BRCA1 mutation spectrum, functions, and therapeutic strategies: The story so far.

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Current Problems in Cancer

• Publication date

  2018-01-08

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.currproblcancer.2018.01.001PMID 29452958
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MicroRNA in breast cancer: The association with BRCA1/2

  2017cited by this paper
• Prevalence and spectrum of BRCA germline variants in mainland Chinese familial breast and ovarian cancer patients

  2016cited by this paper
• Founder and Recurrent Mutations in BRCA1 and BRCA2 Genes in Latin American Countries: State of the Art and Literature Review.

  2016cited by this paper
• The rate of recurrent BRCA1, BRCA2, and TP53 mutations in the general population, and unselected ovarian cancer cases, in Belo Horizonte, Brazil.

  2016cited by this paper
• Cancer statistics, 2016

  2016cited by this paper
• Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites

  2016cited by this paper
• Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.

  2015cited by this paper
• BRCA Genetic Screening in Middle Eastern and North African: Mutational Spectrum and Founder BRCA1 Mutation (c.798_799delTT) in North African

  2015cited by this paper
• Mutation spectrum and prevalence of BRCA1 and BRCA2 genes in patients with familial and early‐onset breast/ovarian cancer from Tunisia

  2015cited by this paper
• Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function.

  2015cited by this paper
• BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability

  2015cited by this paper
• A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy

  2014cited by this paper
• CtIP-mediated resection is essential for viability and can operate independently of BRCA1

  2014cited by this paper
• Geographical distribution of Slovenian BRCA1/2 families according to family origin: implications for genetic screening

  2014cited by this paper
• BRCA1 accelerates CtIP-mediated DNA-end resection.

  2014cited by this paper
• Frequency of 5382insC mutation of BRCA1 gene among breast cancer patients: an experience from Eastern India

  2013cited by this paper
• Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

  2013cited by this paper
• The deletion of exons 3–5 of BRCA1 is the first founder rearrangement identified in breast and/or ovarian cancer Spanish families

  2013cited by this paper
• Novel and recurrent BRCA1/BRCA2 mutations in early onset and familial breast and ovarian cancer detected in the Program of Genetic Counseling in Cancer of Valencian Community (eastern Spain). Relationship of family phenotypes with mutation prevalence

  2013cited by this paper
• BRCA1 gene mutations frequency estimation by allele-specific real-time PCR of pooled genomic DNA samples.

  2013cited by this paper
• Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE.

  2013cited by this paper
• Comprehensive Analysis of BRCA1, BRCA2 and TP53 Germline Mutation and Tumor Characterization: A Portrait of Early-Onset Breast Cancer in Brazil

  2013cited by this paper
• Inhibition of constitutively activated phosphoinositide 3‐kinase/AKT pathway enhances antitumor activity of chemotherapeutic agents in breast cancer susceptibility gene 1‐defective breast cancer cells

  2013cited by this paper
• Novel and recurrent BRCA1/BRCA2 mutations in early onset and familial breast and ovarian cancer detected in the Program of Genetic Counseling in Cancer of Valencian Community (eastern Spain). Relationship of family phenotypes with mutation prevalence

  2013cited by this paper
• A Comprehensive Focus on Global Spectrum of BRCA1 and BRCA2 Mutations in Breast Cancer

  2013cited by this paper
• The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression

  2013cited by this paper
• BRCA1 and BRCA2 germline mutations in Moroccan breast/ovarian cancer families: novel mutations and unclassified variants.

  2012cited by this paper
• BRCA1 and BRCA2 mutations among familial breast cancer patients from Costa Rica

  2012cited by this paper
• BRCA1 tumor suppressor network: focusing on its tail

  2012cited by this paper
• Screening of 185DelAG, 1014DelGT and 3889DelAG BRCA1 mutations in breast cancer patients from North-East India.

  2012cited by this paper
• MIR-99a and MIR-99b Modulate TGF-β Induced Epithelial to Mesenchymal Plasticity in Normal Murine Mammary Gland Cells

  2012cited by this paper
• Prevalence of BRCA1 and BRCA2 mutations in non-familial breast cancer patients with high risks in Korea: The Korean Hereditary Breast Cancer (KOHBRA) Study

  2012cited by this paper
• Mutation Screening of the BRCA1 Gene in Early Onset and Familial Breast/Ovarian Cancer in Moroccan Population

  2012cited by this paper
• FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response

  2012cited by this paper
• Identification of BRCA1/2 Founder Mutations in Southern Chinese Breast Cancer Patients Using Gene Sequencing and High Resolution DNA Melting Analysis

  2012cited by this paper
• Full-Exon Pyrosequencing Screening of BRCA Germline Mutations in Mexican Women with Inherited Breast and Ovarian Cancer

  2012cited by this paper
• BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site

  2012cited by this paper
• Identification of the prevalent BRCA1 and BRCA2 mutations in the female population of Puerto Rico.

  2012cited by this paper
• Accuracy of BRCA1/2 mutation prediction models in Korean breast cancer patients

  2012cited by this paper
• BRCA1 and MicroRNAs: Emerging networks and potential therapeutic targets

  2012cited by this paper
• Seventeen years after BRCA1: what is the BRCA mutation status of the breast cancer patients in Africa? – a systematic review

  2012cited by this paper
• Epidemiology of Genetic Alterations in Progression of Breast Cancer

  2012cited by this paper
• Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer

  2012cited by this paper
• Structure-Function of the Tumor Suppressor BRCA1

  2012cited by this paper
• Prevalence of mutations BRCA1 5382insC, and CHEK2 1100delC in the population of Siberian region

  2012cited by this paper
• Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals

  2011cited by this paper
• NBA1/MERIT40 and BRE Interaction Is Required for the Integrity of Two Distinct Deubiquitinating Enzyme BRCC36-containing Complexes*

  2011cited by this paper
• Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.

  2011cited by this paper
• miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.

  2011cited by this paper
• Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Greece

  2011cited by this paper
• Novel agents and future directions for refractory breast cancer.

  2011cited by this paper
• Breast and Ovarian Cancer Risk due to Prevalence of BRCA1 and BRCA2 Variants in Pakistani Population: A Pakistani Database Report

  2011cited by this paper
• Comprehensive genetic characterization of hereditary breast/ovarian cancer families from Slovakia

  2011cited by this paper
• Germline mutations in BRCA1 and BRCA2 genes in ethnically diverse high risk families in Israel

  2011cited by this paper
• Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population

  2011cited by this paper
• BRCA1 and BRCA2 germline mutations in 85 Iranian breast cancer patients

  2011cited by this paper
• Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

  2011cited by this paper
• Efficacy of neoadjuvant Cisplatin in triple-negative breast cancer.

  2010cited by this paper
• A high prevalence of BRCA1 mutations among breast cancer patients from the Bahamas

  2010cited by this paper
• Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass

  2010cited by this paper
• BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.

  2010cited by this paper
• Searching for large genomic rearrangements of the BRCA1 gene in a Nigerian population

  2010cited by this paper
• BRCA1 and BRCA2 Germline Mutations Screening in Algerian Breast/Ovarian Cancer Families

  2010cited by this paper
• Tumor and Stem Cell Biology Cancer Research BRD 7 , a Subunit of SWI / SNF Complexes , Binds Directly to BRCA 1 and Regulates BRCA 1-Dependent Transcription

  2010cited by this paper
• BRCA1-IRIS overexpression promotes cisplatin resistance in ovarian cancer cells.

  2010cited by this paper
• Presymptomatic breast cancer in Egypt: role of BRCA1 and BRCA2 tumor suppressor genes mutations detection

  2010cited by this paper
• BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.

  2010cited by this paper
• Founder BRCA1/2 mutations in the Europe: implications for hereditary breast-ovarian cancer prevention and control

  2010cited by this paper
• Identification of novel large genomic rearrangements at the BRCA1 locus in Malaysian women with breast cancer.

  2010cited by this paper
• Cancer esearch apeutics , Targets , and Chemical Biology A 1-IRIS Overexpression Promotes Cisplatin R istance in Ovarian Cancer Cells

  2010cited by this paper
• AKT regulates BRCA1 stability in response to hormone signaling.

  2010cited by this paper
• BRCA1 16 years later: DNA damage‐induced BRCA1 shuttling

  2010cited by this paper
• BRCA1 16 years later: risk‐associated BRCA1 mutations and their functional implications

  2010cited by this paper
• High frequency and allele‐specific differences of BRCA1 founder mutations in breast cancer and ovarian cancer patients from Belarus

  2010cited by this paper
• Turnover of BRCA1 Involves in Radiation-Induced Apoptosis

  2010cited by this paper
• CtIP links DNA double-strand break sensing to resection.

  2009cited by this paper
• MicroRNAs in cancer: small molecules with a huge impact.

  2009cited by this paper
• NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control.

  2009cited by this paper
• The Contribution of BRCA1 and BRCA2 to Ovarian Cancer

  2009cited by this paper
• Comprehensive mutational analysis of BRCA1/BRCA2 for Korean breast cancer patients: evidence of a founder mutation

  2009cited by this paper
• BRCA1 and BRCA2 germline mutation analysis among Indian women from south India: identification of four novel mutations and high-frequency occurrence of 185delAG mutation

  2009cited by this paper
• Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes.

  2009cited by this paper
• Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair*S⃞

  2009cited by this paper
• K63‐specific deubiquitination by two JAMM/MPN+ complexes: BRISC‐associated Brcc36 and proteasomal Poh1

  2009cited by this paper
• Predicting invasive phenotype with CDH1, CDH13, CD44, and TIMP3 gene expression in primary breast cancer

  2009cited by this paper
• BRCA1 germline mutations and tumor characteristics in Chinese women with familial or early-onset breast cancer

  2009cited by this paper
• BRCA1 and BRCA2 Germline Mutations in Malaysian Women with Early-Onset Breast Cancer without a Family History

  2008cited by this paper
• Rapid Recruitment of BRCA1 to DNA Double-Strand Breaks Is Dependent on Its Association with Ku80

  2008cited by this paper
• G1738R is a BRCA1 founder mutation in Greek breast/ovarian cancer patients: evaluation of its pathogenicity and inferences on its genealogical history

  2008cited by this paper
• MLPA screening in the BRCA1 gene from 1,506 German hereditary breast cancer cases: novel deletions, frequent involvement of exon 17, and occurrence in single early‐onset cases

  2008cited by this paper
• Novel sequence variants and a high frequency of recurrent polymorphisms in BRCA1 gene in Sri Lankan breast cancer patients and at risk individuals

  2008cited by this paper
• Spectrum and characterisation of BRCA1 and BRCA2 deleterious mutations in high-risk Czech patients with breast and/or ovarian cancer

  2008cited by this paper
• Reverse the curse--the role of deubiquitination in cell cycle control.

  2008cited by this paper
• BRCA1 and BRCA2 mutations in Danish families with hereditary breast and/or ovarian cancer

  2008cited by this paper
• BRCA1 mutations in Algerian breast cancer patients: high frequency in young, sporadic cases

  2008cited by this paper
• Evidence against PALB2 involvement in Icelandic breast cancer susceptibility

  2008cited by this paper
• BRCA1 and BRCA2 Mutation Prevalence and Clinical Characteristics of a Population-Based Series of Ovarian Cancer Cases from Denmark

  2008cited by this paper
• Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba

  2008cited by this paper
• Negative Regulation of AKT Activation by BRCA1.

  2008cited by this paper
• Cross‐sectional analysis of germline BRCA1 and BRCA2 mutations in Japanese patients suspected to have hereditary breast/ovarian cancer

  2008cited by this paper

• Systematic proteomics analysis revealed different expression of laminin interaction proteins in breast cancer: lower in luminal subtype and higher in claudin-low subtype

  2024cites this paper
• Protein Signatures of Parathyroid Adenoma according to Tumor Volume and Functionality

  2024cites this paper
• Unraveling the Role of BRCA1 variants in Dysregulation of Transcriptional and Post-Transcriptional Mechanisms in Breast Cancer

  2024cites this paper
• BRCA1 VUS: A functional analysis to differentiate pathogenic from benign variants identified in clinical diagnostic panels for breast cancer

  2023cites this paper
• The Impact of BRCA1 Expression on Survival Status in Ovarian Serous Carcinoma of Egyptian Patients

  2023cites this paper
• ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of nonapoptotic phosphatidylserine

  2022cites this paper
• S100A9-CXCL12 activation in BRCA1-mutant breast cancer promotes an immunosuppressive microenvironment associated with resistance to immunotherapy

  2022cites this paper
• Identification of the most common BRCA alterations through analysis of germline mutation databases: Is droplet digital PCR an additional strategy for the assessment of such alterations in breast and ovarian cancer families?

  2022cites this paper
• Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects

  2021cites this paper
• Genetic Alterations in Ovarian Cancer as Prognostic and Predictive Biomarkers of Therapy Response and Surgical Outcomes

  2021cites this paper
• Assessing BRCA1 activity in DNA damage repair using human induced pluripotent stem cells as an approach to assist classification of BRCA1 variants of uncertain significance

  2021cites this paper
• Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target

  2021influential citation
• Hypermethylation of RAD9A intron 2 in childhood cancer patients and tumor cell lines CURRENT

  2020cites this paper
• Design of potential anti-tumor PARP-1 inhibitors by QSAR and molecular modeling studies

  2020cites this paper
• Identification of regulatory crosstalks between RKIP and BRCA1 tumor suppressors in healthy tissues and cancer (breast and ovarian): Therapeutic implications

  2020cites this paper
• [Molecular pathways of autophagy regulation by BRCA1: Implications in cancer].

  2020cites this paper
• Synthetic Lethal Activity of Benzophenanthridine Alkaloids From Zanthoxylum coco Against BRCA1-Deficient Cancer Cells

  2020cites this paper
• Distinct associations of the Saccharomyces cerevisiae Rad9 protein link Mac1-regulated transcription to DNA repair

  2019cites this paper
• BCL10 in cell survival after DNA damage.

  2019cites this paper
• A new bioinformatics tool to help assess the significance of BRCA1 variants

  2018cites this paper
• Circulating RANKL , Osteoprotegerin and Breast Cancer Risk in BRCA 1 and BRCA 2 Mutation Carriers

  2018influential citation
• Germline Pathogenic Variants in Homologous Recombination and DNA Repair Genes in an Asian Cohort of Young-Onset Colorectal Cancer

  2018influential citation