The anaphase promoting complex/cyclosome: a machine designed to destroy

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2006-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/nrm1988PMID 16896351
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

  2006cited by this paper
• Mammalian Emi2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc20

  2006cited by this paper
• The processivity of multiubiquitination by the APC determines the order of substrate degradation.

  2006cited by this paper
• Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding

  2006cited by this paper
• An architectural map of the anaphase-promoting complex.

  2006cited by this paper
• CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit.

  2006cited by this paper
• Mammalian Emi 2 mediates cytostatic arrest and transduces the signal for meiotic exit via Cdc 20

  2006cited by this paper
• Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation.

  2005cited by this paper
• Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20

  2005cited by this paper
• Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box.

  2005cited by this paper
• Short Article Mutual Inhibition of Separase and Cdk1 by Two-Step Complex Formation

  2005cited by this paper
• Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.

  2005cited by this paper
• Involvement of the SCF Complex in the Control of Cdh1 Degradation in S-phase

  2005cited by this paper
• The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1.

  2005cited by this paper
• The WD40 propeller domain of Cdh1 functions as a destruction box receptor for APC/C substrates.

  2005cited by this paper
• The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint.

  2005cited by this paper
• A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs.

  2005cited by this paper
• Function and regulation of cullin–RING ubiquitin ligases

  2005cited by this paper
• Coactivator functions in a stoichiometric complex with anaphase‐promoting complex/cyclosome to mediate substrate recognition

  2005cited by this paper
• The Rae1–Nup98 complex prevents aneuploidy by inhibiting securin degradation

  2005cited by this paper
• Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation

  2005cited by this paper
• Fission yeast Mes1p ensures the onset of meiosis II by blocking degradation of cyclin Cdc13p

  2005cited by this paper
• Human Cytomegalovirus Inactivates the G0/G1-APC/C Ubiquitin Ligase by Cdh1 Dissociation

  2005cited by this paper
• Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity.

  2005cited by this paper
• Mnd2, an essential antagonist of the anaphase-promoting complex during meiotic prophase.

  2005cited by this paper
• Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase

  2005cited by this paper
• The APC subunit Doc1 promotes recognition of the substrate destruction box.

  2005cited by this paper
• CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis.

  2005cited by this paper
• The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex

  2004cited by this paper
• The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint

  2004cited by this paper
• Swm1/Apc13 Is an Evolutionarily Conserved Subunit of the Anaphase-Promoting Complex Stabilizing the Association of Cdc16 and Cdc27

  2004cited by this paper
• Roles of polo-like kinase 1 in the assembly of functional mitotic spindles.

  2004cited by this paper
• Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

  2004cited by this paper
• Plk 1 Regulates Activation of the Anaphase Promoting Complex by Phosphorylating and Triggering SCF TrCP-dependent Destruction of the APC Inhibitor Emi 1

  2004cited by this paper
• The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53.

  2004cited by this paper
• Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest.

  2004cited by this paper
• Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing.

  2004cited by this paper
• Getting into position: the catalytic mechanisms of protein ubiquitylation.

  2004cited by this paper
• Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation.

  2004cited by this paper
• Swm 1 / Apc 13 Is an Evolutionarily Conserved Subunit of the Anaphase-Promoting Complex Stabilizing the Association of Cdc 16 and Cdc 27

  2004cited by this paper
• Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis*

  2004cited by this paper
• Regulation of early events in chromosome replication.

  2004cited by this paper
• Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts.

  2004cited by this paper
• Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells

  2004cited by this paper
• The E2-C vihar is required for the correct spatiotemporal proteolysis of cyclin B and itself undergoes cyclical degradation.

  2004cited by this paper
• Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.

  2004cited by this paper
• Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry

  2004cited by this paper
• Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.

  2004cited by this paper
• The spindle checkpoint requires cyclin-dependent kinase activity.

  2003cited by this paper
• Two Ubiquitin-Conjugating Enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, Have Distinct Functions for Ubiquitination of Mitotic Cyclin

  2003cited by this paper
• Doc1 mediates the activity of the anaphase‐promoting complex by contributing to substrate recognition

  2003cited by this paper
• TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1.

  2003cited by this paper
• Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor–mediated metaphase arrest

  2003cited by this paper
• Mitotic regulation of the human anaphase‐promoting complex by phosphorylation

  2003cited by this paper
• Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

  2003cited by this paper
• Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.

  2003cited by this paper
• Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo.

  2003cited by this paper
• Securin and B-cyclin/CDK are the only essential targets of the APC

  2003cited by this paper
• Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint

  2003cited by this paper
• Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs.

  2003cited by this paper
• Mnd2 and Swm1 Are Core Subunits of the Saccharomyces cerevisiae Anaphase-promoting Complex*

  2003cited by this paper
• Control of Meiotic and Mitotic Progression by the F Box Protein β-Trcp1 In Vivo

  2003cited by this paper
• Rca1 inhibits APC-Cdh1(Fzr) and is required to prevent cyclin degradation in G2.

  2002cited by this paper
• The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time

  2002cited by this paper
• E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1

  2002cited by this paper
• Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.

  2002cited by this paper
• The Doc1 subunit is a processivity factor for the anaphase-promoting complex

  2002cited by this paper
• The anaphase-promoting complex: it's not just for mitosis any more.

  2002cited by this paper
• Implications for the ubiquitination reaction of the anaphase-promoting complex from the crystal structure of the Doc1/Apc10 subunit.

  2002cited by this paper
• Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex.

  2002cited by this paper
• Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint

  2002cited by this paper
• Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes.

  2002cited by this paper
• The anaphase promoting complex/cyclosome is required during development for modified cell cycles

  2002cited by this paper
• The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.

  2002cited by this paper
• The anaphase-promoting complex: proteolysis in mitosis and beyond.

  2002cited by this paper
• Cell cycle‐dependent nuclear export of Cdh1p may contribute to the inactivation of APC/CCdh1

  2002cited by this paper
• The Mad 2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes Upon Binding to Either Mad 1 or

  2002cited by this paper
• The Cyclin-Ubiquitin Ligase Activity of Cyclosome/APC Is Jointly Activated by Protein Kinases Cdk1-Cyclin B and Plk*

  2002cited by this paper
• The spindle checkpoint: structural insights into dynamic signalling

  2002cited by this paper
• Emi1 is required for cytostatic factor arrest in vertebrate eggs

  2002cited by this paper
• Cell cycle-dependent nuclear export of Cdh1p may contribute to the inactivation of APC/C(Cdh1).

  2002cited by this paper
• Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1

  2002cited by this paper
• Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

  2001cited by this paper
• The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner.

  2001cited by this paper
• APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.

  2001cited by this paper
• Cyclin a Is Destroyed in Prometaphase and Can Delay Chromosome Alignment and Anaphase

  2001cited by this paper
• Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores

  2001cited by this paper
• APC/C‐mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A‐type D‐box

  2001cited by this paper
• Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex

  2001cited by this paper
• Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities

  2001cited by this paper
• Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts.

  2001cited by this paper
• The Drosophila Geminin homolog: roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis.

  2001cited by this paper
• Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.

  2001cited by this paper
• MAD2B is an inhibitor of the anaphase-promoting complex.

  2001cited by this paper
• A Conserved Cyclin-Binding Domain Determines Functional Interplay between Anaphase-Promoting Complex–Cdh1 and Cyclin A-Cdk2 during Cell Cycle Progression

  2001cited by this paper
• Dual inhibition of sister chromatid separation at metaphase.

  2001cited by this paper
• D box and KEN box motifs in budding yeast Hsl1p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p.

  2001cited by this paper
• Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

  2001cited by this paper
• Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

  2001cited by this paper
• Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

  2001cited by this paper

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