High-Level Production and Long-Term Storage of Engineered Antibodies in Transgenic Tobacco Seeds

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Bio/Technology

• Publication date

  1995-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/NBT1095-1090PMID 9678915
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A sucrose-synthase gene of Vicia faba L.: Expression pattern in developing seeds in relation to starch synthesis and metabolic regulation

  2004cited by this paper
• Upstream sequences regulating legumin gene expression in heterologous transgenic plants

  2004cited by this paper
• Generation and assembly of secretory antibodies in plants

  1995cited by this paper
• Expression of a single-chain Fv antibody against abscisic acid creates a wilty phenotype in transgenic tobacco.

  1995cited by this paper
• Expression of engineered antibodies in plant cells

  1994cited by this paper
• Antigen detection using recombinant, bifunctional single-chain Fv fusion proteins synthesised in Escherichia coli.

  1994cited by this paper
• Expression vectors for high-level gene expression in dicotyledonous and monocotyledonous plants.

  1993cited by this paper
• Bacterial expression of immunoglobulin fragments.

  1993cited by this paper
• Heterologous protein production in transgenic plants.

  1993cited by this paper
• Protein production in transgenic crops: analysis of plant molecular farming.

  1993cited by this paper
• Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack

  1993cited by this paper
• Prospects and progress in the production of foreign proteins and peptides in plants

  1992cited by this paper
• Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

  1992cited by this paper
• Selective inhibition of tumor cell growth by a recombinant single-chain antibody-toxin specific for the erbB-2 receptor.

  1992cited by this paper
• Intracellular trafficking of secretory proteins

  1992cited by this paper
• By-passing immunisation. Human antibodies from synthetic repertoires of germline VH gene segments rearranged in vitro.

  1992cited by this paper
• Engineered Antibodies as Pharmacological Tools

  1992cited by this paper
• Sorting of Proteins in The Secretory System

  1991cited by this paper
• B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.

  1991cited by this paper
• Antibody Engineering: Advances From the Use of Escherichia coli Expression Systems

  1991cited by this paper
• Making antibody fragments using phage display libraries

  1991cited by this paper
• Stable transfer and expression of chimeric genes in licorice (Glycyrrhiza uralensis) using an Ri plasmid binary vector

  1990cited by this paper
• A bifunctional fusion protein containing Fc-binding fragment B of staphylococcal protein A amino terminal to antidigoxin single-chain Fv.

  1990cited by this paper
• Enkephalins Prouduced in Transgenic Plants Using Modified 2S Seed Storage Proteins

  1989cited by this paper
• The Dynamic Nature of the Antibody Repertoire

  1988cited by this paper
• Single-chain antigen-binding proteins.

  1988cited by this paper
• New metal chelate adsorbent selective for proteins and peptides containing neighbouring histidine residues.

  1987cited by this paper
• An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein.

  1986cited by this paper
• Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

  1984cited by this paper
• Ti plasmid vector for the introduction of DNA into plant cells without alteration of their normal regeneration capacity

  1983cited by this paper

• Seed- and leaf-based expression of FGF21-transferrin fusion proteins for oral delivery and treatment of non-alcoholic steatohepatitis

  2022influential citation
• Production of Designer VHH-Based Antibodies in Plants.

  2022cites this paper
• Expression of Single Chain Variable Fragment (scFv) Molecules in Plants: A Comprehensive Update

  2020cites this paper
• Plant genetic engineering: basic concepts and strategies for boosting the accumulation of recombinant proteins in crops

  2019cites this paper
• Tanaman Sebagai Bioreaktor Protein Farmaseutik

  2018cites this paper
• Challenges in developing mucosal vaccines and antibodies against infectious diarrhea in children

  2018cites this paper
• Generation of hapten-specific recombinant antibodies: antibody phage display technology: a review

  2018cites this paper
• Expression of F protein gene in maize for production edible vaccine against Newcastle disease Virus

  2017cites this paper
• Antibodies from plants for bionanomaterials.

  2017cites this paper
• PURIFICATION OF MONOCLONAL ANTIBODIES FROM PLANTS

  2017cites this paper
• Seed-Specific Expression of Spider Silk Protein Multimers Causes Long-Term Stability

  2016cites this paper
• Recombinant Antibody Fragment Production in the Antarctic Marine Bacterium Pseudoalteromonas haloplanktis TAC125

  2016cites this paper
• Microbial Models: From Environmental to Industrial Sustainability

  2016cites this paper
• Plantibodies in human and animal health: a review.

  2016cites this paper
• Increasing abscisic acid levels by immunomodulation in barley grains induces precocious maturation without changing grain composition

  2016cites this paper
• Missile-Type Molecular Breeding of Medicinal Plant Using Compact Monoclonal Antibody Gene

  2015cites this paper
• Engineering Seeds for the Production and Delivery of Oral Vaccines

  2015cites this paper
• Establishment of a phage display platform for the isolation of plasmodium falciparum specific monoclonal antibodies

  2015cites this paper
• Plant Glycomics: Advances and Applications

  2015cites this paper
• Identification and Biophysical Characterization of Acid Induced Conformational State of A Single Chain Antibody Fragment

  2014cites this paper
• Recombinant production of a single-chain antibody fragment in Pseudoalteromonas haloplanktis TAC125

  2014cites this paper
• Induction of recombinant proteins in wheat seed and vegetative tissues

  2013cites this paper
• Spider silks from plants – a challenge to create native‐sized spidroins

  2013cites this paper
• Molecular Farming in the Decades of Omics

  2013cites this paper
• Plant Molecular Pharming, Veterinary Applications plant molecular pharming veterinary applications

  2013cites this paper
• Seeds as a production system for molecular pharming applications: status and prospects.

  2013cites this paper
• Expression analysis of seed-specific genes in four angiosperm species with an emphasis on the unconserved expression patterns of homologous genes

  2013cites this paper
• Maize seeds as a production and delivery platform for HIV microbicides

  2013cites this paper
• Molecular Breeding of Solasodine Glycoside for Solanum khasianum using Anti-Solamargine Single-Chain Fv Gene

  2013cites this paper
• Rice-based oral antibody fragment prophylaxis and therapy against rotavirus infection.

  2013influential citation
• Plant Edible Vaccines: A Revolution in Vaccination

  2013cites this paper
• ELP‐Fusion Technology for Biopharmaceuticals

  2013cites this paper
• Edible vaccines against veterinary parasitic diseases--current status and future prospects.

  2013cites this paper
• Expression and characterisation of recombinant molecules in transgenic soybean.

  2013cites this paper
• PLANT-DERIVED ANTIBODIES FOR ACADEMIC, INDUSTRIAL, AND THERAPEUTIC APPLICATIONS

  2012influential citation
• CLONING TRANSFORMATION AND EXPRESSION OF cDNA OF HUMAN scFv AGAINST HEPATOCELLULAR CARCINOMA IN INDICA RICE VARIETY IR 64

  2012cites this paper
• Synthetic gene networks in plant systems.

  2012cites this paper
• Strategies for recombinant protein production in maize

  2012cites this paper
• Human and Animal Cloning: Boon and Bane in the Light of Islam and Ethics

  2011cites this paper
• Elastin‐like recombinamers: Biosynthetic strategies and biotechnological applications

  2011cites this paper
• Assessment of a N. tabacum L., Variety using Natural Zeolite as Substrate and Confined Conditions for Consistent Biomass, Protein and Plantibody Production

  2011cites this paper
• Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana.

  2011cites this paper
• ENGINEERING OF SEED QUALITY CHARACTERS IN LEGUMES

  2011cites this paper
• Expression of functional recombinant human growth hormone in transgenic soybean seeds

  2011cites this paper
• Accumulation of functional recombinant human coagulation factor IX in transgenic soybean seeds

  2011cites this paper
• Differential N-glycosylation of a monoclonal antibody expressed in tobacco leaves with and without endoplasmic reticulum retention signal apparently induces similar in vivo stability in mice.

  2011cites this paper
• Expression of Antibody Fragments with a Controlled N-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis1[C][W][OA]

  2011cites this paper
• PLANTIBODY: AN OVERVIEW

  2011cites this paper
• Ionic liquids as refolding additives: variation of the anion.

  2010cites this paper
• Expression of Complete Antibodies in Transgenic Plants

  2010cites this paper
• Abscisic acid deficiency of developing pea embryos achieved by immunomodulation attenuates developmental phase transition and storage metabolism.

  2010cites this paper
• Correct targeting of proinsulin in protein storage vacuoles of transgenic soybean seeds.

  2010cites this paper
• Investigation of insecticidal activity of rye α-amylase inhibitor gene expressed in transgenic tobacco (Nicotiana tabacum) toward cotton boll weevil (Anthonomus grandis)

  2010cites this paper
• Short communication Correct targeting of proinsulin in protein storage vacuoles of transgenic soybean seeds

  2010cites this paper
• Production and characterization of soluble human lysosomal enzyme α-iduronidase with high activity from culture media of transgenic tobacco BY-2 cells

  2009cites this paper
• Antibody expressing pea seeds as fodder for prevention of gastrointestinal parasitic infections in chickens

  2009cites this paper
• Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody.

  2009cites this paper
• Production systems for recombinant antibodies.

  2008cites this paper
• Recombinant DNA methods applied to the production of protein-based fibers as biomaterials

  2008cites this paper
• Sustained Expression of Human Cytomegalovirus Glycoprotein B (UL55) in the Seeds of Homozygous Rice Plants

  2008cites this paper
• Preventing unintended proteolysis in plant protein biofactories

  2008cites this paper
• Applications of Biotechnology in Agriculture: The Prospects

  2008cites this paper
• In vitro-refolding of a single-chain Fv fragment in the presence of heteroaromatic thiols.

  2008cites this paper
• Agrobacterium-mediated genetic transformation of embryogenic cell suspension cultures of Santalum album L.

  2008cites this paper
• Preparing recombinant single chain antibodies

  2008cites this paper
• Proteome rebalancing in soybean seeds can be exploited to enhance foreign protein accumulation.

  2008cites this paper
• Lipid fatty acid composition of potato plants transformed with the Δ12-desaturase gene from cyanobacterium

  2007cites this paper
• Taraxacum officinale as an expression system for recombinant proteins : molecular cloning and functional analysis of the genes encoding the major latex proteins

  2007cites this paper
• Plant Molecular Farming: Host Systems, Technology and Products

  2007cites this paper
• Production of vaccines and therapeutic antibodies for veterinary applications in transgenic plants: an overview

  2007cites this paper
• Immunomodulation of jasmonate to manipulate the wound response.

  2007cites this paper
• Single-chain Fv Antibody Stimulates Biosynthesis of Secondary Metabolites in Plants

  2007cites this paper
• Forcing single-chain variable fragment production in tobacco seeds by fusion to elastin-like polypeptides.

  2006cites this paper
• Ionic liquids as refolding additives: N′‐alkyl and N′‐(ω‐hydroxyalkyl) N‐methylimidazolium chlorides

  2005influential citation
• Ionic liquids as refolding additives: N'-alkyl and N'-(omega-hydroxyalkyl) N-methylimidazolium chlorides.

  2005cites this paper
• Expression and characterisation of biopharmaceuticals in heterologous expression systems

  2005cites this paper
• Expression of dsRNA-specific monoclonal antibodies in transgenic plants

  2005cites this paper
• An integral approach towards a practical application for a plant-made monoclonal antibody in vaccine purification.

  2005cites this paper
• Biosynthesis of Very-Long-Chain Polyunsaturated Fatty Acids in Transgenic Oilseeds: Constraints on Their Accumulationw⃞

  2004cites this paper
• Transgenic plants as bioreactors

  2004cites this paper
• Appropriate glycosylation of recombinant proteins for human use

  2004cites this paper
• Expression of active human epidermal growth factor (hEGF) in tobacco plants by integrative and non-integrative systems

  2004cites this paper
• Seed-specific promoters direct gene expression in non-seed tissue.

  2004cites this paper
• Rice cell culture as an alternative production system for functional diagnostic and therapeutic antibodies

  2004cites this paper
• Analysis of Transgenic Tobacco Plants Carrying the Gene for the Surface Antigen of the Hepatitis B Virus

  2004cites this paper
• Considerations for the Recovery of Recombinant Proteins from Plants

  2004cites this paper
• Molecular farming of pharmaceutical proteins

  2004cites this paper
• Seed-specific promoters direct gene expression in

  2004cites this paper
• Expression and long-term stability of a recombinant single-chain Fv antibody fragment in transgenic Nicotiana tabacum seeds

  2004influential citation
• Biotechnology: Production of Proteins for Biopharmaceutical and Industrial Uses in Transgenic Plants

  2004cites this paper
• Antibody molecular farming in plants and plant cells

  2004cites this paper
• Pflanzenzellen als Produktionssystem zur Gewinnung von Interleukin-4 Doppelmutein (IL-4 DM)

  2004cites this paper
• The plant vesicular transport engineering for production of useful recombinant proteins

  2004cites this paper
• Benefits and risks of antibody and vaccine production in transgenic plants.

  2003cites this paper
• Spider Silk Proteins from Transgenic Plants

  2003cites this paper
• Construction of Synthetic Genes for Analogs of Spider Silk Spidroin 1 and Their Expression in Tobacco Plants

  2003influential citation
• Evaluation of putative seed-specific promoters for Linum usitatissimum

  2003cites this paper
• Production of tumor-specific antibodies in tobacco.

  2003cites this paper
• Anti-solasodine glycoside single-chain Fv antibody stimulates biosynthesis of solasodine glycoside in plants

  2003cites this paper
• The assembly and potential applications of immunoglobulins expressed in transgenic plants.

  2003cites this paper