Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Circulation

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 15505105
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1993cited by this paper
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  1991cited by this paper
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  1989cited by this paper
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