Genome-wide association study identifies susceptibility loci for IgA nephropathy

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Nature Genetics

• Publication date

  2011-04-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/ng.787PMID 21399633PMCID PMC3412515
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Galactose-deficient IgA1 in African Americans with IgA nephropathy: serum levels and heritability.

  2010cited by this paper
• HLA has strongest association with IgA nephropathy in genome-wide analysis.

  2010cited by this paper
• Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency

  2010cited by this paper
• Associations of CFHR1–CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent

  2010cited by this paper
• Genetic studies of IgA nephropathy: past, present, and future

  2010cited by this paper
• Origins and functional impact of copy number variation in the human genome

  2010cited by this paper
• Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease

  2010cited by this paper
• Faculty Opinions recommendation of Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls.

  2010cited by this paper
• Genome-wide association study of copy number variation in 16,000 cases of eight common diseases and 3,000 shared controls

  2010cited by this paper
• A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection

  2010cited by this paper
• A SPECTRAL GRAPH APPROACH TO DISCOVERING GENETIC ANCESTRY.

  2009cited by this paper
• Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation.

  2009cited by this paper
• HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans.

  2009cited by this paper
• Whole population, genome-wide mapping of hidden relatedness.

  2009cited by this paper
• Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

  2009cited by this paper
• A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

  2009cited by this paper
• Discovering genetic ancestry using spectral graph theory

  2009cited by this paper
• Report of the Asian Forum of Chronic Kidney Disease Initiative (AFCKDI) 2007. “Current status and perspective of CKD in Asia”: diversity and specificity among Asian countries

  2009cited by this paper
• Common variants at five new loci associated with early-onset inflammatory bowel disease

  2009cited by this paper
• Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy.

  2009cited by this paper
• A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

  2009cited by this paper
• Oncostatin M deficiency leads to thymic hypoplasia, accumulation of apoptotic thymocytes and glomerulonephritis

  2009cited by this paper
• High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions

  2009cited by this paper
• Upregulation of the immunoproteasome in peripheral blood mononuclear cells of patients with IgA nephropathy.

  2009cited by this paper
• Aberrant IgA1 glycosylation is inherited in familial and sporadic IgA nephropathy.

  2008cited by this paper
• On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.

  2008cited by this paper
• HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk

  2008cited by this paper
• Prevalence of chronic kidney disease in the United States.

  2007cited by this paper
• Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.

  2007cited by this paper
• Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

  2007cited by this paper
• Complement factor H and the hemolytic uremic syndrome

  2007cited by this paper
• Deletion of Complement Factor H–Related Genes CFHR1 and CFHR3 Is Associated with Atypical Hemolytic Uremic Syndrome

  2007cited by this paper
• An R Package for Analysis of Whole-Genome Association Studies

  2007cited by this paper
• PLINK: a tool set for whole-genome association and population-based linkage analyses.

  2007cited by this paper
• Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels.

  2007cited by this paper
• Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36.

  2007cited by this paper
• Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

  2006cited by this paper
• Genetic heterogeneity in Italian families with IgA nephropathy: suggestive linkage for two novel IgA nephropathy loci.

  2006cited by this paper
• A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration

  2006cited by this paper
• Is IgA nephropathy the commonest primary glomerulopathy among young adults in the USA?

  2006cited by this paper
• A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC

  2006cited by this paper
• Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration

  2006cited by this paper
• IgA nephropathy.

  2005cited by this paper
• Past, present--and future?

  2005cited by this paper
• Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome.

  2005cited by this paper
• The Italian experience of the national registry of renal biopsies.

  2004cited by this paper
• Statistical significance for genomewide studies

  2003cited by this paper
• Incidence of latent mesangial IgA deposition in renal allograft donors in Japan.

  2003cited by this paper
• Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups.

  2001cited by this paper
• IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22–23

  2000cited by this paper
• Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies.

  1999cited by this paper
• Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy.

  1993cited by this paper
• Immunoglobulin and complement deposition in glomeruli of 756 subjects who had committed suicide or met with a violent death.

  1993cited by this paper
• The commonest glomerulonephritis in the world: IgA nephropathy.

  1987cited by this paper
• [IgA nephropathy].

  1985cited by this paper

• Complement and kidney diseases: unlocking the opportunity of targeted treatments for glomerular diseases, including IgA nephropathy.

  2026cites this paper
• Coexisting genetic kidney disease explains many cases of ‘familial’ IgA nephropathy where the proband has biopsy-confirmed mesangial IgA deposits

  2026cites this paper
• Aberrant signaling in tonsillar B cells producing pathogenic O-glycoforms of IgA1 in IgA nephropathy

  2026cites this paper
• Multi-omics analyses reveal the pathogenic role of terminal ileum-derived IgA+β7+ cells in IgA nephropathy.

  2026cites this paper
• Chronic kidney disease enhances alternative pathway activity: a new paradigm

  2025cites this paper
• Common Haplotypes within the Chromosome 1q31.3 Region Determine Systemic Concentrations of the Entire Complement Factor H Protein Family

  2025cites this paper
• CFHR3*B Haplotype, Complement Activation, and Risk of IgA Nephropathy.

  2025cites this paper
• A Case of IgA Nephropathy in a Patient With Sarcoidosis: Confirmation of Glomerular Galactose-Deficient IgA1 Deposition

  2025cites this paper
• Severe Hypertension with Thrombotic Microangiopathy. The need for Pathogenically-Targeted Treatments.

  2025cites this paper
• The Complement System.

  2025cites this paper
• The Genetics of IgA Nephropathy: Implications for Future Therapies.

  2025cites this paper
• Exploring the Relationship Between 91 Inflammatory Cytokines and IgA Nephropathy Using a Two-Sample Mendelian Randomization Study and the Gene Expression Omnibus Database

  2025cites this paper
• Complement Inhibition in Immunoglobulin A Nephropathy: A Mini-Review.

  2025cites this paper
• IgA Nephropathy and Glomerular Diseases Associated with Infection

  2025cites this paper
• Complement proteins associated with circulatory and glomerular IgA-containing immune complexes in patients with IgA nephropathy

  2025cites this paper
• The Impact of Complement Factor H‐Related Protein Gene Deletions on Kidney Transplantation

  2025cites this paper
• Clinicopathological significance of updated Oxford classification in renal allograft IgA nephropathy, a retrospective study in an Indian cohort with clinicopathological correlations and outcome.

  2025cites this paper
• Systemic lupus erythematosus as the paradigm for understanding the complex immune relationships and therapeutic opportunities for targeting complement in autoimmune diseases

  2025cites this paper
• Changes in the spectrum of kidney diseases: a 14-year single-center retrospective renal biopsy study from southeast China

  2025cites this paper
• Dual Role of Factor H–Related Protein 1 in IgA Nephropathy Kidney Injury

  2025cites this paper
• IgA Nephropathy: Epidemiology and Disease Risk Across the World.

  2025cites this paper
• Identification of Potential Drug Targets for Immunoglobulin A Nephropathy: A Mendelian Randomization Study

  2025cites this paper
• Expected and verified benefits from old and new corticosteroid treatments in IgA nephropathy: from trials in adults to new IPNA-KDIGO guidelines

  2025cites this paper
• Association of HLA Alleles with IgA Nephropathy and Its Recurrence After Kidney Transplantation

  2025cites this paper
• The 4 functional segments of Factor H: Role in physiological target recognition and contribution to disease.

  2025cites this paper
• Long non-coding RNA in IgA nephropathy: a comprehensive review

  2025cites this paper
• Association of urinary LIF levels with disease prognosis and treatment response to methylprednisolone in IgA nephropathy.

  2025cites this paper
• IgA nephropathy new therapies: from data in adults to application in children.

  2025cites this paper
• Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton.

  2025cites this paper
• Advances in Complement-Targeted Therapy for IgA Nephropathy

  2025cites this paper
• KLF15 deficiency contributes complement activation and podocyte injury in IgA nephropathy via regulating p300/ NF-κB axis.

  2025cites this paper
• Genetic Evaluation of the Role of Galactose-Deficient IgA1 in IgA Nephropathy: Evidence from Association Testing and Mendelian Randomization

  2025cites this paper
• Advances in complement research: from pathophysiology to precision medicine.

  2025cites this paper
• Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy

  2025cites this paper
• Complement-Mediated Kidney Diseases: Role of Alternative Pathway in Glomerular Inflammation

  2025cites this paper
• Factor H-related protein 1 in systemic lupus erythematosus

  2024cites this paper
• Post-transplant glomerular diseases: update on pathophysiology, risk factors and management strategies

  2024cites this paper
• Exploring the crosstalk molecular mechanisms between IgA nephropathy and Sjögren’s syndrome based on comprehensive bioinformatics and immunohistochemical analyses

  2024cites this paper
• Targeted therapy of glomerulonephritis via salvianolic acid b-loaded biomimetic hybrid nanovesicles driven by homing

  2024cites this paper
• A Mendelian randomization study investigating the causal relationships between inflammation and immunoglobulin A nephropathy.

  2024cites this paper
• Navigating Adult-Onset IgA Vasculitis-Associated Nephritis

  2024cites this paper
• Research Progress of Complement Factor H-Related Protein 1 in Podocyte Diseases

  2024cites this paper
• A case of non-lupus full-house nephropathy diagnosed by kidney biopsy but observed IgA nephropathy on second biopsy

  2024cites this paper
• Genetics of IgA nephrology: risks, mechanisms, and therapeutic targets

  2024cites this paper
• GWAS-follow-up Studies Identified a Connection between Abnormal LIF/JAK2/STAT1 Signaling and Overproduction of Galactose-Deficient IgA1 in the Tonsillar IgA1-Secreting Cells from Patients with IgA Nephropathy

  2024cites this paper
• Cfhr1 gene deficiency exacerbates Staphylococcus aureus-induced sepsis and acute lung injury through complement alternative pathway hyperactivation.

  2024cites this paper
• The Complement System: An Important New Therapeutic Target in IgA Nephropathy

  2024cites this paper
• Combined Therapy with Azathioprine, Prednisone, and Enalapril in Children with IgAN and IgAVN

  2024cites this paper
• Heterozygous mutations in factor H aggravate pathological damage in a stable IgA deposition model induced by Lactobacillus casei cell wall extract

  2024cites this paper
• Clinical Application of Polygenic Risk Score in IgA Nephropathy

  2024cites this paper
• The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies

  2024cites this paper
• Association of Inflammatory Bowel Disease with Incident IgA Nephropathy

  2024cites this paper
• IgA Nephropathy: Emerging Mechanisms of Disease

  2024cites this paper
• Role of serum complement C3 and C4 on kidney outcomes in IgA nephropathy

  2024cites this paper
• Serum and urine galactose deficient-IgA1 as alternative biomarkers in the management of IgA nephropathy.

  2024cites this paper
• Gene deletions in complement factor H related protein gene locus and kidney transplantation

  2024cites this paper
• Unique target binding by the C-terminal region of FHR1 provides a new perception of aHUS pathology

  2024cites this paper
• Analysis of a Familial IgAN Accompanied by COL4A3 Mutation

  2024cites this paper
• Loss of GalNAc-T14 links O-glycosylation defects to alterations in B cell homing in IgA nephropathy

  2024cites this paper
• Shared germline genomic variants in two patients with double primary gastrointestinal stromal tumours (GISTs)

  2024cites this paper
• Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis

  2024cites this paper
• Towards Risk Stratification in Clinical Care for IgA Nephropathy: Genetic Risk Scores

  2024cites this paper
• IgA nephropathy: Correlation between pathologic findings and complement activation

  2024cites this paper
• Reconstructing the interface between the human intestine and immune system: potential to advance mechanistic studies in IgA nephropathy.

  2024cites this paper
• Safety and Tolerability of Adipose-Derived Mesenchymal Stem Cell (ADR-001) Therapy for IgA Nephropathy

  2024cites this paper
• Emerging perspectives in the management of IgA nephropathy: a comprehensive review

  2024cites this paper
• Pathogenic Immunoglobulin A-Producing Cells in Immunoglobulin A Nephropathy

  2024cites this paper
• New insights into the mucosal immune pathogenesis of IgA nephropathy from the perspective of COVID-19 vaccination.

  2023cites this paper
• Exploring genes for immunoglobulin A nephropathy: a summary data-based mendelian randomization and FUMA analysis

  2023cites this paper
• Genome-Wide Association Study in Acute Tubulointerstitial Nephritis

  2023cites this paper
• An Update on the Genetics of IgA Nephropathy

  2023cites this paper
• Clinical and pathological characteristics in elderly patients with IgA nephropathy

  2023cites this paper
• Advances in the treatment of IgA nephropathy with biological agents

  2023cites this paper
• Ethnicity and IgA nephropathy: worldwide differences in epidemiology, timing of diagnosis, clinical manifestations, management and prognosis

  2023cites this paper
• Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy

  2023cites this paper
• Targeting complement in IgA nephropathy

  2023cites this paper
• LIF/JAK2/STAT1 Signaling Enhances Production of Galactose-Deficient IgA1 by IgA1-Producing Cell Lines Derived From Tonsils of Patients With IgA Nephropathy

  2023cites this paper
• Complement inhibitors in pediatric kidney diseases: new therapeutic opportunities

  2023cites this paper
• Building Towards Clinical Translation: New Study Refines Genetic Architecture of IgA Nephropathy.

  2023cites this paper
• Current Understanding of Complement Proteins as Therapeutic Targets for the Treatment of Immunoglobulin A Nephropathy

  2023cites this paper
• Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study

  2023cites this paper
• Targeting the Endothelin A Receptor in IgA Nephropathy

  2023cites this paper
• Mucosal Immune Defence Gene Polymorphisms as Relevant Players in the Pathogenesis of IgA Vasculitis?

  2023cites this paper
• Expansion of Anticomplement Therapy Indications from Rare Genetic Disorders to Common Kidney Diseases.

  2023cites this paper
• Present and Future of IgA Nephropathy and Membranous Nephropathy Immune Monitoring: Insights from Molecular Studies

  2023cites this paper
• Diagnostik und Therapie IgA Nephropathie – 2023

  2023cites this paper
• A bibliometric analysis of complement in IgA nephropathy from 1991 to 2022

  2023cites this paper
• Roles of interferon regulatory factor 4 in the AKI-CKD transition, glomerular diseases and kidney allograft rejection

  2023cites this paper
• GWAS for the composite traits of hematuria and albuminuria

  2023cites this paper
• Results of a randomized double-blind placebo-controlled Phase 2 study propose iptacopan as an alternative complement pathway inhibitor for IgA nephropathy.

  2023cites this paper
• Uncovering Rare Coding Variants in IgA Nephropathy.

  2023cites this paper
• IgA nephropathy

  2023cites this paper
• The complement system in IgAN: mechanistic context for therapeutic opportunities.

  2023cites this paper
• Immunoglobulin A Nephropathy: A 10-year Analysis in a Single Malaysian Centre

  2023cites this paper
• MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy.

  2023cites this paper
• Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy

  2023cites this paper
• Urinary complement profile in IgA nephropathy and its correlation with the clinical and pathological characteristics

  2023cites this paper
• Omics are Getting Us Closer to Understanding IgA Nephropathy

  2023influential citation
• Characterization of patients with IgA nephropathy with and without associated minimal change disease

  2023cites this paper
• Immune abnormalities in IgA nephropathy

  2023cites this paper