Active‐specific immunotherapy of human cancers with the heat shock protein Gp96—revisited

No abstract is available for this paper.

• Publication year

  2012

• Venue

  International Journal of Cancer

• Publication date

  2012-05-15

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/ijc.27332PMID 22052568
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Listening to Provenge--what a costly cancer treatment says about future Medicare policy.

  2011cited by this paper
• PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

  2011cited by this paper
• Ipilimumab: first global approval.

  2011cited by this paper
• Tumour-associated antigens: considerations for their use in tumour immunotherapy

  2011cited by this paper
• Antitumor activity of mixed heat shock protein/peptide vaccine and cyclophosphamide plus interleukin-12 in mice sarcoma

  2011cited by this paper
• High efficiency CD91- and LOX-1-mediated re-presentation of gp96-chaperoned peptides by MHC II molecules.

  2010cited by this paper
• How do Tumors Actively Escape from Host Immunosurveillance?

  2010cited by this paper
• Ipilimumab efficacy and safety in patients with advanced melanoma: a retrospective analysis of HLA subtype from four trials.

  2010cited by this paper
• Sipuleucel-T immunotherapy for castration-resistant prostate cancer.

  2010cited by this paper
• Ipilimumab: unleashing the power of the immune system through CTLA-4 blockade.

  2010cited by this paper
• Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants

  2010cited by this paper
• Ovalbumin-Derived Precursor Peptides Are Transferred Sequentially from gp96 and Calreticulin to MHC Class I in the Endoplasmic Reticulum

  2010cited by this paper
• Improved survival with ipilimumab in patients with metastatic melanoma.

  2010influential reference
• New therapies for castration-resistant prostate cancer.

  2010cited by this paper
• Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma.

  2010cited by this paper
• Superior Antitumor Response Induced by Large Stress Protein Chaperoned Protein Antigen Compared with Peptide Antigen

  2010cited by this paper
• Involvement of CD91 and scavenger receptors in Hsp70‐facilitated activation of human antigen‐specific CD4+ memory T cells

  2010cited by this paper
• Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma

  2010cited by this paper
• Myeloma cell line-derived, pooled heat shock proteins as a universal vaccine for immunotherapy of multiple myeloma.

  2009cited by this paper
• Interaction of human heat shock protein 70 with tumor-associated peptides

  2009cited by this paper
• A Heat Shock Protein 70-Based Vaccine with Enhanced Immunogenicity for Clinical Use

  2009cited by this paper
• Clinical Use of Anti‐CD25 Antibody Daclizumab to Enhance Immune Responses to Tumor Antigen Vaccination by Targeting Regulatory T cells

  2009cited by this paper
• Treating human cancers with heat shock protein-peptide complexes: the road ahead

  2009cited by this paper
• Enhancement of Th1 immune response by CD8alpha(+) dendritic cells loaded with heat shock proteins enriched tumor extract in tumor-bearing mice.

  2009cited by this paper
• Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.

  2008cited by this paper
• A novel therapeutic fusion protein vaccine by two different families of heat shock proteins linked with HPV16 E7 generates potent antitumor immunity and antiangiogenesis.

  2008cited by this paper
• Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens

  2008cited by this paper
• Heat shock protein-antigen fusions lose their enhanced immunostimulatory capacity after endotoxin depletion.

  2008cited by this paper
• Research, conferences, and FDA actions.

  2008cited by this paper
• An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial.

  2008influential reference
• Vaccination of metastatic renal cell carcinoma patients with autologous tumour-derived vitespen vaccine: clinical findings

  2008cited by this paper
• Heat shock proteins in animal neoplasms and human tumours—a comparison

  2008cited by this paper
• Research, conferences, and FDA actions.

  2008cited by this paper
• Oncophage: step to the future for vaccine therapy in melanoma.

  2008cited by this paper
• Guidelines for the nomenclature of the human heat shock proteins

  2008cited by this paper
• A new population of myeloid-derived suppressor cells in hepatocellular carcinoma patients induces CD4(+)CD25(+)Foxp3(+) T cells.

  2008cited by this paper
• Both CD4+ and CD8+ T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors

  2008cited by this paper
• Vitespen: a vaccine for renal cancer?

  2008cited by this paper
• A Phase I Pilot Study of Autologous Heat Shock Protein Vaccine HSPPC-96 in Patients With Resected Pancreatic Adenocarcinoma

  2007cited by this paper
• A phase II study of Hsp-7 (SGN-00101) in women with high-grade cervical intraepithelial neoplasia.

  2007cited by this paper
• Efficient Cross-Presentation by Heat Shock Protein 90-Peptide Complex-Loaded Dendritic Cells via an Endosomal Pathway

  2007cited by this paper
• Specific Immunogenicity of Heat Shock Protein gp96 Derives from Chaperoned Antigenic Peptides and Not from Contaminating Proteins1

  2007cited by this paper
• Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine.

  2007cited by this paper
• Engineering secretable forms of chaperones for immune modulation and vaccine development.

  2007cited by this paper
• Structure and Function: Heat Shock Proteins and Adaptive Immunity1

  2007cited by this paper
• Molecular and Cellular Requirements for Enhanced Antigen Cross-Presentation to CD8 Cytotoxic T Lymphocytes1

  2007cited by this paper
• Allogeneic tumor-cell-based vaccines secreting endoplasmic reticulum chaperone gp96

  2007cited by this paper
• Heat shock fusion protein-based immunotherapy for treatment of cervical intraepithelial neoplasia III.

  2007cited by this paper
• Experience with heat shock protein‐peptide complex 96 vaccine therapy in patients with indolent non‐Hodgkin lymphoma

  2007influential reference
• Evaluation of anti-tumor effects of tumor cell lysate enriched by HSP-70 against fibrosarcoma tumor in BALB/c mice.

  2007cited by this paper
• A phase II trial of vaccination with autologous, tumor-derived heat-shock protein peptide complexes Gp96, in combination with GM-CSF and interferon-α in metastatic melanoma patients

  2006cited by this paper
• Enhanced Immunogenicity of Heat Shock Protein 70 Peptide Complexes from Dendritic Cell-Tumor Fusion Cells1

  2006cited by this paper
• Interaction of TLR2 and TLR4 Ligands with the N-terminal Domain of Gp96 Amplifies Innate and Adaptive Immune Responses*

  2006cited by this paper
• Improving Antitumor Immune Responses by Circumventing Immunoregulatory Cells and Mechanisms

  2006cited by this paper
• Immune regulation in tumor-bearing hosts.

  2006cited by this paper
• The seven dirty little secrets of major histocompatibility complex class I antigen processing.

  2005cited by this paper
• A listing of human tumor antigens recognized by T cells: March 2004 update

  2005cited by this paper
• Testing the Role of gp96 as Peptide Chaperone in Antigen Processing*

  2005cited by this paper
• Glycoprotein 96–activated dendritic cells induce a CD8-biased T cell response

  2005cited by this paper
• Screening of cytokines to enhance vaccine effects of heat shock protein 70-rich tumor cell lysate.

  2005cited by this paper
• Targeting Heat Shock Proteins for Immunotherapy in Multiple Myeloma: Generation of Myeloma-Specific CTLs Using Dendritic Cells Pulsed with Tumor-Derived gp96

  2005cited by this paper
• Peptides chaperoned by heat-shock proteins are a necessary and sufficient source of antigen in the cross-priming of CD8+ T cells

  2005cited by this paper
• Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications

  2005cited by this paper
• Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma

  2005cited by this paper
• Combination of Imatinib Mesylate with Autologous Leukocyte-Derived Heat Shock Protein and Chronic Myelogenous Leukemia

  2005cited by this paper
• Dendritic cells pulsed with gp96-peptide complexes derived from human hepatocellular carcinoma (HCC) induce specific cytotoxic T lymphocytes

  2005cited by this paper
• HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation.

  2004cited by this paper
• Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8+ T Cell Effector Function 1

  2004cited by this paper
• Analytical challenges and strategies for the characterization of gp96-associated peptides.

  2004cited by this paper
• Development of cancer vaccines using autologous and recombinant high molecular weight stress proteins.

  2004cited by this paper
• Heat shock proteins transfer peptides during antigen processing and CTL priming

  2004cited by this paper
• Treatment of Colon and Lung Cancer Patients with ex Vivo Heat Shock Protein 70-Peptide-Activated, Autologous Natural Killer Cells

  2004cited by this paper
• Glucose-Regulated Protein 94/Glycoprotein 96 Elicits Bystander Activation of CD4+ T Cell Th1 Cytokine Production In Vivo

  2004cited by this paper
• The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity

  2004cited by this paper
• The challenges of bringing autologous HSP-based vaccines to commercial reality.

  2004cited by this paper
• Hsp-antigen fusion and their use for immunization.

  2004cited by this paper
• Identification of tumor antigens and T-cell epitopes, and its clinical application

  2004cited by this paper
• Expression of the heat shock cognate protein HSP73 correlates with tumour thickness of primary melanomas and is enhanced in melanoma metastases.

  2004cited by this paper
• Cytokine function of heat shock proteins.

  2004cited by this paper
• The heat-shock protein receptors: some answers and more questions.

  2004cited by this paper
• Heat Shock Protein-Mediated Cross-Presentation of Exogenous HIV Antigen on HLA Class I and Class II1

  2004cited by this paper
• The three Es of cancer immunoediting.

  2004cited by this paper
• Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers

  2003cited by this paper
• Single-chain Fv-based affinity purification of the cellular stress protein gp96 for vaccine development.

  2003cited by this paper
• Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer.

  2003cited by this paper
• Human Tumor-Derived Heat Shock Protein 96 Mediates In Vitro Activation and In Vivo Expansion of Melanoma- and Colon Carcinoma-Specific T Cells1

  2003cited by this paper
• A Phase II Study of Heat Shock Protein–PeptideComplex–96 Vaccine Therapy in Patients with Indolent Non-Hodgkin's Lymphoma

  2003cited by this paper
• Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity.

  2003cited by this paper
• Scavenger receptor‐A mediates gp96/GRP94 and calreticulin internalization by antigen‐presenting cells

  2003cited by this paper
• Re-evaluating the role of heat-shock protein–peptide interactions in tumour immunity

  2003cited by this paper
• GRP94/gp96 Elicits ERK Activation in Murine Macrophages

  2003cited by this paper
• HSP110-HER2/neu Chaperone Complex Vaccine Induces Protective Immunity Against Spontaneous Mammary Tumors in HER-2/neu Transgenic Mice 1

  2003cited by this paper
• A phase II study of heat shock protein-peptide complex-96 vaccine therapy in patients with indolent non-Hodgkin's lymphoma.

  2003cited by this paper
• Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings.

  2002cited by this paper
• The Danger Model: A Renewed Sense of Self

  2002cited by this paper
• GRP94 (gp96) and GRP94 N-Terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression

  2002cited by this paper
• Heat Shock Proteins gp96 and hsp70 Activate the Release of Nitric Oxide by APCs1

  2002cited by this paper
• Hsp70, an immunological actor playing with the intracellular self under oxidative stress

  2002cited by this paper
• Differential Acquisition of Antigenic Peptides by Hsp70 and Hsc70 under Oxidative Conditions*

  2002cited by this paper
• Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses.

  2002cited by this paper

• Chronic ER Stress Triggers Cell‐Surface Chaperones as the Therapeutic Targets of CAR Cells in Acute Myeloid Leukemia

  2025cites this paper
• Advances in Functional Roles of Heat Shock Protein 110 (HSP110) in Colorectal Cancer

  2025cites this paper
• First-in-human study of high-dose gp96 in ALS: Safety and preliminary immunological effects

  2025cites this paper
• Recombinant CALR polarizes and activates macrophages in tumors

  2025cites this paper
• Recent advancements in cancer vaccines: A systematic review

  2024cites this paper
• PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond

  2024cites this paper
• GPC3 and PEG10 polypeptides associated with placental 1 gp96 elicit specific T cell immunity against hepatocellular 2 carcinoma

  2023cites this paper
• Recent advancements in cancer vaccines: A systematic review

  2023cites this paper
• GPC3 and PEG10 peptides associated with placental gp96 elicit specific T cell immunity against hepatocellular carcinoma

  2023cites this paper
• gp96 Expression in Gliomas and Its Association with Tumor Malignancy and T Cell Infiltrating Level

  2022cites this paper
• MHC Class I Assembly Function and Intracellular Transport Routes for Hepatitis B Virus Antigen Cross-presentation by Heat Shock Protein gp96

  2022cites this paper
• Broadly Protective CD8+ T Cell Immunity to Highly Conserved Epitopes Elicited by Heat Shock Protein gp96-Adjuvanted Influenza Monovalent Split Vaccine

  2021cites this paper
• Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets

  2020cites this paper
• Advances in the Development of Anticancer HSP-based Vaccines.

  2019cites this paper
• Selective targeting of multiple myeloma by B cell maturation antigen (BCMA)-specific central memory CD8+ cytotoxic T lymphocytes: immunotherapeutic application in vaccination and adoptive immunotherapy

  2019cites this paper
• Roles, Mechanisms, and Opportunities of Heat Shock Protein gp96/grp94 in Infections and Inflammation-Associated Malignancies

  2018cites this paper
• Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease

  2018cites this paper
• The Effectiveness of Antitumor Vaccine Enriched with a Heat Shock Protein 70

  2018cites this paper
• Immuno-Stimulating Peptide Derived from HMGB1 is More Effective Than the N-Terminal Domain of Gp96 as an Endogenous Adjuvant for Improvement of Protein Vaccines.

  2017cites this paper
• Biotechnology approaches to produce potent, self-adjuvanting antigen-adjuvant fusion protein subunit vaccines.

  2017cites this paper
• Gastric cancer-derived heat shock protein-gp96 peptide complex enhances dendritic cell activation

  2017cites this paper
• Alpha-synuclein and immune system crosstalk in parkinson's disease; therapeutic approaches of its modulation by molecular chaperones

  2017cites this paper
• HEAT SHOCK PROTEIN GP96 DRIVES DICHOTOMOUS LYMPHOCYTE RESPONSES VIA DNA METHYLOME REMODELING AND STAT1 SIGNALING IN ANTIGEN PRESENTING CELLS

  2017cites this paper
• Immunothérapie et métabolisme tumorale

  2017cites this paper
• 6.02 – Cancer Immunotherapy

  2017cites this paper
• Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α‐synuclein‐elicited immune response

  2016cites this paper
• Chaperony endoplazmatického retikula na povrchu nádorové buňky a v extracelulárním prostředí Endoplasmic Reticulum Chaperones at the Tumor Cell Surface and in the Extracellular

  2016cites this paper
• Interaction of Toll-Like Receptors with the Molecular Chaperone Gp96 Is Essential for Its Activation of Cytotoxic T Lymphocyte Response

  2016cites this paper
• Heat‐Shock Protein gp96 Enhances T Cell Responses and Protective Potential to Bacillus Calmette‐Guérin Vaccine

  2016cites this paper
• Endoplasmic Reticulum Chaperones and Their Roles in the Immunogenicity of Cancer Vaccines

  2015cites this paper
• Approaches to improve development methods for therapeutic cancer vaccines.

  2015cites this paper
• Vaccines in RCC: Clinical and Biological Relevance

  2015cites this paper
• Les protéines de stress HSP90 et Gp96 dans la maladie du greffon contre l'hôte : implication physiopathologique, diagnostique et thérapeutique

  2015cites this paper
• Upregulation of Heat Shock Proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in Tumour Tissues Is Associated with Poor Outcomes from HBV-Related Early-Stage Hepatocellular Carcinoma

  2015cites this paper
• Dendritic-Tumor Fusion Cells Derived Heat Shock Protein70-Peptide Complex Has Enhanced Immunogenicity

  2015cites this paper
• Pharmacogenomics and stratified medicine

  2014cites this paper
• Heat shock protein gp96 adjuvant induces T cell responses and cross-protection to a split influenza vaccine.

  2014cites this paper
• Heat shock proteins purified from autologous tumors using antibody-based affinity chromatography.

  2014cites this paper
• Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice.

  2014cites this paper
• Prophylactic cancer vaccine, from concept to reality?

  2014cites this paper
• Combinatorial therapeutic vaccination strategies for hematologic malignancies in the early period following experimental autologous hematopoietic stem cell transplantation

  2014cites this paper
• HLA-Binding Properties of Tumor Neoepitopes in Humans

  2014cites this paper
• Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

  2014cites this paper
• Clinical evaluation of therapeutic cancer vaccines

  2013cites this paper
• Isolation and Identification of Renal Cell Carcinoma-Derived Peptides Associated with GP96

  2013cites this paper
• Peptides as protein–protein interaction modulators

  2013cites this paper
• The role of glycoprotein 96 in the persistent inflammation of rheumatoid arthritis.

  2013cites this paper
• The allure and peril of hematopoietic stem cell transplantation: overcoming immune challenges to improve success

  2013cites this paper
• Glucose-regulated protein 94 modulates the therapeutic efficacy to taxane in cervical cancer cells

  2013cites this paper
• Placenta-derived gp96 as a multivalent prophylactic cancer vaccine

  2013cites this paper
• Induction of Regulatory T Cells by High-Dose gp96 Suppresses Murine Liver Immune Hyperactivation

  2013cites this paper
• Comparative proteomic analysis of ductal breast carcinoma demonstrates an altered expression of chaperonins and cytoskeletal proteins.

  2013cites this paper
• Quantifying Gp96/Grp94 complexes preparations for vaccines: a key step often inaccurate.

  2013cites this paper
• Investigating Gp96 Biology and its Macrophage-Intrinsic Role in Colitis-Associated Colon Tumorigenesis

  2013cites this paper
• The potential of clusterin to act as an immune modulator

  2013cites this paper
• ANALYSIS OF CELLULAR SENTINELS FOR EXTRACELLULAR HEAT SHOCK PROTEIN-PEPTIDE COMPLEXES

  2013cites this paper
• Immunological monitoring of anticancer vaccines in clinical trials

  2013cites this paper
• TAT-mediated gp96 transduction to APCs enhances gp96-induced antiviral and antitumor T cell responses.

  2013influential citation
• Protein flexibility and conformational states of Leishmania antigen eIF-4A: identification of a novel plausible protein adjuvant using comparative genomics and molecular modeling

  2013cites this paper
• IMA901: a peptide vaccine in renal cell carcinoma

  2013cites this paper
• Augmenting the Skin Immune System

  2013cites this paper
• Heat shock proteins as the efficient vehicle in cancer

  2012cites this paper
• Specific Immunity Elicited by Cross-link Complex Alpha-fetoprotein and Glycoprotein 96

  2012cites this paper
• AT-mediated gp 96 transduction to APCs enhances gp 96-induced antiviral and ntitumor T cell responses

  2012influential citation
• Challenges in the development of an autologous heat shock protein based anti-tumor vaccine

  2012cites this paper