Signalling by Transforming Growth Factor Beta Isoforms in Wound Healing and Tissue Regeneration

Transforming growth factor beta (TGFβ) signalling is essential for wound healing, including both non-specific scar formation and tissue-specific regeneration. Specific TGFβ isoforms and downstream mediators of canonical and non-canonical signalling play different roles in each of these processes. Here we review the role of TGFβ signalling during tissue repair, with a particular focus on the prototypic isoforms TGFβ1, TGFβ2, and TGFβ3. We begin by introducing TGFβ signalling and then discuss the role of these growth factors and their key downstream signalling mediators in determining the balance between scar formation and tissue regeneration. Next we discuss examples of the pleiotropic roles of TGFβ ligands during cutaneous wound healing and blastema-mediated regeneration, and how inhibition of the canonical signalling pathway (using small molecule inhibitors) blocks regeneration. Finally, we review various TGFβ-targeting therapeutic strategies that hold promise for enhancing tissue repair.

• Publication year

  2016

• Venue

  Journal of Developmental Biology

• Publication date

  2016-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.3390/jdb4020021PMID 29615587PMCID 5831781
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

  2016influential reference
• The Scenario : Damage and Remodelling of the Microvasculature in Systemic Sclerosis

  2016cited by this paper
• Effect of pirfenidone delivered using layer-by-layer thin film on excisional wound healing.

  2016cited by this paper
• Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction.

  2016cited by this paper
• Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosis

  2016cited by this paper
• Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases

  2016cited by this paper
• Integrin signalling regulates YAP and TAZ to control skin homeostasis

  2016cited by this paper
• Halofuginone — The Multifaceted Molecule

  2015cited by this paper
• Transforming Growth Factor Beta 1 Augments Calvarial Defect Healing and Promotes Suture Regeneration

  2015cited by this paper
• Development of antisense oligonucleotide (ASO) technology against Tgf‐β signaling to prevent scarring during flexor tendon repair

  2015cited by this paper
• Structural determinants of Smad function in TGF-β signaling.

  2015cited by this paper
• The αvβ1 integrin plays a critical in vivo role in tissue fibrosis

  2015cited by this paper
• Hemichordate genomes and deuterostome origins

  2015cited by this paper
• Pharmacological inhibition of TGFβ receptor improves Nkx2.5 cardiomyoblast-mediated regeneration.

  2015cited by this paper
• A Comparative Analysis of Gene Expression Profiles during Skin Regeneration in Mus and Acomys

  2015cited by this paper
• Angiotensin II inhibitor facilitates epidermal wound regeneration in diabetic mice

  2015cited by this paper
• Effect of P144® (Anti-TGF-β) in an “In Vivo” Human Hypertrophic Scar Model in Nude Mice

  2015cited by this paper
• Clinical development of galunisertib (LY2157299 monohydrate), a small molecule inhibitor of transforming growth factor-beta signaling pathway

  2015cited by this paper
• Angiotensin receptor blockers: a panacea for Marfan syndrome and related disorders?

  2015cited by this paper
• Epithelialization in Wound Healing: A Comprehensive Review

  2014cited by this paper
• Angiogenic sprouting is regulated by endothelial cell expression of Slug

  2014cited by this paper
• New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses.

  2014cited by this paper
• The Role of TGFβ Signaling in Wound Epithelialization

  2014cited by this paper
• Controlled release of transforming growth factor-β3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.

  2014cited by this paper
• The timing of administration of a clinically relevant dose of losartan influences the healing process after contusion induced muscle injury.

  2013cited by this paper
• Pirfenidone Nanoparticles Improve Corneal Wound Healing and Prevent Scarring Following Alkali Burn

  2013cited by this paper
• Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation.

  2013cited by this paper
• Differential topical susceptibility to TGFβ in intact and injured regions of the epithelium: key role in myofibroblast transition

  2013influential reference
• Role of Transforming Growth Factor Beta in Angiogenesis

  2013influential reference
• Targeted Antiscarring Therapy for Tissue Injuries

  2013cited by this paper
• Skin regenerative potentials of curcumin

  2013cited by this paper
• Characterization of TGFβ signaling during tail regeneration in the leopard Gecko (Eublepharis macularius)

  2013cited by this paper
• Gene expression patterns specific to the regenerating limb of the Mexican axolotl

  2012cited by this paper
• SARA is dispensable for functional TGF‐β signaling

  2012cited by this paper
• Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload.

  2012cited by this paper
• Role of endoglin in fibrosis and scleroderma.

  2012cited by this paper
• Skin shedding and tissue regeneration in African spiny mice (Acomys)

  2012cited by this paper
• Induction of epithelial-mesenchymal transition by transforming growth factor β.

  2012influential reference
• Dual action of TGF-β induces vascular growth in vivo through recruitment of angiogenic VEGF-producing hematopoietic effector cells

  2012cited by this paper
• The bright and the dark sides of activin in wound healing and cancer

  2012cited by this paper
• The harmonies played by TGF-β in stem cell biology.

  2012cited by this paper
• Targeting the TGFβ signalling pathway in disease

  2012cited by this paper
• Transforming Growth Factor Beta 3 Is Required for Excisional Wound Repair In Vivo

  2012cited by this paper
• TGFβ signalling in context

  2012cited by this paper
• The regenerative capacity of the zebrafish heart is dependent on TGFβ signaling

  2012influential reference
• Wound Repair and Regeneration

  2012influential reference
• Reprint of: Betaglycan: A multifunctional accessory

  2012cited by this paper
• Schwartz's manual of surgery

  2012cited by this paper
• Randomized phase II clinical trial of avotermin versus placebo for scar improvement

  2011cited by this paper
• Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip

  2011cited by this paper
• Antifibrotic activities of pirfenidone in animal models

  2011cited by this paper
• Molecular mechanisms and clinical applications of angiogenesis

  2011cited by this paper
• The cellular basis for animal regeneration.

  2011cited by this paper
• Exploring anti-TGF-β therapies in cancer and fibrosis

  2011cited by this paper
• Avotermin for Scar Improvement following Scar Revision Surgery: A Randomized, Double-Blind, Within-Patient, Placebo-Controlled, Phase II Clinical Trial

  2011cited by this paper
• Wound healing in adult skin: aiming for perfect regeneration

  2011cited by this paper
• Mouse digit tip regeneration is mediated by fate-restricted progenitor cells

  2011cited by this paper
• The zebrafish heart regenerates after cryoinjury-induced myocardial infarction

  2011cited by this paper
• TGF-β receptor signaling pathways in angiogenesis; emerging targets for anti-angiogenesis therapy.

  2011cited by this paper
• Bone morphogenetic proteins: a critical review.

  2011cited by this paper
• Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring

  2011cited by this paper
• Limb regeneration: a new development?

  2011cited by this paper
• Regenerative phenotype in mice with a point mutation in transforming growth factor β type I receptor (TGFBR1)

  2011cited by this paper
• Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix.

  2011cited by this paper
• Transforming Growth Factor-β and Endoglin Signaling Orchestrate Wound Healing

  2011cited by this paper
• Antibody targeting of TGF-β in cancer patients.

  2011cited by this paper
• Macrophages in skin injury and repair.

  2011cited by this paper
• Gene expression profile of the regeneration epithelium during axolotl limb regeneration

  2011cited by this paper
• Smad anchor for receptor activation (SARA) in TGF-beta signaling.

  2010cited by this paper
• Mechanisms of improved wound healing in Murphy Roths Large (MRL) mice after skin transplantation

  2010cited by this paper
• Tissue geometry patterns epithelial–mesenchymal transition via intercellular mechanotransduction

  2010cited by this paper
• The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

  2010cited by this paper
• Scar-Improving Efficacy of Avotermin Administered into the Wound Margins of Skin Incisions as Evaluated by a Randomized, Double-Blind, Placebo-Controlled, Phase II Clinical Trial

  2010cited by this paper
• TGF beta (transforming growth factor beta) receptor type III directs clathrin-mediated endocytosis of TGF beta receptor types I and II.

  2010cited by this paper
• TGF-β signaling in vascular biology and dysfunction

  2009cited by this paper
• TGF-beta3 and cancer: a review.

  2009cited by this paper
• Control of transforming growth factor β signal transduction by small GTPases

  2009cited by this paper
• TGF-beta3: A potential biological therapy for enhancing chondrogenesis.

  2009cited by this paper
• Acceleration of Palatal Wound Healing in Smad3-deficient Mice

  2009cited by this paper
• Non-Smad pathways in TGF-β signaling

  2009cited by this paper
• Emergence, development and diversification of the TGF-β signalling pathway within the animal kingdom

  2009cited by this paper
• Tgf-beta superfamily signaling in embryonic development and homeostasis.

  2009cited by this paper
• Strategies for TGF-β modulation: a review of recent patents

  2009cited by this paper
• SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism.

  2009cited by this paper
• The regulation of TGFβ signal transduction

  2009cited by this paper
• Prophylactic administration of avotermin for improvement of skin scarring: three double-blind, placebo-controlled, phase I/II studies.

  2009cited by this paper
• Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.

  2009cited by this paper
• Relative roles of TGF-β1 and Wnt in the systemic regulation and aging of satellite cell responses

  2009cited by this paper
• Biomechanical behavior of scar tissue and uninjured skin in a porcine model

  2009cited by this paper
• Cells keep a memory of their tissue origin during axolotl limb regeneration

  2009cited by this paper
• The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

  2009cited by this paper
• TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.

  2008cited by this paper
• TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

  2008cited by this paper
• The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

  2008cited by this paper
• TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling.

  2008cited by this paper
• PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

  2008influential reference
• Cutaneous Wound Healing

  2007cited by this paper
• Transforming Growth Factor: β Signaling Is Essential for Limb Regeneration in Axolotls

  2007cited by this paper
• Cell contact-dependent regulation of epithelial-myofibroblast transition via the rho-rho kinase-phospho-myosin pathway.

  2007cited by this paper
• TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA.

  2007cited by this paper

• Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis.

  2026cites this paper
• Restoring Ag1, an ancient regeneration gene lost in amniotes, accelerates skin healing in mice.

  2026cites this paper
• MECHANISMS AND OUTCOMES OF 1470NM LASER THERAPY FOR VAGINAL REJUVENATION: A MULTI-OMICS OBSERVATIONAL STUDY

  2025cites this paper
• Improving the Culture of Human Skin Explants for Use in Preclinical Testing of Wound Healing Treatments

  2025cites this paper
• Role of Cytokines in Wound Healing Following Wound Catheter Analgesia in Rats

  2025cites this paper
• Understanding the Application of Plant Extracts in Wound Healing of Fish: A Comprehensive Review

  2025cites this paper
• Potential upscaling protocol establishment and wound healing bioactivity screening of exosomes isolated from canine adipose-derived mesenchymal stem cells

  2025cites this paper
• The Effects of Lipid Extracts from Microalgae Chlorococcum amblystomatis and Nannochloropsis oceanica on the Proteome of 3D-Cultured Fibroblasts Exposed to UVA Radiation

  2025cites this paper
• Elevating Dermatology Beyond Aesthetics: Perinatal-Derived Advancements for Rejuvenation, Alopecia Strategies, Scar Therapies, and Progressive Wound Healing

  2025cites this paper
• Identification of 8-(2-methyl phenyl)-9H-benzo[f]indeno[2,1-c]quinolin-9-one (C-5635020) as a novel and selective TGFβ RII kinase inhibitor for breast cancer therapy.

  2025cites this paper
• Lovastatin and Resveratrol Synergistically Improve Wound Healing and Inhibit Bacterial Growth

  2025cites this paper
• Research Progress on the Treatment of Fractures with Traditional Chinese Medicine Based on the TGF-β Signaling Pathway

  2025cites this paper
• Progress in chitosan/essential oil/ZnO nanobiocomposites fabrication for wound healing applications: A review.

  2025cites this paper
• TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy

  2025cites this paper
• A Marine-Derived Steroid from Rhodococcus sp., 3,12-Dioxochola-4,6-dien-24-oic Acid, Enhances Skin Re-Epithelialization and Tissue Repair

  2025cites this paper
• Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing

  2025cites this paper
• Red Deer Umbilical Cord Lining Mesenchymal Stem Cell-Conditioned Media Stimulates Fibroblast Elastin and Hyaluronic Acid Production to Improve Eyelid Aesthetics.

  2025cites this paper
• TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in colorectal cancer

  2025cites this paper
• The Role of Mesenchymal Stem Cell-Derived Exosomes in Skin Moisturization and Repair: A Review

  2025cites this paper
• Opportunities and Risks of Promoting Skin and Bone Healing via Implant Biofunctionalization of Extracellular Matrix Protein ECM1

  2025cites this paper
• The mechanics of the retina: Müller glia role on retinal extracellular matrix and modelling

  2024cites this paper
• Effect of Propolis and Liquid Smoke Nanogel on TGF-β and Macrophage Activity in Rattus Norvegicus with Traumatic Ulcer

  2024cites this paper
• Wildfire-Relevant Woodsmoke and Extracellular Vesicles (EVs): Alterations in EV Proteomic Signatures Involved in Extracellular Matrix Degradation and Tissue Injury in Airway Organotypic Models.

  2024cites this paper
• Comprehensive evaluation of ethanol-preserved amniotic extracts: Exploring antioxidant properties, proliferation enhancement, protective efficacy and regeneration potential in wound healing

  2024cites this paper
• miR-200b-3p accelerates diabetic wound healing through anti-inflammatory and pro-angiogenic effects.

  2024cites this paper
• TGFβ signaling in cancer-associated fibroblasts drives a hepatic gp130-dependent pro-metastatic inflammatory program in CMS4 colorectal cancer subtype

  2024cites this paper
• Regenerative Therapy for Corneal Scarring Disorders

  2024cites this paper
• Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells

  2024cites this paper
• A novel multifunctional chitosan-gelatin/carboxymethyl cellulose-alginate bilayer hydrogel containing human placenta extract for accelerating full-thickness wound healing.

  2023cites this paper
• Increased Levels of BAMBI Inhibit Canonical TGF-β Signaling in Chronic Wound Tissues

  2023cites this paper
• A Comprehensive Assessment of the Biocompatibility and Safety of Diamond Nanoparticles on Reconstructed Human Epidermis

  2023cites this paper
• New insights into balancing wound healing and scarless skin repair

  2023cites this paper
• Platelet-Rich Plasma for Degenerative Spine Disease: A Brief Overview

  2023cites this paper
• The viable bioengineered allogeneic cellularized construct StrataGraft® synthesizes, deposits, and organizes human extracellular matrix proteins into tissue type-specific structures and secretes soluble factors associated with wound healing.

  2023cites this paper
• The diverse effects of transforming growth factor-β and SMAD signaling pathways during the CTL response

  2023cites this paper
• In vitro and in vivo evaluation of electrospun poly (ε-caprolactone)/collagen scaffolds and Wharton's jelly mesenchymal stromal cells (hWJ-MSCs) constructs as potential alternative for skin tissue engineering

  2023cites this paper
• Development of a Silk Fibroin-small Intestinal Submucosa Small-diameter Vascular Graft with Sequential VEGF and TGF-β1 Inhibitor Delivery for In Situ Tissue Engineering.

  2023cites this paper
• A Modified Suture Technique to Improve Scar Appearance in Wounds Under High Tension

  2023cites this paper
• Arthrofibrosis of the elbow joint: mechanisms and factors of development

  2023cites this paper
• Host immune response factors associated with Staphylococcus aureus chronic intramammary infections

  2023cites this paper
• First pan-specific vNAR against human TGF-β as a potential therapeutic application: in silico modeling assessment

  2023cites this paper
• Bioactive ECM-Loaded SIS Generated by the Optimized Decellularization Process Exhibits Skin Wound Healing Ability in Type I Diabetic Rats.

  2023cites this paper
• Characterization of Histone Modifications in Late-Stage Rotator Cuff Tendinopathy

  2023cites this paper
• Mesenchymal stem cell transplantation in burn wound healing: uncovering the mechanisms of local regeneration and tissue repair

  2023cites this paper
• The Effect of Topical Gel Secretome Hypoxia Mesenchymal Stem Cells (SH-MSCs) on TGF-Β and IL-6 Gene Expression in Wistar Rats Excision Wound Models

  2023cites this paper
• Modern anatomical and physiological bases for maintaining the transparency of the corneal stroma

  2023cites this paper
• Whole Genome Sequencing Unravels New Genetic Determinants of Early-Onset Familial Osteoporosis and Low BMD in Malta

  2022cites this paper
• Effect of peripheral iridectomy on VEGF-A and TGF-β levels in rabbit aqueous humour

  2022cites this paper
• Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

  2022cites this paper
• Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing

  2022cites this paper
• Is the future scarless? – Fibroblasts as targets for scarless wound healing: a narrative review

  2022cites this paper
• Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8

  2022cites this paper
• The wound healing effect of Morinda citrifolia leaf extract and biomolecular analysis on inflammation and proliferation stages in Wistar rats.

  2022cites this paper
• Acute Inflammation in Tissue Healing

  2022cites this paper
• The Effect of Aqueous Extract of Robusta Coffee Compared to Neomycin-Bacitracin on Wound Healing by Measuring TNF-1 and bFGF in Fibroblast Cell Cultures

  2022cites this paper
• Role of TGF-β3 and bone marrow mesenchymal stem cells on regeneration of myometrial injury in rats

  2022cites this paper
• P311 promotes type II transforming growth factor-β receptor mediated fibroblast activation and granulation tissue formation in wound healing.

  2022cites this paper
• Clinical analysis of tethered cord syndrome and gene expression profiling of wound healing surgery

  2022cites this paper
• Preclinical Study of Human Bone Marrow-Derived Mesenchymal Stem Cells Using a 3-Dimensional Manufacturing Setting for Enhancing Spinal Fusion

  2022cites this paper
• Modulation of immune response in canine chronic wound stimulated with Class C CpG oligonucleotide

  2022cites this paper
• Co‐overexpression of VEGF and Smad7 improved the therapeutic effects of adipose‐derived stem cells on neurogenic erectile dysfunction in the rat model

  2022cites this paper
• Regulation and Signaling of TGF-β Autoinduction

  2022cites this paper
• Transforming growth factor-β1 negatively regulates SOCS7 via EGR1 during wound healing

  2022cites this paper
• A Novel Approach for Skin Regeneration by a Potent Bioactive Placental-Loaded Microneedle Patch: Comparative Study of Deer, Goat, and Porcine Placentas

  2022cites this paper
• Regenerative capacity of Müller cells and their modulation as a tool to treat retinal degenerations

  2022cites this paper
• Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking

  2022cites this paper
• Incomplete Recovery of Zebrafish Retina Following Cryoinjury

  2022cites this paper
• Understanding and Therapeutically Targeting the Scleroderma Myofibroblast

  2022cites this paper
• Molecular Mechanisms and Physiological Changes behind Benign Tracheal and Subglottic Stenosis in Adults

  2022cites this paper
• Introduction to the Study on Regeneration in Lizards as an Amniote Model of Organ Regeneration

  2021cites this paper
• Post-intubation subglottic stenosis: aetiology at the cellular and molecular level

  2021cites this paper
• Immunogenicity and Protective Activity of Pigeon Circovirus Recombinant Capsid Protein Virus-Like Particles (PiCV rCap-VLPs) in Pigeons (Columba livia) Experimentally Infected with PiCV

  2021cites this paper
• Externally triggered release of growth factors - A tissue regeneration approach.

  2021cites this paper
• Harnessing the Innate and Adaptive Immune System for Tissue Repair and Regeneration: Considering More Than Macrophages.

  2021cites this paper
• The Role of Porphyrinoid Photosensitizers for Skin Wound Healing

  2021cites this paper
• Роль цитокинов, хемокинов и факторов роста в заживлении лунок удаленных зубов

  2021cites this paper
• Clinical, Molecular and Histopathological Evaluation of the Effect Autologus PRP & PRF on the Second Intension Wound Healing in Dogs

  2021cites this paper
• Ca-Alginate-PEGMA Hydrogels for In Situ Delivery of TGF-β Neutralizing Antibodies in a Mouse Model of Wound Healing

  2021cites this paper
• Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity

  2021cites this paper
• The effect of 3% binahong leaf extract gel on the wound healing process of post tooth extraction

  2021cites this paper
• Cell-Free Biological Approach for Corneal Stromal Wound Healing

  2021cites this paper
• Therapeutic effect of mesenchymal stem cells on histopathological, immunohistochemical, and molecular analysis in second-grade burn model

  2021cites this paper
• Long Non-coding RNAs: Potential Players in Cardiotoxicity Induced by Chemotherapy Drugs

  2021cites this paper
• Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing

  2021cites this paper
• Functional Duality of Chondrocyte Hypertrophy and Biomedical Application Trends in Osteoarthritis

  2021cites this paper
• Proteomic Phenotyping of Stimulated Müller Cells Uncovers Profound Pro-Inflammatory Signaling and Antigen-Presenting Capacity

  2021cites this paper
• Thrombospondin-4 Is a Soluble Dermal Inflammatory Signal That Selectively Promotes Fibroblast Migration and Keratinocyte Proliferation for Skin Regeneration and Wound Healing

  2021cites this paper
• TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies.

  2021cites this paper
• TGFβ-Neurotrophin Interactions in Heart, Retina, and Brain

  2021cites this paper
• Chronic Wounds: An Overview of Wound Healing and Experimental Models for Wound Studies

  2021cites this paper
• Effect of Autologous platelet-rich plasma versus platelet-rich fibrin on the Second Intension Wound Healing in Dogs through higher regeneration capacity and modulation of inflammatory cytokines

  2021cites this paper
• A novel multifunctional bilayer scaffold based on chitosan nanofiber/alginate-gelatin methacrylate hydrogel for full-thickness wound healing.

  2021cites this paper
• FAK Inhibition Attenuates Corneal Fibroblast Differentiation In Vitro

  2021cites this paper
• Harnessing the Natural Healing Power of Colostrum: Bovine Milk‐Derived Extracellular Vesicles from Colostrum Facilitating the Transition from Inflammation to Tissue Regeneration for Accelerating Cutaneous Wound Healing

  2021cites this paper
• Role of Secretoglobin+ (club cell) NFκB/RelA-TGFβ signaling in aero-allergen-induced epithelial plasticity and subepithelial myofibroblast transdifferentiation

  2021cites this paper
• High-Throughput Manufacturing of Antibacterial Nanofibers by Melt Coextrusion and Post-Processing Surface-Initiated Atom Transfer Radical Polymerization

  2021cites this paper
• Alkaline activation of endogenous latent TGFβ1 by an injectable hydrogel directs cell homing for in situ complex tissue regeneration

  2021cites this paper
• Aligned and Oriented Collagen Nanocomposite Fibers as Substrates to Activate Fibroblasts.

  2021cites this paper
• Human Skin Keratinocytes on Sustained TGF-β Stimulation Reveal Partial EMT Features and Weaken Growth Arrest Responses

  2020cites this paper
• TGF-β3 regulates adhesion formation through the JNK/c-Jun pathway during flexor tendon healing

  2020cites this paper