Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Science

• Publication date

  1994-04-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1126/SCIENCE.8171325PMID 8171325PMCID PMC3839659
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mouse chromosome 5

  2004cited by this paper
• Circadian clock phenotypes of chromosome aberrations with a breakpoint at the per locus

  2004cited by this paper
• A Macintosh program for storage and analysis of experimental genetic mapping data

  2004cited by this paper
• Negative feedback defining a circadian clock: autoregulation of the clock gene frequency.

  1994cited by this paper
• Phase shifting of the circadian clock by induction of the Drosophila period protein.

  1994cited by this paper
• Circadian rhythms.

  1994cited by this paper
• Suprachiasmatic nucleus: the mind's clock

  1993cited by this paper
• Genetic maps.

  1993cited by this paper
• Circadian-clock regulation of gene expression.

  1993cited by this paper
• Phase Control of Ultradian Feeding Rhythms in the Common Vole ( Microtus arvalis): The Roles of Light and the Circadian System

  1993cited by this paper
• Genetic analysis of circadian clocks.

  1993cited by this paper
• Circadian rhythm in membrane conductance expressed in isolated neurons.

  1993cited by this paper
• A genetic linkage map of the mouse: current applications and future prospects.

  1993cited by this paper
• Positional cloning: Let's not call it reverse anymore

  1992cited by this paper
• A genetic map of the mouse suitable for typing intraspecific crosses.

  1992cited by this paper
• Circadian clock genes are ticking.

  1992cited by this paper
• Circadian oscillations in period gene mRNA levels are transcriptionally regulated.

  1992cited by this paper
• Reassessment of the effect of biological rhythm mutations on learning in Drosophila melanogaster

  1991cited by this paper
• Chemical mutagenesis and fine-structure functional analysis of the mouse genome.

  1991cited by this paper
• Circadian rhythms: from gene expression to behavior.

  1991cited by this paper
• Lesions of the suprachiasmatic nucleus disrupt circadian locomotor rhythms in the mouse.

  1991cited by this paper
• Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains

  1990cited by this paper
• Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels

  1990cited by this paper
• Differential Elimination of Circadian and Ultradian Rhythmicity by Hypothalamic Lesions in the Common Vole, Microtus arvalis

  1990cited by this paper
• Genetics of circadian rhythms.

  1990cited by this paper
• The avian pineal, a vertebrate model system of the circadian oscillator: cellular regulation of circadian rhythms by light, second messengers, and macromolecular synthesis.

  1989cited by this paper
• The molecular biology of circadian rhythms.

  1989cited by this paper
• Circadian period in mice: Analysis of genetic and maternal contributions to inbred strain differences

  1988cited by this paper
• A mutation of the circadian system in golden hamsters.

  1988cited by this paper
• Further Evidence that the Circadian Clock in Drosophila is a Population of Coupled Ultradian Oscillators

  1987cited by this paper
• MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations.

  1987cited by this paper
• Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock

  1987cited by this paper
• Induction of recessive lethal mutations in the T/t-H-2 region of the mouse genome by a point mutagen.

  1986cited by this paper
• Analysis of Human Genetic Linkage

  1985cited by this paper
• Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia.

  1985cited by this paper
• Gene differences modify Aschoff's rule in mice.

  1982cited by this paper
• Development of the mouse circadian pacemaker: Independence from environmental cycles

  1981cited by this paper
• A fine-grained anatomical analysis of the role of the rat suprachiasmatic nucleus in circadian rhythms of feeding and drinking.

  1979cited by this paper
• Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.

  1979cited by this paper
• The chi square periodogram: its utility for analysis of circadian rhythms.

  1978cited by this paper
• Strain differences of the mouse's free-running circadian rhythm in continuous darkness.

  1978cited by this paper
• Analysis of sleep-wakefulness rhythms in male rats after suprachiasmatic nucleus lesions and ocular enucleation.

  1977cited by this paper
• Abnormal development of the suprachiasmatic nuclei of the hypothalamus in a strain of genetically anophthalmic mice

  1977cited by this paper
• Stochastic principles in the temporal control of activity behaviour.

  1977cited by this paper
• Exogenous and endogenous components in circadian rhythms.

  1960cited by this paper

• Non-visual opsins and their role in circadian photoentrainment

  2026cites this paper
• GenAI-Net: A Generative AI Framework for Automated Biomolecular Network Design

  2026cites this paper
• Population Genomics of Incipient Allochronic Divergence in the Pine Processionary Moth

  2025cites this paper
• Harnessing the circadian nature of the choroid plexus and cerebrospinal fluid

  2025cites this paper
• Targeting the central and peripheral nervous system to regulate bone homeostasis: mechanisms and potential therapies

  2025cites this paper
• Development of a circadian-related prognostic signature highlights RBM17 as a stemness regulator in liver cancer

  2025cites this paper
• Macrophages promote collagen deposition through circadian regulation of fibroblasts

  2025cites this paper
• Progress in understanding how clock genes regulate aging and associated metabolic processes

  2025cites this paper
• Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time

  2025cites this paper
• Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons

  2025cites this paper
• Identity-stable multi-animal tracking using bidirectional segmentation with object-level memory

  2025cites this paper
• Designing and Evaluating Circadian Experiments on Mouse Skin.

  2025cites this paper
• Role of circadian CLOCK signaling in cellular senescence

  2025cites this paper
• The ubiquitin-proteasome system in circadian regulation

  2025cites this paper
• Melatonin Supplementation in Alzheimer’s disease: The Potential Role in Neurogenesis

  2025cites this paper
• Noncanonical clock regulators control stress responses in digestive diseases.

  2025cites this paper
• Evolving perspectives on the molecular and neural foundations of mammalian circadian rhythms.

  2025cites this paper
• Spatiotemporal Circadian Oscillator Manipulation for Enhanced Ovarian Cancer Therapy Using a Versatile Nanoplatform.

  2025cites this paper
• Circadian Biology in Parasites: Beyond Known Mechanisms

  2025cites this paper
• Changes in Mitochondrial Transcriptional Rhythms and Depression-like Behavior in the Hippocampus of IL-33-Overexpressing Mice

  2025cites this paper
• Clock Gene Expression Modulation by Low- and High-Intensity Exercise Regimens in Aging Mice

  2025cites this paper
• The redox rhythm gates immune-induced cell death distinctly from the genetic clock

  2025cites this paper
• Mood variation under dual regulation of circadian clock and light

  2025cites this paper
• Forecasting the course of bipolar disorder using rest-activity rhythms: Protocol for a multi-study modelling project

  2025cites this paper
• DNA methylation of core clock genes in patients with major depressive disorder: Association with air pollution exposure and disease severity.

  2025cites this paper
• Evolution of canonical circadian clock genes underlies unique sleep strategies of marine mammals for secondary aquatic adaptation

  2025cites this paper
• Evaluation of the Digital Ventilated Cage® system for circadian phenotyping

  2025cites this paper
• The metabolic significance of peripheral tissue clocks

  2025cites this paper
• The P-loop NTPase RUVBL2 is a conserved clock component across eukaryotes

  2025cites this paper
• Investigating the Aggregation and Prionogenic Properties of Human Cancer-Related Proteins

  2025cites this paper
• The research progress and prospects of circadian rhythm in obesity: a bibliometric analysis

  2025cites this paper
• The circadian clock at the intersection of metabolism and aging - emerging roles of metabolites.

  2025cites this paper
• Neuroendocrine transcriptomics in Eriocheir sinensis: Photoperiod-induced modulation of gonadal development and circadian clock genes in neural tissues.

  2025cites this paper
• A consensus guide to preclinical indirect calorimetry experiments

  2025cites this paper
• Genetic mapping identifies Homer1 as a developmental modifier of attention.

  2025cites this paper
• TRITHORAX and HSP68 Regulate Clock Gene Transcription in the Drosophila Transcriptional Feedback Loop

  2025cites this paper
• Phylogeny of Core Molecular Components of Metazoan Circadian Clocks

  2025cites this paper
• Functional Suppression of CLOCK Activity in Ventromedial Hypothalamic Prodynorphin Neurons Alters Locomotor Activity and Rapid Eye Movement Sleep

  2025cites this paper
• The role and implications of mammalian cellular circadian entrainment.

  2025cites this paper
• Daily liver rhythms: Coupling morphological and molecular oscillations.

  2025cites this paper
• Hippocampal transcriptome analysis in ClockΔ19 mice identifies pathways associated with glial cell differentiation and myelination.

  2025cites this paper
• Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?

  2025cites this paper
• Nurse night shift work and risk of gastrointestinal cancers

  2025cites this paper
• Tonic Dopamine Sensing Reveals a D2/D3 Mediated Dopamine Response to Raclopride in ClockΔ19 Mice Model

  2025cites this paper
• Research progress on the mechanism of tryptophan metabolism regulating circadian rhythm

  2025cites this paper
• The SnackerTracker: A novel home-cage monitoring device for measuring food-intake and food-seeking behaviour in mice

  2025cites this paper
• Circadian rhythm homeostasis biomarkers: current landscape and emerging frontiers

  2025cites this paper
• Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cells

  2025cites this paper
• Misalignment of Circadian Rhythms in Diet-Induced Obesity.

  2024cites this paper
• Systematized Serendipity: Fishing Expeditions for Anesthetic Drugs and Targets.

  2024cites this paper
• Circadian disruption in cancer hallmarks: novel insight into the molecular mechanisms of tumorigenesis and cancer treatment.

  2024cites this paper
• A circadian clock regulates the blood-brain barrier across phylogeny.

  2024cites this paper
• Defining the brain control of physiological stability.

  2024cites this paper
• Circadian Rhythms in Anticancer Immunity: Mechanisms and Treatment Opportunities.

  2024cites this paper
• Circadian rhythms in cardiovascular (dys)function: approaches for future therapeutics

  2024cites this paper
• On knowing a gene: A distributional hypothesis of gene function.

  2024cites this paper
• Circadian rhythm and host genetics.

  2024cites this paper
• CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues

  2024cites this paper
• Diverse genetic alteration dysregulates neuropeptide and intracellular signalling in the suprachiasmatic nuclei

  2024cites this paper
• The circadian rhythm as therapeutic target in inflammatory bowel disease

  2024cites this paper
• Adaptive Differences in Cellular and Behavioral Responses to Circadian Disruption between C57BL/6 and BALB/c Strains

  2024cites this paper
• Knockdown of the Clock gene in the liver aggravates MASLD in mice via inhibiting lipophagy

  2024cites this paper
• The environment and the internal clocks: The study of their relationships from prehistoric to modern times

  2024cites this paper
• Biological clock regulation by the PER gene family: a new perspective on tumor development

  2024cites this paper
• Human and animal cells under influence of different lighting and stimulus

  2024cites this paper
• Circadian Clock and Hypoxia.

  2024cites this paper
• Effects of sleep deprivation on anxiety-depressive-like behavior and neuroinflammation.

  2024cites this paper
• Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure

  2024cites this paper
• Re-scoping ultradian rhythms in the context of metabolism

  2024cites this paper
• Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats

  2024cites this paper
• Dietary restriction modulates ultradian rhythms and autocorrelation properties in mice behavior

  2024cites this paper
• Sleep disturbances and female infertility: a systematic review

  2024cites this paper
• The Anti-Elixir Triad: Non-Synced Circadian Rhythm, Gut Dysbiosis, and Telomeric Damage

  2024cites this paper
• Circadian Rhythm Genes and Sleep Disorders in an Open Population of Men Aged 25–64 Years (an Epidemiological Study under the WHO MONICA-Psychosocial Program)

  2024cites this paper
• Impacts of circadian disruptions on behavioral rhythms in mice

  2024cites this paper
• The suprachiasmatic nucleus at 50: looking back, then looking forward

  2024cites this paper
• Cell-specific regulation of the circadian clock by BMAL1 in the paraventricular nucleus: Implications for regulation of systemic biological rhythms

  2024cites this paper
• The intertwined relationship between circadian dysfunction and Parkinson's disease.

  2024cites this paper
• Lipid mediators in neutrophil biology: inflammation, resolution and beyond

  2024cites this paper
• The Function, Regulation, and Mechanism of Protein Turnover in Circadian Systems in Neurospora and Other Species

  2024cites this paper
• Basic research and opportunities for translational advancement in the field of mammalian ∼12-hour ultradian chronobiology

  2024cites this paper
• The Past and Future of Sleep Medicine.

  2024cites this paper
• Prognosis and diagnosis prediction of lung adenocarcinoma outcome based on a novel model anchored in circadian clock‐related genes

  2024cites this paper
• Brain-wide functional imaging to highlight differences between the diurnal and nocturnal neuronal activity in zebrafish larvae

  2023cites this paper
• Circadian redox rhythm gates immune-induced cell death distinctly from the genetic clock

  2023cites this paper
• Mitochondrial function and E2 synthesis are impaired following alteration of CLOCK gene expression in porcine ovarian granulosa cells.

  2023cites this paper
• The circadian neutrophil, inside-out.

  2023cites this paper
• Interactions of circadian clock genes with the hallmarks of cancer.

  2023cites this paper
• Uncovering the function of the evolutionary conserved Clock gene in the sea anemone Nematostella vectensis

  2023cites this paper
• The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship

  2023cites this paper
• Mmp14 is required for matrisome homeostasis and circadian rhythm in fibroblasts

  2023cites this paper
• Effect of Circadian Rhythm Disturbance on the Human Musculoskeletal System and the Importance of Nutritional Strategies

  2023cites this paper
• Bipolar Chronobiology in Men and Mice: A Narrative Review

  2023cites this paper
• Co‐expression of diurnal and ultradian rhythms in the plasma metabolome of common voles (Microtus arvalis)

  2023cites this paper
• CLOCK evolved in cnidaria to synchronize internal rhythms with circadian environmental cues

  2023cites this paper
• Chronopharmacology of diuresis via metabolic profiling and key biomarker discovery of the traditional Chinese prescription Ji-Ming-San using tandem mass spectrometry in rat models.

  2023cites this paper
• Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism—A Narrative Review

  2023cites this paper
• From Chronodisruption to Sarcopenia: The Therapeutic Potential of Melatonin

  2023cites this paper
• A genome‐wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock

  2023cites this paper
• Microfluidic models of the neurovascular unit: a translational view

  2023cites this paper