Blockade of the chemokine receptor CXCR2 inhibits pancreatic cancer cell-induced angiogenesis.

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cancer Letters

• Publication date

  2006-09-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.CANLET.2005.10.041PMID 16458421
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Angiogenesis in Cancer

  2006cited by this paper
• Melanoma Inhibitory Activity (MIA) increases the invasiveness of pancreatic cancer cells

  2005cited by this paper
• Depletion of CXCR2 Inhibits Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer1

  2004cited by this paper
• Pancreatic tumor growth is regulated by the balance between positive and negative modulators of angiogenesis

  2004cited by this paper
• CXC chemokines in angiogenesis of cancer.

  2004cited by this paper
• Cancer Statistics, 2004

  2004cited by this paper
• Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer

  2004cited by this paper
• Evaluation of vascular endothelial growth factor blockade and matrix metalloproteinase inhibition as a combination therapy for experimental human pancreatic cancer

  2003cited by this paper
• Pancreatic cancer growth is inhibited by blockade of VEGF-RII.

  2003cited by this paper
• Peroxisome Proliferator-Activated Receptor γ Induces Pancreatic Cancer Cell Apoptosis

  2001cited by this paper
• Peroxisome proliferator-activated receptor gamma induces pancreatic cancer cell apoptosis.

  2001cited by this paper
• Expression of thrombospondin-1 in pancreatic carcinoma: correlation with microvessel density

  2001cited by this paper
• A New Family of Mediators of Tumor Angiogenesis

  2001cited by this paper
• Differential expression of chemokines in normal pancreas and in chronic pancreatitis.

  2000cited by this paper
• The CXC Chemokine, Monokine Induced by Interferon-gamma, Inhibits Non-Small Cell Lung Carcinoma Tumor Growth and Metastasis

  2000cited by this paper
• Autocrine Growth Effect of IL-8 and GRO&agr; on a Human Pancreatic Cancer Cell Line, Capan-1

  2000cited by this paper
• Regulation of Interleukin-8 Expression by Cellular pH in Human Pancreatic Adenocarcinoma Cells

  2000cited by this paper
• CXC chemokines in angiogenesis

  2000cited by this paper
• The CXC Chemokine Receptor 2, CXCR2, Is the Putative Receptor for ELR+ CXC Chemokine-Induced Angiogenic Activity1

  2000cited by this paper
• Cooperation Between Transcription Factor AP-1 and NF-kappa B in the Induction of Interleukin-8 in Human Pancreatic Adenocarcinoma Cells by Hypoxia

  1999cited by this paper
• Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic.

  1999cited by this paper
• Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.

  1998cited by this paper
• The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

  1998cited by this paper
• Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression

  1997cited by this paper
• The CXC chemokines, IL-8 and IP-10, regulate angiogenic activity in idiopathic pulmonary fibrosis.

  1997cited by this paper
• Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases

  1996cited by this paper
• Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice.

  1996influential reference
• Angiogenesis in cancer, vascular, rheumatoid and other disease

  1995cited by this paper
• The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis (*)

  1995cited by this paper
• Role of C‐X‐C chemokines as regulators of angiogenesis in lung cancer

  1995cited by this paper
• Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma

  1994cited by this paper

• Exploring the Therapeutic Potential of Evodia rutaecarpa in Early-Onset Pancreatic Cancer: A Network Pharmacology and Molecular Docking Approach.

  2025cites this paper
• Photobiomodulation Reduces Fibrous Scar Formation After Spinal Cord Injury by Downregulating CXCL3 Expression in Macrophages

  2025cites this paper
• Fighting cancer smarter: Using hydrogel delivery systems to target chemokines.

  2025cites this paper
• CXCL3: A key player in tumor microenvironment and inflammatory diseases.

  2024cites this paper
• Adverse effects of CXCR2 deficiency in mice reared under non-gnotobiotic conditions

  2024cites this paper
• CTC-neutrophil interaction: A key driver and therapeutic target of cancer metastasis.

  2024cites this paper
• Neutrophils as promising therapeutic targets in pancreatic cancer liver metastasis.

  2024cites this paper
• 3D cell models for studying tumor-immunity interactions and testing immunotherapeutic drugs

  2023cites this paper
• Chronic inflammation and cancer; the two sides of a coin.

  2023cites this paper
• The roles of phospholipase C-β related signals in the proliferation, metastasis and angiogenesis of malignant tumors, and the corresponding protective measures

  2023cites this paper
• Extracellular vesicles promote activation of pro-inflammatory cancer-associated fibroblasts in oral cancer

  2023cites this paper
• Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers.

  2023cites this paper
• A Bitter Taste Receptor as a Novel Molecular Target on Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma

  2023cites this paper
• Targeting CXCL5 in Pancreatic Cancer Cells Inhibits Cancer Xenograft Growth by Reducing Proliferation and Inhibiting EMT Progression

  2022cites this paper
• Anti-macrophage migration inhibitory factor (MIF) activity of ibudilast: A repurposing drug attenuates the pathophysiology of leptospirosis.

  2022cites this paper
• The Role of CXC Chemokines in Cancer Progression

  2022cites this paper
• Antitumor and Radiosensitization Effects of a CXCR2 Inhibitor in Nasopharyngeal Carcinoma

  2021cites this paper
• Cell-Cell Interaction | Chemokine Receptors

  2021cites this paper
• Macrophage migration inhibitory factor (MIF): A multifaceted cytokine regulated by genetic and physiological strategies.

  2021cites this paper
• Tumor promoting capacity of polymorphonuclear myeloid‐derived suppressor cells and their neutralization

  2021cites this paper
• Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin

  2021cites this paper
• Chronic restraint stress promotes the mobilization and recruitment of myeloid‐derived suppressor cells through β‐adrenergic‐activated CXCL5‐CXCR2‐Erk signaling cascades

  2021cites this paper
• Host Cxcr2-dependent regulation of pancreatic cancer growth, angiogenesis, and metastasis.

  2021cites this paper
• Chronic Pancreatitis and the Development of Pancreatic Cancer.

  2020cites this paper
• 3D Tumor Models and Their Use for the Testing of Immunotherapies

  2020cites this paper
• Centromere protein F is identified as a novel therapeutic target by genomics profile and contributing to the progression of pancreatic cancer.

  2020cites this paper
• CXCR2 signaling promotes secretory cancer‐associated fibroblasts in pancreatic ductal adenocarcinoma

  2020cites this paper
• Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5

  2020cites this paper
• Functions of the CXC ligand family in the pancreatic tumor microenvironment.

  2018cites this paper
• Chemokine Heterocomplexes and Cancer: A Novel Chapter to Be Written in Tumor Immunity

  2018cites this paper
• Prognostic significance of CXCL5 expression in cancer patients: a meta-analysis

  2018cites this paper
• Targeting CXCR2+ Neuroendocrine-like Cells for the Treatment of Castration-resistant Prostate Cancer

  2017cites this paper
• Cxc group chemokines as biomarkersof non-small cell lung cancer

  2017cites this paper
• Role of the CXCL 8-CXCR 1 / 2 Axis in Cancer and Inflammatory Diseases

  2017cites this paper
• PBRM1 regulates proliferation and the cell cycle in renal cell carcinoma through a chemokine/chemokine receptor interaction pathway

  2017cites this paper
• Duffy antigen receptor for chemokines (DARC) expressing in cancer cells inhibits tumor progression by suppressing CXCR2 signaling in human pancreatic ductal adenocarcinoma

  2017cites this paper
• Lymph node metastasis and the physicochemical micro-environment of pancreatic ductal adenocarcinoma xenografts

  2017cites this paper
• CXCR2 +1208 CT genotype may predict earlier clinical stage at diagnosis in patients with prostate cancer

  2017cites this paper
• Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases

  2017cites this paper
• Overexpression of CXCL3 can enhance the oncogenic potential of prostate cancer

  2016cites this paper
• Chemotherapy-Induced Inflammatory Gene Signature and Protumorigenic Phenotype in Pancreatic CAFs via Stress-Associated MAPK

  2016cites this paper
• Silencing of CXCR2 and CXCR7 protects against esophageal cancer.

  2016cites this paper
• The role of the tumour microenvironment in arginine deprivation in malignant pleural mesothelioma

  2016cites this paper
• miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma

  2016cites this paper
• The emerging role of chemokine receptor CXCR2 in cancer progression

  2016cites this paper
• The Role of CXCR2 in Pancreatic Cancer Development and Progression

  2015influential citation
• Association between preeclampsia and the CXC chemokine family (Review).

  2015cites this paper
• Estudo de polimorfismos dos genes CXCR2 e IL-8 em pacientes com câncer de próstata e grupo controle

  2015cites this paper
• Progress of Transforming Growth Factor ( TGF-Beta ) Gene Regulation and Invasion and Metastasis of Pancreatic Cancer

  2015cites this paper
• The concept and controversy of retroperitoneal nerve dissection in pancreatic head carcinoma (Review).

  2015cites this paper
• High expression of CXCR-2 correlates with lymph node metastasis and predicts unfavorable prognosis in resected esophageal carcinoma

  2014cites this paper
• Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

  2014cites this paper
• The chemokine receptors CXCR1 and CXCR2 regulate oral cancer cell behaviour.

  2014cites this paper
• Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue

  2014cites this paper
• University of Dundee Expression of CXCL10 is associated with response to radiotherapy and overall survival in squamous cell carcinoma of the tongue Rentoft,

  2014cites this paper
• Roles of CXCL5 on migration and invasion of liver cancer cells

  2014cites this paper
• Characterising the tumour microenvironment in pancreatic cancer and the changes elicited by targeted therapies

  2014cites this paper
• Proteomic signatures of angiogenesis in androgen‐independent prostate cancer

  2014cites this paper
• The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment

  2014cites this paper
• CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

  2014cites this paper
• The chemokine receptor-CXCR2 plays a critical role in the invasion and metastases of oral squamous cell carcinoma in vitro and in vivo.

  2014cites this paper
• A combination of in vitro techniques for efficient discovery of functional monoclonal antibodies against human CXC chemokine receptor-2 (CXCR2)

  2014cites this paper
• G protein-coupled receptors revisited: therapeutic applications inspired by synthetic biology.

  2014cites this paper
• Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes

  2014cites this paper
• CXCR 2 in Acute Lung Injury

  2014cites this paper
• CXCR2 macromolecular complex in pancreatic cancer: a potential therapeutic target in tumor growth.

  2013cites this paper
• Contribution of bone marrow derived cells to the pancreatic tumor microenvironment

  2013cites this paper
• CXCL5 (chemokine (C-X-C motif) ligand 5)

  2013cites this paper
• An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseases.

  2013cites this paper
• CXCR2: a target for pancreatic cancer treatment?

  2013influential citation
• Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

  2013cites this paper
• The effects of Ang-1, IL-8 and TGF-β1 on the pathogenesis of COPD.

  2012cites this paper
• CXCR2 in Acute Lung Injury

  2012cites this paper
• Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma

  2012cites this paper
• CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer.

  2012cites this paper
• Targeting the cancer-stroma interaction: a potential approach for pancreatic cancer treatment.

  2012cites this paper
• The emerging role of CXC chemokines and their receptors in cancer.

  2012cites this paper
• Chemokines as mediators of tumor angiogenesis and neovascularization.

  2011cites this paper
• Gender-specific genomic profiling in metastatic colorectal cancer patients treated with 5-fluorouracil and oxaliplatin.

  2011cites this paper
• Role of chemokine receptor CXCR2 expression in mammary tumor growth, angiogenesis and metastasis

  2011cites this paper
• Anti-angiogenic agents in pancreatic cancer: a review.

  2011cites this paper
• PEDF inhibits IL8 production in prostate cancer cells through PEDF receptor/phospholipase A2 and regulation of NFκB and PPARγ.

  2011cites this paper
• Proliferative and survival pathways in oesophageal cancer

  2011cites this paper
• Recent Advances in Underlying Pathologies Provide Insight into Interleukin-8 Expression-Mediated Inflammation and Angiogenesis

  2011cites this paper
• Tumorigenesis and Neoplastic Progression Overexpression of CXCL5 Is Associated With Poor Survival in Patients With Pancreatic Cancer

  2011cites this paper
• Suppression of the uPAR–uPA System Retards Angiogenesis, Invasion, and In Vivo Tumor Development in Pancreatic Cancer Cells

  2011cites this paper
• Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer

  2011cites this paper
• Low Molecular Weight CXCR2 Antagonists as Promising Therapeutics

  2011cites this paper
• Envolvimento dos receptores CXCR2 para quimiocinas no carcinoma espinocelular oral

  2010cites this paper
• Angiogenesis signaling pathways as targets in cancer therapy

  2010cites this paper
• Quantitative proteomic profiling studies of pancreatic cancer stem cells.

  2010cites this paper
• CXC chemokines in cancer angiogenesis and metastases.

  2010cites this paper
• The expression of IL-8 and IL-8 receptors in pancreatic adenocarcinomas and pancreatic neuroendocrine tumours.

  2010cites this paper
• Combined effects of IL-8 and CXCR2 gene polymorphisms on breast cancer susceptibility and aggressiveness

  2010cites this paper
• Osteoclasts are important for bone angiogenesis.

  2010cites this paper
• New insights in synovial angiogenesis.

  2010cites this paper
• Actualités sur l'angiogenèse synoviale

  2010cites this paper
• Neutrophils: key mediators of tumour angiogenesis

  2009cites this paper
• CXC‐chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer

  2009cites this paper
• The role of chemokines in cancer immune surveillance by the adaptive immune system.

  2009cites this paper