CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.

• Publication year

  2014

• Venue

  BioMed Research International

• Publication date

  2014-05-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2014/768758PMID 24971349PMCID 4058128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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