The Role of Thymic Epithelium in the Establishment of Transplantation Tolerance

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Immunological Reviews

• Publication date

  1993-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1600-065X.1993.tb01518.xPMID 8225369
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Brief Definitive Report INTRATHYMIC ELIMINATION OF Mlsa-REACTIVE (V06 ' ) CELLS DURING NEONATAL TOLERANCE INDUCTION TO Mlsa-ENCODED ANTIGENS

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• Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness.

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• Thymic epithelium induces neither clonal deletion nor anergy to Mls 1a antigens

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• Transplantation tolerance is unrelated to superantigen-dependent deletion and anergy.

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• Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4+ and CD8+ T cells

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• Suppression of development of diabetes in NOD mice by lactate dehydrogenase virus infection.

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• Some reasons why deletion and anergy do not satisfactorily account for natural tolerance.

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• Reentry of T cells to the adult thymus is restricted to activated T cells

  1991cited by this paper
• Non‐Deletional Mechanisms of Peripheral and Central Tolerance: Studies with Transgenic Mice with Tissue‐Specific Expression of a Foreign MHC Class I Antigen

  1991cited by this paper
• Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice.

  1991influential reference
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• Tissue-specific expression of allogeneic class II MHC molecules induces neither tissue rejection nor clonal inactivation of alloreactive T cells.

  1990cited by this paper
• Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma.

  1990cited by this paper
• Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

  1990cited by this paper
• Neonatal tolerance induction by class II alloantigens activates IL-4-secreting, tolerogen-responsive T cells.

  1990cited by this paper
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  1990cited by this paper
• The expression of influenza virus hemagglutinin in the pancreatic beta cells of transgenic mice results in autoimmune diabetes.

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• Induction of donor-specific unresponsiveness by intrathymic islet transplantation.

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• Evidence for peripheral mechanisms inducing tissue tolerance during ontogeny.

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• Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant.

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• Beyond Clonal Selection and Network

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• Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.

  1989cited by this paper
• Thymic epithelium tolerizes chickens to embryonic graft of quail bursa of Fabricius.

  1989cited by this paper
• Induction of tolerance by embryonic thymic epithelial grafts in birds and mammals.

  1989cited by this paper
• Restoration of T-cell function in nude mice by grafting the epitheliomesenchymal thymic rudiment from 10-day-old euthymic embryos.

  1989cited by this paper
• Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells

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• Tolerize one, tolerize them all: tolerance is self-assertion.

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• Tolerance of class I histocompatibility antigens expressed extrathymically

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• Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy.

  1989cited by this paper
• Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.

  1989cited by this paper
• Transplantation tolerance correlates with high levels of T- and B-lymphocyte activity.

  1989cited by this paper
• Tolerance induction in the adult using monoclonal antibodies to CD4, CD8, and CD11a (LFA-1).

  1989cited by this paper
• T‐Cell Tolerance in Transgenic Mice Expressing Major Histocompatibility Class I Molecules in Defined Tissues

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• V-region connectivity in T cell repertoires.

  1989cited by this paper
• Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells.

  1988cited by this paper
• Implants of quail thymic epithelium generate permanent tolerance in embryonically constructed quail/chick chimeras.

  1988influential reference
• Function of the MHC.

  1988cited by this paper
• Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

  1988cited by this paper
• Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens

  1988cited by this paper
• A novel method to bursectomize avian embryos and obtain quail----chick bursal chimeras. II. Immune response of bursectomized chicks and chimeras and post-natal rejection of the grafted quail bursas.

  1987cited by this paper
• Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

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  1987cited by this paper
• Regulation of Autoimmune Disease Physiological and Therapeutic

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• Antigen recognition by cloned cytotoxic T lymphocytes follows rules predicted by the altered-self hypothesis

  1982cited by this paper
• Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis

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• Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

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• The Origin and Mechanism of the Allograft Reaction

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• T cells mediate transplantation tolerance

  1975cited by this paper
• The clonal nature of allo-antigen-sensitive small lymphocytes in the recirculating pool of normal rats.

  1974cited by this paper
• Importance of chimerism in maintaining tolerance of skin allografts in mice.

  1973cited by this paper
• Effect of blood transfusions on subsequent kidney transplants.

  1973cited by this paper
• Studies on tolerance of the Y chromosome antigen in mice.

  1960cited by this paper
• The induction of tolerance by skin homografts on newborn rats.

  1958cited by this paper
• ‘Actively Acquired Tolerance’ of Foreign Cells

  1953cited by this paper
• Reprints Available Directly from the Publisher Photocopying Permitted by License Only Successful Xenogeneic Transplantation in Embryos" Induction of Tolerance by Extrathymic Chick Tissue Grafted into Quail

  year unknowncited by this paper

• Ferritin heavy chain supports stability and function of the regulatory T cell lineage

  2024cites this paper
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  2021cites this paper
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• An identical mechanism governs self-nonself discrimination and effector class regulation

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