The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Developmental Neurobiology

• Publication date

  2010-04-01

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1002/dneu.20758PMID 20186711
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity

  2010cited by this paper
• emodeling of Hippocampal Spine Synapses in the Rat earned Helplessness Model of Depression

  2009influential reference
• Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia.

  2009cited by this paper
• Pro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses

  2009cited by this paper
• Amitriptyline is a TrkA and TrkB receptor agonist that promotes TrkA/TrkB heterodimerization and has potent neurotrophic activity.

  2009cited by this paper
• Psychobiology and molecular genetics of resilience

  2009cited by this paper
• Chronic fluoxetine treatment increases expression of synaptic proteins in the hippocampus of the ovariectomized rat: role of BDNF signalling.

  2009influential reference
• Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.

  2009influential reference
• Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response.

  2009cited by this paper
• Neuronal release of proBDNF

  2009cited by this paper
• Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

  2009cited by this paper
• TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment.

  2008cited by this paper
• Changes in rat hippocampal CA1 synapses following imipramine treatment

  2008cited by this paper
• The molecular neurobiology of depression

  2008cited by this paper
• Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

  2008cited by this paper
• The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex

  2008influential reference
• Decreased levels of serum brain-derived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders.

  2008cited by this paper
• A Model for Neuronal Competition During Development

  2008cited by this paper
• Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications.

  2008cited by this paper
• Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect

  2008cited by this paper
• Dopamine D1 Receptor-induced Signaling through TrkB Receptors in Striatal Neurons*

  2008cited by this paper
• Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior

  2008cited by this paper
• Role of neurotrophic factors in depression.

  2007influential reference
• Pharmacologically Diverse Antidepressants Rapidly Activate Brain-Derived Neurotrophic Factor Receptor TrkB and Induce Phospholipase-Cγ Signaling Pathways in Mouse Brain

  2007cited by this paper
• Circuit-breakers: optical technologies for probing neural signals and systems

  2007cited by this paper
• Submandibular Glands Contribute to Increases in Plasma BDNF Levels

  2007cited by this paper
• New insights into BDNF function in depression and anxiety

  2007influential reference
• Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.

  2007cited by this paper
• Is it time to reassess the BDNF hypothesis of depression?

  2007cited by this paper
• Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors.

  2007cited by this paper
• Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system

  2007cited by this paper
• High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression

  2007cited by this paper
• Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system

  2007cited by this paper
• A neurotrophic model for stress-related mood disorders.

  2006influential reference
• Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment

  2006cited by this paper
• Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress

  2006cited by this paper
• Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions.

  2006cited by this paper
• Electroconvulsive Seizure Treatment Increases Cell Proliferation in Rat Frontal Cortex

  2005cited by this paper
• Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease

  2005cited by this paper
• Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain Monoamines

  2005cited by this paper
• Critical period plasticity in local cortical circuits

  2005cited by this paper
• Short‐term treatment with the antidepressant fluoxetine triggers pyramidal dendritic spine synapse formation in rat hippocampus

  2005influential reference
• Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus

  2005cited by this paper
• The yin and yang of neurotrophin action

  2005influential reference
• The p75 Neurotrophin Receptor Negatively Modulates Dendrite Complexity and Spine Density in Hippocampal Neurons

  2005cited by this paper
• Activation of p75NTR by proBDNF facilitates hippocampal long-term depression

  2005cited by this paper
• Is mood chemistry?

  2005influential reference
• Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance

  2005cited by this paper
• Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.

  2005cited by this paper
• Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity.

  2005influential reference
• Neurotrophic effects of antidepressant drugs.

  2004cited by this paper
• Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury.

  2004cited by this paper
• From monoamines to genomic targets: a paradigm shift for drug discovery in depression

  2004influential reference
• Essential role of brain-derived neurotrophic factor in adult hippocampal function.

  2004cited by this paper
• Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects

  2003cited by this paper
• Molecular basis of plasticity in the visual cortex.

  2003cited by this paper
• Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.

  2003cited by this paper
• Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

  2003cited by this paper
• Bi-phasic change in BDNF gene expression following antidepressant drug treatment.

  2003cited by this paper
• Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

  2002cited by this paper
• Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus

  2002cited by this paper
• Distinctive features of Trk neurotrophin receptor transactivation by G protein-coupled receptors.

  2002cited by this paper
• High-Speed Imaging Reveals Neurophysiological Links to Behavior in an Animal Model of Depression

  2002cited by this paper
• Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation

  2002cited by this paper
• Activation of Trk Neurotrophin Receptor Signaling by Pituitary Adenylate Cyclase-activating Polypeptides*

  2002cited by this paper
• Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor.

  2002cited by this paper
• The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study.

  2002cited by this paper
• Regulation of Cell Survival by Secreted Proneurotrophins

  2001influential reference
• Neurotrophins: roles in neuronal development and function.

  2001cited by this paper
• Immobilization Stress Rapidly and Differentially Modulates BDNF and TrkB mRNA Expression in the Pituitary Gland of Adult Male Rats

  2001cited by this paper
• Activation of Trk neurotrophin receptors in the absence of neurotrophins

  2001cited by this paper
• Increased neurogenesis in a model of electroconvulsive therapy.

  2000cited by this paper
• Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

  2000cited by this paper
• A comparison of nefazodone, the cognitive behavioral-analysis system of psychotherapy, and their combination for the treatment of chronic depression.

  2000cited by this paper
• Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression

  1999cited by this paper
• Molecular and Cellular Actions of Chronic Electroconvulsive Seizures

  1998cited by this paper
• Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration.

  1998cited by this paper
• A molecular and cellular theory of depression.

  1997cited by this paper
• Protein-coupled Receptors

  1996cited by this paper
• BDNF increases monoaminergic activity in rat brain following intracerebroventricular or intraparenchymal administration.

  1996cited by this paper
• Synaptic Activity and the Construction of Cortical Circuits

  1996cited by this paper
• Neurotrophins and Neuronal Plasticity

  1995cited by this paper
• Stress increases brain-derived neurotropic factor messenger ribonucleic acid in the hypothalamus and pituitary.

  1995cited by this paper
• Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

  1995influential reference
• Neurotrophins and their receptors in the rat pituitary gland: regulation of BDNF and trkB mRNA levels by adrenal hormones.

  1994cited by this paper
• Plasticity of ocular dominance columns in monkey striate cortex.

  1977cited by this paper
• Decreased uptake of 5-hydroxytryptamine in blood platelets from depressed patients

  1976cited by this paper
• Effects of monocular deprivation in kittens

  1964cited by this paper

• Underlying Mechanisms of the Treatment Efficacy of ( R, S )‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

  2026cites this paper
• BDNF Val66Met Variant as a Genetic Risk Factor for Major Depressive Disorder in Saudis

  2026cites this paper
• Antidepressant exploration of moxidectin: Effects on behavior, neurotrophic factors and oxidative stress biomarkers in mice

  2026cites this paper
• Puerarin's multidimensional antidepressant action: decoding the gut-liver-brain axis through gut microbiota, hepatic homeostasis, and neuroimmune regulation.

  2026cites this paper
• The synaptic triad in depression: how stress-related pathways converge on BDNF, NMDA receptor, and MMP-9.

  2026cites this paper
• From synapse to system: mechanistic pathways of neural signaling dysfunction in psychiatric disorders.

  2026cites this paper
• Studying the Stress, Gene Expression, and Behavioral Changes Induced by Diazepam and Sertraline in a Zebrafish Model.

  2026cites this paper
• The associations between sedentary behavior and risk of depression: a systematic review and dose response meta-analysis

  2025cites this paper
• Myelin Repair as a Novel Mechanism for Ketamine’s Sustained Antidepressant Effects

  2025cites this paper
• Discovery of Rapid-Acting, Orally Available Antidepressants by Activating TrkB Signaling.

  2025cites this paper
• From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation

  2025cites this paper
• Neuroanatomical and Functional Correlates in Depressive Spectrum: A Narrative Review

  2025cites this paper
• Decoding serotonin: the molecular symphony behind depression

  2025cites this paper
• Patofisiologi Biomedik Depresi: Tinjauan Komprehensif terhadap Mekanisme Neurobiologis

  2025cites this paper
• Ecdysterone and High-Intensity Interval Training Mitigate Alzheimer’s Pathology in Rats: Impacts on Depression, Synaptic Plasticity, and Neuroinflammation

  2025cites this paper
• BDNF Signaling and Pain Modulation

  2025cites this paper
• Molecular genetic basis of the primary emotions in young adults: an exploratory analysis of genetic polymorphisms across dopamine, serotonin, oxytocin, endogenous opioid, and neurotrophic factor pathways

  2025cites this paper
• Identifying behavior regulatory leverage over mental disorders transcriptomic network hubs toward lifestyle-dependent psychiatric drugs repurposing

  2025cites this paper
• A Comprehensive Overview of Stress, Resilience, and Neuroplasticity Mechanisms

  2025cites this paper
• Advances in Gut Microbiome and Metabolomics Research in the Comorbidity of Inflammatory Bowel Disease and Depressive Disorder

  2025cites this paper
• LSD: Mechanisms and Relevance to the Treatment of Depression.

  2025cites this paper
• Evaluation of proliferative activity of the dipeptide mimetics of the 1st, 2nd and 4th loops of the brain-derived neurotrophic factor in vitro

  2025cites this paper
• Pemafibrate treatment produces antidepressant-like effects in CUMS and CRS models through activation of hippocampal PPARα and BDNF signaling

  2025cites this paper
• Exercise improves pulmonary fibrosis and neurological symptoms via S100A12 inhibition

  2025cites this paper
• No changes in plasma brain-derived neurotrophic factor levels in treatment-resistant depression patients who underwent convulsive therapy

  2025cites this paper
• Extracellular vesicles derived from mesenchymal stem cells alleviate depressive-like behavior in a rat model of chronic stress.

  2025cites this paper
• Spirostanol‐Type Saponins From Allium Macrostemonis Bulbus Alleviate Chronic Unpredictable Mild Stress–Induced Depression‐Like Behavior in Mice

  2025cites this paper
• The Modulatory Effects of Fecal Microbiota Transplantation on the Intestinal Epithelial Barrier in Experimental Colitis Mice with Comorbid Depressive-like Behaviors

  2025cites this paper
• Predicted plasma proteomics from genetic scores and treatment outcomes in major depression: a meta-analysis.

  2025cites this paper
• Decoding Depression: Insights into Molecular Biomarkers and Neuroimaging of Depression

  2025cites this paper
• Impact of Sleep Deprivation on the Central Nervous System Neurotransmitters and Immune Function in Male Albino Rats

  2025cites this paper
• New perspectives on galectin in major depressive disorder treatment.

  2025cites this paper
• 7-Tesla ultra-high field MRI of the parahippocampal cortex reveals evidence of common neurobiological mechanisms of major depressive disorder and neurotic personality traits

  2025cites this paper
• Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy

  2025cites this paper
• Association of the neutrophil-to-platelet ratio with response to electroconvulsive therapy in adolescents with major depressive disorder

  2024cites this paper
• Depression unveiled: Insights into etiology and animal models for behavioral assessment, exploring the multifactorial nature and treatment of depression.

  2024cites this paper
• Effects and mechanisms of Apelin in treating central nervous system diseases.

  2024cites this paper
• Elucidating the bidirectional association between autoimmune diseases and depression: a systematic review and meta-analysis

  2024cites this paper
• Impact of postpartum physical activity on maternal depression and anxiety: a systematic review and meta-analysis

  2024cites this paper
• Psychopharmacological Approaches for Neural Plasticity and Neurogenesis in Major Depressive Disorders.

  2024cites this paper
• Stress-Related Roles of Exosomes and Exosomal miRNAs in Common Neuropsychiatric Disorders

  2024cites this paper
• Study on the Association between Coronary Heart Disease Combined with Depression Patients Brain-Derived Neurotrophic Factor and Coronary Artery Lesions

  2024cites this paper
• Therapeutic potential of Erxian decoction and its special chemical markers in depression: a review of clinical and preclinical studies

  2024cites this paper
• The Compelling Role of Brain‐Derived Neurotrophic Factor Signaling in Multiple Sclerosis: Role of BDNF Activators

  2024cites this paper
• Effectiveness of non-pharmacological therapies for treating post-stroke depression: A systematic review and network meta-analysis.

  2024cites this paper
• A New Augmentation Strategy against Depression Combining SSRIs and the N-terminal Fragment of Galanin (1-15)

  2024cites this paper
• Antidepressant effect of PT-31, an α₂-adrenoceptor agonist, on lipopolysaccharide-induced depressive-like behavior in mice

  2024cites this paper
• Vilazodone Alleviates Neurogenesis-Induced Anxiety in the Chronic Unpredictable Mild Stress Female Rat Model: Role of Wnt/β-Catenin Signaling

  2024cites this paper
• Curcumin in Alzheimer’s Disease and Depression: Therapeutic Potential and Mechanisms of Action

  2024cites this paper
• BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis.

  2024cites this paper
• Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats

  2024cites this paper
• Treatment of catatonia using ketamine in a patient with physical comorbidities.

  2024cites this paper
• Methylone is a rapid-acting neuroplastogen with less off-target activity than MDMA

  2024cites this paper
• An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders.

  2024cites this paper
• Participation of Ca2+-Calmodulin–Dependent Protein Kinase II in the Antidepressant-Like Effects of Melatonin

  2024cites this paper
• Evidence for the Contribution of the miR-206/BDNF Pathway in the Pathophysiology of Depression

  2024cites this paper
• MiR-184-3p in the paraventricular nucleus participates in the neurobiology of depression via regulation of the hypothalamus-pituitary-adrenal axis.

  2024cites this paper
• Pharmacogenetic Testing to Optimise Antidepressant Treatment in Children and Adolescents: A Narrative Review

  2024cites this paper
• Connecting the Emotional-Cognitive Puzzle: The Role of Tyrosine Kinase (TrkB) Receptor Isoform Imbalance in Age-Related Emotional and Cognitive impairments.

  2024cites this paper
• The multifaceted effects of fluoxetine treatment on cognitive functions

  2024cites this paper
• Unveiling behavioral and molecular neuroadaptations related to the antidepressant action of cannabidiol in the unpredictable chronic mild stress model

  2023cites this paper
• A comprehensive review and meta-analysis of neurological side effects related to second-generation antidepressants in individuals with major depressive disorder.

  2023cites this paper
• Transplanted Autologous Neural Stem Cells Show Promise in Restoring Motor Function in Monkey Spinal Cord Injury

  2023cites this paper
• Gut microbiota from sigma-1 receptor knockout mice induces depression-like behaviors and modulates the cAMP/CREB/BDNF signaling pathway

  2023cites this paper
• MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

  2023cites this paper
• The Impact of BDNF, NTRK2, NGFR, CREB1, GSK3B, AKT, MAPK1, MTOR, PTEN, ARC, and SYN1 Genetic Polymorphisms in Antidepressant Treatment Response Phenotypes

  2023cites this paper
• Exercise-induced Brain-derived neurotrophic factor regulation in the brain dysfunctions

  2023cites this paper
• Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1/M2 polarization and JAK1/STAT3 pathway

  2023cites this paper
• Heterogeneity in major depressive disorder: The need for biomarker-based personalized treatments.

  2023cites this paper
• AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models

  2023cites this paper
• Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

  2023cites this paper
• Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis

  2023cites this paper
• Irisin at the Crossroad of Autophagy and BNDF Signaling for Neuroplasticity Regulation

  2023cites this paper
• Immune mechanisms of depression in rheumatoid arthritis

  2023cites this paper
• Association of BDNF risk variant and dorsolateral cortical thickness with long‐term treatment response to valproate in type I bipolar disorder: An exploratory study

  2023cites this paper
• The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy

  2023cites this paper
• Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a Diisopropyl Fluorophosphate–Based Rat Model of Gulf War Illness

  2023cites this paper
• Cortical Plasticity under Ketamine: From Synapse to Map

  2023cites this paper
• Physical activity, physical frailty and depressive symptoms among Chinese male and female older adults: do different indicators make a difference?

  2023cites this paper
• Antidepressant mechanisms of ketamine: a review of actions with relevance to treatment-resistance and neuroprogression

  2023cites this paper
• Effects of Antidepressant Medication on Brain-derived Neurotrophic Factor Concentration and Neuroplasticity in Depression: A Review of Preclinical and Clinical Studies

  2023cites this paper
• Forced Swimming-Induced Depressive-like Behavior and Anxiety Are Reduced by Chlorpheniramine via Suppression of Oxidative and Inflammatory Mediators and Activating the Nrf2-BDNF Signaling Pathway

  2023cites this paper
• A review of new insights into existing major depressive disorder biomarkers

  2023cites this paper
• Effects of Two Environmental Enrichment Methods on Cognitive Ability and Growth Performance of Juvenile Black Rockfish Sebastes schlegelii

  2023influential citation
• Regulatory Molecules of Synaptic Plasticity in Anxiety Disorder

  2023cites this paper
• Irisin at the Croasroad of Autophagy and BNDF Signaling for Neuroplasticity Regulation

  2023cites this paper
• Utility of pharmacogenetic testing to optimise antidepressant pharmacotherapy in youth: a narrative literature review

  2023cites this paper
• Stress-induced alterations in hippocampal BDNF in the pathophysiology of Major Depressive Disorder and the antidepressant effect of saffron.

  2023cites this paper
• Biological Diagnosis of Depression: A Biomarker Panel from Several Nonspecial Indicators Instead of the Specific Biomarker(s)

  2022cites this paper
• Methanolic Extract of Aerva javanica Leaves Prevents LPS-Induced Depressive Like Behavior in Experimental Mice

  2022cites this paper
• RECORDS OF PHARMACEUTICAL AND BIOMEDICAL SCIENCES Brain Derived Neurotrophic Factor has A Role in the Antidepressant Effect of Atorvastatin and Fenofibrate in Wistar Rats

  2022cites this paper
• A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms

  2022influential citation
• Correlating electroconvulsive therapy response to electroencephalographic markers: Study protocol

  2022cites this paper
• Evaluation of DNA methylation in BDNF, SLC6A4, NR3C1 and FKBP5 before and after treatment with selective serotonin-reuptake inhibitor in major depressive disorder.

  2022cites this paper
• Enhanced social reward response and anxiety-like behavior with downregulation of nucleus accumbens glucocorticoid receptor in BALB/c mice

  2022influential citation
• Brain-Derived Neurotrophic Factor: A Novel Dynamically Regulated Therapeutic Modulator in Neurological Disorders

  2022cites this paper
• A Bibliometric Analysis of Research on the Role of BDNF in Depression and Treatment

  2022cites this paper
• Long-term depressive symptoms and midlife brain age.

  2022cites this paper
• Molecular targets of endothelial phosphatidic acid regulating major depressive disorder

  2022cites this paper
• Boophone disticha attenuates five day repeated forced swim-induced stress and adult hippocampal neurogenesis impairment in male Balb/c mice

  2022cites this paper