a Multiethnic Asian Population

  2020cites this paper
• Effects of exercise and dietary interventions on serum metabolites in men with insomnia symptoms: A 6-month randomized controlled trial

  2020cites this paper
• Commentary: Metabolomics-Based Studies Assessing Exercise-Induced Alterations of the Human Metabolome: A Systematic Review

  2020cites this paper
• Changes of Differential Urinary Metabolites after High-Intensive Training in Teenage Football Players

  2020cites this paper
• Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men

  2020influential citation
• Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases

  2019cites this paper
• Effects of low-carbohydrate diet and resistance exercise training on physical characteristics and concentrations of plasma metabolites and hormones

  2019cites this paper
• Obesity and Cage Environment Modulate Metabolism in the Zucker Rat: A Multiple Biological Matrix Approach to Characterizing Metabolic Phenomena.

  2019cites this paper
• Drug Development for Diabetes Mellitus: Beyond Hemoglobin A1c

  2019cites this paper
• Neuromuscular Electrical Stimulation: A Novel Treatment Intervention for Improving Metabolic Health in an Overweight/obese Population

  2019cites this paper
• The effect of eight-week walking program on plasma levels of amino acids in early/mid pubertal obese girls

  2019influential citation
• Plasma High‐Resolution Metabolomics Differentiates Adults with Normal Weight Obesity from Lean Individuals

  2019cites this paper
• Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction

  2019cites this paper
• The Effects of BCAAs on Insulin Resistance in Athletes.

  2019cites this paper
• MCEE 2.0: more options and enhanced performance

  2019cites this paper
• Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity.

  2019cites this paper
• Comparison of the Serum Metabolic Fingerprint of Different Exercise Modes in Men with and without Metabolic Syndrome

  2019cites this paper
• Basal and Postprandial Myofibrillar Protein Synthesis Rates Do Not Differ between Lean and Obese Middle-Aged Men

  2019cites this paper
• A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

  2018cites this paper
• Untargeted metabolomics identifies a plasma sphingolipid-related signature associated with lifestyle intervention in prepubertal children with obesity

  2018cites this paper
• 2020 vision - An overview of prospects for diabetes management and prevention in the next decade.

  2018cites this paper
• Lower Fasted State but Greater Change in Plasma Amino Acid-Induced Rise in Muscle Protein Synthesis in People with Obesity

  2018cites this paper
• Metabolomic Signatures and Metabolic Complications in Childhood Obesity

  2018cites this paper
• A Distinct Pattern of Circulating Amino Acids Characterizes Older Persons with Physical Frailty and Sarcopenia: Results from the BIOSPHERE Study

  2018cites this paper
• Alterations in branched-chain amino acid kinetics in nonobese but insulin-resistant Asian men.

  2018cites this paper
• Comprehensive Assessment of the Effects of Sleeve Gastrectomy on Glucose, Lipid, and Amino Acid Metabolism in Asian Individuals with Morbid Obesity

  2018cites this paper
• Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart.

  2018cites this paper